mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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	Gene Summary
	Ligand Binding Site Mutation Information
	Protein Structure Related Information
	Gene Expression and Gene-Gene Network
	Phenotype Information
	Pharmacological Information
	Conservation Information for LBS

Gene summary for GAPDH

Gene summary

Basic gene Info.	Gene symbol	GAPDH
	Gene name	glyceraldehyde-3-phosphate dehydrogenase
	Synonyms	G3PD\|GAPD\|HEL-S-162eP
	Cytomap	UCSC genome browser: 12p13
	Type of gene	protein-coding
	RefGenes	NM_001256799.2, NM_001289745.1,NM_001289746.1,NM_002046.5,
	Description	aging-associated gene 9 proteinepididymis secretory sperm binding protein Li 162ePpeptidyl-cysteine S-nitrosylase GAPDH
	Modification date	20141222
dbXrefs	MIM : 138400
	HGNC : HGNC
	Ensembl : ENSG00000111640
	HPRD : 00713
	Vega : OTTHUMG00000137379
Protein	UniProt: P04406 go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_GAPDH
	BioGPS: 2597
Pathway	NCI Pathway Interaction Database: GAPDH
	KEGG: GAPDH
	REACTOME: GAPDH
	Pathway Commons: GAPDH
Context	iHOP: GAPDH
	ligand binding site mutation search in PubMed: GAPDH
	UCL Cancer Institute: GAPDH
Assigned class in mutLBSgeneDB	C: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

GO ID	GO Term	PubMed ID
GO:0017148	negative regulation of translation	23071094
GO:0071346	cellular response to interferon-gamma	15479637

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Ligand binding site mutations for GAPDH

Cancer type specific mutLBS sorted by frequency

LBS	AAchange of nsSNV	Cancer type	# samples
D35	D35Y	COAD	1
A183	Q185H	LUSC	1

cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

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Protein structure related information for GAPDH

Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
(ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)

: nsSNV at non-LBS

: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.

LBS	AAchange of nsSNV	Relative stability change
D35	D35Y	-0.84850676
A183	Q185H	-0.72250103

(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for GAPDH from PDB

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Differential gene expression and gene-gene network for GAPDH

Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)

* Left PPI network was created from samples with mutations in the LBS of GAPDH and the right PPI network was created from samples without mutations in the LBS of GAPDH. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.

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Phenotype information for GAPDH

Gene level disease information (DisGeNet)

Disease ID	Disease name	# PubMed	Association type
umls:C2239176	Carcinoma, Hepatocellular	11	Biomarker
umls:C0007137	Carcinoma, Squamous Cell	3	Biomarker
umls:C0948089	Acute Coronary Syndrome	1	Biomarker
umls:C0003130	Anoxia	1	Biomarker
umls:C0014859	Esophageal Neoplasms	1	Biomarker
umls:C0026640	Mouth Neoplasms	1	Biomarker
umls:C0029408	Osteoarthritis	1	Biomarker
umls:C0029456	Osteoporosis	1	Biomarker

Mutation level pathogenic information (ClinVar annotation)

Allele ID

AA change

Clinical significance

Origin

Phenotype IDs

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Pharmacological information for GAPDH

Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network

Drug information targeting mutLBSgene (Approved drugs only)

Drug status	DrugBank ID	Name	Type	Drug structure
Nutraceutical	DB00157	NADH	Small molecule
Experimental	DB02059	Adenosine-5-Diphosphoribose	Small molecule
Experimental	DB03893	Thionicotinamide-Adenine-Dinucleotide	Small molecule
Experimental	DB07347	4-(2-AMINOETHYL)BENZENESULFONYL FLUORIDE	Small molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of GAPDH go to BioLip

Ligand ID	Ligand short name	Ligand long name	PDB ID	PDB name	mutLBS
NAD		NAD ZWITTERION	1u8f	R	D35
NAD		NAD ZWITTERION	1znq	P	D35
NAD		NAD ZWITTERION	1znq	Q	D35
NAD		NAD ZWITTERION	1u8f	P	D35 A183
NAD		NAD ZWITTERION	1u8f	Q	D35 A183
NAD		NAD ZWITTERION	1znq	O	D35 A183
NAD		NAD ZWITTERION	1znq	R	D35 A183

