mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for KDM1A
Gene summary
Basic gene Info.Gene symbolKDM1A
Gene namelysine (K)-specific demethylase 1A
SynonymsAOF2|BHC110|KDM1|LSD1
CytomapUCSC genome browser: 1p36.12
Type of geneprotein-coding
RefGenesNM_001009999.2,
NM_015013.3,
DescriptionBRAF35-HDAC complex protein BHC110FAD-binding protein BRAF35-HDAC complex, 110 kDa subunitamine oxidase (flavin containing) domain 2flavin-containing amine oxidase domain-containing protein 2lysine (K)-specific demethylase 1lysine-specific histone de
Modification date20141207
dbXrefs MIM : 609132
HGNC : HGNC
Ensembl : ENSG00000004487
HPRD : 09800
Vega : OTTHUMG00000003220
ProteinUniProt: O60341
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_KDM1A
BioGPS: 23028
PathwayNCI Pathway Interaction Database: KDM1A
KEGG: KDM1A
REACTOME: KDM1A
Pathway Commons: KDM1A
ContextiHOP: KDM1A
ligand binding site mutation search in PubMed: KDM1A
UCL Cancer Institute: KDM1A
Assigned class in mutLBSgeneDBB: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0033169histone H3-K9 demethylation16079795
GO:0034720histone H3-K4 demethylation15620353
GO:0043433negative regulation of sequence-specific DNA binding transcription factor activity19497860
GO:0045892negative regulation of transcription, DNA-templated19497860
GO:0045944positive regulation of transcription from RNA polymerase II promoter20833138
GO:0051091positive regulation of sequence-specific DNA binding transcription factor activity20833138


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Ligand binding site mutations for KDM1A
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
 : non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
S289G290CCOAD1
G800G800ELUAD1
R321R321CSKCM1
L307L307MSKCM1
T624L622VSKCM1
W751W751CSTAD1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for KDM1A
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
S289G290C0.002721865
R321R321C-1.2985989
W751W751C-1.2686177
L307L307M-1.0657468
T624L622V-0.57699759
G800G800E-0.16006408
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for KDM1A from PDB

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Differential gene expression and gene-gene network for KDM1A
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of KDM1A and the right PPI network was created from samples without mutations in the LBS of KDM1A. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for KDM1A
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0007131Carcinoma, Non-Small-Cell Lung1Biomarker
umls:C0010340Critical Illness1Biomarker
umls:C0242656Disease Progression1Biomarker
