mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for FOXO3
Gene summary
Basic gene Info.Gene symbolFOXO3
Gene nameforkhead box O3
SynonymsAF6q21|FKHRL1|FKHRL1P2|FOXO2|FOXO3A
CytomapUCSC genome browser: 6q21
Type of geneprotein-coding
RefGenesNM_001455.3,
NM_201559.2,
Descriptionforkhead box O3Aforkhead box protein O3forkhead homolog (rhabdomyosarcoma) like 1forkhead in rhabdomyosarcoma-like 1forkhead, Drosophila, homolog of, in rhabdomyosarcoma-like 1
Modification date20141222
dbXrefs MIM : 602681
HGNC : HGNC
Ensembl : ENSG00000118689
HPRD : 04061
Vega : OTTHUMG00000015327
ProteinUniProt: O43524
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_FOXO3
BioGPS: 2309
PathwayNCI Pathway Interaction Database: FOXO3
KEGG: FOXO3
REACTOME: FOXO3
Pathway Commons: FOXO3
ContextiHOP: FOXO3
ligand binding site mutation search in PubMed: FOXO3
UCL Cancer Institute: FOXO3
Assigned class in mutLBSgeneDBB: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0006417regulation of translation21329882
GO:0045648positive regulation of erythrocyte differentiation14734530
GO:0045893positive regulation of transcription, DNA-templated10102273
GO:0045944positive regulation of transcription from RNA polymerase II promoter10102273


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Ligand binding site mutations for FOXO3
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
 
: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
R250R250QCOAD1
K245G244AHNSC1
Y162D164NLUAD1
R222R222WSTAD1
R250R250WSTAD1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for FOXO3
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
Y162D164N-1.1484641
R250R250Q-1.0081758
R250R250W-0.72397024
R222R222W-0.70311364
K245G244A-0.64041818
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for FOXO3 from PDB

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Differential gene expression and gene-gene network for FOXO3
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of FOXO3 and the right PPI network was created from samples without mutations in the LBS of FOXO3. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for FOXO3
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0152013Adenocarcinoma of lung4Biomarker
umls:C0010606Carcinoma, Adenoid Cystic1Biomarker
umls:C0007131Carcinoma, Non-Small-Cell Lung1Biomarker
umls:C0011853Diabetes Mellitus, Experimental1Biomarker
umls:C0028754Obesity1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for FOXO3
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of FOXO3 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
NUCNucleic Acids2uzkAR222 R250
NUCNucleic Acids2uzkAY162 K245


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Conservation information for LBS of FOXO3
Multiple alignments for O43524 in multiple species
LBSAA sequence# speciesSpecies


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