mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for ARIH1
Gene summary
Basic gene Info.Gene symbolARIH1
Gene nameariadne RBR E3 ubiquitin protein ligase 1
SynonymsARI|HARI|HHARI|UBCH7BP
CytomapUCSC genome browser: 15q24
Type of geneprotein-coding
RefGenesNM_005744.3,
DescriptionARI-1E3 ubiquitin-protein ligase ARIH1H7-AP2MOP-6ariadne homolog, ubiquitin-conjugating enzyme E2 binding protein, 1ariadne, Drosophila, homolog ofmonocyte protein 6protein ariadne-1 homologubcH7-binding proteinubcM4-interacting proteinubiquitin
Modification date20141207
dbXrefs MIM : 605624
HGNC : HGNC
HPRD : 05730
ProteinUniProt: Q9Y4X5
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_ARIH1
BioGPS: 25820
PathwayNCI Pathway Interaction Database: ARIH1
KEGG: ARIH1
REACTOME: ARIH1
Pathway Commons: ARIH1
ContextiHOP: ARIH1
ligand binding site mutation search in PubMed: ARIH1
UCL Cancer Institute: ARIH1
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0016567protein ubiquitination14623119


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Ligand binding site mutations for ARIH1

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
H205F207LCOAD1
C203L201RKIRC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for ARIH1
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
C203L201R-1.2363224
H205F207L-0.44116144
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for ARIH1 from PDB

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Differential gene expression and gene-gene network for ARIH1
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of ARIH1 and the right PPI network was created from samples without mutations in the LBS of ARIH1. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for ARIH1
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for ARIH1
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of ARIH1 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
ZNZINC(2+)4kblAC203 H205
ZNZINC(2+)4kblBC203 H205
ZNZINC(2+)4kc9AC203 H205


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Conservation information for LBS of ARIH1
Multiple alignments for Q9Y4X5 in multiple species
LBSAA sequence# speciesSpecies
C203FTGLECGHKFC6Homo sapiens, Xenopus tropicalis, Mus musculus, Bos taurus, Danio rerio, Danio rerio
C203MTRMDCGHCFC1Arabidopsis thaliana
C203LTRMDCGHSFC1Arabidopsis thaliana
C203FSA-ECDHEFC1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C203MAGLECGHRFC1Drosophila melanogaster
C231GQTISCPAHGC4Homo sapiens, Xenopus tropicalis, Mus musculus, Bos taurus
C231SKRIRCMAHQC1Arabidopsis thaliana
C231SKRIICMAHKC1Arabidopsis thaliana
C231ESVIQCPEESC1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C231GQTISCAAHGC1Drosophila melanogaster
C231GQTISCPAHNC1Danio rerio
C231GQTISCPAHSC1Danio rerio
C236CPAHGCDILVD4Homo sapiens, Xenopus tropicalis, Mus musculus, Bos taurus
C236CMAHQCNAICD1Arabidopsis thaliana
C236CMAHKCNAICD1Arabidopsis thaliana
C236CPEESCTQIVS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C236CAAHGCDILVD1Drosophila melanogaster
C236CPAHNCDILVD1Danio rerio
C236CPAHSCDILVD1Danio rerio
C344ANTKECPKCHV6Homo sapiens, Xenopus tropicalis, Mus musculus, Bos taurus, Danio rerio, Danio rerio
C344VHTKLCPKCYK1Arabidopsis thaliana
C344VHTKPCPKCHK1Arabidopsis thaliana
C344ANTKECPKCST1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C344ANTKECPRCSV1Drosophila melanogaster
C347KECPKCHVTIE6Homo sapiens, Xenopus tropicalis, Mus musculus, Bos taurus, Danio rerio, Danio rerio
C347KLCPKCYKPVE1Arabidopsis thaliana
C347KPCPKCHKPVE1Arabidopsis thaliana
C347KECPKCSTTIE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C347KECPRCSVTIE1Drosophila melanogaster
C362CNHMVCRNQNC6Homo sapiens, Xenopus tropicalis, Mus musculus, Bos taurus, Danio rerio, Danio rerio
C362CNLVRCI---C1Arabidopsis thaliana
C362CNLVTCL---C1Arabidopsis thaliana
C362CNHMTCK--KC1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C362CNHMVCKNQNC1Drosophila melanogaster
C367CRNQNCKAEFC6Homo sapiens, Xenopus tropicalis, Mus musculus, Bos taurus, Danio rerio, Danio rerio
C367CI---CGQCFC1Arabidopsis thaliana
C367CL---CRQSFC1Arabidopsis thaliana
C367CK--KCKYEFC1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C367CKNQNCKNEFC1Drosophila melanogaster
C372CKAEFCWVCLG6Homo sapiens, Xenopus tropicalis, Mus musculus, Bos taurus, Danio rerio, Danio rerio
C372CGQCFCWLC-G1Arabidopsis thaliana
C372CRQSFCWLC-G1Arabidopsis thaliana
C372CKYEFCWVCLG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C372CKNEFCWVCLG1Drosophila melanogaster
C375EFCWVCLGPWE6Homo sapiens, Xenopus tropicalis, Mus musculus, Bos taurus, Danio rerio, Danio rerio
C375CFCWLC-GGAT1Arabidopsis thaliana
C375SFCWLC-GEAT1Arabidopsis thaliana
C375EFCWVCLGPWT1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C375EFCWVCLGSWE1Drosophila melanogaster
C389---YNCNRYNE6Homo sapiens, Xenopus tropicalis, Mus musculus, Bos taurus, Danio rerio, Danio rerio
C389IAGHSCGRYQD1Arabidopsis thaliana
C389ISGHSCGRFQE1Arabidopsis thaliana
C389---YTCNRYEE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C389---YNCNRYDE1Drosophila melanogaster
F371NCKAEFCWVCL6Homo sapiens, Xenopus tropicalis, Mus musculus, Bos taurus, Danio rerio, Danio rerio
F371-CGQCFCWLC-1Arabidopsis thaliana
F371-CRQSFCWLC-1Arabidopsis thaliana
F371KCKYEFCWVCL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F371NCKNEFCWVCL1Drosophila melanogaster
H205GLECGHKFCMQ6Homo sapiens, Xenopus tropicalis, Mus musculus, Bos taurus, Danio rerio, Danio rerio
H205RMDCGHCFCNN1Arabidopsis thaliana
H205RMDCGHSFCNN1Arabidopsis thaliana
H205A-ECDHEFCLA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H205GLECGHRFCMP1Drosophila melanogaster
H382GPWEPHGSAW-6Homo sapiens, Xenopus tropicalis, Mus musculus, Bos taurus, Danio rerio, Danio rerio
H382GGATGSDHTYR1Arabidopsis thaliana
H382GEATGRDHTWA1Arabidopsis thaliana
H382GPWTEHGNNW-1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H382GSWEPHGSSW-1Drosophila melanogaster


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