umls:C0020507Hyperplasia1Biomarker
umls:C0027626Neoplasm Invasiveness1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for KDM1A
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of KDM1A go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
IIIPeptide ligand (LEU,SER,PHE,LEU,VAL)3zmvAR321
FADFAD2x0lAS289 L307 T624 G800
FADFAD2y48AS289 L307 T624 G800
FADFAD3zmsAS289 L307 T624 G800
FADFAD3zn0AS289 L307 T624 G800
FADFAD4kumAS289 L307 T624 G800
FADFAD2dw4AS289 L307 T624 W751 G800
F2N1-HYDRO-5-(3-PHENYLPROPANOYL)-FLAVIN-ADENINEDINUCLEOTIDE2ejrAS289 L307 T624 W751 G800
FADFAD2h94AS289 L307 T624 W751 G800
FADFAD2hkoAS289 L307 T624 W751 G800
FADFAD2iw5AS289 L307 T624 W751 G800
FDAFADH22uxnAS289 L307 T624 W751 G800
FA9[(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL (2R,3S,4S)-5-[(3R,3AS,7AR)-10,11-DIMETHYL-1,4,6-TRIOXO-3-PHENYL-2,3,5,6,7,7A-HEXAHYDRO-1H-BENZO[G]PYRROLO[2,1-E]PTERIDIN-8(4H)-YL]-2,3,4-TRIHYDROXYPENTYL DIHYDROGEN DIPHOSPH2uxxAS289 L307 T624 W751 G800
FADFAD2v1dAS289 L307 T624 W751 G800
FADFAD2xafAS289 L307 T624 W751 G800
FADFAD2xagAS289 L307 T624 W751 G800
FADFAD2xahAS289 L307 T624 W751 G800
FADFAD2xajAS289 L307 T624 W751 G800
FADFAD2xasAS289 L307 T624 W751 G800
F2N1-HYDRO-5-(3-PHENYLPROPANOYL)-FLAVIN-ADENINEDINUCLEOTIDE2z3yAS289 L307 T624 W751 G800
FA9[(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL (2R,3S,4S)-5-[(3R,3AS,7AR)-10,11-DIMETHYL-1,4,6-TRIOXO-3-PHENYL-2,3,5,6,7,7A-HEXAHYDRO-1H-BENZO[G]PYRROLO[2,1-E]PTERIDIN-8(4H)-YL]-2,3,4-TRIHYDROXYPENTYL DIHYDROGEN DIPHOSPH2z5uAS289 L307 T624 W751 G800
2PF[(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL (2R,3S,4S)-2,3,4-TRIHYDROXY-5-[(1R,3R,3AS)-1-HYDROXY-10,11-DIMETHYL-4,6-DIOXO-3-(PENTAFLUOROPHENYL)-2,3,5,6-TETRAHYDRO-1H-BENZO[G]PYRROLO[2,1-E]PTERIDIN-8(4H)-YL]PENTYLDIHYD3abtAS289 L307 T624 W751 G800
12F[(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL (2R,3S,4S)-5-[(1R,3R,3AS)-1-HYDROXY-10,11-DIMETHYL-4,6-DIOXO-3-(3-FLUORO-2-BENZYLOXYPHENYL)-2,3,5,6-TETRAHYDRO-1H-BENZO[G] PYRROLO[2,1-E]PTERIDIN-8(4H)-YL]-2,3,4-TRIHYDROXYP3abuAS289 L307 T624 W751 G800
FADFAD3zmtAS289 L307 T624 W751 G800
FADFAD3zmuAS289 L307 T624 W751 G800
FADFAD3zmvAS289 L307 T624 W751 G800
FADFAD3zmzAS289 L307 T624 W751 G800
FADFAD3zn1AS289 L307 T624 W751 G800
FADFAD4bayAS289 L307 T624 W751 G800
D69[[(2R,3S,4S)-5-[(4AS,10AS)-4A-[(1S)-3- AZANYLIDENE-1,4-DIPHENYL-BUTYL]-7,8-DIMETHYL-2,4- BIS(OXIDANYLIDENE)-5,10A-DIHYDRO-1H-BENZO[G] PTERIDIN-10-YL]-2,3,4-TRIS(OXIDANYL)PENTOXY]- OXIDANYL-PHOSPHORYL] [(2R,3S,4R,5R)-5-(6- AMINOPURIN-9-YL)-3,4-BIS(OXIDANYL4uv8AS289 L307 T624 W751 G800
