mutLBSgeneDB |
Gene summary for FHL3 |
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Basic gene Info. | Gene symbol | FHL3 |
Gene name | four and a half LIM domains 3 | |
Synonyms | SLIM2 | |
Cytomap | UCSC genome browser: 1p34 | |
Type of gene | protein-coding | |
RefGenes | NM_001243878.1, NM_004468.4, | |
Description | FHL-3LIM-only protein FHL3SLIM-2four and a half LIM domains protein 3skeletal muscle LIM-protein 2 | |
Modification date | 20141207 | |
dbXrefs | MIM : 602790 | |
HGNC : HGNC | ||
Ensembl : ENSG00000183386 | ||
HPRD : 09101 | ||
Vega : OTTHUMG00000004434 | ||
Protein | UniProt: Q13643 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_FHL3 | |
BioGPS: 2275 | ||
Pathway | NCI Pathway Interaction Database: FHL3 | |
KEGG: FHL3 | ||
REACTOME: FHL3 | ||
Pathway Commons: FHL3 | ||
Context | iHOP: FHL3 | |
ligand binding site mutation search in PubMed: FHL3 | ||
UCL Cancer Institute: FHL3 | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
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GO ID | GO Term | PubMed ID |
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Ligand binding site mutations for FHL3 |
![]() We represented ligand binding site mutations only. (You can see big image via clicking.) ![]() |
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LBS | AAchange of nsSNV | Cancer type | # samples | C65 | G65A | HNSC | 1 | C92 | S94P | KIRC | 1 | C28 | S30F | LUSC | 1 | C92 | F92L | SKCM | 1 | C132 | D133N | SKCM | 1 | H62 | T60M | UCEC | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for FHL3 |
![]() Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
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![]() Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
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Differential gene expression and gene-gene network for FHL3 |
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Phenotype information for FHL3 |
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Disease ID | Disease name | # PubMed | Association type |
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Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for FHL3 |
![]() Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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Drug status | DrugBank ID | Name | Type | Drug structure |
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Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | ZN | ZINC(2+) | 2cuq | A | C65 |
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Conservation information for LBS of FHL3 |
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LBS | AA sequence | # species | Species | C101 | AFSSQCSACGE | 3 | Homo sapiens, Bos taurus, Mus musculus | C104 | SQCSACGETVM | 3 | Homo sapiens, Bos taurus, Mus musculus | C126 | TWHEHCFLCSG | 3 | Homo sapiens, Bos taurus, Mus musculus | C129 | EHCFLCSGCEQ | 3 | Homo sapiens, Bos taurus, Mus musculus | C132 | FLCSGCEQPLG | 3 | Homo sapiens, Bos taurus, Mus musculus | C153 | HYCVPCYENKF | 3 | Homo sapiens, Bos taurus, Mus musculus | C162 | KFAPRCARCSK | 3 | Homo sapiens, Bos taurus, Mus musculus | C165 | PRCARCSKTLT | 3 | Homo sapiens, Bos taurus, Mus musculus | C185 | PWHRECLVCTG | 3 | Homo sapiens, Bos taurus, Mus musculus | C188 | RECLVCTGCQT | 2 | Homo sapiens, Bos taurus | C188 | RECLVCTGCKT | 1 | Mus musculus | C191 | LVCTGCQTPLA | 2 | Homo sapiens, Bos taurus | C191 | LVCTGCKTPLA | 1 | Mus musculus | C209 | DEDPYCVACFG | 1 | Homo sapiens | C209 | EDDPYCVTCFG | 1 | Bos taurus | C209 | DDDPYCVACFG | 1 | Mus musculus | C212 | PYCVACFGELF | 2 | Homo sapiens, Mus musculus | C212 | PYCVTCFGELF | 1 | Bos taurus | C28 | DSGPYCVPCYD | 2 | Homo sapiens, Mus musculus | C28 | DDGPYCVPCYD | 1 | Bos taurus | C40 | TFANTCAECQQ | 3 | Homo sapiens, Bos taurus, Mus musculus | C43 | NTCAECQQLIG | 3 | Homo sapiens, Bos taurus, Mus musculus | C65 | HFHEGCFRCCR | 3 | Homo sapiens, Bos taurus, Mus musculus | C68 | EGCFRCCRCQR | 3 | Homo sapiens, Bos taurus, Mus musculus | C71 | FRCCRCQRSLA | 3 | Homo sapiens, Bos taurus, Mus musculus | C89 | DSELLCNDCYC | 2 | Homo sapiens, Bos taurus | C89 | DSELLCNECYC | 1 | Mus musculus | C92 | LLCNDCYCSAF | 2 | Homo sapiens, Bos taurus | C92 | LLCNECYCTAF | 1 | Mus musculus | H123 | GGQTWHEHCFL | 3 | Homo sapiens, Bos taurus, Mus musculus | H182 | RDQPWHRECLV | 3 | Homo sapiens, Bos taurus, Mus musculus | H62 | EDRHFHEGCFR | 3 | Homo sapiens, Bos taurus, Mus musculus |
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