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mutLBSgeneDB |
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| Gene summary for FABP2 |
 Gene summary |
| Basic gene Info. | Gene symbol | FABP2 |
| Gene name | fatty acid binding protein 2, intestinal | |
| Synonyms | FABPI|I-FABP | |
| Cytomap | UCSC genome browser: 4q28-q31 | |
| Type of gene | protein-coding | |
| RefGenes | NM_000134.3, | |
| Description | fatty acid-binding protein 2fatty acid-binding protein, intestinalintestinal-type fatty acid-binding protein | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 134640 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000145384 | ||
| HPRD : 00611 | ||
| Vega : OTTHUMG00000132972 | ||
| Protein | UniProt: P12104 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_FABP2 | |
| BioGPS: 2169 | ||
| Pathway | NCI Pathway Interaction Database: FABP2 | |
| KEGG: FABP2 | ||
| REACTOME: FABP2 | ||
| Pathway Commons: FABP2 | ||
| Context | iHOP: FABP2 | |
| ligand binding site mutation search in PubMed: FABP2 | ||
| UCL Cancer Institute: FABP2 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
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| Ligand binding site mutations for FABP2 |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | D75,T77 | G76E | SKCM | 2 | Y15 | D16E | BRCA | 1 | L103 | E102K | COAD | 1 | L103 | N104D | COAD | 1 | L103 | N104I | COAD | 1 | L103 | N104K | OV | 1 | M19 | M19I | SKCM | 1 | L103 | E102K | SKCM | 1 | F56 | R57Q | STAD | 1 | L79 | R80K | STAD | 1 | Y118 | V119A | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for FABP2 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | Y118 | V119A | -1.9036613 | L79 | R80K | -1.0731011 | Y15 | D16E | -0.94562151 | L103 | E102K | -0.86985325 | F56 | R57Q | -0.78370392 | L103 | N104D | -0.70155449 | M19 | M19I | -0.67223231 | L103 | N104K | -0.54098764 | L103 | N104I | -0.13939208 | D75 | G76E | -0.10616453 | T77 | G76E | -0.10616453 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for FABP2 from PDB |
| PDB ID | PDB title | PDB structure | 1KZW | Solution structure of Human Intestinal Fatty acid binding protein |  |
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| Differential gene expression and gene-gene network for FABP2 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for FABP2 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for FABP2 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Gene-centered drug-gene interaction network |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Approved | DB01050 | Ibuprofen | Small molecule |  |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of FABP2 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
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| Conservation information for LBS of FABP2 |
| Multiple alignments for P12104 in multiple species |