D70[(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4- DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL (2R,3S, 4S)-2,3,4-TRIHYDROXY-5-[(4AS,10AS)-4A-[(1S,3E) -3-IMINO-1-PHENYLPENTYL]-7,8-DIMETHYL-2,4- DIOXO-1,3,4,4A,5,10A-HEXAHYDROBENZO[G]PTERIDIN- 10(2H)-YL]PENTYL DIHYDROGE4uv9AS289 L307 T624 W751 G800
D73[(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4- DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL (2R,3S, 4S)-2,3,4-TRIHYDROXY-5-[(4AS)-4A-[(1S,3E)-3- IMINO-1-PHENYLBUTYL]-7,8-DIMETHYL-2,4-DIOXO-3, 4,4A,5-TETRAHYDROBENZO[G]PTERIDIN-10(2H)-YL] PENTYL DIHYDROGEN DIPHOSPHA4uvaAS289 L307 T624 W751 G800
D51[(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4- DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL (2R,3S, 4S)-5-[(1R,3S,3AS,7AS)-1-AMINO-1,10,11- TRIMETHYL-4,6-DIOXO-3-PHENYL-2,3,5,6,7,7A-HEXAHYDRO- 1H-BENZO[G]PYRROLO[2,1-E]PTERIDIN-8(4H)-YL]- 2,3,4-TRIHYDROXYPENTYL DIH4uvbAS289 L307 T624 W751 G800
D52[[(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4- BIS(OXIDANYL)OXOLAN-2-YL]METHOXY-OXIDANYL- PHOSPHORYL] [(2R,3S,4S)-5-[5-[(1S)-1-AZANYL-1,3- DIPHENYL-PROPYL]-7,8-DIMETHYL-2,4- BIS(OXIDANYLIDENE)-4AH-BENZO[G]PTERIDIN-10-YL]-2,3,4- TRIS(OXIDANYL)PENTYL] HYDROGEN 4uvcAS289 L307 T624 W751 G800
FADFAD4uxnAS289 L307 T624 W751 G800
FADFAD4czzAS289 L307 W751 G800
FADFAD2xaqAS289 W751 G800


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Conservation information for LBS of KDM1A
Multiple alignments for O60341 in multiple species
LBSAA sequence# speciesSpecies
A309VTLLEARDRVG2Homo sapiens, Mus musculus
A309VIVLEARNCIG1Caenorhabditis elegans
A309VIVLEARDRVG1Drosophila melanogaster
A309VLVLEGRSRPG1Arabidopsis thaliana
A309VLVLEGRARPG1Oryza sativa subsp. japonica
A331VADLGAMVVTG2Homo sapiens, Mus musculus
A331AVELGGSVITG2Arabidopsis thaliana, Oryza sativa subsp. japonica
A331IMETGGDTLRK1Caenorhabditis elegans
A331IADVGAMVVTG1Drosophila melanogaster
A539ANLEFANATPL2Homo sapiens, Mus musculus
A539GFEEYLVGAQL1Caenorhabditis elegans
A539ANLEFANATRL1Drosophila melanogaster
A539ANLEYANAGCL1Arabidopsis thaliana
A539ANLEFSNAGCL1Oryza sativa subsp. japonica
A589IKLNTAVRQVR2Homo sapiens, Mus musculus
A589IRLKHRVLDID1Caenorhabditis elegans
A589IRVNSAVKEIK1Drosophila melanogaster
A589IIYGKSVDTIK1Arabidopsis thaliana
A589VLYEKTVKRIE1Oryza sativa subsp. japonica
A809IRNYPATVHGA3Homo sapiens, Drosophila melanogaster, Mus musculus
A809CSSYTSTIQGA1Caenorhabditis elegans
A809TRQHPATMHGA1Arabidopsis thaliana
A809NRAYPATMHGA1Oryza sativa subsp. japonica
A814ATVHGALLSGL2Homo sapiens, Mus musculus
A814STIQGAWMSGA1Caenorhabditis elegans
A814ATVHGAYLSGL1Drosophila melanogaster
A814ATMHGAYLSGL1Arabidopsis thaliana
