mutLBSgeneDB |
Gene summary for ARIH1 |
Gene summary |
Basic gene Info. | Gene symbol | ARIH1 |
Gene name | ariadne RBR E3 ubiquitin protein ligase 1 | |
Synonyms | ARI|HARI|HHARI|UBCH7BP | |
Cytomap | UCSC genome browser: 15q24 | |
Type of gene | protein-coding | |
RefGenes | NM_005744.3, | |
Description | ARI-1E3 ubiquitin-protein ligase ARIH1H7-AP2MOP-6ariadne homolog, ubiquitin-conjugating enzyme E2 binding protein, 1ariadne, Drosophila, homolog ofmonocyte protein 6protein ariadne-1 homologubcH7-binding proteinubcM4-interacting proteinubiquitin | |
Modification date | 20141207 | |
dbXrefs | MIM : 605624 | |
HGNC : HGNC | ||
HPRD : 05730 | ||
Protein | UniProt: Q9Y4X5 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_ARIH1 | |
BioGPS: 25820 | ||
Pathway | NCI Pathway Interaction Database: ARIH1 | |
KEGG: ARIH1 | ||
REACTOME: ARIH1 | ||
Pathway Commons: ARIH1 | ||
Context | iHOP: ARIH1 | |
ligand binding site mutation search in PubMed: ARIH1 | ||
UCL Cancer Institute: ARIH1 | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO Term | PubMed ID | GO:0016567 | protein ubiquitination | 14623119 |
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Ligand binding site mutations for ARIH1 |
Cancer type specific mutLBS sorted by frequency |
LBS | AAchange of nsSNV | Cancer type | # samples | H205 | F207L | COAD | 1 | C203 | L201R | KIRC | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for ARIH1 |
Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
: nsSNV at non-LBS: nsSNV at LBS |
nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | C203 | L201R | -1.2363224 | H205 | F207L | -0.44116144 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
Structure image for ARIH1 from PDB |
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Differential gene expression and gene-gene network for ARIH1 |
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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Phenotype information for ARIH1 |
Gene level disease information (DisGeNet) |
Disease ID | Disease name | # PubMed | Association type |
Mutation level pathogenic information (ClinVar annotation) |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for ARIH1 |
Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
Drug information targeting mutLBSgene (Approved drugs only) |
Drug status | DrugBank ID | Name | Type | Drug structure |
Gene-centered ligand-gene interaction network |
Ligands binding to mutated ligand binding site of ARIH1 go to BioLip |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | ZN | ZINC(2+) | 4kbl | A | C203 H205 | ZN | ZINC(2+) | 4kbl | B | C203 H205 | ZN | ZINC(2+) | 4kc9 | A | C203 H205 |
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Conservation information for LBS of ARIH1 |
Multiple alignments for Q9Y4X5 in multiple species |
LBS | AA sequence | # species | Species | C203 | FTGLECGHKFC | 6 | Homo sapiens, Xenopus tropicalis, Mus musculus, Bos taurus, Danio rerio, Danio rerio | C203 | MTRMDCGHCFC | 1 | Arabidopsis thaliana | C203 | LTRMDCGHSFC | 1 | Arabidopsis thaliana | C203 | FSA-ECDHEFC | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | C203 | MAGLECGHRFC | 1 | Drosophila melanogaster | C231 | GQTISCPAHGC | 4 | Homo sapiens, Xenopus tropicalis, Mus musculus, Bos taurus | C231 | SKRIRCMAHQC | 1 | Arabidopsis thaliana | C231 | SKRIICMAHKC | 1 | Arabidopsis thaliana | C231 | ESVIQCPEESC | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | C231 | GQTISCAAHGC | 1 | Drosophila melanogaster | C231 | GQTISCPAHNC | 1 | Danio rerio | C231 | GQTISCPAHSC | 1 | Danio rerio | C236 | CPAHGCDILVD | 4 | Homo sapiens, Xenopus tropicalis, Mus musculus, Bos taurus | C236 | CMAHQCNAICD | 1 | Arabidopsis thaliana | C236 | CMAHKCNAICD | 1 | Arabidopsis thaliana | C236 | CPEESCTQIVS | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | C236 | CAAHGCDILVD | 1 | Drosophila melanogaster | C236 | CPAHNCDILVD | 1 | Danio rerio | C236 | CPAHSCDILVD | 1 | Danio rerio | C344 | ANTKECPKCHV | 6 | Homo sapiens, Xenopus tropicalis, Mus musculus, Bos taurus, Danio rerio, Danio rerio | C344 | VHTKLCPKCYK | 1 | Arabidopsis thaliana | C344 | VHTKPCPKCHK | 1 | Arabidopsis thaliana | C344 | ANTKECPKCST | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | C344 | ANTKECPRCSV | 1 | Drosophila melanogaster | C347 | KECPKCHVTIE | 6 | Homo sapiens, Xenopus tropicalis, Mus musculus, Bos taurus, Danio rerio, Danio rerio | C347 | KLCPKCYKPVE | 1 | Arabidopsis thaliana | C347 | KPCPKCHKPVE | 1 | Arabidopsis thaliana | C347 | KECPKCSTTIE | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | C347 | KECPRCSVTIE | 1 | Drosophila melanogaster | C362 | CNHMVCRNQNC | 6 | Homo sapiens, Xenopus tropicalis, Mus musculus, Bos taurus, Danio rerio, Danio rerio | C362 | CNLVRCI---C | 1 | Arabidopsis thaliana | C362 | CNLVTCL---C | 1 | Arabidopsis thaliana | C362 | CNHMTCK--KC | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | C362 | CNHMVCKNQNC | 1 | Drosophila melanogaster | C367 | CRNQNCKAEFC | 6 | Homo sapiens, Xenopus tropicalis, Mus musculus, Bos taurus, Danio rerio, Danio rerio | C367 | CI---CGQCFC | 1 | Arabidopsis thaliana | C367 | CL---CRQSFC | 1 | Arabidopsis thaliana | C367 | CK--KCKYEFC | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | C367 | CKNQNCKNEFC | 1 | Drosophila melanogaster | C372 | CKAEFCWVCLG | 6 | Homo sapiens, Xenopus tropicalis, Mus musculus, Bos taurus, Danio rerio, Danio rerio | C372 | CGQCFCWLC-G | 1 | Arabidopsis thaliana | C372 | CRQSFCWLC-G | 1 | Arabidopsis thaliana | C372 | CKYEFCWVCLG | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | C372 | CKNEFCWVCLG | 1 | Drosophila melanogaster | C375 | EFCWVCLGPWE | 6 | Homo sapiens, Xenopus tropicalis, Mus musculus, Bos taurus, Danio rerio, Danio rerio | C375 | CFCWLC-GGAT | 1 | Arabidopsis thaliana | C375 | SFCWLC-GEAT | 1 | Arabidopsis thaliana | C375 | EFCWVCLGPWT | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | C375 | EFCWVCLGSWE | 1 | Drosophila melanogaster | C389 | ---YNCNRYNE | 6 | Homo sapiens, Xenopus tropicalis, Mus musculus, Bos taurus, Danio rerio, Danio rerio | C389 | IAGHSCGRYQD | 1 | Arabidopsis thaliana | C389 | ISGHSCGRFQE | 1 | Arabidopsis thaliana | C389 | ---YTCNRYEE | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | C389 | ---YNCNRYDE | 1 | Drosophila melanogaster | F371 | NCKAEFCWVCL | 6 | Homo sapiens, Xenopus tropicalis, Mus musculus, Bos taurus, Danio rerio, Danio rerio | F371 | -CGQCFCWLC- | 1 | Arabidopsis thaliana | F371 | -CRQSFCWLC- | 1 | Arabidopsis thaliana | F371 | KCKYEFCWVCL | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | F371 | NCKNEFCWVCL | 1 | Drosophila melanogaster | H205 | GLECGHKFCMQ | 6 | Homo sapiens, Xenopus tropicalis, Mus musculus, Bos taurus, Danio rerio, Danio rerio | H205 | RMDCGHCFCNN | 1 | Arabidopsis thaliana | H205 | RMDCGHSFCNN | 1 | Arabidopsis thaliana | H205 | A-ECDHEFCLA | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | H205 | GLECGHRFCMP | 1 | Drosophila melanogaster | H382 | GPWEPHGSAW- | 6 | Homo sapiens, Xenopus tropicalis, Mus musculus, Bos taurus, Danio rerio, Danio rerio | H382 | GGATGSDHTYR | 1 | Arabidopsis thaliana | H382 | GEATGRDHTWA | 1 | Arabidopsis thaliana | H382 | GPWTEHGNNW- | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | H382 | GSWEPHGSSW- | 1 | Drosophila melanogaster |
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