| LBS | AA sequence | # species | Species | A32 | VKRKLAAHDNL | 2 | Homo sapiens, Bos taurus | A32 | MKRKLGAHDNL | 1 | Mus musculus | A32 | VKRKLGAHDNL | 1 | Rattus norvegicus | A74 | FNYNLADGTEL | 1 | Homo sapiens | A74 | FPYSLADGTEL | 1 | Mus musculus | A74 | FAYSLADGTEL | 1 | Rattus norvegicus | A74 | FNYSLADGTEL | 1 | Bos taurus | D75 | NYNLADGTELR | 1 | Homo sapiens | D75 | PYSLADGTELT | 1 | Mus musculus | D75 | AYSLADGTELT | 1 | Rattus norvegicus | D75 | NYSLADGTELS | 1 | Bos taurus | E52 | KFTVKESSNFR | 2 | Mus musculus, Rattus norvegicus | E52 | KFTVKESSAFR | 1 | Homo sapiens | E52 | KFTVKESSTFR | 1 | Bos taurus | F18 | ENYEKFMEKMG | 3 | Mus musculus, Rattus norvegicus, Bos taurus | F18 | ENYDKFMEKMG | 1 | Homo sapiens | F56 | KESSNFRNIDV | 2 | Mus musculus, Rattus norvegicus | F56 | KESSAFRNIEV | 1 | Homo sapiens | F56 | KESSTFRSIEI | 1 | Bos taurus | F63 | NIEVVFELGVT | 1 | Homo sapiens | F63 | NIDVVFELGVN | 1 | Mus musculus | F63 | NIDVVFELGVD | 1 | Rattus norvegicus | F63 | SIEIIFELGVT | 1 | Bos taurus | F69 | ELGVTFNYNLA | 1 | Homo sapiens | F69 | ELGVNFPYSLA | 1 | Mus musculus | F69 | ELGVDFAYSLA | 1 | Rattus norvegicus | F69 | ELGVTFNYSLA | 1 | Bos taurus | F94 | KLIGKFKRTDN | 1 | Homo sapiens | F94 | KLIGKFTRVDN | 1 | Mus musculus | F94 | KLVGKFKRVDN | 1 | Rattus norvegicus | F94 | KLVGKFKRLDN | 1 | Bos taurus | K28 | GVNIVKRKLAA | 1 | Homo sapiens | K28 | GINVMKRKLGA | 1 | Mus musculus | K28 | GINVVKRKLGA | 1 | Rattus norvegicus | K28 | GINVVKRKLAA | 1 | Bos taurus | L103 | DNGKELIAVRE | 2 | Mus musculus, Rattus norvegicus | L103 | DNGNELNTVRE | 1 | Homo sapiens | L103 | DNGNALNTVRE | 1 | Bos taurus | L73 | TFNYNLADGTE | 1 | Homo sapiens | L73 | NFPYSLADGTE | 1 | Mus musculus | L73 | DFAYSLADGTE | 1 | Rattus norvegicus | L73 | TFNYSLADGTE | 1 | Bos taurus | L79 | ADGTELRGTWS | 1 | Homo sapiens | L79 | ADGTELTGAWT | 1 | Mus musculus | L79 | ADGTELTGTWT | 1 | Rattus norvegicus | L79 | ADGTELSGAWA | 1 | Bos taurus | M19 | NYEKFMEKMGI | 3 | Mus musculus, Rattus norvegicus, Bos taurus | M19 | NYDKFMEKMGV | 1 | Homo sapiens | M22 | KFMEKMGINVV | 2 | Rattus norvegicus, Bos taurus | M22 | KFMEKMGVNIV | 1 | Homo sapiens | M22 | KFMEKMGINVM | 1 | Mus musculus | Q116 | GNELIQTYTYE | 2 | Mus musculus, Rattus norvegicus | Q116 | GDELVQTYVYE | 1 | Homo sapiens | Q116 | GGEMVQTYTYE | 1 | Bos taurus | R107 | ELNTVREIIGD | 1 | Homo sapiens | R107 | ELIAVREVSGN | 1 | Mus musculus | R107 | ELIAVREISGN | 1 | Rattus norvegicus | R107 | ALNTVREIIGG | 1 | Bos taurus | R127 | GVEAKRIFKKE | 2 | Rattus norvegicus, Bos taurus | R127 | GVEAKRIFKKD | 1 | Homo sapiens | R127 | GVEAKRFFKKE | 1 | Mus musculus | T77 | NLADGTELRGT | 1 | Homo sapiens | T77 | SLADGTELTGA | 1 | Mus musculus | T77 | SLADGTELTGT | 1 | Rattus norvegicus | T77 | SLADGTELSGA | 1 | Bos taurus | V24 | MEKMGINVVKR | 2 | Rattus norvegicus, Bos taurus | V24 | MEKMGVNIVKR | 1 | Homo sapiens | V24 | MEKMGINVMKR | 1 | Mus musculus | V50 | GNKFTVKESSN | 2 | Mus musculus, Rattus norvegicus | V50 | GNKFTVKESSA | 1 | Homo sapiens | V50 | GNKFTVKESST | 1 | Bos taurus | V61 | FRNIDVVFELG | 2 | Mus musculus, Rattus norvegicus | V61 | FRNIEVVFELG | 1 | Homo sapiens | V61 | FRSIEIIFELG | 1 | Bos taurus | W83 | ELRGTWSLEGN | 1 | Homo sapiens | W83 | ELTGAWTIEGN | 1 | Mus musculus | W83 | ELTGTWTMEGN | 1 | Rattus norvegicus | W83 | ELSGAWALEGD | 1 | Bos taurus | Y118 | ELIQTYTYEGV | 2 | Mus musculus, Rattus norvegicus | Y118 | ELVQTYVYEGV | 1 | Homo sapiens | Y118 | EMVQTYTYEGV | 1 | Bos taurus | Y15 | DRNENYEKFME | 3 | Mus musculus, Rattus norvegicus, Bos taurus | Y15 | DRSENYDKFME | 1 | Homo sapiens | Y71 | GVTFNYNLADG | 1 | Homo sapiens | Y71 | GVNFPYSLADG | 1 | Mus musculus | Y71 | GVDFAYSLADG | 1 | Rattus norvegicus | Y71 | GVTFNYSLADG | 1 | Bos taurus |
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