A814ATMHGALLSGL1Oryza sativa subsp. japonica
C360KIKQKCPLYEA2Homo sapiens, Mus musculus
C360GVFDFTSVF-V1Caenorhabditis elegans
C360PIQQTCPLYGP1Drosophila melanogaster
C360KVRDNCPLYNS1Arabidopsis thaliana
C360KVRDSCPLYHH1Oryza sativa subsp. japonica
D375VPKEKDEMVEQ2Homo sapiens, Mus musculus
D375LNEEKIHLFLD1Caenorhabditis elegans
D375VPKEKDDVIER1Drosophila melanogaster
D375VDKVADSNVEF1Arabidopsis thaliana
D375VDMKLDRSMDL1Oryza sativa subsp. japonica
D553SLKHWDQDDDF3Homo sapiens, Drosophila melanogaster, Mus musculus
D553QFSCDSMQNKE1Caenorhabditis elegans
D553SAAYWDQDDPY1Arabidopsis thaliana
D553SLAHWDQDDQY1Oryza sativa subsp. japonica
D555KHWDQDDDFEF3Homo sapiens, Drosophila melanogaster, Mus musculus
D555SCDSMQNKEN-1Caenorhabditis elegans
D555AYWDQDDPYEM1Arabidopsis thaliana
D555AHWDQDDQYEM1Oryza sativa subsp. japonica
D556HWDQDDDFEFT2Homo sapiens, Mus musculus
D556CDSMQNKEN--1Caenorhabditis elegans
D556HWDQDDDFEFI1Drosophila melanogaster
D556YWDQDDPYEMG1Arabidopsis thaliana
D556HWDQDDQYEMG1Oryza sativa subsp. japonica
E308DVTLLEARDRV2Homo sapiens, Mus musculus
E308DVIVLEARNCI1Caenorhabditis elegans
E308DVIVLEARDRV1Drosophila melanogaster
E308KVLVLEGRSRP1Arabidopsis thaliana
E308RVLVLEGRARP1Oryza sativa subsp. japonica
E379KDEMVEQEFNR2Homo sapiens, Mus musculus
E379KIHLFLDHYKS1Caenorhabditis elegans
E379KDDVIEREFNR1Drosophila melanogaster
E379ADSNVEFGFNK1Arabidopsis thaliana
E379LDRSMDLVFNT1Oryza sativa subsp. japonica
E387FNRLLEATSYL2Homo sapiens, Mus musculus
E387YKSAHGALNYQ1Caenorhabditis elegans
E387FNRLLESASYL1Drosophila melanogaster
E387FNKLLDKVTEV1Arabidopsis thaliana
E387FNTLLEHATRL1Oryza sativa subsp. japonica
E559QDDDFEFTGSH2Homo sapiens, Mus musculus
E559MQNKEN--GVA1Caenorhabditis elegans
E559QDDDFEFIGHH1Drosophila melanogaster
E559QDDPYEMGGDH1Arabidopsis thaliana
E559QDDQYEMGGDH1Oryza sativa subsp. japonica
E801LFFAGEHTIRN3Homo sapiens, Drosophila melanogaster, Mus musculus
E801VYFAGEHTCSS1Caenorhabditis elegans
E801LFFAGEATTRQ1Arabidopsis thaliana
E801LFFAGEATNRA1Oryza sativa subsp. japonica
F382MVEQEFNRLLE2Homo sapiens, Mus musculus
F382LFLDHYKSAHG1Caenorhabditis elegans
F382VIEREFNRLLE1Drosophila melanogaster
F382NVEFGFNKLLD1Arabidopsis thaliana
F382SMDLVFNTLLE1Oryza sativa subsp. japonica
F538FANLEFANATP2Homo sapiens, Mus musculus
F538LGFEEYLVGAQ1Caenorhabditis elegans
F538FANLEFANATR1Drosophila melanogaster
F538LANLEYANAGC1Arabidopsis thaliana
F538LANLEFSNAGC1Oryza sativa subsp. japonica
G285KVIIIGSGVSG2Homo sapiens, Mus musculus
G285SVIVIGAGAAG1Caenorhabditis elegans
G285KVIVIGAGISG1Drosophila melanogaster
G285SVIVVGAGLAG1Arabidopsis thaliana
