mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

Home

Download

 Statistics

Help

About Us
Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for PTGR1
Gene summary
Basic gene Info.Gene symbolPTGR1
Gene nameprostaglandin reductase 1
SynonymsLTB4DH|PGR1|ZADH3
CytomapUCSC genome browser: 9q31.3
Type of geneprotein-coding
RefGenesNM_001146108.1,
NM_001146109.1,NM_012212.3,
Description15-oxoprostaglandin 13-reductaseNADP-dependent leukotriene B4 12-hydroxydehydrogenasePRG-1leukotriene B4 12-hydroxydehydrogenasezinc binding alcohol dehydrogenase domain containing 3
Modification date20141207
dbXrefs MIM : 601274
HGNC : HGNC
Ensembl : ENSG00000106853
HPRD : 03173
Vega : OTTHUMG00000020493
ProteinUniProt: Q14914
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_PTGR1
BioGPS: 22949
PathwayNCI Pathway Interaction Database: PTGR1
KEGG: PTGR1
REACTOME: PTGR1
Pathway Commons: PTGR1
ContextiHOP: PTGR1
ligand binding site mutation search in PubMed: PTGR1
UCL Cancer Institute: PTGR1
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID


Top
Ligand binding site mutations for PTGR1
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
 : non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
G319,N321D320YLUSC1
I242,G240A241VSTAD1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


Top
Protein structure related information for PTGR1
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
G319D320Y-0.49761253
N321D320Y-0.49761253
I242A241V-0.17702679
G240A241V-0.17702679
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for PTGR1 from PDB

Top
Differential gene expression and gene-gene network for PTGR1
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of PTGR1 and the right PPI network was created from samples without mutations in the LBS of PTGR1. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Top

Top
Phenotype information for PTGR1
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Top
Pharmacological information for PTGR1

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
ExperimentalDB034612'-Monophosphoadenosine 5'-DiphosphoriboseSmall molecule
ExperimentalDB04066Para-Coumaric AcidSmall molecule
ExperimentalDB07177(5E,13E)-11-HYDROXY-9,15-DIOXOPROSTA-5,13-DIEN-1-OIC ACIDSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of PTGR1 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
NAPNADP ZWITTERION2y05AG240 I242 G319 N321
NAPNADP ZWITTERION2y05BG240 I242 G319 N321
NAPNADP ZWITTERION2y05CG240 I242 G319 N321
NAPNADP ZWITTERION2y05DG240 I242 G319 N321


