mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for AGTR1
Gene summary
Basic gene Info.Gene symbolAGTR1
Gene nameangiotensin II receptor, type 1
CytomapUCSC genome browser: 3q24
Type of geneprotein-coding
Descriptiontype-1 angiotensin II receptortype-1B angiotensin II receptor
Modification date20141222
dbXrefs MIM : 106165
Ensembl : ENSG00000144891
HPRD : 00107
Vega : OTTHUMG00000159503
ProteinUniProt: P30556
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_AGTR1
BioGPS: 185
PathwayNCI Pathway Interaction Database: AGTR1
Pathway Commons: AGTR1
ContextiHOP: AGTR1
ligand binding site mutation search in PubMed: AGTR1
UCL Cancer Institute: AGTR1
Assigned class in mutLBSgeneDBB: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO:0007186G-protein coupled receptor signaling pathway1378723
GO:0007204positive regulation of cytosolic calcium ion concentration1567413
GO:0007266Rho protein signal transduction15611106
GO:0019229regulation of vasoconstriction15117835
GO:0019722calcium-mediated signaling1567413
GO:0038166angiotensin-activated signaling pathway15611106
GO:0051482positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway1567413
GO:0060326cell chemotaxis15635042
GO:0086097phospholipase C-activating angiotensin-activated signaling pathway10993080

Ligand binding site mutations for AGTR1
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for AGTR1
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for AGTR1 from PDB

Differential gene expression and gene-gene network for AGTR1
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of AGTR1 and the right PPI network was created from samples without mutations in the LBS of AGTR1. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for AGTR1
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0020538Hypertension194AlteredExpression, Biomarker, GeneticVariation
umls:C0085580Hypertension, Essential44Biomarker, GeneticVariation
umls:C0022658Kidney Diseases22Biomarker, GeneticVariation
umls:C0018801Heart Failure14AlteredExpression, Biomarker, GeneticVariation, Therapeutic
umls:C0162871Aortic Aneurysm, Abdominal7Biomarker, GeneticVariation
umls:C0033687Proteinuria5Biomarker, GeneticVariation
umls:C0011884Diabetic Retinopathy4Biomarker, GeneticVariation
umls:C0013274Ductus Arteriosus, Patent2Biomarker, GeneticVariation
umls:C0000786Abortion, Spontaneous2Biomarker, GeneticVariation
umls:C0266313Allanson Pantzar McLeod syndrome1Biomarker, GeneticVariation
umls:C0887833Carcinoma, Pancreatic Ductal1Biomarker
umls:C0027627Neoplasm Metastasis1Biomarker
umls:C0032019Pituitary Neoplasms1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for AGTR1
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
Approved|investigationalDB00177ValsartanSmall molecule
Approved|investigationalDB00275OlmesartanSmall molecule
ApprovedDB00678LosartanSmall molecule
ApprovedDB00796CandesartanSmall molecule
ApprovedDB00876EprosartanSmall molecule
Approved|investigationalDB00966TelmisartanSmall molecule
Approved|investigationalDB01029IrbesartanSmall molecule
ApprovedDB01342ForasartanSmall molecule
ApprovedDB01347SaprisartanSmall molecule
ApprovedDB01349TasosartanSmall molecule
ApprovedDB08822Azilsartan medoxomilSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of AGTR1 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
ZD75,7-DIETHYL-1-{[2'-(1H-TETRAZOL-5-YL)BIPHENYL-4- YL]METHYL}-3,4-DIHYDRO-1,6-NAPHTHYRIDIN-2(1H)-ONE4yayAY35 V108 A163 R167 P285 Y292
OLMOLMESARTAN4zudAY35 V108 R167 Y292

Conservation information for LBS of AGTR1
Multiple alignments for P30556 in multiple species
LBSAA sequence# speciesSpecies

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