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Conservation information for LBS of GAPDH

Multiple alignments for P04406 in multiple species

LBS	AA sequence	# species	Species
A123	RVIISAPSADA	7	Homo sapiens, Danio rerio, Gallus gallus, Bos taurus, Mus musculus, Mus musculus, Rattus norvegicus
A123	KVIISAPSADA	7	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987), Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Drosophila melanogaster, Drosophila melanogaster
A123	KVVITAPSSTA	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A123	RVIISAPSKDA	2	Schizosaccharomyces pombe (strain 972 / ATCC 24843), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A123	KVVISAPSKDA	1	Oryza sativa subsp. japonica
A123	KVVITAPSKTA	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
A123	KVVITAPSSSA	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A183	VHAITATQKTV	8	Homo sapiens, Oryza sativa subsp. japonica, Danio rerio, Gallus gallus, Bos taurus, Mus musculus, Mus musculus, Rattus norvegicus
A183	VHATTATQKTV	4	Schizosaccharomyces pombe (strain 972 / ATCC 24843), Schizosaccharomyces pombe (strain 972 / ATCC 24843), Drosophila melanogaster, Drosophila melanogaster
A183	VHAVTATQKTV	4	Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans
A183	VHSMTATQKTV	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A183	VHSITATQKTV	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
A183	VHSLTATQKTV	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A183	VHSYTATQKTV	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
C152	VSNASCTTNCL	14	Oryza sativa subsp. japonica, Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cere
C152	ISNASCTTNCL	7	Homo sapiens, Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987), Schizosaccharomyces pombe (strain 972 / ATCC 24843), Schizosaccharomyces pombe (strain 972 / ATCC 24843), Caenorhabditis elegans, Caenorhabditis elegans,
D35	IVAINDPFIDL	6	Homo sapiens, Danio rerio, Bos taurus, Mus musculus, Mus musculus, Rattus norvegicus
D35	VVAINDPFIDL	2	Schizosaccharomyces pombe (strain 972 / ATCC 24843), Gallus gallus
D35	VVAVNDPFITI	2	Caenorhabditis elegans, Caenorhabditis elegans
D35	VVAVNDPFISI	2	Caenorhabditis elegans, Caenorhabditis elegans
D35	VVAVNDPFIDV	2	Drosophila melanogaster, Drosophila melanogaster
D35	LVAVNDPFITT	1	Oryza sativa subsp. japonica
D35	VVAVNDPFISV	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
D35	VVAVNDPFISN	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D35	VVALNDPFITN	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D35	VVALNDPFISN	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D35	IVAVNDPFIEP	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
D35	VVAVNDPFIDL	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E317	SWYDNEFGYSN	7	Homo sapiens, Caenorhabditis elegans, Caenorhabditis elegans, Drosophila melanogaster, Drosophila melanogaster, Gallus gallus, Bos taurus
E317	SWYDNEYGYSN	5	Caenorhabditis elegans, Caenorhabditis elegans, Mus musculus, Mus musculus, Rattus norvegicus
E317	SWYDNEYGYST	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E317	SWYDNEWGYSR	2	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E317	AWYDNEWGYSN	1	Oryza sativa subsp. japonica
E317	AWYDNEYGYSE	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
E317	SWYDNEYGYSA	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E317	SWYDNEWGYSH	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E317	TWYDNEFGYSN	1	Danio rerio
F102	ESTGVFTTMEK	6	Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Mus musculus, Rattus norvegicus
F102	DSTGVFKELDT	3	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F102	ESTGVFTTIEK	3	Caenorhabditis elegans, Caenorhabditis elegans, Danio rerio
F102	ESTGVFTTKEK	2	Caenorhabditis elegans, Caenorhabditis elegans
F102	ESTGVFTTIDK	2	Drosophila melanogaster, Drosophila melanogaster
F102	ESTGVFTDKEK	1	Oryza sativa subsp. japonica
F102	DSTGVFKELDS	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
F102	ESTGVFTTTEK	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
F102	ESTGVFTTQET	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F102	ESTGVFTTKET	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F11	VGINGFGRIGR	8	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987), Schizosaccharomyces pombe (strain 972 / ATCC 24843), Schizosaccharomyces pombe (strain 972 / ATCC 24843), Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis
F11	VGVNGFGRIGR	6	Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Mus musculus, Rattus norvegicus
F11	IGINGFGRIGR	3	Oryza sativa subsp. japonica, Drosophila melanogaster, Drosophila melanogaster
F11	VAINGFGRIGR	3	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F11	IAINGFGRIGR	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F37	AINDPFIDLNY	5	Homo sapiens, Gallus gallus, Mus musculus, Mus musculus, Rattus norvegicus
F37	AVNDPFITIDY	2	Caenorhabditis elegans, Caenorhabditis elegans
F37	AVNDPFISIDY	2	Caenorhabditis elegans, Caenorhabditis elegans
F37	AVNDPFIDVNY	2	Drosophila melanogaster, Drosophila melanogaster
F37	AVNDPFITTDY	1	Oryza sativa subsp. japonica
F37	AVNDPFISVDY	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
F37	AVNDPFISNDY	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F37	ALNDPFITNDY	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F37	ALNDPFISNDY	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F37	AVNDPFIEPKY	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
F37	AINDPFIDLEY	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F37	AVNDPFIDLDY	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F37	AINDPFIDLDY	1	Danio rerio
F37	AINDPFIDLHY	1	Bos taurus
G10	KVGVNGFGRIG	6	Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Mus musculus, Rattus norvegicus
G10	KVGINGFGRIG	4	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987), Schizosaccharomyces pombe (strain 972 / ATCC 24843), Schizosaccharomyces pombe (strain 972 / ATCC 24843), Danio rerio
G10	KIGINGFGRIG	3	Oryza sativa subsp. japonica, Drosophila melanogaster, Drosophila melanogaster
G10	RVAINGFGRIG	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G10	NVGINGFGRIG	2	Caenorhabditis elegans, Caenorhabditis elegans
G10	SVGINGFGRIG	2	Caenorhabditis elegans, Caenorhabditis elegans
G10	KVAINGFGRIG	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
G10	RIAINGFGRIG	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G100	VVESTGVFTTM	6	Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Mus musculus, Rattus norvegicus
G100	VVESTGVFTTI	4	Caenorhabditis elegans, Caenorhabditis elegans, Drosophila melanogaster, Danio rerio
G100	AIDSTGVFKEL	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G100	VVESTGVFTTK	2	Caenorhabditis elegans, Caenorhabditis elegans
G100	VVESTGVFTDK	1	Oryza sativa subsp. japonica
G100	VIDSTGVFKEL	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
G100	AVDSTGVFKEL	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G100	IVESTGVFTTT	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
G100	VIESTGVFTTQ	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G100	VIESTGVFTTK	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G100	IVESTGVFTTI	1	Drosophila melanogaster
G12	GINGFGRIGRL	8	Oryza sativa subsp. japonica, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Drosophila melanogaster, Drosophila melanogaster, Danio rerio
G12	GVNGFGRIGRL	6	Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Mus musculus, Rattus norvegicus
G12	AINGFGRIGRL	4	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S
G12	GINGFGRIGRI	3	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987), Schizosaccharomyces pombe (strain 972 / ATCC 24843), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I14	NGFGRIGRLVL	8	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Drosoph
I14	NGFGRIGRLVT	7	Homo sapiens, Danio rerio, Gallus gallus, Bos taurus, Mus musculus, Mus musculus, Rattus norvegicus
I14	NGFGRIGRLVM	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I14	NGFGRIGRIVL	2	Schizosaccharomyces pombe (strain 972 / ATCC 24843), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I14	NGFGRIGRLVA	1	Oryza sativa subsp. japonica
I14	NGFGRIGRIVF	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
I181	TTVHAITATQK	7	Homo sapiens, Oryza sativa subsp. japonica, Gallus gallus, Bos taurus, Mus musculus, Mus musculus, Rattus norvegicus
I181	TTVHATTATQK	4	Schizosaccharomyces pombe (strain 972 / ATCC 24843), Schizosaccharomyces pombe (strain 972 / ATCC 24843), Drosophila melanogaster, Drosophila melanogaster
I181	TTVHAVTATQK	4	Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans
I181	TTVHSMTATQK	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I181	TTVHSITATQK	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
I181	TTVHSLTATQK	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I181	TTVHSYTATQK	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
I181	STVHAITATQK	1	Danio rerio
I38	INDPFIDLNYM	5	Homo sapiens, Gallus gallus, Mus musculus, Mus musculus, Rattus norvegicus
I38	VNDPFITIDYM	2	Caenorhabditis elegans, Caenorhabditis elegans
I38	VNDPFISIDYM	2	Caenorhabditis elegans, Caenorhabditis elegans
I38	VNDPFIDVNYM	2	Drosophila melanogaster, Drosophila melanogaster
I38	VNDPFITTDYM	1	Oryza sativa subsp. japonica
I38	VNDPFISVDYA	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
I38	VNDPFISNDYA	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I38	LNDPFITNDYA	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I38	LNDPFISNDYS	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I38	VNDPFIEPKYA	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
I38	INDPFIDLEYM	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I38	VNDPFIDLDYM	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I38	INDPFIDLDYM	1	Danio rerio
I38	INDPFIDLHYM	1	Bos taurus
N316	ISWYDNEFGYS	4	Homo sapiens, Drosophila melanogaster, Drosophila melanogaster, Bos taurus
N316	ISWYDNEYGYS	4	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Mus musculus, Mus musculus, Rattus norvegicus
N316	VSWYDNEYGYS	4	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Caenorhabditis elegans, Caenorhabditis elegans
N316	VSWYDNEWGYS	3	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987), Schizosaccharomyces pombe (strain 972 / ATCC 24843), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N316	VSWYDNEFGYS	3	Caenorhabditis elegans, Caenorhabditis elegans, Gallus gallus
N316	VAWYDNEWGYS	1	Oryza sativa subsp. japonica
N316	VAWYDNEYGYS	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
N316	VTWYDNEFGYS	1	Danio rerio
N34	DIVAINDPFID	3	Homo sapiens, Bos taurus, Rattus norvegicus
N34	EIVAINDPFID	3	Danio rerio, Mus musculus, Mus musculus
N34	EVVAVNDPFIS	2	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N34	QVVAINDPFID	2	Schizosaccharomyces pombe (strain 972 / ATCC 24843), Gallus gallus
N34	QVVAVNDPFIT	2	Caenorhabditis elegans, Caenorhabditis elegans
N34	NVVAVNDPFIS	2	Caenorhabditis elegans, Caenorhabditis elegans
N34	ELVAVNDPFIT	1	Oryza sativa subsp. japonica
N34	EVVALNDPFIT	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N34	EVVALNDPFIS	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N34	HIVAVNDPFIE	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
N34	QVVAVNDPFID	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N34	NVVAVNDPFID	1	Drosophila melanogaster
N34	SVVAVNDPFID	1	Drosophila melanogaster
N9	VKVGVNGFGRI	6	Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Mus musculus, Rattus norvegicus
N9	VRVAINGFGRI	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N9	VKVGINGFGRI	2	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987), Danio rerio
N9	PKVGINGFGRI	2	Schizosaccharomyces pombe (strain 972 / ATCC 24843), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N9	ANVGINGFGRI	2	Caenorhabditis elegans, Caenorhabditis elegans
N9	PSVGINGFGRI	2	Caenorhabditis elegans, Caenorhabditis elegans
N9	SKIGINGFGRI	2	Drosophila melanogaster, Drosophila melanogaster
N9	IKIGINGFGRI	1	Oryza sativa subsp. japonica
N9	VKVAINGFGRI	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
N9	IRIAINGFGRI	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P36	VAINDPFIDLN	5	Homo sapiens, Gallus gallus, Mus musculus, Mus musculus, Rattus norvegicus
P36	VAVNDPFITID	2	Caenorhabditis elegans, Caenorhabditis elegans
P36	VAVNDPFISID	2	Caenorhabditis elegans, Caenorhabditis elegans
P36	VAVNDPFIDVN	2	Drosophila melanogaster, Drosophila melanogaster
P36	VAVNDPFITTD	1	Oryza sativa subsp. japonica
P36	VAVNDPFISVD	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
P36	VAVNDPFISND	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P36	VALNDPFITND	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P36	VALNDPFISND	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P36	VAVNDPFIEPK	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
P36	VAINDPFIDLE	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P36	VAVNDPFIDLD	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P36	VAINDPFIDLD	1	Danio rerio
