mutLBSgeneDB |
Gene summary for ETS1 |
Gene summary |
Basic gene Info. | Gene symbol | ETS1 |
Gene name | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | |
Synonyms | ETS-1|EWSR2|p54 | |
Cytomap | UCSC genome browser: 11q23.3 | |
Type of gene | protein-coding | |
RefGenes | NM_001143820.1, NM_001162422.1,NM_005238.3, | |
Description | Avian erythroblastosis virus E26 (v-ets) oncogene homolog-1protein C-ets-1v-ets avian erythroblastosis virus E2 oncogene homolog 1 | |
Modification date | 20141222 | |
dbXrefs | MIM : 164720 | |
HGNC : HGNC | ||
Ensembl : ENSG00000134954 | ||
HPRD : 01260 | ||
Vega : OTTHUMG00000165799 | ||
Protein | UniProt: P14921 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_ETS1 | |
BioGPS: 2113 | ||
Pathway | NCI Pathway Interaction Database: ETS1 | |
KEGG: ETS1 | ||
REACTOME: ETS1 | ||
Pathway Commons: ETS1 | ||
Context | iHOP: ETS1 | |
ligand binding site mutation search in PubMed: ETS1 | ||
UCL Cancer Institute: ETS1 | ||
Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO Term | PubMed ID | GO:0006366 | transcription from RNA polymerase II promoter | 7753825 | GO:0030578 | PML body organization | 11909962 | GO:0042981 | regulation of apoptotic process | 9266972 | GO:0045648 | positive regulation of erythrocyte differentiation | 8620536 | GO:0045786 | negative regulation of cell cycle | 9266972 | GO:0045893 | positive regulation of transcription, DNA-templated | 10698492 | GO:0045944 | positive regulation of transcription from RNA polymerase II promoter | 15247905 | GO:0046677 | response to antibiotic | 9266972 |
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Ligand binding site mutations for ETS1 |
Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.) : non-synonymous mutation on LBS, Circle size denotes number of samples. |
Cancer type specific mutLBS sorted by frequency |
LBS | AAchange of nsSNV | Cancer type | # samples | R409 | R409H | BRCA | 1 | K399 | K399I | SKCM | 1 | R391 | R391H | THCA | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for ETS1 |
Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
: nsSNV at non-LBS: nsSNV at LBS |
nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | R409 | R409H | -0.98129974 | K399 | K399I | -0.58026579 | R391 | R391H | -0.39401143 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
Structure image for ETS1 from PDB |
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Differential gene expression and gene-gene network for ETS1 |
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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Phenotype information for ETS1 |
Gene level disease information (DisGeNet) |
Disease ID | Disease name | # PubMed | Association type |
umls:C0024141 | Lupus Erythematosus, Systemic | 14 | Biomarker, GeneticVariation |
umls:C0007570 | Celiac Disease | 1 | Biomarker, GeneticVariation |
umls:C0035126 | Reperfusion Injury | 1 | Biomarker |
Mutation level pathogenic information (ClinVar annotation) |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for ETS1 |
Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
Drug information targeting mutLBSgene (Approved drugs only) |
Drug status | DrugBank ID | Name | Type | Drug structure |
Gene-centered ligand-gene interaction network |
Ligands binding to mutated ligand binding site of ETS1 go to BioLip |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | NUC | Nucleic Acids | 3wtt | H | K399 | NUC | Nucleic Acids | 3wtu | H | K399 | NUC | Nucleic Acids | 3wtw | C | K399 | NUC | Nucleic Acids | 3mfk | B | R391 | NUC | Nucleic Acids | 3mfk | B | R391 | NUC | Nucleic Acids | 4l0y | B | R391 | NUC | Nucleic Acids | 4l0z | B | R391 | NUC | Nucleic Acids | 4l18 | B | R391 | NUC | Nucleic Acids | 4l18 | F | R391 | NUC | Nucleic Acids | 3wts | C | R391 | NUC | Nucleic Acids | 3wts | H | R391 | NUC | Nucleic Acids | 3wtt | C | R391 | NUC | Nucleic Acids | 3wtu | C | R391 | NUC | Nucleic Acids | 3wtv | C | R391 | NUC | Nucleic