mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

Home

Download

 Statistics

Help

About Us
Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for METAP1
Gene summary
Basic gene Info.Gene symbolMETAP1
Gene namemethionyl aminopeptidase 1
SynonymsMAP1A|MetAP1A
CytomapUCSC genome browser: 4q23
Type of geneprotein-coding
RefGenesNM_015143.2,
DescriptionMAP 1metAP 1methionine aminopeptidase 1peptidase M 1
Modification date20141207
dbXrefs MIM : 610151
HGNC : HGNC
Ensembl : ENSG00000164024
HPRD : 10071
Vega : OTTHUMG00000161231
ProteinUniProt: P53582
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_METAP1
BioGPS: 23173
PathwayNCI Pathway Interaction Database: METAP1
KEGG: METAP1
REACTOME: METAP1
Pathway Commons: METAP1
ContextiHOP: METAP1
ligand binding site mutation search in PubMed: METAP1
UCL Cancer Institute: METAP1
Assigned class in mutLBSgeneDBB: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID


Top
Ligand binding site mutations for METAP1

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
M329M329VUCEC2
D231D231YBRCA1
Y291R289QCOAD1
H301H301YSKCM1
Y291R289QUCEC1
N305V306AUCEC1
M329,E327P328SUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


Top
Protein structure related information for METAP1
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
M329P328S-1.6276281
E327P328S-1.6276281
N305V306A-1.3417962
M329M329V-0.72354
D231D231Y-0.69984677
Y291R289Q-0.62506529
H301H301Y-0.5419706
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for METAP1 from PDB
PDB IDPDB titlePDB structure
2B3KCrystal structure of Human Methionine Aminopeptidase Type I in the holo form

Top
Differential gene expression and gene-gene network for METAP1
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of METAP1 and the right PPI network was created from samples without mutations in the LBS of METAP1. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Top

Top
Phenotype information for METAP1
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Top
Pharmacological information for METAP1
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
ExperimentalDB04324OvalicinSmall molecule
ExperimentalDB079015-CHLORO-6-METHYL-N-(2-PHENYLETHYL)-2-PYRIDIN-2-YLPYRIMIDIN-4-AMINESmall molecule
ExperimentalDB07902TERT-BUTYL {2-[(1,3-THIAZOL-2-YLAMINO)CARBONYL]PYRIDIN-3-YL}CARBAMATESmall molecule
ExperimentalDB079033-[(2,2-DIMETHYLPROPANOYL)AMINO]-N-1,3-THIAZOL-2-YLPYRIDINE-2-CARBOXAMIDESmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of METAP1 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS


