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mutLBSgeneDB |
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| Gene summary for ENO1 |
 Gene summary |
| Basic gene Info. | Gene symbol | ENO1 |
| Gene name | enolase 1, (alpha) | |
| Synonyms | ENO1L1|MPB1|NNE|PPH | |
| Cytomap | UCSC genome browser: 1p36.2 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001201483.1, NM_001428.3, | |
| Description | 2-phospho-D-glycerate hydro-lyaseMYC promoter-binding protein 1alpha enolase like 1alpha-enolaseenolase-alphanon-neural enolasephosphopyruvate hydrataseplasminogen-binding proteintau-crystallin | |
| Modification date | 20141222 | |
| dbXrefs | MIM : 172430 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000074800 | ||
| HPRD : 01400 | ||
| Vega : OTTHUMG00000001773 | ||
| Protein | UniProt: P06733 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_ENO1 | |
| BioGPS: 2023 | ||
| Pathway | NCI Pathway Interaction Database: ENO1 | |
| KEGG: ENO1 | ||
| REACTOME: ENO1 | ||
| Pathway Commons: ENO1 | ||
| Context | iHOP: ENO1 | |
| ligand binding site mutation search in PubMed: ENO1 | ||
| UCL Cancer Institute: ENO1 | ||
| Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0030308 | negative regulation of cell growth | 10082554 | GO:0045892 | negative regulation of transcription, DNA-templated | 10082554 |
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| Ligand binding site mutations for ENO1 |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | Q166 | M165I | KIRC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for ENO1 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | Q166 | M165I | -0.80914561 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for ENO1 from PDB |
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| Differential gene expression and gene-gene network for ENO1 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for ENO1 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C0003873 | Arthritis, Rheumatoid | 10 | AlteredExpression, Biomarker |
| umls:C0002395 | Alzheimer Disease | 3 | Biomarker |
| umls:C2239176 | Carcinoma, Hepatocellular | 3 | Biomarker |
| umls:C1458155 | Breast Neoplasms | 2 | Biomarker |
| umls:C0007097 | Carcinoma | 2 | Biomarker |
| umls:C0007137 | Carcinoma, Squamous Cell | 2 | Biomarker |
| umls:C0029408 | Osteoarthritis | 2 | Biomarker |
| umls:C0948089 | Acute Coronary Syndrome | 1 | Biomarker |
| umls:C0001418 | Adenocarcinoma | 1 | Biomarker |
| umls:C0152013 | Adenocarcinoma of lung | 1 | Biomarker |
| umls:C0007131 | Carcinoma, Non-Small-Cell Lung | 1 | Biomarker |
| umls:C0860207 | Drug-Induced Liver Injury | 1 | Biomarker |
| umls:C0520459 | Enterocolitis, Necrotizing | 1 | Biomarker |
| umls:C0014859 | Esophageal Neoplasms | 1 | Biomarker |
| umls:C0024667 | Mammary Neoplasms, Animal | 1 | Biomarker |
| umls:C0024668 | Mammary Neoplasms, Experimental | 1 | Biomarker |
| umls:C0026640 | Mouth Neoplasms | 1 | Biomarker |
| umls:C0027626 | Neoplasm Invasiveness | 1 | Biomarker |
| umls:C0029456 | Osteoporosis | 1 | Biomarker |
| umls:C0038356 | Stomach Neoplasms | 1 | Biomarker |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for ENO1 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of ENO1 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
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| Conservation information for LBS of ENO1 |
| Multiple alignments for P06733 in multiple species |
| LBS | AA sequence | # species | Species | D245 | VVIGMDVAASE | 6 | Homo sapiens, Gallus gallus, Mus musculus, Mus musculus, Rattus norvegicus, Bos taurus | D245 | VKVGIDSAPSV | 3 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | D245 | IKIGMDVAASE | 1 | Arabidopsis thaliana | D245 | IEIGMDVAASE | 1 | Drosophila melanogaster | D245 | ISIGMDVAASE | 1 | Caenorhabditis elegans | D318 | IQVVGDDLTVT | 6 | Homo sapiens, Gallus gallus, Mus musculus, Mus musculus, Rattus norvegicus, Bos taurus | D318 | VQIIADDLTCT | 3 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | D318 | IQLVGDDLLVT | 1 | Arabidopsis thaliana | D318 | IQIVGDDLTVT | 1 | Drosophila melanogaster | D318 | IQLVGDDLTVT | 1 | Caenorhabditis elegans | E293 | PVVSIEDPFDQ | 6 | Homo sapiens, Gallus gallus, Mus musculus, Mus musculus, Rattus norvegicus, Bos taurus | E293 | PIISLEDPYAE | 3 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | E293 | PIVSIEDPFDQ | 2 | Arabidopsis thaliana, Drosophila melanogaster | E293 | PVVSIEDAFDQ | 1 | Caenorhabditis elegans | K343 | NCLLLKVNQIG | 8 | Homo sapiens, Drosophila melanogaster, Caenorhabditis elegans, Gallus gallus, Mus musculus, Mus musculus, Rattus norvegicus, Bos taurus | K343 | NTLLLKLNQIG | 3 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | K343 | NALLLKVNQIG | 1 | Arabidopsis thaliana | K394 | CTGQIKTGAPC | 5 | Homo sapiens, Gallus gallus, Mus musculus, Mus musculus, Rattus norvegicus | K394 | RCGQIKSGALS | 3 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | K394 | ASGQIKTGAPC | 1 | Arabidopsis thaliana | K394 | STGQIKTGAPC | 1 | Drosophila melanogaster | K394 | ATGQIKTGAPC | 1 | Caenorhabditis elegans | K394 | CTGQIKTVAPC | 1 | Bos taurus | Q166 | NKLAMQEFMIL | 8 | Homo sapiens, Drosophila melanogaster, Caenorhabditis elegans, Gallus gallus, Mus musculus, Mus musculus, Rattus norvegicus, Bos taurus | Q166 | GSLAMQEFKIA | 3 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | Q166 | NSLAMQEFMIL | 1 | Arabidopsis thaliana | S40 | VPSGASTGIYE | 7 | Homo sapiens, Arabidopsis thaliana, Gallus gallus, Mus musculus, Mus musculus, Rattus norvegicus, Bos taurus | S40 | VPSGASTGIHE | 3 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | S40 | VPSGASTGVHE | 2 | Drosophila melanogaster, Caenorhabditis elegans |
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