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mutLBSgeneDB |
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| Gene summary for MRPL21 |
 Gene summary |
| Basic gene Info. | Gene symbol | MRPL21 |
| Gene name | mitochondrial ribosomal protein L21 | |
| Synonyms | L21mt|MRP-L21 | |
| Cytomap | UCSC genome browser: 11q13.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_181514.1, NM_181515.1,NM_181512.1,NM_181513.1, | |
| Description | 39S ribosomal protein L21, mitochondrial | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 611834 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000197345 | ||
| HPRD : 14747 | ||
| Vega : OTTHUMG00000167893 | ||
| Protein | UniProt: Q7Z2W9 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_MRPL21 | |
| BioGPS: 219927 | ||
| Pathway | NCI Pathway Interaction Database: MRPL21 | |
| KEGG: MRPL21 | ||
| REACTOME: MRPL21 | ||
| Pathway Commons: MRPL21 | ||
| Context | iHOP: MRPL21 | |
| ligand binding site mutation search in PubMed: MRPL21 | ||
| UCL Cancer Institute: MRPL21 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
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| Ligand binding site mutations for MRPL21 |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | R104 | R104H | LUSC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for MRPL21 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | R104 | R104H | -0.37476789 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for MRPL21 from PDB |
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| Differential gene expression and gene-gene network for MRPL21 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for MRPL21 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for MRPL21 |
| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of MRPL21 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | NUC | Nucleic Acids | 3j7y | S | R104 |
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| Conservation information for LBS of MRPL21 |
| Multiple alignments for Q7Z2W9 in multiple species |
| LBS | AA sequence | # species | Species | A102 | AVVHFASHQWK | 2 | Mus musculus, Bos taurus | A102 | AVVHFASRQWK | 1 | Homo sapiens | F174 | RIIMRFRKRKN | 1 | Homo sapiens | F174 | KINMKFRKRKN | 1 | Mus musculus | F174 | RVNMRFQKRKN | 1 | Bos taurus | F180 | RKRKNFKKKRI | 1 | Homo sapiens | F180 | RKRKNFRKKKI | 1 | Mus musculus | F180 | QKRKNYKRKRI | 1 | Bos taurus | I171 | SWPRIIMRFRK | 1 | Homo sapiens | I171 | SWPKINMKFRK | 1 | Mus musculus | I171 | SWPRVNMRFQK | 1 | Bos taurus | K176 | IMRFRKRKNFK | 1 | Homo sapiens | K176 | NMKFRKRKNFR | 1 | Mus musculus | K176 | NMRFQKRKNYK | 1 | Bos taurus | K178 | RFRKRKNFKKK | 1 | Homo sapiens | K178 | KFRKRKNFRKK | 1 | Mus musculus | K178 | RFQKRKNYKRK | 1 | Bos taurus | K181 | KRKNFKKKRIV | 1 | Homo sapiens | K181 | KRKNFRKKKII | 1 | Mus musculus | K181 | KRKNYKRKRII | 1 | Bos taurus | K182 | RKNFKKKRIVT | 1 | Homo sapiens | K182 | RKNFRKKKIIV | 1 | Mus musculus | K182 | RKNYKRKRIIV | 1 | Bos taurus | K183 | KNFKKKRIVTT | 1 | Homo sapiens | K183 | KNFRKKKIIVN | 1 | Mus musculus | K183 | KNYKRKRIIVN | 1 | Bos taurus | N118 | LILIGNELDLA | 1 | Homo sapiens | N118 | LILIENELDIK | 1 | Mus musculus | N118 | LILIENKLDIA | 1 | Bos taurus | P60 | SLSSPPWPEVV | 2 | Homo sapiens, Bos taurus | P60 | SLSSPPWQEVV | 1 | Mus musculus | R104 | VHFASHQWKVT | 2 | Mus musculus, Bos taurus | R104 | VHFASRQWKVT | 1 | Homo sapiens | R169 | TESWPRIIMRF | 1 | Homo sapiens | R169 | TESWPKINMKF | 1 | Mus musculus | R169 | TESWPRVNMRF | 1 | Bos taurus | R173 | PRIIMRFRKRK | 1 | Homo sapiens | R173 | PKINMKFRKRK | 1 | Mus musculus | R173 | PRVNMRFQKRK | 1 | Bos taurus | R175 | IIMRFRKRKNF | 1 | Homo sapiens | R175 | INMKFRKRKNF | 1 | Mus musculus | R175 | VNMRFQKRKNY | 1 | Bos taurus | R177 | MRFRKRKNFKK | 1 | Homo sapiens | R177 | MKFRKRKNFRK | 1 | Mus musculus | R177 | MRFQKRKNYKR | 1 | Bos taurus | R184 | NFKKKRIVTTP | 1 | Homo sapiens | R184 | NFRKKKIIVNP | 1 | Mus musculus | R184 | NYKRKRIIVNP | 1 | Bos taurus | S103 | VVHFASHQWKV | 2 | Mus musculus, Bos taurus | S103 | VVHFASRQWKV | 1 | Homo sapiens | T188 | KRIVTTPQTVL | 1 | Homo sapiens | T188 | KKIIVNPQTIL | 1 | Mus musculus | T188 | KRIIVNPQTVL | 1 | Bos taurus | W61 | LSSPPWPEVVL | 2 | Homo sapiens, Bos taurus | W61 | LSSPPWQEVVL | 1 | Mus musculus |
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