Top
Conservation information for LBS of METAP1
Multiple alignments for P53582 in multiple species
LBSAA sequence# speciesSpecies
A303KLFHTAPNVPH6Homo sapiens, Danio rerio, Xenopus tropicalis, Gallus gallus, Bos taurus, Mus musculus
A303EFFHCSPNIPH1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A303QLFHCSPSIPH1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A303DLFHCAPNIPH1Arabidopsis thaliana
C194FPKSCCTSVNE7Homo sapiens, Arabidopsis thaliana, Danio rerio, Xenopus tropicalis, Gallus gallus, Bos taurus, Mus musculus
C194FPKSLCTSVNE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
C194FPKSVCTSVNE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C202VNEVICHGIPD7Homo sapiens, Arabidopsis thaliana, Danio rerio, Xenopus tropicalis, Gallus gallus, Bos taurus, Mus musculus
C202VNEVICHGVPD1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
C202VNEIICHGIPD1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C292VVRSYCGHGIH6Homo sapiens, Danio rerio, Xenopus tropicalis, Gallus gallus, Bos taurus, Mus musculus
C292VVRTYCGHGVG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
C292VVRTYCGHGIN1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C292VVRSYCGHGIG1Arabidopsis thaliana
D220DIVNVDITLYR3Homo sapiens, Bos taurus, Mus musculus
D220DIVNVDITVYR2Xenopus tropicalis, Gallus gallus
D220DIVNLDVSLYY1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D220DIVNIDVSLYH1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D220DIVNVDVTVCY1Arabidopsis thaliana
D220DILNIDITVYH1Danio rerio
D231NGYHGDLNETF5Homo sapiens, Danio rerio, Gallus gallus, Bos taurus, Mus musculus
D231QGYHADLNETY1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D231NGFHGDLNETY1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D231KGCHGDLNETY1Arabidopsis thaliana
D231DGYHGDLNETF1Xenopus tropicalis
E119GMSESEQALKG5Homo sapiens, Xenopus tropicalis, Gallus gallus, Bos taurus, Mus musculus
E119GLPVSEQRNDR1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E119GVSRSEQIEGR1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E119GTPKVEPNSDL1Arabidopsis thaliana
E119GMSESEQTMKG1Danio rerio
E327HVFTIEPMICE6Homo sapiens, Danio rerio, Xenopus tropicalis, Gallus gallus, Bos taurus, Mus musculus
E327MVFTIEPMINE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E327MTFTIEPMLTL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E327QTFTIEPMINA1Arabidopsis thaliana
E358RSAQFEHTLLV7Homo sapiens, Arabidopsis thaliana, Danio rerio, Xenopus tropicalis, Gallus gallus, Bos taurus, Mus musculus
E358LSAQFEHTLLV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E358CSAQFEHTLLV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F189LNYYNFPKSCC6Homo sapiens, Danio rerio, Xenopus tropicalis, Gallus gallus, Bos taurus, Mus musculus
F189LNYYNFPKSLC1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F189LNYYAFPKSVC1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F189LNYYFFPKSCC1Arabidopsis thaliana
F300GIHKLFHTAPN6Homo sapiens, Danio rerio, Xenopus tropicalis, Gallus gallus, Bos taurus, Mus musculus
F300GVGEFFHCSPN1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F300GINQLFHCSPS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F300GIGDLFHCAPN1Arabidopsis thaliana
H203NEVICHGIPDR6Homo sapiens, Danio rerio, Xenopus tropicalis, Gallus gallus, Bos taurus, Mus musculus
H203NEVICHGVPDK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H203NEIICHGIPDQ1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H203NEVICHGIPDA1Arabidopsis thaliana
H294RSYCGHGIHKL6Homo sapiens, Danio rerio, Xenopus tropicalis, Gallus gallus, Bos taurus, Mus musculus
H294RTYCGHGVGEF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H294RTYCGHGINQL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H294RSYCGHGIGDL1Arabidopsis thaliana
H301IHKLFHTAPNV6Homo sapiens, Danio rerio, Xenopus tropicalis, Gallus gallus, Bos taurus, Mus musculus
H301VGEFFHCSPNI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H301INQLFHCSPSI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H301IGDLFHCAPNI1Arabidopsis thaliana
K123SEQALKGTSQI5Homo sapiens, Xenopus tropicalis, Gallus gallus, Bos taurus, Mus musculus
K123SEQRNDRLNNI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K123SEQIEGRSFKL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K123VEPNSDLQHVV1Arabidopsis thaliana
K123SEQTMKGTSQI1Danio rerio
M329FTIEPMICEGG6Homo sapiens, Danio rerio, Xenopus tropicalis, Gallus gallus, Bos taurus, Mus musculus
M329FTIEPMINEGT1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
M329FTIEPMLTLGP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M329FTIEPMINAGG1Arabidopsis thaliana
N198CCTSVNEVICH7Homo sapiens, Arabidopsis thaliana, Danio rerio, Xenopus tropicalis, Gallus gallus, Bos taurus, Mus musculus
