mutLBSgeneDB |
Gene summary for CTTN |
Gene summary |
Basic gene Info. | Gene symbol | CTTN |
Gene name | cortactin | |
Synonyms | EMS1 | |
Cytomap | UCSC genome browser: 11q13 | |
Type of gene | protein-coding | |
RefGenes | NM_001184740.1, NM_005231.3,NM_138565.2, | |
Description | 1110020L01Rikamplaxinems1 sequence (mammary tumor and squamous cell carcinoma-associated (p80/85 src substrate)oncogene EMS1src substrate cortactin | |
Modification date | 20141222 | |
dbXrefs | MIM : 164765 | |
HGNC : HGNC | ||
Ensembl : ENSG00000085733 | ||
HPRD : 01268 | ||
Vega : OTTHUMG00000134307 | ||
Protein | UniProt: Q14247 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_CTTN | |
BioGPS: 2017 | ||
Pathway | NCI Pathway Interaction Database: CTTN | |
KEGG: CTTN | ||
REACTOME: CTTN | ||
Pathway Commons: CTTN | ||
Context | iHOP: CTTN | |
ligand binding site mutation search in PubMed: CTTN | ||
UCL Cancer Institute: CTTN | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO Term | PubMed ID |
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Ligand binding site mutations for CTTN |
Cancer type specific mutLBS sorted by frequency |
LBS | AAchange of nsSNV | Cancer type | # samples | E510 | E510K | BLCA | 1 | Y501 | L500M | LUSC | 1 | G528 | G528R | LUSC | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for CTTN |
Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
: nsSNV at non-LBS: nsSNV at LBS |
nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | Y501 | L500M | -1.2857891 | E510 | E510K | -1.1253327 | G528 | G528R | -0.91679757 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
Structure image for CTTN from PDB |
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Differential gene expression and gene-gene network for CTTN |
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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Phenotype information for CTTN |
Gene level disease information (DisGeNet) |
Disease ID | Disease name | # PubMed | Association type |
Mutation level pathogenic information (ClinVar annotation) |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for CTTN |
Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
Drug information targeting mutLBSgene (Approved drugs only) |
Drug status | DrugBank ID | Name | Type | Drug structure |
Gene-centered ligand-gene interaction network |
Ligands binding to mutated ligand binding site of CTTN go to BioLip |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
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Conservation information for LBS of CTTN |
Multiple alignments for Q14247 in multiple species |
LBS | AA sequence | # species | Species | A506 | YDYQAAGDDEI | 4 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus | D502 | AIALYDYQAAG | 3 | Gallus gallus, Mus musculus, Rattus norvegicus | D502 | AVALYDYQAAG | 1 | Homo sapiens | D509 | QAAGDDEISFD | 4 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus | E510 | AAGDDEISFDP | 4 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus | G528 | EMIDDGWWRGV | 4 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus | L540 | KGRYGLFPANY | 4 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus | N544 | GLFPANYVELR | 4 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus | P542 | RYGLFPANYVE | 4 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus | W529 | MIDDGWWRGVC | 4 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus | Y501 | TAIALYDYQAA | 3 | Gallus gallus, Mus musculus, Rattus norvegicus | Y501 | TAVALYDYQAA | 1 | Homo sapiens | Y545 | LFPANYVELRQ | 4 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus |
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