mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

Home

Download

 Statistics

Help

About Us
Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for TES
Gene summary
Basic gene Info.Gene symbolTES
Gene nametestis derived transcript (3 LIM domains)
SynonymsTESS|TESS-2
CytomapUCSC genome browser: 7q31.2
Type of geneprotein-coding
RefGenesNM_015641.3,
NM_152829.2,
Descriptiontestin
Modification date20141222
dbXrefs MIM : 606085
HGNC : HGNC
Ensembl : ENSG00000135269
HPRD : 05833
Vega : OTTHUMG00000023092
ProteinUniProt: Q9UGI8
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_TES
BioGPS: 26136
PathwayNCI Pathway Interaction Database: TES
KEGG: TES
REACTOME: TES
Pathway Commons: TES
ContextiHOP: TES
ligand binding site mutation search in PubMed: TES
UCL Cancer Institute: TES
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID


Top
Ligand binding site mutations for TES
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
 : non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
C393C393YUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


Top
Protein structure related information for TES
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
C393C393Y-0.45360862
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for TES from PDB

Top
Differential gene expression and gene-gene network for TES
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of TES and the right PPI network was created from samples without mutations in the LBS of TES. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Top

Top
Phenotype information for TES
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0017636Glioblastoma3Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Top
Pharmacological information for TES
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of TES go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
ZNZINC(2+)2xqnTC393


