mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for STRA13
Gene summary
Basic gene Info.Gene symbolSTRA13
Gene namestimulated by retinoic acid 13
SynonymsCENP-X|CENPX|D9|FAAP10|MHF2
CytomapUCSC genome browser: 17q25.3
Type of geneprotein-coding
RefGenesNM_001271006.1,
NM_001271007.1,NM_144998.3,
DescriptionFANCM-interacting histone fold protein 2Fanconi anemia-associated polypeptide of 10 kDacentromere protein Xretinoic acid-inducible gene D9 protein homologstimulated by retinoic acid 13 homologstimulated by retinoic acid gene 13 protein homolog
Modification date20141207
dbXrefs MIM : 615128
HGNC : HGNC
Ensembl : ENSG00000169689
HPRD : 18121
Vega : OTTHUMG00000132129
ProteinUniProt: A8MT69
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_STRA13
BioGPS: 201254
PathwayNCI Pathway Interaction Database: STRA13
KEGG: STRA13
REACTOME: STRA13
Pathway Commons: STRA13
ContextiHOP: STRA13
ligand binding site mutation search in PubMed: STRA13
UCL Cancer Institute: STRA13
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID


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Ligand binding site mutations for STRA13

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
E13L14RUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for STRA13
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
E13L14R-1.3010401
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for STRA13 from PDB

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Differential gene expression and gene-gene network for STRA13
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of STRA13 and the right PPI network was created from samples without mutations in the LBS of STRA13. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for STRA13
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for STRA13
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of STRA13 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
NUCNucleic Acids4ndyME13
NUCNucleic Acids4ndyVE13
NUCNucleic Acids4ne1pE13


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Conservation information for LBS of STRA13
Multiple alignments for A8MT69 in multiple species
LBSAA sequence# speciesSpecies
D80PQLLLDF3Homo sapiens, Bos taurus, Mus musculus
E13SGFRKELVSRL2Homo sapiens, Mus musculus
E13AVFRKELVSKL1Bos taurus
G32KTKVSGDALQL3Homo sapiens, Bos taurus, Mus musculus
H20VSRLLHLHFKD1Homo sapiens
H20VSKLLHLHFKD1Bos taurus
H20VSRLLHLHFRD1Mus musculus
K29KDDKTKVSGDA1Homo sapiens
K29KDKKTKVSGDA1Bos taurus
K29RDCKTKVSGDA1Mus musculus
Q76EKVLPQLLLDF3Homo sapiens, Bos taurus, Mus musculus
R17KELVSRLLHLH2Homo sapiens, Mus musculus
R17KELVSKLLHLH1Bos taurus
S16RKELVSRLLHL2Homo sapiens, Mus musculus
S16RKELVSKLLHL1Bos taurus
S31DKTKVSGDALQ1Homo sapiens
S31KKTKVSGDALQ1Bos taurus
S31CKTKVSGDALQ1Mus musculus
T28FKDDKTKVSGD1Homo sapiens
T28FKDKKTKVSGD1Bos taurus
T28FRDCKTKVSGD1Mus musculus
V30DDKTKVSGDAL1Homo sapiens
V30DKKTKVSGDAL1Bos taurus
V30DCKTKVSGDAL1Mus musculus


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