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mutLBSgeneDB |
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| Gene summary for HIST1H2BA |
 Gene summary |
| Basic gene Info. | Gene symbol | HIST1H2BA |
| Gene name | histone cluster 1, H2ba | |
| Synonyms | H2BFU|STBP|TSH2B|TSH2B.1|bA317E16.3 | |
| Cytomap | UCSC genome browser: 6p22.2 | |
| Type of gene | protein-coding | |
| RefGenes | NM_170610.2, | |
| Description | H2B histone family, member U, (testis-specific)histone 1, H2bahistone H2B type 1-Ahistone H2B, testistestis-specific histone H2B | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 609904 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000146047 | ||
| HPRD : 11024 | ||
| Vega : OTTHUMG00000014408 | ||
| Protein | UniProt: Q96A08 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_HIST1H2BA | |
| BioGPS: 255626 | ||
| Pathway | NCI Pathway Interaction Database: HIST1H2BA | |
| KEGG: HIST1H2BA | ||
| REACTOME: HIST1H2BA | ||
| Pathway Commons: HIST1H2BA | ||
| Context | iHOP: HIST1H2BA | |
| ligand binding site mutation search in PubMed: HIST1H2BA | ||
| UCL Cancer Institute: HIST1H2BA | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
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| Ligand binding site mutations for HIST1H2BA |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | I41 | S40C | BLCA | 1 | R35 | R35H | COAD | 1 | R88 | R88H | COAD | 1 | T34 | T34A | STAD | 1 | R35 | R35C | STAD | 1 | E37 | E37D | UCEC | 1 | R35 | R35C | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for HIST1H2BA |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | R88 | R88H | -1.5001819 | R35 | R35H | -1.3034593 | T34 | T34A | -1.131612 | E37 | E37D | -1.0696072 | R35 | R35C | -1.0498893 | I41 | S40C | -0.79587592 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for HIST1H2BA from PDB |
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| Differential gene expression and gene-gene network for HIST1H2BA |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for HIST1H2BA |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for HIST1H2BA |
| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of HIST1H2BA go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
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| Conservation information for LBS of HIST1H2BA |
| Multiple alignments for Q96A08 in multiple species |
| LBS | AA sequence | # species | Species | E37 | KRCRKESYSIY | 2 | Mus musculus, Rattus norvegicus | E37 | KRTRKESYSIY | 1 | Homo sapiens | G55 | VHPDTGISSKA | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | I41 | KESYSIYIYKV | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | I56 | HPDTGISSKAM | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | K36 | RKRCRKESYSI | 2 | Mus musculus, Rattus norvegicus | K36 | RKRTRKESYSI | 1 | Homo sapiens | R35 | KRKRCRKESYS | 2 | Mus musculus, Rattus norvegicus | R35 | KRKRTRKESYS | 1 | Homo sapiens | R88 | AHYNKRSTITS | 2 | Mus musculus, Rattus norvegicus | R88 | AHYSKRSTISS | 1 | Homo sapiens | S38 | RCRKESYSIYI | 2 | Mus musculus, Rattus norvegicus | S38 | RTRKESYSIYI | 1 | Homo sapiens | S57 | PDTGISSKAMS | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | S58 | DTGISSKAMSI | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | S89 | HYNKRSTITSR | 2 | Mus musculus, Rattus norvegicus | S89 | HYSKRSTISSR | 1 | Homo sapiens | T34 | RKRKRCRKESY | 2 | Mus musculus, Rattus norvegicus | T34 | KKRKRTRKESY | 1 | Homo sapiens | T90 | YNKRSTITSRE | 2 | Mus musculus, Rattus norvegicus | T90 | YSKRSTISSRE | 1 | Homo sapiens | Y42 | ESYSIYIYKVL | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | Y44 | YSIYIYKVLKQ | 3 | Homo sapiens, Mus musculus, Rattus norvegicus |
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