mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for AHCY
Gene summary
Basic gene Info.Gene symbolAHCY
Gene nameadenosylhomocysteinase
SynonymsSAHH|adoHcyase
CytomapUCSC genome browser: 20q11.22
Type of geneprotein-coding
RefGenesNM_000687.2,
NM_001161766.1,
DescriptionS-adenosyl-L-homocysteine hydrolaseS-adenosylhomocysteine hydrolase
Modification date20141207
dbXrefs MIM : 180960
HGNC : HGNC
Ensembl : ENSG00000101444
HPRD : 01621
Vega : OTTHUMG00000140098
ProteinUniProt: P23526
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_AHCY
BioGPS: 191
PathwayNCI Pathway Interaction Database: AHCY
KEGG: AHCY
REACTOME: AHCY
Pathway Commons: AHCY
ContextiHOP: AHCY
ligand binding site mutation search in PubMed: AHCY
UCL Cancer Institute: AHCY
Assigned class in mutLBSgeneDBB: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID


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Ligand binding site mutations for AHCY

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
K426P427LBRCA1
T242I241TCOAD1
E156E155KHNSC1
C195R196LLUAD1
K426K426NUCEC1
N248A249TUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for AHCY
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
C195R196L0.53481114
T242I241T-1.2780587
K426K426N-0.96028224
N248A249T-0.676496
E156E155K-0.59218987
K426P427L-0.52185195
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for AHCY from PDB

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Differential gene expression and gene-gene network for AHCY
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of AHCY and the right PPI network was created from samples without mutations in the LBS of AHCY. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for AHCY
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C3151058Hypermethioninemia with Deficiency of S-Adenosylhomocysteine Hydrolase2GeneticVariation
umls:C0002514Amino Acid Metabolism, Inborn Errors1Biomarker
umls:C0003130Anoxia1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for AHCY
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
ApprovedDB02325Isopropyl AlcoholSmall molecule
ExperimentalDB03216(1'r,2's)-9-(2-Hydroxy-3'-Keto-Cyclopenten-1-Yl)AdenineSmall molecule
ExperimentalDB032733'-Oxo-AdenosineSmall molecule
ExperimentalDB03769D-EritadenineSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of AHCY go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
NADNAD ZWITTERION3nj4BC195 T242 N248
NADNAD ZWITTERION4pfjAC195 T242 N248
NADNAD ZWITTERION4pfjBC195 T242 N248
NADNAD ZWITTERION4pgfAC195 T242 N248
NADNAD ZWITTERION4pgfBC195 T242 N248
NAINADH4yvfAC195 T242 N248
NAINADH4yvfBC195 T242 N248
ADC(1'R,2'S)-9-(2-HYDROXY-3'-KETO-CYCLOPENTEN-1-YL)ADENINE1a7aAE156
ADC(1'R,2'S)-9-(2-HYDROXY-3'-KETO-CYCLOPENTEN-1-YL)ADENINE1a7aBE156
NOC 2-[(6-AMINOPURIN-7-YL)METHOXY]ETHANOL1li4AE156
AFX(4S,5S)-4-(6-AMINO-9H-PURIN-9-YL)-3-FLUORO-5-HYDROXY-2-(HYDROXYMETHYL)CYCLOPENT-2-EN-1-ONE3nj4AE156
AFX(4S,5S)-4-(6-AMINO-9H-PURIN-9-YL)-3-FLUORO-5-HYDROXY-2-(HYDROXYMETHYL)CYCLOPENT-2-EN-1-ONE3nj4BE156
AFX(4S,5S)-4-(6-AMINO-9H-PURIN-9-YL)-3-FLUORO-5-HYDROXY-2-(HYDROXYMETHYL)CYCLOPENT-2-EN-1-ONE3nj4CE156
AFX(4S,5S)-4-(6-AMINO-9H-PURIN-9-YL)-3-FLUORO-5-HYDROXY-2-(HYDROXYMETHYL)CYCLOPENT-2-EN-1-ONE3nj4DE156
ADNADENOSINE4pfjAE156
ADNADENOSINE4pfjBE156
ADNADENOSINE4pgfAE156
ADNADENOSINE4pgfBE156
NADNAD ZWITTERION1a7aAK426
NADNAD ZWITTERION1a7aBK426
NADNAD ZWITTERION3nj4AK426
NADNAD ZWITTERION3nj4BK426
NADNAD ZWITTERION3nj4CK426
NADNAD ZWITTERION3nj4DK426
NAINADH4yvfAK426
NAINADH4yvfBK426
NADNAD ZWITTERION1a7aAN248
NADNAD ZWITTERION1a7aBN248
NADNAD ZWITTERION1li4AT242 N248
NADNAD ZWITTERION3nj4AT242 N248
NADNAD ZWITTERION3nj4CT242 N248
NADNAD ZWITTERION3nj4DT242 N248


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Conservation information for LBS of AHCY
Multiple alignments for P23526 in multiple species