G285SVLVVGAGLAG1Oryza sativa subsp. japonica
G287IIIGSGVSGLA2Homo sapiens, Mus musculus
G287IVIGAGAAGIS1Caenorhabditis elegans
G287IVIGAGISGLA1Drosophila melanogaster
G287IVVGAGLAGLA1Arabidopsis thaliana
G287LVVGAGLAGLA1Oryza sativa subsp. japonica
G314ARDRVGGRVAT2Homo sapiens, Mus musculus
G314ARNCIGGRIHS1Caenorhabditis elegans
G314ARDRVGGRIST1Drosophila melanogaster
G314GRSRPGGRVYT1Arabidopsis thaliana
G314GRARPGGRVYT1Oryza sativa subsp. japonica
G315RDRVGGRVATF2Homo sapiens, Mus musculus
G315RNCIGGRIHSF1Caenorhabditis elegans
G315RDRVGGRISTF1Drosophila melanogaster
G315RSRPGGRVYTQ1Arabidopsis thaliana
G315RARPGGRVYTT1Oryza sativa subsp. japonica
G330YVADLGAMVVT2Homo sapiens, Mus musculus
G330AAVELGGSVIT2Arabidopsis thaliana, Oryza sativa subsp. japonica
G330EIMETGGDTLR1Caenorhabditis elegans
G330YIADVGAMVVT1Drosophila melanogaster
G800RLFFAGEHTIR3Homo sapiens, Drosophila melanogaster, Mus musculus
G800RVYFAGEHTCS1Caenorhabditis elegans
G800RLFFAGEATTR1Arabidopsis thaliana
G800RLFFAGEATNR1Oryza sativa subsp. japonica
H564EFTGSHLTVRN2Homo sapiens, Mus musculus
H564EMGGDHCFLAG2Arabidopsis thaliana, Oryza sativa subsp. japonica
H564N--GVAARLTE1Caenorhabditis elegans
H564EFIGHHTTVRN1Drosophila melanogaster
I284GKVIIIGSGVS2Homo sapiens, Mus musculus
I284RSVIVIGAGAA1Caenorhabditis elegans
I284GKVIVIGAGIS1Drosophila melanogaster
I284GSVIVVGAGLA1Arabidopsis thaliana
I284ASVLVVGAGLA1Oryza sativa subsp. japonica
I356MELAKIKQKCP2Homo sapiens, Mus musculus
I356FEEHGVFDFTS1Caenorhabditis elegans
I356MDLVPIQQTCP1Drosophila melanogaster
I356IPLHKVRDNCP1Arabidopsis thaliana
I356IPLHKVRDSCP1Oryza sativa subsp. japonica
K322VATFRKGN---2Homo sapiens, Mus musculus
K322IHSFKSKSG--1Caenorhabditis elegans
K322ISTFRKNS---1Drosophila melanogaster
K322VYTQKMGGKDR1Arabidopsis thaliana
K322VYTTHLGGDQ-1Oryza sativa subsp. japonica
K661FGNLNKVVLCF3Homo sapiens, Drosophila melanogaster, Mus musculus
K661CGSVNKCILEF1Caenorhabditis elegans
K661FGLLNKVAMLF1Arabidopsis thaliana
K661FGLLNKVAMVF1Oryza sativa subsp. japonica
L307MDVTLLEARDR2Homo sapiens, Mus musculus
L307FDVIVLEARNC1Caenorhabditis elegans
L307MDVIVLEARDR1Drosophila melanogaster
L307FKVLVLEGRSR1Arabidopsis thaliana
L307LRVLVLEGRAR1Oryza sativa subsp. japonica
L329-YVADLGAMVV2Homo sapiens, Mus musculus
L329-EIMETGGDTL1Caenorhabditis elegans
L329-YIADVGAMVV1Drosophila melanogaster
L329FAAVELGGSVI1Arabidopsis thaliana
L329-AAVELGGSVI1Oryza sativa subsp. japonica
L362KQKCPLYEANG2Homo sapiens, Mus musculus
L362FDFTSVF-VEG1Caenorhabditis elegans
L362QQTCPLYGPDG1Drosophila melanogaster
L362RDNCPLYNSEG1Arabidopsis thaliana
L362RDSCPLYHHDG1Oryza sativa subsp. japonica
