mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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	Gene Summary
	Ligand Binding Site Mutation Information
	Protein Structure Related Information
	Gene Expression and Gene-Gene Network
	Phenotype Information
	Pharmacological Information
	Conservation Information for LBS

Gene summary for PABPC1

Gene summary

Basic gene Info.	Gene symbol	PABPC1
	Gene name	poly(A) binding protein, cytoplasmic 1
	Synonyms	PAB1\|PABP\|PABP1\|PABPC2\|PABPL1
	Cytomap	UCSC genome browser: 8q22.2-q23
	Type of gene	protein-coding
	RefGenes	NM_002568.3,
	Description	poly(A) binding protein, cytoplasmic 2polyadenylate-binding protein 1
	Modification date	20141222
dbXrefs	MIM : 604679
	HGNC : HGNC
	Ensembl : ENSG00000070756
	HPRD : 05247
	Vega : OTTHUMG00000164779
Protein	UniProt: P11940 go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_PABPC1
	BioGPS: 26986
Pathway	NCI Pathway Interaction Database: PABPC1
	KEGG: PABPC1
	REACTOME: PABPC1
	Pathway Commons: PABPC1
Context	iHOP: PABPC1
	ligand binding site mutation search in PubMed: PABPC1
	UCL Cancer Institute: PABPC1
Assigned class in mutLBSgeneDB	C: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

GO ID	GO Term	PubMed ID
GO:2000623	negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	18447585

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Ligand binding site mutations for PABPC1

Cancer type specific mutLBS sorted by frequency

LBS	AAchange of nsSNV	Cancer type	# samples
R179	A181T	KIRC	2
K129	V131A	COAD	1
Q556,Q558	E557G	KIRC	1
H617	H617N	LUAD	1
E564	R565W	LUAD	1
S4	P6L	SKCM	1
S4	A5V	STAD	1
R94	R94H	UCEC	1
R172	R172Q	UCEC	1

cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

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Protein structure related information for PABPC1

Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
(ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)

: nsSNV at non-LBS

: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.

LBS	AAchange of nsSNV	Relative stability change
K129	V131A	-1.3565543
R172	R172Q	-1.3147892
R94	R94H	-1.261667
Q556	E557G	-1.1687009
Q558	E557G	-1.1687009
E564	R565W	-0.93982739
H617	H617N	-0.76603618
S4	P6L	-0.58918007
S4	A5V	-0.54800804
R179	A181T	-0.2697792

(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for PABPC1 from PDB

PDB ID	PDB title	PDB structure
1CVJ	X-RAY CRYSTAL STRUCTURE OF THE POLY(A)-BINDING PROTEIN IN COMPLEX WITH POLYADENYLATE RNA

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Differential gene expression and gene-gene network for PABPC1

Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)

* Left PPI network was created from samples with mutations in the LBS of PABPC1 and the right PPI network was created from samples without mutations in the LBS of PABPC1. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.

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Phenotype information for PABPC1

Gene level disease information (DisGeNet)

Disease ID	Disease name	# PubMed	Association type
umls:C1458155	Breast Neoplasms	1	Biomarker

Mutation level pathogenic information (ClinVar annotation)

Allele ID

AA change

Clinical significance

Origin

Phenotype IDs

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Pharmacological information for PABPC1

Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Drug information targeting mutLBSgene (Approved drugs only)