P36	VAINDPFIDLH	1	Bos taurus
R13	INGFGRIGRLV	12	Oryza sativa subsp. japonica, Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cere
R13	VNGFGRIGRLV	6	Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Mus musculus, Rattus norvegicus
R13	INGFGRIGRIV	3	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987), Schizosaccharomyces pombe (strain 972 / ATCC 24843), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R80	ATYQERDPANL	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R80	KVFNSKDPAAI	2	Caenorhabditis elegans, Caenorhabditis elegans
R80	KVYNSRDPAEI	2	Caenorhabditis elegans, Caenorhabditis elegans
R80	TVFSERDPANI	2	Drosophila melanogaster, Drosophila melanogaster
R80	TIFQERDPANI	2	Bos taurus, Rattus norvegicus
R80	TIFQERDPTNI	2	Mus musculus, Mus musculus
R80	TIFQERDPSKI	1	Homo sapiens
R80	TVFGIRNPDEI	1	Oryza sativa subsp. japonica
R80	AVFQEKDPANL	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
R80	ATFQERDPANL	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R80	KFYTERDPAAI	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
R80	DVHNERDPADI	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R80	DVHNERDPANI	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R80	TVYSERDPANI	1	Danio rerio
R80	TIFQERDPSNI	1	Gallus gallus
S122	KRVIISAPSAD	7	Homo sapiens, Danio rerio, Gallus gallus, Bos taurus, Mus musculus, Mus musculus, Rattus norvegicus
S122	KKVIISAPSAD	7	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987), Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Drosophila melanogaster, Drosophila melanogaster
S122	KKVVITAPSST	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S122	KRVIISAPSKD	2	Schizosaccharomyces pombe (strain 972 / ATCC 24843), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S122	KKVVISAPSKD	1	Oryza sativa subsp. japonica
S122	KKVVITAPSKT	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
S122	KKVVITAPSSS	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S98	EYVVESTGVFT	8	Homo sapiens, Oryza sativa subsp. japonica, Drosophila melanogaster, Gallus gallus, Bos taurus, Mus musculus, Mus musculus, Rattus norvegicus
S98	DIAIDSTGVFK	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S98	DFVVESTGVFT	2	Caenorhabditis elegans, Caenorhabditis elegans
S98	DYVVESTGVFT	2	Caenorhabditis elegans, Caenorhabditis elegans
S98	DIVIDSTGVFK	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
S98	DVAVDSTGVFK	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S98	DYIVESTGVFT	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
S98	DYVIESTGVFT	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S98	EYVIESTGVFT	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S98	EYIVESTGVFT	1	Drosophila melanogaster
S98	TYVVESTGVFT	1	Danio rerio
T99	YVVESTGVFTT	10	Homo sapiens, Caenorhabditis elegans, Caenorhabditis elegans, Drosophila melanogaster, Danio rerio, Gallus gallus, Bos taurus, Mus musculus, Mus musculus, Rattus norvegicus
T99	IAIDSTGVFKE	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T99	YIVESTGVFTT	2	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987), Drosophila melanogaster
T99	YVIESTGVFTT	2	Schizosaccharomyces pombe (strain 972 / ATCC 24843), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T99	FVVESTGVFTT	2	Caenorhabditis elegans, Caenorhabditis elegans
T99	YVVESTGVFTD	1	Oryza sativa subsp. japonica
T99	IVIDSTGVFKE	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
T99	VAVDSTGVFKE	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y320	DNEFGYSNRVV	5	Homo sapiens, Caenorhabditis elegans, Caenorhabditis elegans, Gallus gallus, Bos taurus
Y320	DNEYGYSNRVV	5	Caenorhabditis elegans, Caenorhabditis elegans, Mus musculus, Mus musculus, Rattus norvegicus
Y320	DNEYGYSTRVV	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y320	DNEFGYSNRVI	2	Drosophila melanogaster, Drosophila melanogaster
Y320	DNEWGYSNRVI	1	Oryza sativa subsp. japonica
Y320	DNEYGYSERVV	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
Y320	DNEYGYSARVV	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y320	DNEWGYSRRVL	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Y320	DNEWGYSRRVV	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y320	DNEWGYSHRVV	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y320	DNEFGYSNRVC	1	Danio rerio