Top
Conservation information for LBS of PTGR1
Multiple alignments for Q14914 in multiple species
LBSAA sequence# speciesSpecies
A153NAAAGAVGSVV2Homo sapiens, Rattus norvegicus
A153SAASGAVGQLV2Arabidopsis thaliana, Arabidopsis thaliana
A153SAAAGAVGSIV1Bos taurus
A153SAAAGAVGSVV1Mus musculus
A153SAASGAVGQMA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C239GRIAICGAISQ2Mus musculus, Rattus norvegicus
C239GRIAVCGMISQ2Arabidopsis thaliana, Arabidopsis thaliana
C239GRIAICGAIST1Homo sapiens
C239GRIAICGAISV1Bos taurus
C239GRIIFCGAISQ1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F270LRMEAFVVYRW1Homo sapiens
F270LHLQGFVVYRW1Bos taurus
F270LRMEGFIVNRW1Mus musculus
F270LRMEGFIVTRW1Rattus norvegicus
F270LTIQGFIVANI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F270IRIQGFVVADF1Arabidopsis thaliana
F270IRIQGFVVSDF1Arabidopsis thaliana
G152VNAAAGAVGSV2Homo sapiens, Rattus norvegicus
G152VSAASGAVGQL2Arabidopsis thaliana, Arabidopsis thaliana
G152VSAAAGAVGSI1Bos taurus
G152VSAAAGAVGSV1Mus musculus
G152ISAASGAVGQM1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G174VVGTAGSDEKV3Bos taurus, Mus musculus, Rattus norvegicus
G174VVGSAGSKEKV2Arabidopsis thaliana, Arabidopsis thaliana
G174VVGAVGSDEKV1Homo sapiens
G174VVGSVGSDEKF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G240RIAICGAISQY2Mus musculus, Rattus norvegicus
G240RIAVCGMISQY2Arabidopsis thaliana, Arabidopsis thaliana
G240RIAICGAISTY1Homo sapiens
G240RIAICGAISVY1Bos taurus
G240RIIFCGAISQY1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G319MGMLKGDNLGK2Homo sapiens, Rattus norvegicus
G319VGLFHGKNVGK2Arabidopsis thaliana, Arabidopsis thaliana
G319IGLLKGENLGK1Bos taurus
G319MGMLKGENLGK1Mus musculus
G319IGMLQGKNSGK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I242AICGAISQYNR2Mus musculus, Rattus norvegicus
I242AVCGMISQYNL2Arabidopsis thaliana, Arabidopsis thaliana
I242AICGAISTYNR1Homo sapiens
I242AICGAISVYNR1Bos taurus
I242IFCGAISQYNN1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K178AGSDEKVAYLK2Mus musculus, Rattus norvegicus
K178AGSKEKVDLLK2Arabidopsis thaliana, Arabidopsis thaliana
K178VGSDEKVAYLQ1Homo sapiens
K178AGSDEKVAWLK1Bos taurus
K178VGSDEKFKICL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L317AFMGMLKGDNL2Homo sapiens, Rattus norvegicus
L317ALVGLFHGKNV2Arabidopsis thaliana, Arabidopsis thaliana
L317AFIGLLKGENL1Bos taurus
L317AFMGMLKGENL1Mus musculus
L317AFIGMLQGKNS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M124LGTVGMPGLTA4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
M124TGLLGMPGMTA2Arabidopsis thaliana, Arabidopsis thaliana
M124VGSLGMPSQTA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M316AAFMGMLKGDN2Homo sapiens, Rattus norvegicus
M316EALVGLFHGKN2Arabidopsis thaliana, Arabidopsis thaliana
M316AAFIGLLKGEN1Bos taurus
M316AAFMGMLKGEN1Mus musculus
M316EAFIGMLQGKN1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N217DCYFDNVGGEF4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
N217DIYFENVGGET1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N217DMYFENVGGKM1Arabidopsis thaliana
N217DIYFENVGGKM1Arabidopsis thaliana
N321MLKGDNLGKTI2Homo sapiens, Rattus norvegicus
N321LFHGKNVGKQV2Arabidopsis thaliana, Arabidopsis thaliana
N321LLKGENLGKAI1Bos taurus
N321MLKGENLGKTI1Mus musculus
N321MLQGKNSGKTI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P48FLSVDPYMRVA2Mus musculus, Rattus norvegicus
P48FLTVDPYMRVA1Homo sapiens
P48YLTVDPYMRIM1Bos taurus
P48YTSVDPYLRMR1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P48YLSCDPYMRSR1Arabidopsis thaliana
P48YLSCDPYMRIR1Arabidopsis thaliana
R274AFVVYRWQGDA1Homo sapiens
R274GFVVYRWQGEV1Bos taurus