LBSAA sequence# speciesSpecies
C195DNLYGCRESLI5Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Drosophila melanogaster
C195DNLYGCRHSLP2Arabidopsis thaliana, Arabidopsis thaliana
C195DNLYGCRESLV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
C195DNLFGCKESLV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C195DNLYGIRESLP1Caenorhabditis elegans
C195DNLYGCRESLL1Anopheles gambiae
C278VTTTGCVDIIL2Mus musculus, Rattus norvegicus
C278VTTTGCIDIIL1Homo sapiens
C278CTTTGNKDIIM1Arabidopsis thaliana
C278VTTTGNKDIIM1Arabidopsis thaliana
C278VTTTGCRDIIN1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
C278VTTTGCRDIIR1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C278VTTTGCKDIVT1Caenorhabditis elegans
C278VTTTGCTDIIL1Bos taurus
C278VTTTGCRDIIT1Drosophila melanogaster
C278VTTTGCTDIIM1Anopheles gambiae
D131NMILDDGGDLT8Homo sapiens, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Caenorhabditis elegans, Bos taurus, Mus musculus, Rattus norvegicus, Drosophila melanogaster, Anopheles gambiae
D131DLIVDDGGDAT2Arabidopsis thaliana, Arabidopsis thaliana
D131NLILDDGGDLT1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D190TKSKFDNLYGC9Homo sapiens, Arabidopsis thaliana, Arabidopsis thaliana, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Bos taurus, Mus musculus, Rattus norvegicus, Drosophila melanogaster, Anopheles gambiae
D190TKSKFDNLFGC1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D190TKSKFDNLYGI1Caenorhabditis elegans
D223VAGYGDVGKGC7Homo sapiens, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Bos taurus, Mus musculus, Rattus norvegicus, Drosophila melanogaster, Anopheles gambiae
D223ICGYGDVGKGC2Arabidopsis thaliana, Arabidopsis thaliana
D223VAGFGDVGKGC1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D223VAGYGDVGKGS1Caenorhabditis elegans
D245IITEIDPINAL4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
D245IVTEIDPICAL2Arabidopsis thaliana, Arabidopsis thaliana
D245IVTEVDPINAL2Schizosaccharomyces pombe (strain 972 / ATCC 24843), Drosophila melanogaster
D245LVTEIDPINAL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D245IVTEIDPINAL1Caenorhabditis elegans
D245LITEIDPINAL1Anopheles gambiae
E156RGISEETTTGV5Homo sapiens, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Bos taurus, Mus musculus, Rattus norvegicus
E156VGVSEETTTGV2Arabidopsis thaliana, Arabidopsis thaliana
E156RGLSEETTTGV2Caenorhabditis elegans, Anopheles gambiae
E156FGLSEETTTGV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E156KGLSEETTTGV1Drosophila melanogaster
E243RVIITEIDPIN4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
E243RVIVTEIDPIC2Arabidopsis thaliana, Arabidopsis thaliana
E243RVIVTEVDPIN2Schizosaccharomyces pombe (strain 972 / ATCC 24843), Drosophila melanogaster
E243RVLVTEIDPIN1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E243RVIVTEIDPIN1Caenorhabditis elegans
E243RVLITEIDPIN1Anopheles gambiae
E59LHMTIQTAVLI6Arabidopsis thaliana, Arabidopsis thaliana, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843), Caenorhabditis elegans, Anopheles gambiae
E59LHMTVETAVLI4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
E59LHMTVQTAVLI1Drosophila melanogaster
F362VMSNSFTNQVL4Caenorhabditis elegans, Bos taurus, Drosophila melanogaster, Anopheles gambiae
F362VMSNSFTNQVM3Homo sapiens, Mus musculus, Rattus norvegicus
F362VMSCSFTNQVI2Arabidopsis thaliana, Arabidopsis thaliana
F362VMSCSFSNQVL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F362VMSCSFTNQVL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G220VAVVAGYGDVG6Homo sapiens, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Caenorhabditis elegans, Bos taurus, Mus musculus, Rattus norvegicus
G220VAVICGYGDVG2Arabidopsis thaliana, Arabidopsis thaliana
G220VAVVAGFGDVG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G220VCCVAGYGDVG1Drosophila melanogaster