Acids | 2nny | A | R391 K399 | NUC | Nucleic Acids | 2nny | B | R391 K399 | NUC | Nucleic Acids | 3mfk | A | R391 K399 | NUC | Nucleic Acids | 3ri4 | A | R391 K399 | NUC | Nucleic Acids | 3ri4 | D | R391 K399 | NUC | Nucleic Acids | 4lg0 | B | R391 K399 | NUC | Nucleic Acids | 3wtx | C | R391 K399 | NUC | Nucleic Acids | 3wtx | H | R391 K399 | NUC | Nucleic Acids | 3wty | C | R391 K399 | NUC | Nucleic Acids | 3wty | H | R391 K399 | NUC | Nucleic Acids | 3wtv | H | R391 K399 | NUC | Nucleic Acids | 3wtw | H | R391 K399 | NUC | Nucleic Acids | 3wu1 | B | R391 K399 | NUC | Nucleic Acids | 2nny | A | R391 R409 | NUC | Nucleic Acids | 2nny | B | R391 R409 | NUC | Nucleic Acids | 3mfk | A | R391 R409 | NUC | Nucleic Acids | 3ri4 | A | R391 R409 | NUC | Nucleic Acids | 3ri4 | D | R391 R409 | NUC | Nucleic Acids | 4l0y | B | R391 R409 | NUC | Nucleic Acids | 4l0z | B | R391 R409 | NUC | Nucleic Acids | 4l18 | B | R391 R409 | NUC | Nucleic Acids | 4l18 | F | R391 R409 | NUC | Nucleic Acids | 4lg0 | B | R391 R409 | NUC | Nucleic Acids | 3wts | C | R391 R409 | NUC | Nucleic Acids | 3wts | H | R391 R409 | NUC | Nucleic Acids | 3wtt | C | R391 R409 | NUC | Nucleic Acids | 3wtt | H | R391 R409 | NUC | Nucleic Acids | 3wtu | C | R391 R409 | NUC | Nucleic Acids | 3wtu | H | R391 R409 | NUC | Nucleic Acids | 3wtx | C | R391 R409 | NUC | Nucleic Acids | 3wtx | H | R391 R409 | NUC | Nucleic Acids | 3wty | C | R391 R409 | NUC | Nucleic Acids | 3wty | H | R391 R409 | NUC | Nucleic Acids | 3wtv | C | R391 R409 | NUC | Nucleic Acids | 3wtv | H | R391 R409 | NUC | Nucleic Acids | 3wtw | C | R391 R409 | NUC | Nucleic Acids | 3wtw | H | R391 R409 | NUC | Nucleic Acids | 3wu1 | B | R391 R409 |
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Conservation information for LBS of ETS1 |
Multiple alignments for P14921 in multiple species |
LBS | AA sequence | # species | Species | D398 | LRYYYDKNIIH | 4 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus | E387 | PKMNYEKLSRG | 4 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus | G333 | GYTGSGPIQLW | 4 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus | G392 | EKLSRGLRYYY | 4 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus | K379 | RWGKRKNKPKM | 4 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus | K381 | GKRKNKPKMNY | 4 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus | K383 | RKNKPKMNYEK | 4 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus | K388 | KMNYEKLSRGL | 4 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus | K399 | RYYYDKNIIHK | 4 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus | K404 | KNIIHKTAGKR | 4 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus | K408 | HKTAGKRYVYR | 4 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus | L337 | SGPIQLWQFLL | 4 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus | M384 | KNKPKMNYEKL | 4 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus | P334 | YTGSGPIQLWQ | 4 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus | Q336 | GSGPIQLWQFL | 4 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus | R391 | YEKLSRGLRYY | 4 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus | R394 | LSRGLRYYYDK | 4 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus | R409 | KTAGKRYVYRF | 4 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus | S390 | NYEKLSRGLRY | 4 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus | W375 | EVARRWGKRKN | 4 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus | Y386 | KPKMNYEKLSR | 4 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus | Y395 | SRGLRYYYDKN | 4 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus | Y396 | RGLRYYYDKNI | 4 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus | Y397 | GLRYYYDKNII | 4 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus | Y410 | TAGKRYVYRFV | 4 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus |
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