mutLBSgeneDB |
Gene summary for FOXO3 |
Gene summary |
Basic gene Info. | Gene symbol | FOXO3 |
Gene name | forkhead box O3 | |
Synonyms | AF6q21|FKHRL1|FKHRL1P2|FOXO2|FOXO3A | |
Cytomap | UCSC genome browser: 6q21 | |
Type of gene | protein-coding | |
RefGenes | NM_001455.3, NM_201559.2, | |
Description | forkhead box O3Aforkhead box protein O3forkhead homolog (rhabdomyosarcoma) like 1forkhead in rhabdomyosarcoma-like 1forkhead, Drosophila, homolog of, in rhabdomyosarcoma-like 1 | |
Modification date | 20141222 | |
dbXrefs | MIM : 602681 | |
HGNC : HGNC | ||
Ensembl : ENSG00000118689 | ||
HPRD : 04061 | ||
Vega : OTTHUMG00000015327 | ||
Protein | UniProt: O43524 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_FOXO3 | |
BioGPS: 2309 | ||
Pathway | NCI Pathway Interaction Database: FOXO3 | |
KEGG: FOXO3 | ||
REACTOME: FOXO3 | ||
Pathway Commons: FOXO3 | ||
Context | iHOP: FOXO3 | |
ligand binding site mutation search in PubMed: FOXO3 | ||
UCL Cancer Institute: FOXO3 | ||
Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO Term | PubMed ID | GO:0006417 | regulation of translation | 21329882 | GO:0045648 | positive regulation of erythrocyte differentiation | 14734530 | GO:0045893 | positive regulation of transcription, DNA-templated | 10102273 | GO:0045944 | positive regulation of transcription from RNA polymerase II promoter | 10102273 |
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Ligand binding site mutations for FOXO3 |
Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.) : non-synonymous mutation on LBS, Circle size denotes number of samples. |
Cancer type specific mutLBS sorted by frequency |
LBS | AAchange of nsSNV | Cancer type | # samples | R250 | R250Q | COAD | 1 | K245 | G244A | HNSC | 1 | Y162 | D164N | LUAD | 1 | R222 | R222W | STAD | 1 | R250 | R250W | STAD | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for FOXO3 |
Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
: nsSNV at non-LBS: nsSNV at LBS |
nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | Y162 | D164N | -1.1484641 | R250 | R250Q | -1.0081758 | R250 | R250W | -0.72397024 | R222 | R222W | -0.70311364 | K245 | G244A | -0.64041818 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
Structure image for FOXO3 from PDB |
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Differential gene expression and gene-gene network for FOXO3 |
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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Phenotype information for FOXO3 |
Gene level disease information (DisGeNet) |
Disease ID | Disease name | # PubMed | Association type |
umls:C0152013 | Adenocarcinoma of lung | 4 | Biomarker |
umls:C0010606 | Carcinoma, Adenoid Cystic | 1 | Biomarker |
umls:C0007131 | Carcinoma, Non-Small-Cell Lung | 1 | Biomarker |
umls:C0011853 | Diabetes Mellitus, Experimental | 1 | Biomarker |
umls:C0028754 | Obesity | 1 | Biomarker |
Mutation level pathogenic information (ClinVar annotation) |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for FOXO3 |
Drug information targeting mutLBSgene (Approved drugs only) |
Drug status | DrugBank ID | Name | Type | Drug structure |
Gene-centered ligand-gene interaction network |
Ligands binding to mutated ligand binding site of FOXO3 go to BioLip |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | NUC | Nucleic Acids | 2uzk | A | R222 R250 | NUC | Nucleic Acids | 2uzk | A | Y162 K245 |
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Conservation information for LBS of FOXO3 |
Multiple alignments for O43524 in multiple species |
LBS | AA sequence | # species | Species |
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