G220VCVVAGYGDVG1Anopheles gambiae
G222VVAGYGDVGKG7Homo sapiens, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Caenorhabditis elegans, Bos taurus, Mus musculus, Rattus norvegicus, Anopheles gambiae
G222VICGYGDVGKG2Arabidopsis thaliana, Arabidopsis thaliana
G222VVAGFGDVGKG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G222CVAGYGDVGKG1Drosophila melanogaster
G277FVTTTGCRDII3Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843), Drosophila melanogaster
G277FVTTTGCTDII2Bos taurus, Anopheles gambiae
G277FVTTTGCVDII2Mus musculus, Rattus norvegicus
G277FVTTTGCIDII1Homo sapiens
G277FCTTTGNKDII1Arabidopsis thaliana
G277FVTTTGNKDII1Arabidopsis thaliana
G277IVTTTGCKDIV1Caenorhabditis elegans
G300IVCNIGHFDVE5Homo sapiens, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Bos taurus, Mus musculus, Rattus norvegicus
G300IVCNIGHFDNE2Arabidopsis thaliana, Arabidopsis thaliana
G300IVCNIGHFDIE2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Drosophila melanogaster
G300IVCNVGHFDCE1Caenorhabditis elegans
G300IVCNIGHFDCE1Anopheles gambiae
G352LGCAMGHPSFV4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
G352LGCATGHPSFV4Arabidopsis thaliana, Arabidopsis thaliana, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Caenorhabditis elegans
G352LGCATGHSSFV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G352LGCAHGHPSFV1Drosophila melanogaster
G352LGCAMGHSSFV1Anopheles gambiae
H301VCNIGHFDVEI5Homo sapiens, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Bos taurus, Mus musculus, Rattus norvegicus
H301VCNIGHFDNEI2Arabidopsis thaliana, Arabidopsis thaliana
H301VCNIGHFDIEI2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Drosophila melanogaster
H301VCNVGHFDCEI1Caenorhabditis elegans
H301VCNIGHFDCEI1Anopheles gambiae
H353GCAMGHPSFVM4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
H353GCATGHPSFVM4Arabidopsis thaliana, Arabidopsis thaliana, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Caenorhabditis elegans
H353GCATGHSSFVM1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H353GCAHGHPSFVM1Drosophila melanogaster
H353GCAMGHSSFVM1Anopheles gambiae
H55IAGCLHMTVET4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
H55IAGCLHMTIQT4Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843), Caenorhabditis elegans, Anopheles gambiae
H55ITGSLHMTIQT2Arabidopsis thaliana, Arabidopsis thaliana
H55ITGCLHMTVQT1Drosophila melanogaster
I244VIITEIDPINA4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
I244VIVTEIDPICA2Arabidopsis thaliana, Arabidopsis thaliana
I244VIVTEVDPINA2Schizosaccharomyces pombe (strain 972 / ATCC 24843), Drosophila melanogaster
I244VLVTEIDPINA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I244VIVTEIDPINA1Caenorhabditis elegans
I244VLITEIDPINA1Anopheles gambiae
I281TGNKDIIMVDH2Arabidopsis thaliana, Arabidopsis thaliana
I281TGCVDIILGRH2Mus musculus, Rattus norvegicus
I281TGCIDIILGRH1Homo sapiens
I281TGCRDIINGEH1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I281TGCRDIIRGEH1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I281TGCKDIVTGKH1Caenorhabditis elegans
I281TGCTDIILGQH1Bos taurus
I281TGCRDIITSVH1Drosophila melanogaster
I281TGCTDIIMGEH1Anopheles gambiae
I299AIVCNIGHFDV4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
I299AIVCNIGHFDN2Arabidopsis thaliana, Arabidopsis thaliana
I299AIVCNIGHFDI2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Drosophila melanogaster
I299SIVCNIGHFDV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I299AIVCNVGHFDC1Caenorhabditis elegans
I299SIVCNIGHFDC1Anopheles gambiae
K186NDSVTKSKFDN11Homo sapiens, Arabidopsis thaliana, Arabidopsis thaliana, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843), Caenorhabditis elegans, Bos taurus, Mus musculus, Rattus norvegicus, Drosophila melanogas
K426INGPFKPDHYR2Mus musculus, Rattus norvegicus
K426CDGPFKPDHYR1Homo sapiens
