|
mutLBSgeneDB |
| |
| |
| |
| |
| |
| |
|
| Gene summary for GPD1L |
 Gene summary |
| Basic gene Info. | Gene symbol | GPD1L |
| Gene name | glycerol-3-phosphate dehydrogenase 1-like | |
| Synonyms | GPD1-L | |
| Cytomap | UCSC genome browser: 3p22.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_015141.3, | |
| Description | glycerol-3-phosphate dehydrogenase 1-like protein | |
| Modification date | 20141219 | |
| dbXrefs | MIM : 611778 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000152642 | ||
| HPRD : 10008 | ||
| Vega : OTTHUMG00000155846 | ||
| Protein | UniProt: Q8N335 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_GPD1L | |
| BioGPS: 23171 | ||
| Pathway | NCI Pathway Interaction Database: GPD1L | |
| KEGG: GPD1L | ||
| REACTOME: GPD1L | ||
| Pathway Commons: GPD1L | ||
| Context | iHOP: GPD1L | |
| ligand binding site mutation search in PubMed: GPD1L | ||
| UCL Cancer Institute: GPD1L | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
| Top |
| Ligand binding site mutations for GPD1L |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
 |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | P96 | H97N | LUAD | 1 | I121 | I121M | LUSC | 1 | T266 | I264F | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
| Top |
| Protein structure related information for GPD1L |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
 |
| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | I121 | I121M | -1.5792571 | P96 | H97N | -1.1952482 | T266 | I264F | -1.1551751 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for GPD1L from PDB |
| Top |
| Differential gene expression and gene-gene network for GPD1L |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
| Top |
| Top |
| Phenotype information for GPD1L |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C0038644 | Sudden Infant Death | 2 | Biomarker, GeneticVariation |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
| Top |
| Pharmacological information for GPD1L |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
 |
| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
 |
| Ligands binding to mutated ligand binding site of GPD1L go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | NAD | NAD ZWITTERION | 2pla | A | P96 I121 | NAD | NAD ZWITTERION | 2pla | B | P96 I121 | PO4 | PHOSPHATE ION | 2pla | A | T266 | PO4 | PHOSPHATE ION | 2pla | B | T266 |
| Top |
| Conservation information for LBS of GPD1L |
| Multiple alignments for Q8N335 in multiple species |
| LBS | AA sequence | # species | Species | A155 | MGANIANEVAA | 3 | Homo sapiens, Danio rerio, Xenopus tropicalis | A155 | MGANIANEIAV | 1 | Arabidopsis thaliana | A155 | MGANIASEVAA | 1 | Mus musculus | F43 | VKMWVFEETV- | 2 | Homo sapiens, Mus musculus | F43 | VRMWVFEEVLP | 1 | Arabidopsis thaliana | F43 | VKMWVYEEMV- | 1 | Danio rerio | F43 | VNMWVFEENI- | 1 | Xenopus tropicalis | F99 | VIPHQFIHKIC | 2 | Xenopus tropicalis, Mus musculus | F99 | VIPHQFIHRIC | 1 | Homo sapiens | F99 | VTPHQFMDGIC | 1 | Arabidopsis thaliana | F99 | VVPHQFIRKLC | 1 | Danio rerio | G14 | CIVGSGNWGSA | 4 | Homo sapiens, Danio rerio, Xenopus tropicalis, Mus musculus | G14 | TVVGSGNWGSV | 1 | Arabidopsis thaliana | G17 | GSGNWGSAVAK | 3 | Homo sapiens, Xenopus tropicalis, Mus musculus | G17 | GSGNWGSVAAK | 1 | Arabidopsis thaliana | G17 | GSGNWGSAIAR | 1 | Danio rerio | G270 | TTCYGGRNRRV | 3 | Homo sapiens, Danio rerio, Mus musculus | G270 | TTCLGGRNRRV | 1 | Arabidopsis thaliana | G270 | TTCYGGRNRKV | 1 | Xenopus tropicalis | G296 | KEMLNGQKLQG | 3 | Homo sapiens, Danio rerio, Xenopus tropicalis | G296 | AEMLQGQKLQG | 1 | Arabidopsis thaliana | G296 | KELLNGQKLQG | 1 | Mus musculus | H69 | KYLPGHKLPEN | 2 | Homo sapiens, Mus musculus | H69 | KYLPGYKLPEN | 2 | Danio rerio, Xenopus tropicalis | H69 | KYLPGIKLGRN | 1 | Arabidopsis thaliana | I121 | LGITLIKGIDE | 3 | Homo sapiens, Xenopus tropicalis, Mus musculus | I121 | EAISLVKGMEV | 1 | Arabidopsis thaliana | I121 | RGITLIKGIDE | 1 | Danio rerio | I154 | LMGANIANEVA | 3 | Homo sapiens, Danio rerio, Xenopus tropicalis | I154 | LMGANIANEIA | 1 | Arabidopsis thaliana | I154 | LMGANIASEVA | 1 | Mus musculus | I95 | LLVFVIPHQFI | 2 | Homo sapiens, Mus musculus | I95 | MLVFVTPHQFM | 1 | Arabidopsis thaliana | I95 | LLVFVVPHQFI | 1 | Danio rerio | I95 | LLIFVIPHQFI | 1 | Xenopus tropicalis | K122 | GITLIKGIDEG | 4 | Homo sapiens, Danio rerio, Xenopus tropicalis, Mus musculus | K122 | AISLVKGMEVK | 1 | Arabidopsis thaliana | K206 | LCGALKNIVAV | 4 | Homo sapiens, Danio rerio, Xenopus tropicalis, Mus musculus | K206 | LCGTLKNVVAI | 1 | Arabidopsis thaliana | K22 | GSAVAKIIGNN | 1 | Homo sapiens | K22 | GSVAAKLIASN | 1 | Arabidopsis thaliana | K22 | GSAIARIIGSN | 1 | Danio rerio | K22 | GSAVAKIIGHN | 1 | Xenopus tropicalis | K22 | GSAVAKIIGSN | 1 | Mus musculus | K298 | MLNGQKLQGPQ | 2 | Homo sapiens, Xenopus tropicalis | K298 | MLQGQKLQGVS | 1 | Arabidopsis thaliana | K298 | MLNGQKLQGPL | 1 | Danio rerio | K298 | LLNGQKLQGPQ | 1 | Mus musculus | K70 | YLPGHKLPENV | 2 | Homo sapiens, Mus musculus | K70 | YLPGYKLPENV | 2 | Danio rerio, Xenopus tropicalis | K70 | YLPGIKLGRNV | 1 | Arabidopsis thaliana | L120 | ALGITLIKGID | 3 | Homo sapiens, Xenopus tropicalis, Mus musculus | L120 | VEAISLVKGME | 1 | Arabidopsis thaliana | L120 | ARGITLIKGID | 1 | Danio rerio | N15 | IVGSGNWGSAV | 3 | Homo sapiens, Xenopus tropicalis, Mus musculus | N15 | VVGSGNWGSVA | 1 | Arabidopsis thaliana | N15 | IVGSGNWGSAI | 1 | Danio rerio | N153 | VLMGANIANEV | 3 | Homo sapiens, Danio rerio, Xenopus tropicalis | N153 | VLMGANIANEI | 1 | Arabidopsis thaliana | N153 | VLMGANIASEV | 1 | Mus musculus | N272 | CYGGRNRRVAE | 3 | Homo sapiens, Danio rerio, Mus musculus | N272 | CLGGRNRRVAE | 1 | Arabidopsis thaliana | N272 | CYGGRNRKVSE | 1 | Xenopus tropicalis | P96 | LVFVIPHQFIH | 2 | Homo sapiens, Mus musculus | P96 | LVFVTPHQFMD | 1 | Arabidopsis thaliana | P96 | LVFVVPHQFIR | 1 | Danio rerio | P96 | LIFVIPHQFIH | 1 | Xenopus tropicalis | Q297 | EMLNGQKLQGP | 3 | Homo sapiens, Danio rerio, Xenopus tropicalis | Q297 | EMLQGQKLQGV | 1 | Arabidopsis thaliana | Q297 | ELLNGQKLQGP | 1 | Mus musculus | Q300 | NGQKLQGPQTS | 3 | Homo sapiens, Xenopus tropicalis, Mus musculus | Q300 | QGQKLQGVSTA | 1 | Arabidopsis thaliana | Q300 | NGQKLQGPLTS | 1 | Danio rerio | R102 | HQFIHRICDEI | 1 | Homo sapiens | R102 | HQFMDGICKKL | 1 | Arabidopsis thaliana | R102 | HQFIRKLCDEM | 1 | Danio rerio | R102 | HQFIHKICQEI | 1 | Xenopus tropicalis | R102 | HQFIHKICDEI | 1 | Mus musculus | R271 | TCYGGRNRRVA | 3 | Homo sapiens, Danio rerio, Mus musculus | R271 | TCLGGRNRRVA | 1 | Arabidopsis thaliana | R271 | TCYGGRNRKVS | 1 | Xenopus tropicalis | T266 | ADLITTCYGGR | 4 | Homo sapiens, Danio rerio, Xenopus tropicalis, Mus musculus | T266 | ADVITTCLGGR | 1 | Arabidopsis thaliana | V94 | DLLVFVIPHQF | 2 | Homo sapiens, Mus musculus | V94 | NMLVFVTPHQF | 1 | Arabidopsis thaliana | V94 | DLLVFVVPHQF | 1 | Danio rerio | V94 | DLLIFVIPHQF | 1 | Xenopus tropicalis | W16 | VGSGNWGSAVA | 3 | Homo sapiens, Xenopus tropicalis, Mus musculus | W16 | VGSGNWGSVAA | 1 | Arabidopsis thaliana | W16 | VGSGNWGSAIA | 1 | Danio rerio | Y65 | HENVKYLPGHK | 2 | Homo sapiens, Mus musculus | Y65 | HENVKYLPGYK | 2 | Danio rerio, Xenopus tropicalis | Y65 | NENVKYLPGIK | 1 | Arabidopsis thaliana |
 |
Copyright © 2016-Present - The University of Texas Health Science Center at Houston |