L386EFNRLLEATSY2Homo sapiens, Mus musculus
L386HYKSAHGALNY1Caenorhabditis elegans
L386EFNRLLESASY1Drosophila melanogaster
L386GFNKLLDKVTE1Arabidopsis thaliana
L386VFNTLLEHATR1Oryza sativa subsp. japonica
L536WHFANLEFANA3Homo sapiens, Drosophila melanogaster, Mus musculus
L536FMLGFEEYLVG1Caenorhabditis elegans
L536WHLANLEYANA1Arabidopsis thaliana
L536WHLANLEFSNA1Oryza sativa subsp. japonica
L625AVLCTLPLGVL2Homo sapiens, Mus musculus
L625FVVSTLPIGVL1Caenorhabditis elegans
L625LVVCTLTLGVL1Drosophila melanogaster
L625MILCTVPLGVL1Arabidopsis thaliana
L625MALCTAPLGVL1Oryza sativa subsp. japonica
L659MGFGNLNKVVL2Homo sapiens, Mus musculus
L659LGFGLLNKVAM2Arabidopsis thaliana, Oryza sativa subsp. japonica
L659IGCGSVNKCIL1Caenorhabditis elegans
L659LGFGNLNKVVL1Drosophila melanogaster
L677S--VNLFGHVG2Homo sapiens, Mus musculus
L677NGGRNQFVTVS1Caenorhabditis elegans
L677N--ANLFGHVG1Drosophila melanogaster
L677E--LDTFGCLN1Arabidopsis thaliana
L677E--IDTFGCLN1Oryza sativa subsp. japonica
L693RGELFLFWN--2Homo sapiens, Mus musculus
L693RGSMNIWSS--1Caenorhabditis elegans
L693RGEMFLFWS--1Drosophila melanogaster
L693RGEFFLFYAYH1Arabidopsis thaliana
L693RGEFFLFYSYH1Oryza sativa subsp. japonica
M332ADLGAMVVTGL2Homo sapiens, Mus musculus
M332METGGDTLRKI1Caenorhabditis elegans
M332ADVGAMVVTGV1Drosophila melanogaster
M332VELGGSVITGL1Arabidopsis thaliana
M332VELGGSVITGI1Oryza sativa subsp. japonica
N383VEQEFNRLLEA2Homo sapiens, Mus musculus
N383FLDHYKSAHGA1Caenorhabditis elegans
N383IEREFNRLLES1Drosophila melanogaster
N383VEFGFNKLLDK1Arabidopsis thaliana
N383MDLVFNTLLEH1Oryza sativa subsp. japonica
N535DWHFANLEFAN3Homo sapiens, Drosophila melanogaster, Mus musculus
N535NFMLGFEEYLV1Caenorhabditis elegans
N535DWHLANLEYAN1Arabidopsis thaliana
N535DWHLANLEFSN1Oryza sativa subsp. japonica
N540NLEFANATPLS2Homo sapiens, Mus musculus
N540FEEYLVGAQLE1Caenorhabditis elegans
N540NLEFANATRLN1Drosophila melanogaster
N540NLEYANAGCLS1Arabidopsis thaliana
N540NLEFSNAGCLS1Oryza sativa subsp. japonica
P626VLCTLPLGVLK2Homo sapiens, Mus musculus
P626VVSTLPIGVLK1Caenorhabditis elegans
P626VVCTLTLGVLK1Drosophila melanogaster
P626ILCTVPLGVLK1Arabidopsis thaliana
P626ALCTAPLGVLK1Oryza sativa subsp. japonica
P808TIRNYPATVHG3Homo sapiens, Drosophila melanogaster, Mus musculus
P808TCSSYTSTIQG1Caenorhabditis elegans
P808TTRQHPATMHG1Arabidopsis thaliana
P808TNRAYPATMHG1Oryza sativa subsp. japonica
Q358LAKIKQKCPLY2Homo sapiens, Mus musculus
Q358EHGVFDFTSVF1Caenorhabditis elegans
Q358LVPIQQTCPLY1Drosophila melanogaster
Q358LHKVRDNCPLY1Arabidopsis thaliana
Q358LHKVRDSCPLY1Oryza sativa subsp. japonica
R310TLLEARDRVGG2Homo sapiens, Mus musculus