K426VEGPYKPVHYR1Arabidopsis thaliana
K426IEGPYKPPHYR1Arabidopsis thaliana
K426EEGPFKADHYR1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K426VDGPYKADHYR1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K426VAGPYKPDHYR1Caenorhabditis elegans
K426REGPFKPDHYR1Bos taurus
K426QTGPFKPDHYR1Drosophila melanogaster
K426AEGPYKPEHYR1Anopheles gambiae
L344LAEGRLVNLGC7Homo sapiens, Caenorhabditis elegans, Bos taurus, Mus musculus, Rattus norvegicus, Drosophila melanogaster, Anopheles gambiae
L344LAEGRLMNLGC2Arabidopsis thaliana, Arabidopsis thaliana
L344LANGRLVNLGC1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L344LADGRLVNLGC1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L347GRLVNLGCAMG5Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Anopheles gambiae
L347GRLVNLGCATG3Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843), Caenorhabditis elegans
L347GRLMNLGCATG2Arabidopsis thaliana, Arabidopsis thaliana
L347GRLVNLGCAHG1Drosophila melanogaster
L54RIAGCLHMTVE4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
L54RIAGCLHMTIQ4Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843), Caenorhabditis elegans, Anopheles gambiae
L54RITGSLHMTIQ2Arabidopsis thaliana, Arabidopsis thaliana
L54RITGCLHMTVQ1Drosophila melanogaster
M351NLGCAMGHPSF4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
M351NLGCATGHPSF4Arabidopsis thaliana, Arabidopsis thaliana, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Caenorhabditis elegans
M351NLGCATGHSSF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
M351NLGCAHGHPSF1Drosophila melanogaster
M351NLGCAMGHSSF1Anopheles gambiae
M358HPSFVMSNSFT6Homo sapiens, Caenorhabditis elegans, Bos taurus, Mus musculus, Rattus norvegicus, Drosophila melanogaster
M358HPSFVMSCSFT3Arabidopsis thaliana, Arabidopsis thaliana, Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M358HSSFVMSCSFS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
M358HSSFVMSNSFT1Anopheles gambiae
N191KSKFDNLYGCR9Homo sapiens, Arabidopsis thaliana, Arabidopsis thaliana, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Bos taurus, Mus musculus, Rattus norvegicus, Drosophila melanogaster, Anopheles gambiae
N191KSKFDNLFGCK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N191KSKFDNLYGIR1Caenorhabditis elegans
N248EIDPINALQAA7Homo sapiens, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Caenorhabditis elegans, Bos taurus, Mus musculus, Rattus norvegicus, Anopheles gambiae
N248EIDPICALQAL2Arabidopsis thaliana, Arabidopsis thaliana
N248EVDPINALQAA2Schizosaccharomyces pombe (strain 972 / ATCC 24843), Drosophila melanogaster
N346EGRLVNLGCAM5Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Anopheles gambiae
N346EGRLMNLGCAT2Arabidopsis thaliana, Arabidopsis thaliana
N346NGRLVNLGCAT1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N346DGRLVNLGCAT1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N346EGRLVNLGCAT1Caenorhabditis elegans
N346EGRLVNLGCAH1Drosophila melanogaster
Q85NIFSTQDHAAA8Homo sapiens, Arabidopsis thaliana, Arabidopsis thaliana, Caenorhabditis elegans, Bos taurus, Mus musculus, Rattus norvegicus, Anopheles gambiae
Q85NIYSTQDHAAA2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q85NIFSTQDNAAA1Drosophila melanogaster
S361FVMSNSFTNQV7Homo sapiens, Caenorhabditis elegans, Bos taurus, Mus musculus, Rattus norvegicus, Drosophila melanogaster, Anopheles gambiae
S361FVMSCSFTNQV3Arabidopsis thaliana, Arabidopsis thaliana, Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S361FVMSCSFSNQV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S83SCNIFSTQDHA8Homo sapiens, Arabidopsis thaliana, Arabidopsis thaliana, Caenorhabditis elegans, Bos taurus, Mus musculus, Rattus norvegicus, Anopheles gambiae
S83SCNIYSTQDHA2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S83SCNIFSTQDNA1Drosophila melanogaster
