mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for STK32A
Gene summary
Basic gene Info.Gene symbolSTK32A
Gene nameserine/threonine kinase 32A
SynonymsYANK1
CytomapUCSC genome browser: 5q32
Type of geneprotein-coding
RefGenesNM_001112724.1,
NM_001287740.1,NM_145001.3,
DescriptionA930015B13Rikserine/threonine-protein kinase 32Ayet another novel kinase 1
Modification date20141207
dbXrefs HGNC : HGNC
Ensembl : ENSG00000169302
HPRD : 15445
Vega : OTTHUMG00000163411
ProteinUniProt: Q8WU08
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_STK32A
BioGPS: 202374
PathwayNCI Pathway Interaction Database: STK32A
KEGG: STK32A
REACTOME: STK32A
Pathway Commons: STK32A
ContextiHOP: STK32A
ligand binding site mutation search in PubMed: STK32A
UCL Cancer Institute: STK32A
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID


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Ligand binding site mutations for STK32A

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
I29A28VCOAD1
D150K148ESTAD1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for STK32A
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
D150K148E-0.82151004
I29A28V-0.43941834
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for STK32A from PDB

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Differential gene expression and gene-gene network for STK32A
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of STK32A and the right PPI network was created from samples without mutations in the LBS of STK32A. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for STK32A
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for STK32A

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of STK32A go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
STUSTAUROSPORINE4fr4AI29 D150
STUSTAUROSPORINE4fr4BI29 D150
STUSTAUROSPORINE4fr4CI29 D150
STUSTAUROSPORINE4fr4DI29 D150
STUSTAUROSPORINE4fr4EI29 D150
STUSTAUROSPORINE4fr4FI29 D150


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Conservation information for LBS of STK32A
Multiple alignments for Q8WU08 in multiple species
LBSAA sequence# speciesSpecies
A50TKKMYAMKYMN2Homo sapiens, Mus musculus
A50TKQRFALKCIN1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D101MFMVVDLLLGG2Homo sapiens, Mus musculus
D101IYLVTDLMLGG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D107LLLGGDLRYHL2Homo sapiens, Mus musculus
D107LMLGGDLRYHI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D150RDMKPDNILLD2Homo sapiens, Mus musculus
D150RDVKPDNILLD1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D164HVHITDFNIAA2Homo sapiens, Mus musculus
D164HCKLADFNVAA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G106DLLLGGDLRYH2Homo sapiens, Mus musculus
G106DLMLGGDLRYH1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G30ILRAIGKGSFG2Homo sapiens, Mus musculus
G30IRNVIGKGSWS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I29EILRAIGKGSF2Homo sapiens, Mus musculus
I29KIRNVIGKGSW1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K31LRAIGKGSFGK2Homo sapiens, Mus musculus
K31RNVIGKGSWST1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K52KMYAMKYMNKQ2Homo sapiens, Mus musculus
K52QRFALKCINKK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L102FMVVDLLLGGD2Homo sapiens, Mus musculus
L102YLVTDLMLGGD1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L103MVVDLLLGGDL2Homo sapiens, Mus musculus
L103LVTDLMLGGDL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L153KPDNILLDEHG2Homo sapiens, Mus musculus
L153KPDNILLDEKG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L305PNKGRLNCDPT1Homo sapiens
L305PKSGKVYVDPI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L305PTKGRLNCDPT1Mus musculus
N151DMKPDNILLDE2Homo sapiens, Mus musculus
N151DVKPDNILLDE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R304IPNKGRLNCDP1Homo sapiens
R304RPKSGKVYVDP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R304IPTKGRLNCDP1Mus musculus
T163GHVHITDFNIA2Homo sapiens, Mus musculus
T163GHCKLADFNVA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V100DMFMVVDLLLG2Homo sapiens, Mus musculus
V100KIYLVTDLMLG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V37GSFGKVCIVQK1Homo sapiens
V37GSWSTVFVVKH1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V37GSFGKVCIVRK1Mus musculus
V84EHPFLVNLWYS2Homo sapiens, Mus musculus
V84NHPLLCKFYSE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)


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