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mutLBSgeneDB |
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| Gene summary for FHL3 |
 Gene summary |
| Basic gene Info. | Gene symbol | FHL3 |
| Gene name | four and a half LIM domains 3 | |
| Synonyms | SLIM2 | |
| Cytomap | UCSC genome browser: 1p34 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001243878.1, NM_004468.4, | |
| Description | FHL-3LIM-only protein FHL3SLIM-2four and a half LIM domains protein 3skeletal muscle LIM-protein 2 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 602790 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000183386 | ||
| HPRD : 09101 | ||
| Vega : OTTHUMG00000004434 | ||
| Protein | UniProt: Q13643 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_FHL3 | |
| BioGPS: 2275 | ||
| Pathway | NCI Pathway Interaction Database: FHL3 | |
| KEGG: FHL3 | ||
| REACTOME: FHL3 | ||
| Pathway Commons: FHL3 | ||
| Context | iHOP: FHL3 | |
| ligand binding site mutation search in PubMed: FHL3 | ||
| UCL Cancer Institute: FHL3 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
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| Ligand binding site mutations for FHL3 |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | C65 | G65A | HNSC | 1 | C92 | S94P | KIRC | 1 | C28 | S30F | LUSC | 1 | C92 | F92L | SKCM | 1 | C132 | D133N | SKCM | 1 | H62 | T60M | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for FHL3 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for FHL3 from PDB |
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| Differential gene expression and gene-gene network for FHL3 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for FHL3 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for FHL3 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of FHL3 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | ZN | ZINC(2+) | 2cuq | A | C65 |
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| Conservation information for LBS of FHL3 |
| Multiple alignments for Q13643 in multiple species |
| LBS | AA sequence | # species | Species | C101 | AFSSQCSACGE | 3 | Homo sapiens, Bos taurus, Mus musculus | C104 | SQCSACGETVM | 3 | Homo sapiens, Bos taurus, Mus musculus | C126 | TWHEHCFLCSG | 3 | Homo sapiens, Bos taurus, Mus musculus | C129 | EHCFLCSGCEQ | 3 | Homo sapiens, Bos taurus, Mus musculus | C132 | FLCSGCEQPLG | 3 | Homo sapiens, Bos taurus, Mus musculus | C153 | HYCVPCYENKF | 3 | Homo sapiens, Bos taurus, Mus musculus | C162 | KFAPRCARCSK | 3 | Homo sapiens, Bos taurus, Mus musculus | C165 | PRCARCSKTLT | 3 | Homo sapiens, Bos taurus, Mus musculus | C185 | PWHRECLVCTG | 3 | Homo sapiens, Bos taurus, Mus musculus | C188 | RECLVCTGCQT | 2 | Homo sapiens, Bos taurus | C188 | RECLVCTGCKT | 1 | Mus musculus | C191 | LVCTGCQTPLA | 2 | Homo sapiens, Bos taurus | C191 | LVCTGCKTPLA | 1 | Mus musculus | C209 | DEDPYCVACFG | 1 | Homo sapiens | C209 | EDDPYCVTCFG | 1 | Bos taurus | C209 | DDDPYCVACFG | 1 | Mus musculus | C212 | PYCVACFGELF | 2 | Homo sapiens, Mus musculus | C212 | PYCVTCFGELF | 1 | Bos taurus | C28 | DSGPYCVPCYD | 2 | Homo sapiens, Mus musculus | C28 | DDGPYCVPCYD | 1 | Bos taurus | C40 | TFANTCAECQQ | 3 | Homo sapiens, Bos taurus, Mus musculus | C43 | NTCAECQQLIG | 3 | Homo sapiens, Bos taurus, Mus musculus | C65 | HFHEGCFRCCR | 3 | Homo sapiens, Bos taurus, Mus musculus | C68 | EGCFRCCRCQR | 3 | Homo sapiens, Bos taurus, Mus musculus | C71 | FRCCRCQRSLA | 3 | Homo sapiens, Bos taurus, Mus musculus | C89 | DSELLCNDCYC | 2 | Homo sapiens, Bos taurus | C89 | DSELLCNECYC | 1 | Mus musculus | C92 | LLCNDCYCSAF | 2 | Homo sapiens, Bos taurus | C92 | LLCNECYCTAF | 1 | Mus musculus | H123 | GGQTWHEHCFL | 3 | Homo sapiens, Bos taurus, Mus musculus | H182 | RDQPWHRECLV | 3 | Homo sapiens, Bos taurus, Mus musculus | H62 | EDRHFHEGCFR | 3 | Homo sapiens, Bos taurus, Mus musculus |
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