T157GISEETTTGVH5Homo sapiens, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Bos taurus, Mus musculus, Rattus norvegicus
T157GLSEETTTGVH4Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Caenorhabditis elegans, Drosophila melanogaster, Anopheles gambiae
T157GVSEETTTGVK2Arabidopsis thaliana, Arabidopsis thaliana
T158ISEETTTGVHN5Homo sapiens, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Bos taurus, Mus musculus, Rattus norvegicus
T158LSEETTTGVHN3Caenorhabditis elegans, Drosophila melanogaster, Anopheles gambiae
T158VSEETTTGVKR2Arabidopsis thaliana, Arabidopsis thaliana
T158LSEETTTGVHH1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T159SEETTTGVHNL8Homo sapiens, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Caenorhabditis elegans, Bos taurus, Mus musculus, Rattus norvegicus, Drosophila melanogaster, Anopheles gambiae
T159SEETTTGVKRL2Arabidopsis thaliana, Arabidopsis thaliana
T159SEETTTGVHHL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T242ARVIITEIDPI4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
T242ARVIVTEIDPI2Arabidopsis thaliana, Arabidopsis thaliana
T242ARVLVTEIDPI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T242ARVIVTEVDPI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T242SRVIVTEIDPI1Caenorhabditis elegans
T242GRVIVTEVDPI1Drosophila melanogaster
T242GRVLITEIDPI1Anopheles gambiae
T275NIFVTTTGCVD2Mus musculus, Rattus norvegicus
T275NIFVTTTGCID1Homo sapiens
T275DIFCTTTGNKD1Arabidopsis thaliana
T275DIFVTTTGNKD1Arabidopsis thaliana
T275QVFVTTTGCRD1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T275QIFVTTTGCRD1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T275NIIVTTTGCKD1Caenorhabditis elegans
T275NIFVTTTGCTD1Bos taurus
T275SIFVTTTGCRD1Drosophila melanogaster
T275QIFVTTTGCTD1Anopheles gambiae
T276IFVTTTGCRDI2Schizosaccharomyces pombe (strain 972 / ATCC 24843), Drosophila melanogaster
T276IFVTTTGCTDI2Bos taurus, Anopheles gambiae
T276IFVTTTGCVDI2Mus musculus, Rattus norvegicus
T276IFVTTTGCIDI1Homo sapiens
T276IFCTTTGNKDI1Arabidopsis thaliana
T276IFVTTTGNKDI1Arabidopsis thaliana
T276VFVTTTGCRDI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T276IIVTTTGCKDI1Caenorhabditis elegans
T57GCLHMTVETAV4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
T57GCLHMTIQTAV4Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843), Caenorhabditis elegans, Anopheles gambiae
T57GSLHMTIQTAV2Arabidopsis thaliana, Arabidopsis thaliana
T57GCLHMTVQTAV1Drosophila melanogaster
T60HMTIQTAVLIE6Arabidopsis thaliana, Arabidopsis thaliana, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843), Caenorhabditis elegans, Anopheles gambiae
T60HMTVETAVLIE4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
T60HMTVQTAVLIE1Drosophila melanogaster
V224AGYGDVGKGCA7Homo sapiens, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Bos taurus, Mus musculus, Rattus norvegicus, Drosophila melanogaster, Anopheles gambiae
V224CGYGDVGKGCA2Arabidopsis thaliana, Arabidopsis thaliana
V224AGFGDVGKGCS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V224AGYGDVGKGSA1Caenorhabditis elegans
Y221AVVAGYGDVGK6Homo sapiens, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Caenorhabditis elegans, Bos taurus, Mus musculus, Rattus norvegicus
Y221AVICGYGDVGK2Arabidopsis thaliana, Arabidopsis thaliana
Y221AVVAGFGDVGK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y221CCVAGYGDVGK1Drosophila melanogaster
Y221CVVAGYGDVGK1Anopheles gambiae
Y430FKPDHYRY5Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Drosophila melanogaster
Y430YKPVHYRY1Arabidopsis thaliana
Y430YKPPHYRY1Arabidopsis thaliana
Y430FKADHYRY1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y430YKADHYRY1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y430YKPDHYRY1Caenorhabditis elegans
Y430YKPEHYRY1Anopheles gambiae


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