Drug status

DrugBank ID

Name

Type

Drug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of PABPC1 go to BioLip

Ligand ID	Ligand short name	Ligand long name	PDB ID	PDB name	mutLBS
III		Peptide ligand (ALA,LYS,PRO,PHE,VAL,PRO,ASN,VAL,HIS,ALA,ALA,GLU,PHE,VAL,PRO,SER,PHE,LEU,ARG,GLY,PRO,ALA)	2rqh	B	E564 H617
III		Peptide ligand (THR,LEU,ASN,PRO,ASN,ALA,LYS,GLU,PHE,ASN,PRO,ARG,SER,PHE,SER,GLN)	3ktr	A	E564 H617
III		Peptide ligand (ARG,GLN,LEU,ASN,VAL,ASN,ALA,LYS,PRO,PHE,VAL,PRO,ASN)	3kui	A	E564 H617
III		Peptide ligand (PHE,VAL,PRO,ASN,VAL,HIS,ALA,ALA,GLU,PHE,VAL,PRO,SER,PHE,LEU)	3kuj	A	E564 H617
III		Peptide ligand (LEU,ASN,PRO,ASN,ALA,LYS,GLU,PHE,VAL,PRO,GLY)	3kus	A	E564 H617
III		Peptide ligand (ASN,LEU,ASN,PRO,ASN,ALA,LYS,GLU,PHE,VAL,PRO,GLY,VAL,LYS)	3kus	B	E564 H617
III		Peptide ligand (ASN,LEU,ASN,PRO,ASN,ALA,ALA,GLU,PHE,VAL,PRO,GLY,VAL,LYS,TYR,GLY)	3kut	A	E564 H617
III		Peptide ligand (SER,ASN,LEU,ASN,PRO,ASN,ALA,ALA,GLU,PHE,VAL,PRO,GLY,VAL,LYS)	3kut	B	E564 H617
III		Peptide ligand (LEU,ASN,PRO,ASN,ALA,LYS,VAL,TRP,GLN,GLU,ILE)	3pkn	A	E564 H617
III		Peptide ligand (GLU,LEU,ASN,PRO,ASN,ALA,GLU,VAL,TRP,GLY,ALA,PRO,VAL,LEU,HIS)	3pth	A	E564 H617
III		Peptide ligand (TRP,PRO,PRO,GLU,PHE,HIS,PRO,GLY,VAL,PRO,TRP,LYS,GLY,LEU,GLN)	2x04	A	Q556 E564
III		Peptide ligand (TRP,PRO,PRO,GLU,PHE,HIS,PRO,GLY,VAL,PRO,TRP,LYS,GLY,LEU,GLN)	2x04	B	Q556 E564
III		Peptide ligand (ALA,PHE,SER,ARG,GLN,LEU,ASN,VAL,ASN,ALA,LYS,PRO,PHE,VAL,PRO,ASN,VAL,HIS,ALA)	2rqg	B	Q556 E564 H617
III		Peptide ligand (ASN,TRP,PRO,PRO,GLU,PHE,HIS,PRO,GLY,VAL,PRO,TRP,LYS,GLY,LEU,GLN)	3ktp	A	Q556 E564 H617
NUC		Nucleic Acids	1cvj	F	R94 K129
NUC		Nucleic Acids	1cvj	H	R94 K129
NUC		Nucleic Acids	1cvj	B	R94 K129 R172
NUC		Nucleic Acids	1cvj	C	R94 K129 R172
NUC		Nucleic Acids	1cvj	D	R94 K129 R172
NUC		Nucleic Acids	1cvj	E	R94 K129 R172
NUC		Nucleic Acids	4f02	A	R94 K129 R172 R179
NUC		Nucleic Acids	1cvj	G	R94 R172
NUC		Nucleic Acids	1cvj	A	R94 R172 R179
NUC		Nucleic Acids	4f02	D	R94 R172 R179

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Conservation information for LBS of PABPC1

