mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for DUSP3
Gene summary
Basic gene Info.Gene symbolDUSP3
Gene namedual specificity phosphatase 3
SynonymsVHR
CytomapUCSC genome browser: 17q21
Type of geneprotein-coding
RefGenesNM_004090.3,
Descriptiondual specificity protein phosphatase 3dual specificity protein phosphatase VHRserine/threonine specific protein phosphatasevaccinia H1-related phosphatasevaccinia virus phosphatase VH1-related
Modification date20141207
dbXrefs MIM : 600183
HGNC : HGNC
Ensembl : ENSG00000108861
HPRD : 02553
Vega : OTTHUMG00000180889
ProteinUniProt: P51452
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_DUSP3
BioGPS: 1845
PathwayNCI Pathway Interaction Database: DUSP3
KEGG: DUSP3
REACTOME: DUSP3
Pathway Commons: DUSP3
ContextiHOP: DUSP3
ligand binding site mutation search in PubMed: DUSP3
UCL Cancer Institute: DUSP3
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0035335peptidyl-tyrosine dephosphorylation11863439
GO:0046329negative regulation of JNK cascade11085983
GO:0050860negative regulation of T cell receptor signaling pathway12447358
GO:0050868negative regulation of T cell activation12447358
GO:0070373negative regulation of ERK1 and ERK2 cascade11085983


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Ligand binding site mutations for DUSP3

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
C124V122ICOAD2
D92D92GCOAD1
D164G165DCOAD1
R130R130CKIRC1
D164G165VLUAD1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for DUSP3
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
C124V122I-0.95908219
R130R130C-0.60949169
D164G165D-0.42431989
D92D92G-0.39959925
D164G165V-0.15794103
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for DUSP3 from PDB
PDB IDPDB titlePDB structure
1VHRHUMAN VH1-RELATED DUAL-SPECIFICITY PHOSPHATASE

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Differential gene expression and gene-gene network for DUSP3
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of DUSP3 and the right PPI network was created from samples without mutations in the LBS of DUSP3. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for DUSP3
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0007131Carcinoma, Non-Small-Cell Lung3Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for DUSP3
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of DUSP3 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
STT2-(5-METHYL-4-OXO-2-THIOXO-2,4-DIHYDRO-3H-1LAMBDA~4~,3-THIAZOL-3-YL)ETHANESULFONIC ACID3f81AD92 C124 R130
STT2-(5-METHYL-4-OXO-2-THIOXO-2,4-DIHYDRO-3H-1LAMBDA~4~,3-THIAZOL-3-YL)ETHANESULFONIC ACID3f81BD92 C124 R130
IIIPeptide ligand (ASP,ASP,GLU,ALA,THR,GLY,TYR,VAL,ALA,THR,ARG)1j4xAD92 R130 D164


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Conservation information for LBS of DUSP3
Multiple alignments for P51452 in multiple species
LBSAA sequence# speciesSpecies


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