Top
Conservation information for LBS of TES
Multiple alignments for Q9UGI8 in multiple species
LBSAA sequence# speciesSpecies
A384NFSWHASTECF5Homo sapiens, Rattus norvegicus, Pan troglodytes, Canis lupus familiaris, Bos taurus
A384GFHWHAAPECF1Xenopus tropicalis
A384NFNWHATQECF1Gallus gallus
C301SEKPRCAGCDE7Homo sapiens, Xenopus tropicalis, Gallus gallus, Rattus norvegicus, Pan troglodytes, Canis lupus familiaris, Bos taurus
C304PRCAGCDELIF7Homo sapiens, Xenopus tropicalis, Gallus gallus, Rattus norvegicus, Pan troglodytes, Canis lupus familiaris, Bos taurus
C361NHAVVCQGCHN4Homo sapiens, Rattus norvegicus, Pan troglodytes, Canis lupus familiaris
C361NHAVSCQGCHN1Xenopus tropicalis
C361KHAAICQGCHN1Gallus gallus
C361NHAEVCQGCHN1Bos taurus
C364VVCQGCHNAID4Homo sapiens, Rattus norvegicus, Pan troglodytes, Canis lupus familiaris
C364VSCQGCHNAID1Xenopus tropicalis
C364AICQGCHNAID1Gallus gallus
C364EVCQGCHNAID1Bos taurus
C388HASTECFLCSC5Homo sapiens, Rattus norvegicus, Pan troglodytes, Canis lupus familiaris, Bos taurus
C388HAAPECFICSC1Xenopus tropicalis
C388HATQECFLCSC1Gallus gallus
C391TECFLCSCCSK5Homo sapiens, Rattus norvegicus, Pan troglodytes, Canis lupus familiaris, Bos taurus
C391PECFICSCCSK1Xenopus tropicalis
C391QECFLCSCCSK1Gallus gallus
C393CFLCSCCSKCL6Homo sapiens, Gallus gallus, Rattus norvegicus, Pan troglodytes, Canis lupus familiaris, Bos taurus
C393CFICSCCSKCL1Xenopus tropicalis
C394FLCSCCSKCLI6Homo sapiens, Gallus gallus, Rattus norvegicus, Pan troglodytes, Canis lupus familiaris, Bos taurus
C394FICSCCSKCLI1Xenopus tropicalis
C397SCCSKCLIGQK7Homo sapiens, Xenopus tropicalis, Gallus gallus, Rattus norvegicus, Pan troglodytes, Canis lupus familiaris, Bos taurus
C412EGMVFCSVECK6Homo sapiens, Gallus gallus, Rattus norvegicus, Pan troglodytes, Canis lupus familiaris, Bos taurus
C412QGMVFCSVDCK1Xenopus tropicalis
C416FCSVECKKMMS3Rattus norvegicus, Canis lupus familiaris, Bos taurus
C416FCSVECKKRMS2Homo sapiens, Pan troglodytes
C416FCSVDCKKKMS1Xenopus tropicalis
C416FCSVECKKKMM1Gallus gallus
E312LIFSNEYTQAE7Homo sapiens, Xenopus tropicalis, Gallus gallus, Rattus norvegicus, Pan troglodytes, Canis lupus familiaris, Bos taurus
E338SILAGEIYVMV2Homo sapiens, Pan troglodytes
E338CVLAGEIYVMV2Xenopus tropicalis, Gallus gallus
E338NILAGEIYVMV2Canis lupus familiaris, Bos taurus
E338NILAGKIYVMV1Rattus norvegicus
E387WHASTECFLCS5Homo sapiens, Rattus norvegicus, Pan troglodytes, Canis lupus familiaris, Bos taurus
E387WHAAPECFICS1Xenopus tropicalis
E387WHATQECFLCS1Gallus gallus
F389ASTECFLCSCC5Homo sapiens, Rattus norvegicus, Pan troglodytes, Canis lupus familiaris, Bos taurus
F389AAPECFICSCC1Xenopus tropicalis
F389ATQECFLCSCC1Gallus gallus
F403LIGQKFMPVEG6Homo sapiens, Gallus gallus, Rattus norvegicus, Pan troglodytes, Canis lupus familiaris, Bos taurus
F403LIGQKFMPIQG1Xenopus tropicalis
G337DSILAGEIYVM2Homo sapiens, Pan troglodytes
G337DCVLAGEIYVM2Xenopus tropicalis, Gallus gallus
G337DNILAGEIYVM2Canis lupus familiaris, Bos taurus
G337DNILAGKIYVM1Rattus norvegicus
G400SKCLIGQKFMP7Homo sapiens, Xenopus tropicalis, Gallus gallus, Rattus norvegicus, Pan troglodytes, Canis lupus familiaris, Bos taurus
H322ENQNWHLKHFC5Homo sapiens, Rattus norvegicus, Pan troglodytes, Canis lupus familiaris, Bos taurus
H322EGLNWHLKHFC1Xenopus tropicalis
H322EGQNWHLKHFC1Gallus gallus
H325NWHLKHFCCFD7Homo sapiens, Xenopus tropicalis, Gallus gallus, Rattus norvegicus, Pan troglodytes, Canis lupus familiaris, Bos taurus