Multiple alignments for P11940 in multiple species

LBS	AA sequence	# species	Species
A114	SIDNKALYDTF	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
A114	SIDHKALHETF	1	Arabidopsis thaliana
A114	SIDHKALHDTF	1	Arabidopsis thaliana
A121	YDTFSAFGNIL	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
A121	HETFSAFGPIL	1	Arabidopsis thaliana
A121	HDTFSSFGNIV	1	Arabidopsis thaliana
A610	SKVDEAVAVLQ	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
A610	AKVTEAMDVLR	1	Arabidopsis thaliana
A610	AKVAEAMDVLR	1	Arabidopsis thaliana
A612	VDEAVAVLQAH	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
A612	VTEAMDVLRSV	1	Arabidopsis thaliana
A612	VAEAMDVLRSV	1	Arabidopsis thaliana
D117	NKALYDTFSAF	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
D117	HKALHETFSAF	1	Arabidopsis thaliana
D117	HKALHDTFSSF	1	Arabidopsis thaliana
D165	GMLLNDRKVFV	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
D165	GMLLNDKQVYV	2	Arabidopsis thaliana, Arabidopsis thaliana
D45	IRVCRDMITRR	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
D45	VRVCRDMTTRR	1	Arabidopsis thaliana
D45	VRVCRDLVTRR	1	Arabidopsis thaliana
D589	MLLEIDNSELL	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
D589	MLLEMDQTEVL	2	Arabidopsis thaliana, Arabidopsis thaliana
E24	HPDVTEAMLYE	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
E24	DATVTDSQLFE	1	Arabidopsis thaliana
E24	DFNVTDSQLFD	1	Arabidopsis thaliana
E564	KQMLGERLFPL	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
E564	RTMLGENLYPL	1	Arabidopsis thaliana
E564	RTMLGEVLYPL	1	Arabidopsis thaliana
E587	TGMLLEIDNSE	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
E587	TGMLLEMDQTE	2	Arabidopsis thaliana, Arabidopsis thaliana
E592	EIDNSELLHML	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
E592	EMDQTEVLHLL	2	Arabidopsis thaliana, Arabidopsis thaliana
E609	RSKVDEAVAVL	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
E609	KAKVTEAMDVL	1	Arabidopsis thaliana
E609	KAKVAEAMDVL	1	Arabidopsis thaliana
F102	GVGNIFIKNLD	5	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Arabidopsis thaliana
F102	GAGNIFIKNLD	1	Arabidopsis thaliana
F122	DTFSAFGNILS	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
F122	ETFSAFGPILS	1	Arabidopsis thaliana
F122	DTFSSFGNIVS	1	Arabidopsis thaliana
F142	SKGYGFVHFET	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
F142	SKGYGFVQYDT	1	Arabidopsis thaliana
F142	SKGYGFVQYAN	1	Arabidopsis thaliana
F169	NDRKVFVGRFK	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
F169	NDKQVYVGPFV	1	Arabidopsis thaliana
F169	NDKQVYVGPFL	1	Arabidopsis thaliana
F173	VFVGRFKSRKE	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
F173	VYVGPFVHKLQ	1	Arabidopsis thaliana
F173	VYVGPFLRRQE	1	Arabidopsis thaliana
F31	MLYEKFSPAGP	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
F31	QLFEAFTQAGQ	1	Arabidopsis thaliana
F31	QLFDAFGQMGT	1	Arabidopsis thaliana
F567	LGERLFPLIQA	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
F567	LGENLYPLVEQ	1	Arabidopsis thaliana
F567	LGEVLYPLVEQ	1	Arabidopsis thaliana
G139	NG-SKGYGFVH	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
G139	SGQSKGYGFVQ	2	Arabidopsis thaliana, Arabidopsis thaliana
G160	IEKMNGMLLND	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
G160	IDKLNGMLLND	1	Arabidopsis thaliana
G160	IEKLNGMLLND	1	Arabidopsis thaliana
G563	QKQMLGERLFP	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
G563	QRTMLGENLYP	1	Arabidopsis thaliana
G563	QRTMLGEVLYP	1	Arabidopsis thaliana
G579	HPTLAGKITGM	2	Homo sapiens, Bos taurus
G579	HPSLAGKITGM	2	Mus musculus, Rattus norvegicus
G579	EPESAAKVTGM	1	Arabidopsis thaliana
G579	EAESAAKVTGM	1	Arabidopsis thaliana
G583	AGKITGMLLEI	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
G583	AAKVTGMLLEM	2	Arabidopsis thaliana, Arabidopsis thaliana
H144	GYGFVHFETQE	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
H144	GYGFVQYDTDE	1	Arabidopsis thaliana
H144	GYGFVQYANEE	1	Arabidopsis thaliana
H617	AVLQAH---QA	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
H617	DVLRSVAQQQA	1	Arabidopsis thaliana
H617	DVLRSV---AA	1	Arabidopsis thaliana
I110	NLDKSIDNKAL	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
I110	NLDKSIDHKAL	1	Arabidopsis thaliana
I110	NLDESIDHKAL	1	Arabidopsis thaliana
I588	GMLLEIDNSEL	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
I588	GMLLEMDQTEV	2	Arabidopsis thaliana, Arabidopsis thaliana
K104	GNIFIKNLDKS	5	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Arabidopsis thaliana
K104	GNIFIKNLDES	1	Arabidopsis thaliana
K129	NILSCKVVCDE	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
K129	PILSCKVAVDP	1	Arabidopsis thaliana
K129	NIVSCKVAVDS	1	Arabidopsis thaliana
K138	ENG-SKGYGFV	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
K138	PSGQSKGYGFV	1	Arabidopsis thaliana
K138	SSGQSKGYGFV	1	Arabidopsis thaliana