R310IVLEARNCIGG1Caenorhabditis elegans
R310IVLEARDRVGG1Drosophila melanogaster
R310LVLEGRSRPGG1Arabidopsis thaliana
R310LVLEGRARPGG1Oryza sativa subsp. japonica
R312LEARDRVGGRV2Homo sapiens, Mus musculus
R312LEARNCIGGRI1Caenorhabditis elegans
R312LEARDRVGGRI1Drosophila melanogaster
R312LEGRSRPGGRV1Arabidopsis thaliana
R312LEGRARPGGRV1Oryza sativa subsp. japonica
R316DRVGGRVATFR2Homo sapiens, Mus musculus
R316NCIGGRIHSFK1Caenorhabditis elegans
R316DRVGGRISTFR1Drosophila melanogaster
R316SRPGGRVYTQK1Arabidopsis thaliana
R316ARPGGRVYTTH1Oryza sativa subsp. japonica
R321RVATFRKGN--2Homo sapiens, Mus musculus
R321RIHSFKSKSG-1Caenorhabditis elegans
R321RISTFRKNS--1Drosophila melanogaster
R321RVYTQKMGGKD1Arabidopsis thaliana
R321RVYTTHLGGDQ1Oryza sativa subsp. japonica
S286VIIIGSGVSGL2Homo sapiens, Mus musculus
S286VIVIGAGAAGI1Caenorhabditis elegans
S286VIVIGAGISGL1Drosophila melanogaster
S286VIVVGAGLAGL1Arabidopsis thaliana
S286VLVVGAGLAGL1Oryza sativa subsp. japonica
S289IGSGVSGLAAA2Homo sapiens, Mus musculus
S289VGAGLAGLAAA2Arabidopsis thaliana, Oryza sativa subsp. japonica
S289IGAGAAGISAA1Caenorhabditis elegans
S289IGAGISGLAVA1Drosophila melanogaster
S572VRNGYSCVPVA3Homo sapiens, Drosophila melanogaster, Mus musculus
S572LTEGIAELLTQ1Caenorhabditis elegans
S572LAGGNWRLINA1Arabidopsis thaliana
S572LAGGNARLVHA1Oryza sativa subsp. japonica
S760PWARGSYSYVA2Homo sapiens, Mus musculus
S760ELAFGSGAFMS1Caenorhabditis elegans
S760PWARGSYSYVS1Drosophila melanogaster
S760PLSYGSYSHVR1Arabidopsis thaliana
S760PLCSGSYSHIR1Oryza sativa subsp. japonica
T319GGRVATFRKGN2Homo sapiens, Mus musculus
T319GGRIHSFKSKS1Caenorhabditis elegans
T319GGRISTFRKNS1Drosophila melanogaster
T319GGRVYTQKMGG1Arabidopsis thaliana
T319GGRVYTTHLGG1Oryza sativa subsp. japonica
T335GAMVVTGLGGN2Homo sapiens, Mus musculus
T335GGDTLRKIEDS1Caenorhabditis elegans
T335GAMVVTGVYGN1Drosophila melanogaster
T335GGSVITGLHAN1Arabidopsis thaliana
T335GGSVITGIHTN1Oryza sativa subsp. japonica
T588DIKLNTAVRQV2Homo sapiens, Mus musculus
T588DIRLKHRVLDI1Caenorhabditis elegans
T588DIRVNSAVKEI1Drosophila melanogaster
T588PIIYGKSVDTI1Arabidopsis thaliana
T588PVLYEKTVKRI1Oryza sativa subsp. japonica
T624DAVLCTLPLGV2Homo sapiens, Mus musculus
T624AFVVSTLPIGV1Caenorhabditis elegans
T624DLVVCTLTLGV1Drosophila melanogaster
T624DMILCTVPLGV1Arabidopsis thaliana
T624DMALCTAPLGV1Oryza sativa subsp. japonica
T810RNYPATVHGAL2Homo sapiens, Mus musculus
T810SSYTSTIQGAW1Caenorhabditis elegans
T810RNYPATVHGAY1Drosophila melanogaster
T810RQHPATMHGAY1Arabidopsis thaliana
T810RAYPATMHGAL1Oryza sativa subsp. japonica
V288IIGSGVSGLAA2Homo sapiens, Mus musculus
