mutLBSgeneDB |
Gene summary for FOS |
Gene summary |
Basic gene Info. | Gene symbol | FOS |
Gene name | FBJ murine osteosarcoma viral oncogene homolog | |
Synonyms | AP-1|C-FOS|p55 | |
Cytomap | UCSC genome browser: 14q24.3 | |
Type of gene | protein-coding | |
RefGenes | NM_005252.3, | |
Description | FBJ murine osteosarcoma viral (v-fos) oncogene homolog (oncogene FOS)G0/G1 switch regulatory protein 7activator protein 1cellular oncogene c-fosproto-oncogene c-Fos | |
Modification date | 20141222 | |
dbXrefs | MIM : 164810 | |
HGNC : HGNC | ||
Ensembl : ENSG00000170345 | ||
HPRD : 01275 | ||
Vega : OTTHUMG00000171774 | ||
Protein | UniProt: P01100 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_FOS | |
BioGPS: 2353 | ||
Pathway | NCI Pathway Interaction Database: FOS | |
KEGG: FOS | ||
REACTOME: FOS | ||
Pathway Commons: FOS | ||
Context | iHOP: FOS | |
ligand binding site mutation search in PubMed: FOS | ||
UCL Cancer Institute: FOS | ||
Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO Term | PubMed ID | GO:0007179 | transforming growth factor beta receptor signaling pathway | 9732876 | GO:0034614 | cellular response to reactive oxygen species | 17217916 | GO:0045893 | positive regulation of transcription, DNA-templated | 9732876 | GO:0060395 | SMAD protein signal transduction | 9732876 |
Top |
Ligand binding site mutations for FOS |
Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.) : non-synonymous mutation on LBS, Circle size denotes number of samples. |
Cancer type specific mutLBS sorted by frequency |
LBS | AAchange of nsSNV | Cancer type | # samples | R144 | R143Q | BLCA | 1 | R144 | R143Q | LUSC | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
Top |
Protein structure related information for FOS |
Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
: nsSNV at non-LBS: nsSNV at LBS |
nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | R144 | R143Q | -1.0535365 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
Structure image for FOS from PDB |
Top |
Differential gene expression and gene-gene network for FOS |
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
Top |
Top |
Phenotype information for FOS |
Gene level disease information (DisGeNet) |
Disease ID | Disease name | # PubMed | Association type |
umls:C2239176 | Carcinoma, Hepatocellular | 11 | AlteredExpression, Biomarker |
umls:C1458155 | Breast Neoplasms | 4 | AlteredExpression, Biomarker |
umls:C0036572 | Seizures | 4 | Biomarker |
umls:C0038220 | Status Epilepticus | 4 | Biomarker |
umls:C0020538 | Hypertension | 3 | Biomarker, GeneticVariation |
umls:C0014175 | Endometriosis | 3 | AlteredExpression, Biomarker |
umls:C0236736 | Cocaine-Related Disorders | 3 | Biomarker |
umls:C0038587 | Substance Withdrawal Syndrome | 3 | Biomarker |
umls:C0035126 | Reperfusion Injury | 2 | Biomarker |
umls:C0003469 | Anxiety Disorders | 2 | Biomarker |
umls:C0236733 | Amphetamine-Related Disorders | 1 | Biomarker |
umls:C1862939 | Amyotrophic lateral sclerosis 1 | 1 | Biomarker |
umls:C0270611 | Brain Injuries | 1 | Biomarker |
umls:C0014544 | Epilepsy | 1 | Biomarker |
umls:C0016063 | Fibrous Dysplasia of Bone | 1 | Biomarker |
umls:C0018843 | Heat Stroke | 1 | Biomarker |
umls:C0019080 | Hemorrhage | 1 | Biomarker |
umls:C0424295 | Hyperkinesis | 1 | Biomarker |
umls:C0740392 | Infarction, Middle Cerebral Artery | 1 | Biomarker |
umls:C0024121 | Lung Neoplasms | 1 | Biomarker |
umls:C0027765 | Nervous System Diseases | 1 | Biomarker |
umls:C0235032 | Neurotoxicity Syndromes | 1 | Therapeutic |
Mutation level pathogenic information (ClinVar annotation) |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
Top |
Pharmacological information for FOS |
Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
Gene-centered drug-gene interaction network |
Drug information targeting mutLBSgene (Approved drugs only) |
Drug status | DrugBank ID | Name | Type | Drug structure |
Approved | DB08813 | Nadroparin | Small molecule |
Gene-centered ligand-gene interaction network |
Ligands binding to mutated ligand binding site of FOS go to BioLip |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | NUC | Nucleic Acids | 1a02 | F | R144 | NUC | Nucleic Acids | 1fos | G | R144 | NUC | Nucleic Acids | 1s9k | D | R144 |
Top |
Conservation information for LBS of FOS |
Multiple alignments for P01100 in multiple species |
LBS | AA sequence | # species | Species | C154 | MAAAKCRNRRR | 5 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus | K148 | RRERNKMAAAK | 5 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus | K153 | KMAAAKCRNRR | 5 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus | N147 | IRRERNKMAAA | 5 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus | R140 | EEEEKRRIRRE | 5 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus | R144 | KRRIRRERNKM | 5 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus | R146 | RIRRERNKMAA | 5 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus | R155 | AAAKCRNRRRE | 5 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus | R157 | AKCRNRRRELT | 5 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus | R158 | KCRNRRRELTD | 5 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus | R159 | CRNRRRELTDT | 5 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus |
Copyright © 2016-Present - The University of Texas Health Science Center at Houston |