N198LCTSVNEVICH1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N198VCTSVNEIICH1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N233YHGDLNETFFV4Homo sapiens, Danio rerio, Bos taurus, Mus musculus
N233YHGDLNETFYV2Xenopus tropicalis, Gallus gallus
N233YHADLNETYYV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N233FHGDLNETYYV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N233CHGDLNETYFV1Arabidopsis thaliana
N305FHTAPNVPHYA5Homo sapiens, Danio rerio, Xenopus tropicalis, Gallus gallus, Mus musculus
N305FHCSPNIPHYA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N305FHCSPSIPHYS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N305FHCAPNIPHYA1Arabidopsis thaliana
N305FHTAPNVPHYS1Bos taurus
P183NCYPSPLNYYN6Homo sapiens, Danio rerio, Xenopus tropicalis, Gallus gallus, Bos taurus, Mus musculus
P183GAYPSPLNYYN1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P183DCFPSTLNYYA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P183GGYPSPLNYYF1Arabidopsis thaliana
Q120MSESEQALKGT5Homo sapiens, Xenopus tropicalis, Gallus gallus, Bos taurus, Mus musculus
Q120LPVSEQRNDRL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q120VSRSEQIEGRS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q120TPKVEPNSDLQ1Arabidopsis thaliana
Q120MSESEQTMKGT1Danio rerio
S182RNCYPSPLNYY6Homo sapiens, Danio rerio, Xenopus tropicalis, Gallus gallus, Bos taurus, Mus musculus
S182RGAYPSPLNYY1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S182RDCFPSTLNYY1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S182AGGYPSPLNYY1Arabidopsis thaliana
S196KSCCTSVNEVI7Homo sapiens, Arabidopsis thaliana, Danio rerio, Xenopus tropicalis, Gallus gallus, Bos taurus, Mus musculus
S196KSLCTSVNEVI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S196KSVCTSVNEII1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S354RDGKRSAQFEH6Homo sapiens, Danio rerio, Xenopus tropicalis, Gallus gallus, Bos taurus, Mus musculus
S354QDGKLSAQFEH1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S354ASGRCSAQFEH1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S354ADGKRSAQFEH1Arabidopsis thaliana
T222VNVDITLYRNG3Homo sapiens, Bos taurus, Mus musculus
T222VNLDVSLYYQG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T222VNIDVSLYHNG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T222VNVDVTVCYKG1Arabidopsis thaliana
T222LNIDITVYHNG1Danio rerio
T222VNVDITVYRDG1Xenopus tropicalis
T222VNVDITVYRNG1Gallus gallus
T302HKLFHTAPNVP6Homo sapiens, Danio rerio, Xenopus tropicalis, Gallus gallus, Bos taurus, Mus musculus
T302GEFFHCSPNIP1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T302NQLFHCSPSIP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T302GDLFHCAPNIP1Arabidopsis thaliana
T325PGHVFTIEPMI3Danio rerio, Xenopus tropicalis, Gallus gallus
T325SGHVFTIEPMI2Homo sapiens, Mus musculus
T325PGMVFTIEPMI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T325PGMTFTIEPML1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T325AGQTFTIEPMI1Arabidopsis thaliana
T325AGHVFTIEPMI1Bos taurus
V197SCCTSVNEVIC7Homo sapiens, Arabidopsis thaliana, Danio rerio, Xenopus tropicalis, Gallus gallus, Bos taurus, Mus musculus
V197SLCTSVNEVIC1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V197SVCTSVNEIIC1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V200TSVNEVICHGI7Homo sapiens, Arabidopsis thaliana, Danio rerio, Xenopus tropicalis, Gallus gallus, Bos taurus, Mus musculus
V200TSVNEVICHGV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V200TSVNEIICHGI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
W344TWPDGWTAVTR5Homo sapiens, Danio rerio, Gallus gallus, Bos taurus, Mus musculus
W344TWPDDWTSTTQ1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
W344TWPDDWTSSTA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
W344TWPDGWTAVTA1Arabidopsis thaliana
W344TWPDGWTAITR1Xenopus tropicalis
Y186PSPLNYYNFPK7Homo sapiens, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Danio rerio, Xenopus tropicalis, Gallus gallus, Bos taurus, Mus musculus
Y186PSTLNYYAFPK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y186PSPLNYYFFPK1Arabidopsis thaliana
Y187SPLNYYNFPKS7Homo sapiens, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Danio rerio, Xenopus tropicalis, Gallus gallus, Bos taurus, Mus musculus
Y187STLNYYAFPKS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y187SPLNYYFFPKS1Arabidopsis thaliana
Y291SVVRSYCGHGI7Homo sapiens, Arabidopsis thaliana, Danio rerio, Xenopus tropicalis, Gallus gallus, Bos taurus, Mus musculus
Y291SVVRTYCGHGV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y291SVVRTYCGHGI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)


Copyright © 2016-Present - The University of Texas Health Science Center at Houston
Site Policies | State of Texas