mutLBSgeneDB |
Gene summary for DUSP3 |
Gene summary |
Basic gene Info. | Gene symbol | DUSP3 |
Gene name | dual specificity phosphatase 3 | |
Synonyms | VHR | |
Cytomap | UCSC genome browser: 17q21 | |
Type of gene | protein-coding | |
RefGenes | NM_004090.3, | |
Description | dual specificity protein phosphatase 3dual specificity protein phosphatase VHRserine/threonine specific protein phosphatasevaccinia H1-related phosphatasevaccinia virus phosphatase VH1-related | |
Modification date | 20141207 | |
dbXrefs | MIM : 600183 | |
HGNC : HGNC | ||
Ensembl : ENSG00000108861 | ||
HPRD : 02553 | ||
Vega : OTTHUMG00000180889 | ||
Protein | UniProt: P51452 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_DUSP3 | |
BioGPS: 1845 | ||
Pathway | NCI Pathway Interaction Database: DUSP3 | |
KEGG: DUSP3 | ||
REACTOME: DUSP3 | ||
Pathway Commons: DUSP3 | ||
Context | iHOP: DUSP3 | |
ligand binding site mutation search in PubMed: DUSP3 | ||
UCL Cancer Institute: DUSP3 | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO Term | PubMed ID | GO:0035335 | peptidyl-tyrosine dephosphorylation | 11863439 | GO:0046329 | negative regulation of JNK cascade | 11085983 | GO:0050860 | negative regulation of T cell receptor signaling pathway | 12447358 | GO:0050868 | negative regulation of T cell activation | 12447358 | GO:0070373 | negative regulation of ERK1 and ERK2 cascade | 11085983 |
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Ligand binding site mutations for DUSP3 |
Cancer type specific mutLBS sorted by frequency |
LBS | AAchange of nsSNV | Cancer type | # samples | C124 | V122I | COAD | 2 | D92 | D92G | COAD | 1 | D164 | G165D | COAD | 1 | R130 | R130C | KIRC | 1 | D164 | G165V | LUAD | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for DUSP3 |
Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
: nsSNV at non-LBS: nsSNV at LBS |
nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | C124 | V122I | -0.95908219 | R130 | R130C | -0.60949169 | D164 | G165D | -0.42431989 | D92 | D92G | -0.39959925 | D164 | G165V | -0.15794103 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
Structure image for DUSP3 from PDB |
PDB ID | PDB title | PDB structure | 1VHR | HUMAN VH1-RELATED DUAL-SPECIFICITY PHOSPHATASE |
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Differential gene expression and gene-gene network for DUSP3 |
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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Phenotype information for DUSP3 |
Gene level disease information (DisGeNet) |
Disease ID | Disease name | # PubMed | Association type |
umls:C0007131 | Carcinoma, Non-Small-Cell Lung | 3 | Biomarker |
Mutation level pathogenic information (ClinVar annotation) |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for DUSP3 |
Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
Gene-centered drug-gene interaction network |
Drug information targeting mutLBSgene (Approved drugs only) |
Drug status | DrugBank ID | Name | Type | Drug structure |
Gene-centered ligand-gene interaction network |
Ligands binding to mutated ligand binding site of DUSP3 go to BioLip |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | STT | 2-(5-METHYL-4-OXO-2-THIOXO-2,4-DIHYDRO-3H-1LAMBDA~4~,3-THIAZOL-3-YL)ETHANESULFONIC ACID | 3f81 | A | D92 C124 R130 | STT | 2-(5-METHYL-4-OXO-2-THIOXO-2,4-DIHYDRO-3H-1LAMBDA~4~,3-THIAZOL-3-YL)ETHANESULFONIC ACID | 3f81 | B | D92 C124 R130 | III | Peptide ligand (ASP,ASP,GLU,ALA,THR,GLY,TYR,VAL,ALA,THR,ARG) | 1j4x | A | D92 R130 D164 |
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Conservation information for LBS of DUSP3 |
Multiple alignments for P51452 in multiple species |
LBS | AA sequence | # species | Species |
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