mutLBSgeneDB |
Gene summary for SCRIB |
Gene summary |
Basic gene Info. | Gene symbol | SCRIB |
Gene name | scribbled planar cell polarity protein | |
Synonyms | CRIB1|SCRB1|SCRIB1|Vartul | |
Cytomap | UCSC genome browser: 8q24.3 | |
Type of gene | protein-coding | |
RefGenes | NM_015356.4, NM_182706.4, | |
Description | protein scribble homologscribbled homolog | |
Modification date | 20141207 | |
dbXrefs | MIM : 607733 | |
HGNC : HGNC | ||
Ensembl : ENSG00000180900 | ||
HPRD : 06984 | ||
Vega : OTTHUMG00000165154 | ||
Protein | UniProt: Q14160 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_SCRIB | |
BioGPS: 23513 | ||
Pathway | NCI Pathway Interaction Database: SCRIB | |
KEGG: SCRIB | ||
REACTOME: SCRIB | ||
Pathway Commons: SCRIB | ||
Context | iHOP: SCRIB | |
ligand binding site mutation search in PubMed: SCRIB | ||
UCL Cancer Institute: SCRIB | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO Term | PubMed ID | GO:0008283 | cell proliferation | 16965391 | GO:0045930 | negative regulation of mitotic cell cycle | 16965391 |
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Ligand binding site mutations for SCRIB |
Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.) : non-synonymous mutation on LBS, Circle size denotes number of samples. |
Cancer type specific mutLBS sorted by frequency |
LBS | AAchange of nsSNV | Cancer type | # samples | V1019 | V1019I | LUSC | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for SCRIB |
Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
: nsSNV at non-LBS: nsSNV at LBS |
nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | V1019 | V1019I | -1.191084 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
Structure image for SCRIB from PDB |
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Differential gene expression and gene-gene network for SCRIB |
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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Phenotype information for SCRIB |
Gene level disease information (DisGeNet) |
Disease ID | Disease name | # PubMed | Association type |
umls:C0027794 | Neural Tube Defects | 1 | GeneticVariation |
Mutation level pathogenic information (ClinVar annotation) |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for SCRIB |
Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
Drug information targeting mutLBSgene (Approved drugs only) |
Drug status | DrugBank ID | Name | Type | Drug structure |
Gene-centered ligand-gene interaction network |
Ligands binding to mutated ligand binding site of SCRIB go to BioLip |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
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Conservation information for LBS of SCRIB |
Multiple alignments for Q14160 in multiple species |
LBS | AA sequence | # species | Species | G1015 | AGGPLGLSIVG | 3 | Homo sapiens, Danio rerio, Mus musculus | G1015 | ----------- | 1 | Caenorhabditis elegans | G1167 | QQSLLGLTHGE | 1 | Homo sapiens | G1167 | ----------- | 1 | Caenorhabditis elegans | G1167 | NNSLLGMTHTE | 1 | Danio rerio | G1167 | QQSLLGLTHAE | 1 | Mus musculus | H1071 | VRDATHQEAVS | 1 | Homo sapiens | H1071 | MINASQDNAME | 1 | Caenorhabditis elegans | H1071 | LRHATHQEAVR | 1 | Danio rerio | H1071 | VREATHQEAVS | 1 | Mus musculus | I1018 | PLGLSIVGGSD | 3 | Homo sapiens, Danio rerio, Mus musculus | I1018 | ----------- | 1 | Caenorhabditis elegans | K1040 | GVFISKVLPRG | 2 | Homo sapiens, Mus musculus | K1040 | ----------- | 1 | Caenorhabditis elegans | K1040 | GVFISKVIPNG | 1 | Danio rerio | L1014 | RAGGPLGLSIV | 2 | Homo sapiens, Mus musculus | L1014 | ----------- | 1 | Caenorhabditis elegans | L1014 | KAGGPLGLSIV | 1 | Danio rerio | L1016 | GGPLGLSIVGG | 3 | Homo sapiens, Danio rerio, Mus musculus | L1016 | ----------- | 1 | Caenorhabditis elegans | L1078 | EAVSALLRPCL | 2 | Homo sapiens, Mus musculus | L1078 | NAMEAIKKRET | 1 | Caenorhabditis elegans | L1078 | EAVRALLSNKQ | 1 | Danio rerio | L1079 | AVSALLRPCLE | 2 | Homo sapiens, Mus musculus | L1079 | AMEAIKKRETV | 1 | Caenorhabditis elegans | L1079 | AVRALLSNKQE | 1 | Danio rerio | L1166 | NQQSLLGLTHG | 1 | Homo sapiens | L1166 | ----------- | 1 | Caenorhabditis elegans | L1166 | GNNSLLGMTHT | 1 | Danio rerio | L1166 | NQQSLLGLTHA | 1 | Mus musculus | P1013 | PRAGGPLGLSI | 2 | Homo sapiens, Mus musculus | P1013 | ----------- | 1 | Caenorhabditis elegans | P1013 | IKAGGPLGLSI | 1 | Danio rerio | S1017 | GPLGLSIVGGS | 3 | Homo sapiens, Danio rerio, Mus musculus | S1017 | ----------- | 1 | Caenorhabditis elegans | S1025 | GGSDHSSHPFG | 2 | Homo sapiens, Mus musculus | S1025 | ----------- | 1 | Caenorhabditis elegans | S1025 | GGSDHASHPFG | 1 | Danio rerio | S1026 | GSDHSSHPFGV | 2 | Homo sapiens, Mus musculus | S1026 | ----------- | 1 | Caenorhabditis elegans | S1026 | GSDHASHPFGI | 1 | Danio rerio | S1039 | PGVFISKVLPR | 2 | Homo sapiens, Mus musculus | S1039 | ----------- | 1 | Caenorhabditis elegans | S1039 | PGVFISKVIPN | 1 | Danio rerio | S1164 | EVNQQSLLGLT | 2 | Homo sapiens, Mus musculus | S1164 | ----------- | 1 | Caenorhabditis elegans | S1164 | EVGNNSLLGMT | 1 | Danio rerio | V1019 | LGLSIVGGSDH | 3 | Homo sapiens, Danio rerio, Mus musculus | V1019 | ----------- | 1 | Caenorhabditis elegans |
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