V288VVGAGLAGLAA2Arabidopsis thaliana, Oryza sativa subsp. japonica
V288VIGAGAAGISA1Caenorhabditis elegans
V288VIGAGISGLAV1Drosophila melanogaster
V317RVGGRVATFRK2Homo sapiens, Mus musculus
V317CIGGRIHSFKS1Caenorhabditis elegans
V317RVGGRISTFRK1Drosophila melanogaster
V317RPGGRVYTQKM1Arabidopsis thaliana
V317RPGGRVYTTHL1Oryza sativa subsp. japonica
V333DLGAMVVTGLG2Homo sapiens, Mus musculus
V333ETGGDTLRKIE1Caenorhabditis elegans
V333DVGAMVVTGVY1Drosophila melanogaster
V333ELGGSVITGLH1Arabidopsis thaliana
V333ELGGSVITGIH1Oryza sativa subsp. japonica
V576YSCVPVALAE-2Homo sapiens, Mus musculus
V576IAELLTQLSEK1Caenorhabditis elegans
V576YSCVPVALTE-1Drosophila melanogaster
V576NWRLINALAE-1Arabidopsis thaliana
V576NARLVHALCD-1Oryza sativa subsp. japonica
V590KLNTAVRQVRY2Homo sapiens, Mus musculus
V590RLKHRVLDIDY1Caenorhabditis elegans
V590RVNSAVKEIKY1Drosophila melanogaster
V590IYGKSVDTIKY1Arabidopsis thaliana
V590LYEKTVKRIEH1Oryza sativa subsp. japonica
V637QQPPAVQFVPP2Homo sapiens, Mus musculus
V637ADERAPTFTPS1Caenorhabditis elegans
V637QQSNTVKFDPP1Drosophila melanogaster
V637--KRSIKFEPE1Arabidopsis thaliana
V637--SRSIIFEPE1Oryza sativa subsp. japonica
V811NYPATVHGALL2Homo sapiens, Mus musculus
V811SYTSTIQGAWM1Caenorhabditis elegans
V811NYPATVHGAYL1Drosophila melanogaster
V811QHPATMHGAYL1Arabidopsis thaliana
V811AYPATMHGALL1Oryza sativa subsp. japonica
W531RQILDWHFANL2Homo sapiens, Mus musculus
W531FATFNFMLGFE1Caenorhabditis elegans
W531RLILDWHFANL1Drosophila melanogaster
W531RKLFDWHLANL1Arabidopsis thaliana
W531REVLDWHLANL1Oryza sativa subsp. japonica
W552LSLKHWDQDDD3Homo sapiens, Drosophila melanogaster, Mus musculus
W552VQFSCDSMQNK1Caenorhabditis elegans
W552LSAAYWDQDDP1Arabidopsis thaliana
W552LSLAHWDQDDQ1Oryza sativa subsp. japonica
W695ELFLFWN---L2Homo sapiens, Mus musculus
W695SMNIWSS---V1Caenorhabditis elegans
W695EMFLFWS---I1Drosophila melanogaster
W695EFFLFYAYHTV1Arabidopsis thaliana
W695EFFLFYSYHTV1Oryza sativa subsp. japonica
W751TVVSRWRADPW2Homo sapiens, Mus musculus
W751AHITRWHDDEL1Caenorhabditis elegans
W751TVVTRWRSDPW1Drosophila melanogaster
W751TVCTRWGSDPL1Arabidopsis thaliana
W751SCCTRWGSDPL1Oryza sativa subsp. japonica
W756WRADPWARGSY2Homo sapiens, Mus musculus
W756WHDDELAFGSG1Caenorhabditis elegans
W756WRSDPWARGSY1Drosophila melanogaster
W756WGSDPLSYGSY1Arabidopsis thaliana
W756WGSDPLCSGSY1Oryza sativa subsp. japonica
Y761WARGSYSYVAA2Homo sapiens, Mus musculus
Y761LAFGSGAFMSL1Caenorhabditis elegans
Y761WARGSYSYVSV1Drosophila melanogaster
Y761LSYGSYSHVRV1Arabidopsis thaliana
Y761LCSGSYSHIRV1Oryza sativa subsp. japonica


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