R274GFIVNRWQGEV1Mus musculus
R274GFIVTRWQGEV1Rattus norvegicus
R274GFIVANILPQY1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R274GFVVADFYDKY1Arabidopsis thaliana
R274GFVVSDFYDKY1Arabidopsis thaliana
R56RVAAKKLKE--2Mus musculus, Rattus norvegicus
R56RVAAKRLKE--1Homo sapiens
R56RIMAKSLKE--1Bos taurus
R56RMRMQSPKHAS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R56RSRMGKPDPSS1Arabidopsis thaliana
R56RIRMGKPDPST1Arabidopsis thaliana
S243ICGAISQYNRT2Mus musculus, Rattus norvegicus
S243VCGMISQYNLE2Arabidopsis thaliana, Arabidopsis thaliana
S243ICGAISTYNRT1Homo sapiens
S243ICGAISVYNRT1Bos taurus
S243FCGAISQYNNP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S88TIVLASPGWTT1Homo sapiens
S88TIVLAPSGWTT1Bos taurus
S88TIVAALLGWTS1Mus musculus
S88TIVVALLGWTS1Rattus norvegicus
S88DVVF-VSGWEE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S88DLLWGIVGWEE1Arabidopsis thaliana
S88DLLWGIVAWEE1Arabidopsis thaliana
T128GMPGLTAYFGL4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
T128GMPGMTAYAGF2Arabidopsis thaliana, Arabidopsis thaliana
T128GMPSQTAYCGL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V154AAAGAVGSVVG3Homo sapiens, Mus musculus, Rattus norvegicus
V154AASGAVGQLVG2Arabidopsis thaliana, Arabidopsis thaliana
V154AAAGAVGSIVG1Bos taurus
V154AASGAVGQMAG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V173KVVGTAGSDEK3Bos taurus, Mus musculus, Rattus norvegicus
V173YVVGSAGSKEK2Arabidopsis thaliana, Arabidopsis thaliana
V173KVVGAVGSDEK1Homo sapiens
V173HVVGSVGSDEK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V218CYFDNVGGEFS4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
V218IYFENVGGETM1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V218MYFENVGGKML1Arabidopsis thaliana
V218IYFENVGGKML1Arabidopsis thaliana
V271RMEAFVVYRWQ1Homo sapiens
V271HLQGFVVYRWQ1Bos taurus
V271RMEGFIVNRWQ1Mus musculus
V271RMEGFIVTRWQ1Rattus norvegicus
V271TIQGFIVANIL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V271RIQGFVVADFY1Arabidopsis thaliana
V271RIQGFVVSDFY1Arabidopsis thaliana
V272MEAFVVYRWQG1Homo sapiens
V272LQGFVVYRWQG1Bos taurus
V272MEGFIVNRWQG1Mus musculus
V272MEGFIVTRWQG1Rattus norvegicus
V272IQGFIVANILP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V272IQGFVVADFYD1Arabidopsis thaliana
V272IQGFVVSDFYD1Arabidopsis thaliana
V52DPYMRVAAKKL2Mus musculus, Rattus norvegicus
V52DPYMRVAAKRL1Homo sapiens
V52DPYMRIMAKSL1Bos taurus
V52DPYLRMRMQSP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V52DPYMRSRMGKP1Arabidopsis thaliana
V52DPYMRIRMGKP1Arabidopsis thaliana
Y193DVAFNYKTVKS2Mus musculus, Rattus norvegicus
Y193DDAFNYKEESD2Arabidopsis thaliana, Arabidopsis thaliana
Y193DVVFNYKTVES1Homo sapiens
Y193DVALNYKTVKS1Bos taurus
Y193DSVFNYKKESP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y245GAISQYNRTGP2Mus musculus, Rattus norvegicus
Y245GMISQYNLENQ2Arabidopsis thaliana, Arabidopsis thaliana
Y245GAISTYNRTGP1Homo sapiens
Y245GAISVYNRTSP1Bos taurus
Y245GAISQYNNPNP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y273EAFVVYRWQGD1Homo sapiens
Y273QGFVVYRWQGE1Bos taurus
Y273EGFIVNRWQGE1Mus musculus
Y273EGFIVTRWQGE1Rattus norvegicus
Y273QGFIVANILPQ1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y273QGFVVADFYDK1Arabidopsis thaliana
Y273QGFVVSDFYDK1Arabidopsis thaliana
Y49LSVDPYMRVAA2Mus musculus, Rattus norvegicus
Y49LTVDPYMRVAA1Homo sapiens
Y49LTVDPYMRIMA1Bos taurus
Y49TSVDPYLRMRM1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y49LSCDPYMRSRM1Arabidopsis thaliana
Y49LSCDPYMRIRM1Arabidopsis thaliana


Copyright © 2016-Present - The University of Texas Health Science Center at Houston
Site Policies | State of Texas