mutLBSgeneDB |
Gene summary for STK32A |
Gene summary |
Basic gene Info. | Gene symbol | STK32A |
Gene name | serine/threonine kinase 32A | |
Synonyms | YANK1 | |
Cytomap | UCSC genome browser: 5q32 | |
Type of gene | protein-coding | |
RefGenes | NM_001112724.1, NM_001287740.1,NM_145001.3, | |
Description | A930015B13Rikserine/threonine-protein kinase 32Ayet another novel kinase 1 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000169302 | ||
HPRD : 15445 | ||
Vega : OTTHUMG00000163411 | ||
Protein | UniProt: Q8WU08 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_STK32A | |
BioGPS: 202374 | ||
Pathway | NCI Pathway Interaction Database: STK32A | |
KEGG: STK32A | ||
REACTOME: STK32A | ||
Pathway Commons: STK32A | ||
Context | iHOP: STK32A | |
ligand binding site mutation search in PubMed: STK32A | ||
UCL Cancer Institute: STK32A | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO Term | PubMed ID |
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Ligand binding site mutations for STK32A |
Cancer type specific mutLBS sorted by frequency |
LBS | AAchange of nsSNV | Cancer type | # samples | I29 | A28V | COAD | 1 | D150 | K148E | STAD | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for STK32A |
Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
: nsSNV at non-LBS: nsSNV at LBS |
nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | D150 | K148E | -0.82151004 | I29 | A28V | -0.43941834 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
Structure image for STK32A from PDB |
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Differential gene expression and gene-gene network for STK32A |
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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Phenotype information for STK32A |
Gene level disease information (DisGeNet) |
Disease ID | Disease name | # PubMed | Association type |
Mutation level pathogenic information (ClinVar annotation) |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for STK32A |
Gene-centered drug-gene interaction network |
Drug information targeting mutLBSgene (Approved drugs only) |
Drug status | DrugBank ID | Name | Type | Drug structure |
Gene-centered ligand-gene interaction network |
Ligands binding to mutated ligand binding site of STK32A go to BioLip |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | STU | STAUROSPORINE | 4fr4 | A | I29 D150 | STU | STAUROSPORINE | 4fr4 | B | I29 D150 | STU | STAUROSPORINE | 4fr4 | C | I29 D150 | STU | STAUROSPORINE | 4fr4 | D | I29 D150 | STU | STAUROSPORINE | 4fr4 | E | I29 D150 | STU | STAUROSPORINE | 4fr4 | F | I29 D150 |
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Conservation information for LBS of STK32A |
Multiple alignments for Q8WU08 in multiple species |
LBS | AA sequence | # species | Species | A50 | TKKMYAMKYMN | 2 | Homo sapiens, Mus musculus | A50 | TKQRFALKCIN | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | D101 | MFMVVDLLLGG | 2 | Homo sapiens, Mus musculus | D101 | IYLVTDLMLGG | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | D107 | LLLGGDLRYHL | 2 | Homo sapiens, Mus musculus | D107 | LMLGGDLRYHI | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | D150 | RDMKPDNILLD | 2 | Homo sapiens, Mus musculus | D150 | RDVKPDNILLD | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | D164 | HVHITDFNIAA | 2 | Homo sapiens, Mus musculus | D164 | HCKLADFNVAA | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | G106 | DLLLGGDLRYH | 2 | Homo sapiens, Mus musculus | G106 | DLMLGGDLRYH | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | G30 | ILRAIGKGSFG | 2 | Homo sapiens, Mus musculus | G30 | IRNVIGKGSWS | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | I29 | EILRAIGKGSF | 2 | Homo sapiens, Mus musculus | I29 | KIRNVIGKGSW | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | K31 | LRAIGKGSFGK | 2 | Homo sapiens, Mus musculus | K31 | RNVIGKGSWST | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | K52 | KMYAMKYMNKQ | 2 | Homo sapiens, Mus musculus | K52 | QRFALKCINKK | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | L102 | FMVVDLLLGGD | 2 | Homo sapiens, Mus musculus | L102 | YLVTDLMLGGD | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | L103 | MVVDLLLGGDL | 2 | Homo sapiens, Mus musculus | L103 | LVTDLMLGGDL | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | L153 | KPDNILLDEHG | 2 | Homo sapiens, Mus musculus | L153 | KPDNILLDEKG | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | L305 | PNKGRLNCDPT | 1 | Homo sapiens | L305 | PKSGKVYVDPI | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | L305 | PTKGRLNCDPT | 1 | Mus musculus | N151 | DMKPDNILLDE | 2 | Homo sapiens, Mus musculus | N151 | DVKPDNILLDE | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | R304 | IPNKGRLNCDP | 1 | Homo sapiens | R304 | RPKSGKVYVDP | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | R304 | IPTKGRLNCDP | 1 | Mus musculus | T163 | GHVHITDFNIA | 2 | Homo sapiens, Mus musculus | T163 | GHCKLADFNVA | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | V100 | DMFMVVDLLLG | 2 | Homo sapiens, Mus musculus | V100 | KIYLVTDLMLG | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | V37 | GSFGKVCIVQK | 1 | Homo sapiens | V37 | GSWSTVFVVKH | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | V37 | GSFGKVCIVRK | 1 | Mus musculus | V84 | EHPFLVNLWYS | 2 | Homo sapiens, Mus musculus | V84 | NHPLLCKFYSE | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) |
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