mutLBSgeneDB |
Gene summary for FYN |
Gene summary |
Basic gene Info. | Gene symbol | FYN |
Gene name | FYN proto-oncogene, Src family tyrosine kinase | |
Synonyms | SLK|SYN|p59-FYN | |
Cytomap | UCSC genome browser: 6q21 | |
Type of gene | protein-coding | |
RefGenes | NM_002037.5, NM_153047.3,NM_153048.3,NM_001242779.1, | |
Description | FYN oncogene related to SRC, FGR, YESOKT3-induced calcium influx regulatorc-syn protooncogeneproto-oncogene Synproto-oncogene c-Fynsrc-like kinasesrc/yes-related noveltyrosine kinase p59fyn(T)tyrosine-protein kinase Fyn | |
Modification date | 20141207 | |
dbXrefs | MIM : 137025 | |
HGNC : HGNC | ||
Ensembl : ENSG00000010810 | ||
HPRD : 00655 | ||
Vega : OTTHUMG00000016305 | ||
Protein | UniProt: P06241 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_FYN | |
BioGPS: 2534 | ||
Pathway | NCI Pathway Interaction Database: FYN | |
KEGG: FYN | ||
REACTOME: FYN | ||
Pathway Commons: FYN | ||
Context | iHOP: FYN | |
ligand binding site mutation search in PubMed: FYN | ||
UCL Cancer Institute: FYN | ||
Assigned class in mutLBSgeneDB | A: This gene has a literature evidence and it belongs to targetable_mutLBSgenes. | |
References showing study about ligand binding site mutation for FYN. | 1. "Fernandez-Ballester G, Blanes-Mira C, Serrano L. The tryptophan switch:changing ligand-binding specificity from type I to type II in SH3 domains. J Mol Biol. 2004 Jan 9;335(2):619-29. PubMed PMID: 14672668. " 14672668 2. "Panchamoorthy G, Fukazawa T, Stolz L, Payne G, Reedquist K, Shoelson S, Songyang Z, Cantley L, Walsh C, Band H. Physical and functional interactions between SH2 and SH3 domains of the Src family protein tyrosine kinase p59fyn. Mol Cell Biol. 1994 Sep;14(9):6372-85. PubMed PMID: 7520528; PubMed Central PMCID: PMC359163. " 7520528 |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO Term | PubMed ID | GO:0050852 | T cell receptor signaling pathway | 7722293 |
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Ligand binding site mutations for FYN |
Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.) : non-synonymous mutation on LBS, Circle size denotes number of samples. |
Cancer type specific mutLBS sorted by frequency |
LBS | AAchange of nsSNV | Cancer type | # samples | K204 | R206C | COAD | 3 | H104 | F103L | HNSC | 1 | G348 | K347N | HNSC | 1 | H104 | H104Y | HNSC | 1 | D408 | A407V | KIRC | 1 | R96 | R96Q | LUAD | 1 | G348 | G348V | LUAD | 1 | H104 | K105N | LUSC | 1 | A394 | R392Q | STAD | 1 | L397 | L397I | UCEC | 1 | R176,S178 | E177G | UCEC | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
Clinical information for FYN from My Cancer Genome. |
FYN proto-oncogene, Src family tyrosine kinase (FYN) is a gene that encodes a protein that functions as a membrane-associated tyrosine kinase that regulates cell growth. Missense mutations, nonsense mutations, silent mutations, and frameshift insertions are observed in cancers such as intestinal cancer, skin cancer, and stomach cancer.Modified: July 1, 2015 |
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Protein structure related information for FYN |
Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
: nsSNV at non-LBS: nsSNV at LBS |
nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | G348 | G348V | 0.21925768 | L397 | L397I | -1.3178546 | A394 | R392Q | -1.3120438 | S178 | E177G | -1.3029461 | R176 | E177G | -1.3029461 | R96 | R96Q | -1.1716163 | H104 | H104Y | -1.1590147 | K204 | R206C | -1.1350457 | D408 | A407V | -1.1107899 | H104 | F103L | -0.63849164 | G348 | K347N | -0.32359769 | H104 | K105N | -0.17321995 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
Structure image for FYN from PDB |
PDB ID | PDB title | PDB structure | 1AOT | NMR STRUCTURE OF THE FYN SH2 DOMAIN COMPLEXED WITH A PHOSPHOTYROSYL PEPTIDE, MINIMIZED AVERAGE STRUCTURE |
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Differential gene expression and gene-gene network for FYN |
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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Phenotype information for FYN |
Gene level disease information (DisGeNet) |
Disease ID | Disease name | # PubMed | Association type |
umls:C0079774 | Lymphoma, T-Cell, Peripheral | 1 | Biomarker |
umls:C0007370 | Catalepsy | 1 | Biomarker |
umls:C0038356 | Stomach Neoplasms | 1 | Biomarker |
Mutation level pathogenic information (ClinVar annotation) |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for FYN |
Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
Gene-centered drug-gene interaction network |
Drug information targeting mutLBSgene (Approved drugs only) |
Drug status | DrugBank ID | Name | Type | Drug structure |
Approved|investigational | DB01254 | Dasatinib | Small molecule | |
Experimental | DB02078 | 1-Methoxy-2-[2-(2-Methoxy-Ethoxy]-Ethane | Small molecule |
Gene-centered ligand-gene interaction network |
Ligands binding to mutated ligand binding site of FYN go to BioLip |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | ZN | ZINC(2+) | 3ua7 | C | H104 | ZN | ZINC(2+) | 3ua7 | D | H104 | III | Peptide ligand (GLU,PRO,GLN,TYR,GLN,PRO,GLY,GLU,ASN,LEU) | 2mrk | A | R176 S178 K204 | III | Peptide ligand (PRO,PRO,ALA,TYR,PRO,PRO,PRO,PRO,VAL,PRO) | 1fyn | A | R96 | III | Peptide ligand (ACE,ALA,PRO,PRO,ILE,PRO,PRO,PRO,ARG) | 3ua7 | A | R96 |
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Conservation information for LBS of FYN |
Multiple alignments for P06241 in multiple species |
LBS | AA sequence | # species | Species | A297 | GNTKVAIKTLK | 5 | Homo sapiens, Danio rerio, Bos taurus, Rattus norvegicus, Mus musculus | A297 | GIVEVAIKTMK | 1 | Caenorhabditis elegans | A394 | RDLRSANILVG | 5 | Homo sapiens, Danio rerio, Bos taurus, Rattus norvegicus, Mus musculus | A394 | RDLAARNVLVG | 1 | Caenorhabditis elegans | D100 | ARTEDDLSFHK | 4 | Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus | D100 | SRADGDLSFQK | 1 | Caenorhabditis elegans | D100 | ARTEDDLSFRK | 1 | Danio rerio | D118 | NSSEGDWWEAR | 4 | Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus | D118 | DHSNCDWWYVR | 1 | Caenorhabditis elegans | D118 | NSTEGDWWDAR | 1 | Danio rerio | D408 | ICKIADFGLAR | 4 | Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus | D408 | VVKVADFGLAR | 1 | Caenorhabditis elegans | D408 | VCKIADFGLAR | 1 | Danio rerio | D99 | EARTEDDLSFH | 4 | Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus | D99 | DSRADGDLSFQ | 1 | Caenorhabditis elegans | D99 | EARTEDDLSFR | 1 | Danio rerio | E107 | SFHKGEKFQIL | 4 | Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus | E107 | SFQKGDAMYLL | 1 | Caenorhabditis elegans | E107 | SFRKGEKFQII | 1 | Danio rerio | E116 | ILNSSEGDWWE | 4 | Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus | E116 | LLDHSNCDWWY | 1 | Caenorhabditis elegans | E116 | IINSTEGDWWD | 1 | Danio rerio | E179 | LIRESETTKGA | 5 | Homo sapiens, Danio rerio, Bos taurus, Rattus norvegicus, Mus musculus | E179 | LIREREADTRE | 1 | Caenorhabditis elegans | E343 | IYIVTEYMNKG | 3 | Homo sapiens, Bos taurus, Rattus norvegicus | E343 | FYIITEYMING | 1 | Caenorhabditis elegans | E343 | IYIVTEYMGKG | 1 | Danio rerio | E343 | IYIVTEYMSKG | 1 | Mus musculus | G117 | LNSSEGDWWEA | 4 | Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus | G117 | LDHSNCDWWYV | 1 | Caenorhabditis elegans | G117 | INSTEGDWWDA | 1 | Danio rerio | G237 | SERAAGLCCRL | 4 | Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus | G237 | SDVPDGLCCQL | 1 | Caenorhabditis elegans | G237 | TERAAGLCCRL | 1 | Danio rerio | G348 | EYMNKGSLLDF | 3 | Homo sapiens, Bos taurus, Rattus norvegicus | G348 | EYMINGSLLQY | 1 | Caenorhabditis elegans | G348 | EYMGKGSLLDF | 1 | Danio rerio | G348 | EYMSKGSLLDF | 1 | Mus musculus | H104 | DDLSFHKGEKF | 4 | Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus | H104 | GDLSFQKGDAM | 1 | Caenorhabditis elegans | H104 | DDLSFRKGEKF | 1 | Danio rerio | H202 | GDHVKHYKIRK | 5 | Homo sapiens, Danio rerio, Bos taurus, Rattus norvegicus, Mus musculus | H202 | GGTVKHYKIKR | 1 | Caenorhabditis elegans | I215 | NGGYYITTRAQ | 4 | Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus | I215 | DQGYFITTRRT | 1 | Caenorhabditis elegans | I215 | SGGYYITTRAQ | 1 | Danio rerio | K201 | -GDHVKHYKIR | 5 | Homo sapiens, Danio rerio, Bos taurus, Rattus norvegicus, Mus musculus | K201 | NGGTVKHYKIK | 1 | Caenorhabditis elegans | K204 | HVKHYKIRKLD | 5 | Homo sapiens, Danio rerio, Bos taurus, Rattus norvegicus, Mus musculus | K204 | TVKHYKIKRLD | 1 | Caenorhabditis elegans | K299 | TKVAIKTLKPG | 5 | Homo sapiens, Danio rerio, Bos taurus, Rattus norvegicus, Mus musculus | K299 | VEVAIKTMKPG | 1 | Caenorhabditis elegans | L238 | ERAAGLCCRLV | 5 | Homo sapiens, Danio rerio, Bos taurus, Rattus norvegicus, Mus musculus | L238 | DVPDGLCCQLT | 1 | Caenorhabditis elegans | L277 | QLIKRLGNGQF | 5 | Homo sapiens, Danio rerio, Bos taurus, Rattus norvegicus, Mus musculus | L277 | HLKRKLGDGNF | 1 | Caenorhabditis elegans | L397 | RSANILVGNGL | 4 | Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus | L397 | AARNVLVGDKI | 1 | Caenorhabditis elegans | L397 | RSANILVGDSL | 1 | Danio rerio | M345 | IVTEYMNKGSL | 3 | Homo sapiens, Bos taurus, Rattus norvegicus | M345 | IITEYMINGSL | 1 | Caenorhabditis elegans | M345 | IVTEYMGKGSL | 1 | Danio rerio | M345 | IVTEYMSKGSL | 1 | Mus musculus | N136 | GYIPSNYVAPV | 5 | Homo sapiens, Danio rerio, Bos taurus, Rattus norvegicus, Mus musculus | N136 | GYVPRNFVAKQ | 1 | Caenorhabditis elegans | N279 | IKRLGNGQFGE | 5 | Homo sapiens, Danio rerio, Bos taurus, Rattus norvegicus, Mus musculus | N279 | KRKLGDGNFGE | 1 | Caenorhabditis elegans | P134 | ETGYIPSNYVA | 4 | Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus | P134 | QTGYVPRNFVA | 1 | Caenorhabditis elegans | P134 | GTGYIPSNYVA | 1 | Danio rerio | R156 | FGKLGRKDAER | 5 | Homo sapiens, Danio rerio, Bos taurus, Rattus norvegicus, Mus musculus | R156 | AGKIPRNRAER | 1 | Caenorhabditis elegans | R176 | GTFLIRESETT | 5 | Homo sapiens, Danio rerio, Bos taurus, Rattus norvegicus, Mus musculus | R176 | GTFLIREREAD | 1 | Caenorhabditis elegans | R218 | YYITTRAQFET | 5 | Homo sapiens, Danio rerio, Bos taurus, Rattus norvegicus, Mus musculus | R218 | YFITTRRTFRS | 1 | Caenorhabditis elegans | R96 | YDYEARTEDDL | 5 | Homo sapiens, Danio rerio, Bos taurus, Rattus norvegicus, Mus musculus | R96 | YPYDSRADGDL | 1 | Caenorhabditis elegans | S135 | TGYIPSNYVAP | 5 | Homo sapiens, Danio rerio, Bos taurus, Rattus norvegicus, Mus musculus | S135 | TGYVPRNFVAK | 1 | Caenorhabditis elegans | S178 | FLIRESETTKG | 5 | Homo sapiens, Danio rerio, Bos taurus, Rattus norvegicus, Mus musculus | S178 | FLIREREADTR | 1 | Caenorhabditis elegans | S186 | TKGAYSLSIRD | 4 | Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus | S186 | DTREFALTIRD | 1 | Caenorhabditis elegans | S186 | TKGAFSLSIRD | 1 | Danio rerio | T180 | IRESETTKGAY | 4 | Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus | T180 | IREREADTREF | 1 | Caenorhabditis elegans | T180 | IRESETTKGAF | 1 | Danio rerio | T216 | GGYYITTRAQF | 5 | Homo sapiens, Danio rerio, Bos taurus, Rattus norvegicus, Mus musculus | T216 | QGYFITTRRTF | 1 | Caenorhabditis elegans | T342 | PIYIVTEYMNK | 3 | Homo sapiens, Bos taurus, Rattus norvegicus | T342 | PFYIITEYMIN | 1 | Caenorhabditis elegans | T342 | PIYIVTEYMGK | 1 | Danio rerio | T342 | PIYIVTEYMSK | 1 | Mus musculus | T97 | DYEARTEDDLS | 5 | Homo sapiens, Danio rerio, Bos taurus, Rattus norvegicus, Mus musculus | T97 | PYDSRADGDLS | 1 | Caenorhabditis elegans | V285 | GQFGEVWMGTW | 5 | Homo sapiens, Danio rerio, Bos taurus, Rattus norvegicus, Mus musculus | V285 | GNFGEVWYGKW | 1 | Caenorhabditis elegans | W119 | SSEGDWWEARS | 4 | Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus | W119 | HSNCDWWYVRH | 1 | Caenorhabditis elegans | W119 | STEGDWWDARS | 1 | Danio rerio | Y132 | TGETGYIPSNY | 4 | Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus | Y132 | TGQTGYVPRNF | 1 | Caenorhabditis elegans | Y132 | TGGTGYIPSNY | 1 | Danio rerio | Y137 | YIPSNYVAPVD | 5 | Homo sapiens, Danio rerio, Bos taurus, Rattus norvegicus, Mus musculus | Y137 | YVPRNFVAKQQ | 1 | Caenorhabditis elegans | Y203 | DHVKHYKIRKL | 5 | Homo sapiens, Danio rerio, Bos taurus, Rattus norvegicus, Mus musculus | Y203 | GTVKHYKIKRL | 1 | Caenorhabditis elegans | Y344 | YIVTEYMNKGS | 3 | Homo sapiens, Bos taurus, Rattus norvegicus | Y344 | YIITEYMINGS | 1 | Caenorhabditis elegans | Y344 | YIVTEYMGKGS | 1 | Danio rerio | Y344 | YIVTEYMSKGS | 1 | Mus musculus | Y91 | LFVALYDYEAR | 5 | Homo sapiens, Danio rerio, Bos taurus, Rattus norvegicus, Mus musculus | Y91 | TLVALYPYDSR | 1 | Caenorhabditis elegans | Y93 | VALYDYEARTE | 5 | Homo sapiens, Danio rerio, Bos taurus, Rattus norvegicus, Mus musculus | Y93 | VALYPYDSRAD | 1 | Caenorhabditis elegans |
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