mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for ENO2
Gene summary
Basic gene Info.Gene symbolENO2
Gene nameenolase 2 (gamma, neuronal)
SynonymsHEL-S-279|NSE
CytomapUCSC genome browser: 12p13
Type of geneprotein-coding
RefGenesNM_001975.2,
Description2-phospho-D-glycerate hydro-lyase2-phospho-D-glycerate hydrolyaseepididymis secretory protein Li 279gamma-enolaseneural enolaseneuron specific gamma enolaseneuron-specific enolaseneurone-specific enolase
Modification date20141207
dbXrefs MIM : 131360
HGNC : HGNC
Ensembl : ENSG00000111674
HPRD : 00573
Vega : OTTHUMG00000168967
ProteinUniProt: P09104
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_ENO2
BioGPS: 2026
PathwayNCI Pathway Interaction Database: ENO2
KEGG: ENO2
REACTOME: ENO2
Pathway Commons: ENO2
ContextiHOP: ENO2
ligand binding site mutation search in PubMed: ENO2
UCL Cancer Institute: ENO2
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID


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Ligand binding site mutations for ENO2

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
K394I393MBLCA1
G38P36SSKCM1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for ENO2
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
K394I393M-1.0578231
G38P36S-0.31782312
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for ENO2 from PDB

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Differential gene expression and gene-gene network for ENO2
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of ENO2 and the right PPI network was created from samples without mutations in the LBS of ENO2. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for ENO2
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0007131Carcinoma, Non-Small-Cell Lung5Biomarker
umls:C0007621Cell Transformation, Neoplastic1Biomarker
umls:C0023467Leukemia, Myeloid, Acute1Biomarker
umls:C0023904Liver Neoplasms, Experimental1Biomarker
umls:C0027659Neoplasms, Experimental1Biomarker
umls:C0005695Urinary Bladder Neoplasms1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for ENO2
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
ExperimentalDB027262-Phosphoglycolic AcidSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of ENO2 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS


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Conservation information for LBS of ENO2
Multiple alignments for P09104 in multiple species
LBSAA sequence# speciesSpecies
A39AVPSGASTGIY5Homo sapiens, Gallus gallus, Rattus norvegicus, Rattus norvegicus, Mus musculus
A39IVPSGASTGVH4Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Ashbya gossypii (strain ATCC 10895 / CBS 109.51
A39MVPSGASTGEW1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A39IVPSGASTGIW1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D245MVIGMDVAASE3Rattus norvegicus, Rattus norvegicus, Mus musculus
D245IVIGMDVAASE2Homo sapiens, Gallus gallus
D245VKIGFDVAASE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D245IKIGLDVASSE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D245IKIGLDCASSE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D245VKIGLDCASSE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D245IDIGLDCASSE1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
D245IDIALDCASSE1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
D318IQIVGDDLTVT5Homo sapiens, Gallus gallus, Rattus norvegicus, Rattus norvegicus, Mus musculus
D318IQIVADDLTVT2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D318VQIVADDLTVT2Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
D318VEVIADDLTVT1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D318FQIVGDDLTVT1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E167KLAMQEFMILP5Homo sapiens, Gallus gallus, Rattus norvegicus, Rattus norvegicus, Mus musculus
E167ALALQEFMIAP4Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Ashbya gossypii (strain ATCC 10895 / CBS 109.51
E167DLAFQEFMIMP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E167DLAFQEFMILP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E210TNVGDEGGFAP5Homo sapiens, Gallus gallus, Rattus norvegicus, Rattus norvegicus, Mus musculus
E210GNVGDEGGVAP4Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Ashbya gossypii (strain ATCC 10895 / CBS 109.51
E210GNVGDEGGIAP2Schizosaccharomyces pombe (strain 972 / ATCC 24843), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E293PVVSIEDPFDQ4Homo sapiens, Rattus norvegicus, Rattus norvegicus, Mus musculus
E293PIVSIEDPFAE4Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Ashbya gossypii (strain ATCC 10895 / CBS 109.51
E293PVLSIEDPFDQ1Gallus gallus
E293PIVFIEDPFSE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E293PIVSIEDPFDQ1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G38AAVPSGASTGI5Homo sapiens, Gallus gallus, Rattus norvegicus, Rattus norvegicus, Mus musculus
G38SIVPSGASTGV4Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Ashbya gossypii (strain ATCC 10895 / CBS 109.51
G38SMVPSGASTGE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G38AIVPSGASTGI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H158INGGSHAGNKL5Homo sapiens, Gallus gallus, Rattus norvegicus, Rattus norvegicus, Mus musculus
H158LNGGSHAGGAL4Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Ashbya gossypii (strain ATCC 10895 / CBS 109.51
H158LNGGRHAGGDL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H158LNGGSHAGGDL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H371GVMVSHRSGET10Homo sapiens, Gallus gallus, Rattus norvegicus, Rattus norvegicus, Mus musculus, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyc
H371GLMVSHRSGET1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K343NCLLLKVNQIG5Homo sapiens, Gallus gallus, Rattus norvegicus, Rattus norvegicus, Mus musculus
K343DALLLKVNQIG4Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Ashbya gossypii (strain ATCC 10895 / CBS 109.51
K343NALLVKINQIG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K343NALLLKVNQIG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K394CTGQIKTGAPC5Homo sapiens, Gallus gallus, Rattus norvegicus, Rattus norvegicus, Mus musculus
K394RTGQIKTGAPA4Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Ashbya gossypii (strain ATCC 10895 / CBS 109.51
K394EAGQMKSGAPC1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K394GAGQLKSGAPC1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L341ACNCLLLKVNQ5Homo sapiens, Gallus gallus, Rattus norvegicus, Rattus norvegicus, Mus musculus
L341AADALLLKVNQ4Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Ashbya gossypii (strain ATCC 10895 / CBS 109.51
L341CANALLVKINQ1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L341CANALLLKVNQ1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q166NKLAMQEFMIL5Homo sapiens, Gallus gallus, Rattus norvegicus, Rattus norvegicus, Mus musculus
Q166GALALQEFMIA4Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Ashbya gossypii (strain ATCC 10895 / CBS 109.51
Q166GDLAFQEFMIM1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q166GDLAFQEFMIL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R372VMVSHRSGETE9Homo sapiens, Gallus gallus, Rattus norvegicus, Rattus norvegicus, Mus musculus, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 /
R372LMVSHRSGETD1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R372VMVSHRSGETA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S373MVSHRSGETED9Homo sapiens, Gallus gallus, Rattus norvegicus, Rattus norvegicus, Mus musculus, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 /
S373MVSHRSGETDD1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S373MVSHRSGETAD1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S40VPSGASTGIYE5Homo sapiens, Gallus gallus, Rattus norvegicus, Rattus norvegicus, Mus musculus
S40VPSGASTGVHE4Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Ashbya gossypii (strain ATCC 10895 / CBS 109.51
S40VPSGASTGEWE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S40VPSGASTGIWE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)


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