H383NNFSWHASTEC5Homo sapiens, Rattus norvegicus, Pan troglodytes, Canis lupus familiaris, Bos taurus
H383NGFHWHAAPEC1Xenopus tropicalis
H383NNFNWHATQEC1Gallus gallus
I339ILAGEIYVMVN4Homo sapiens, Pan troglodytes, Canis lupus familiaris, Bos taurus
I339VLAGEIYVMVN2Xenopus tropicalis, Gallus gallus
I339ILAGKIYVMVR1Rattus norvegicus
K402CLIGQKFMPVE6Homo sapiens, Gallus gallus, Rattus norvegicus, Pan troglodytes, Canis lupus familiaris, Bos taurus
K402CLIGQKFMPIQ1Xenopus tropicalis
L323NQNWHLKHFCC5Homo sapiens, Rattus norvegicus, Pan troglodytes, Canis lupus familiaris, Bos taurus
L323GLNWHLKHFCC1Xenopus tropicalis
L323GQNWHLKHFCC1Gallus gallus
L335DCDSILAGEIY2Homo sapiens, Pan troglodytes
L335DCDCVLAGEIY2Xenopus tropicalis, Gallus gallus
L335DCDNILAGEIY2Canis lupus familiaris, Bos taurus
L335DCDNILAGKIY1Rattus norvegicus
L398CCSKCLIGQKF7Homo sapiens, Xenopus tropicalis, Gallus gallus, Rattus norvegicus, Pan troglodytes, Canis lupus familiaris, Bos taurus
M404IGQKFMPVEGM6Homo sapiens, Gallus gallus, Rattus norvegicus, Pan troglodytes, Canis lupus familiaris, Bos taurus
M404IGQKFMPIQGM1Xenopus tropicalis
P370HNAIDPEVQRV7Homo sapiens, Xenopus tropicalis, Gallus gallus, Rattus norvegicus, Pan troglodytes, Canis lupus familiaris, Bos taurus
P405GQKFMPVEGMV6Homo sapiens, Gallus gallus, Rattus norvegicus, Pan troglodytes, Canis lupus familiaris, Bos taurus
P405GQKFMPIQGMV1Xenopus tropicalis
Q315SNEYTQAENQN5Homo sapiens, Rattus norvegicus, Pan troglodytes, Canis lupus familiaris, Bos taurus
Q315SNEYTQAEGLN1Xenopus tropicalis
Q315SNEYTQAEGQN1Gallus gallus
Q373IDPEVQRVTYN6Homo sapiens, Gallus gallus, Rattus norvegicus, Pan troglodytes, Canis lupus familiaris, Bos taurus
Q373IDPEVQRVSYN1Xenopus tropicalis
Q401KCLIGQKFMPV6Homo sapiens, Gallus gallus, Rattus norvegicus, Pan troglodytes, Canis lupus familiaris, Bos taurus
Q401KCLIGQKFMPI1Xenopus tropicalis
R374DPEVQRVTYNN6Homo sapiens, Gallus gallus, Rattus norvegicus, Pan troglodytes, Canis lupus familiaris, Bos taurus
R374DPEVQRVSYNG1Xenopus tropicalis
S413GMVFCSVECKK6Homo sapiens, Gallus gallus, Rattus norvegicus, Pan troglodytes, Canis lupus familiaris, Bos taurus
S413GMVFCSVDCKK1Xenopus tropicalis
T314FSNEYTQAENQ5Homo sapiens, Rattus norvegicus, Pan troglodytes, Canis lupus familiaris, Bos taurus
T314FSNEYTQAEGL1Xenopus tropicalis
T314FSNEYTQAEGQ1Gallus gallus
T376EVQRVTYNNFS5Homo sapiens, Rattus norvegicus, Pan troglodytes, Canis lupus familiaris, Bos taurus
T376EVQRVSYNGFH1Xenopus tropicalis
T376EVQRVTYNNFN1Gallus gallus
V341AGEIYVMVNDK6Homo sapiens, Xenopus tropicalis, Gallus gallus, Pan troglodytes, Canis lupus familiaris, Bos taurus
V341AGKIYVMVRDK1Rattus norvegicus
V372AIDPEVQRVTY6Homo sapiens, Gallus gallus, Rattus norvegicus, Pan troglodytes, Canis lupus familiaris, Bos taurus
V372AIDPEVQRVSY1Xenopus tropicalis
V375PEVQRVTYNNF6Homo sapiens, Gallus gallus, Rattus norvegicus, Pan troglodytes, Canis lupus familiaris, Bos taurus
V375PEVQRVSYNGF1Xenopus tropicalis
Y313IFSNEYTQAEN5Homo sapiens, Rattus norvegicus, Pan troglodytes, Canis lupus familiaris, Bos taurus
Y313IFSNEYTQAEG2Xenopus tropicalis, Gallus gallus
Y340LAGEIYVMVND6Homo sapiens, Xenopus tropicalis, Gallus gallus, Pan troglodytes, Canis lupus familiaris, Bos taurus
Y340LAGKIYVMVRD1Rattus norvegicus
Y377VQRVTYNNFSW5Homo sapiens, Rattus norvegicus, Pan troglodytes, Canis lupus familiaris, Bos taurus
Y377VQRVSYNGFHW1Xenopus tropicalis
Y377VQRVTYNNFNW1Gallus gallus


Copyright © 2016-Present - The University of Texas Health Science Center at Houston
Site Policies | State of Texas