K174	FVGRFKSRKER	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
K174	YVGPFVHKLQR	1	Arabidopsis thaliana
K174	YVGPFLRRQER	1	Arabidopsis thaliana
K559	PPQEQKQMLGE	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
K559	APEQQRTMLGE	1	Arabidopsis thaliana
K559	TPEQQRTMLGE	1	Arabidopsis thaliana
K580	PTLAGKITGML	2	Homo sapiens, Bos taurus
K580	PSLAGKITGML	2	Mus musculus, Rattus norvegicus
K580	PESAAKVTGML	1	Arabidopsis thaliana
K580	AESAAKVTGML	1	Arabidopsis thaliana
K606	ESLRSKVDEAV	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
K606	EALKAKVTEAM	1	Arabidopsis thaliana
K606	EALKAKVAEAM	1	Arabidopsis thaliana
K95	DPSLRKSGVGN	5	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Arabidopsis thaliana
K95	DPSVRRSGAGN	1	Arabidopsis thaliana
L162	KMNGMLLNDRK	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
L162	KLNGMLLNDKQ	2	Arabidopsis thaliana, Arabidopsis thaliana
L163	MNGMLLNDRKV	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
L163	LNGMLLNDKQV	2	Arabidopsis thaliana, Arabidopsis thaliana
L52	ITRRSLGYAYV	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
L52	TTRRSLGYGYV	1	Arabidopsis thaliana
L52	VTRRSLGYGYV	1	Arabidopsis thaliana
L585	KITGMLLEIDN	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
L585	KVTGMLLEMDQ	2	Arabidopsis thaliana, Arabidopsis thaliana
L586	ITGMLLEIDNS	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
L586	VTGMLLEMDQT	2	Arabidopsis thaliana, Arabidopsis thaliana
L614	EAVAVLQAH--	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
L614	EAMDVLRSVAQ	1	Arabidopsis thaliana
L614	EAMDVLRSV--	1	Arabidopsis thaliana
M158	RAIEKMNGMLL	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
M158	GAIDKLNGMLL	1	Arabidopsis thaliana
M158	KAIEKLNGMLL	1	Arabidopsis thaliana
M161	EKMNGMLLNDR	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
M161	DKLNGMLLNDK	1	Arabidopsis thaliana
M161	EKLNGMLLNDK	1	Arabidopsis thaliana
M46	RVCRDMITRRS	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
M46	RVCRDMTTRRS	1	Arabidopsis thaliana
M46	RVCRDLVTRRS	1	Arabidopsis thaliana
M561	QEQKQMLGERL	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
M561	EQQRTMLGENL	1	Arabidopsis thaliana
M561	EQQRTMLGEVL	1	Arabidopsis thaliana
M584	GKITGMLLEID	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
M584	AKVTGMLLEMD	2	Arabidopsis thaliana, Arabidopsis thaliana
M85	KPVRIMWSQRD	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
M85	RAIRVMYSVRD	1	Arabidopsis thaliana
M85	KPIRVMYSHRD	1	Arabidopsis thaliana
N100	KSGVGNIFIKN	5	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Arabidopsis thaliana
N100	RSGAGNIFIKN	1	Arabidopsis thaliana
N105	NIFIKNLDKSI	5	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Arabidopsis thaliana
N105	NIFIKNLDESI	1	Arabidopsis thaliana
N164	NGMLLNDRKVF	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
N164	NGMLLNDKQVY	2	Arabidopsis thaliana, Arabidopsis thaliana
N58	GYAYVNFQQPA	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
N58	GYGYVNYATPQ	1	Arabidopsis thaliana
N58	GYGYVNFTNPQ	1	Arabidopsis thaliana
N590	LLEIDNSELLH	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
N590	LLEMDQTEVLH	2	Arabidopsis thaliana, Arabidopsis thaliana
P555	LASAPPQEQKQ	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
P555	LANAAPEQQRT	1	Arabidopsis thaliana
P555	LSNATPEQQRT	1	Arabidopsis thaliana
P568	GERLFPLIQAM	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
P568	GENLYPLVEQL	1	Arabidopsis thaliana
P568	GEVLYPLVEQV	1	Arabidopsis thaliana
Q556	ASAPPQEQKQM	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
Q556	ANAAPEQQRTM	1	Arabidopsis thaliana
Q556	SNATPEQQRTM	1	Arabidopsis thaliana
Q558	APPQEQKQMLG	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
Q558	AAPEQQRTMLG	1	Arabidopsis thaliana
Q558	ATPEQQRTMLG	1	Arabidopsis thaliana
Q560	PQEQKQMLGER	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
Q560	PEQQRTMLGEN	1	Arabidopsis thaliana
Q560	PEQQRTMLGEV	1	Arabidopsis thaliana
Q571	LFPLIQAMHPT	2	Homo sapiens, Bos taurus
Q571	LFPLIQAMHPS	2	Mus musculus, Rattus norvegicus
Q571	LYPLVEQLEPE	1	Arabidopsis thaliana
Q571	LYPLVEQVEAE	1	Arabidopsis thaliana
Q88	RIMWSQRDPSL	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
Q88	RVMYSVRDPSL	1	Arabidopsis thaliana
Q88	RVMYSHRDPSV	1	Arabidopsis thaliana
R172	KVFVGRFKSRK	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
R172	QVYVGPFVHKL	1	Arabidopsis thaliana
R172	QVYVGPFLRRQ	1	Arabidopsis thaliana
R176	GRFKSRKEREA	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
R176	GPFVHKLQRDP	1	Arabidopsis thaliana
R176	GPFLRRQERDS	1	Arabidopsis thaliana
R179	KSRKEREAELG	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
R179	VHKLQRDPS--	1	Arabidopsis thaliana
R179	LRRQERDST--	1	Arabidopsis thaliana
R41	PILSIRVCRDM	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
R41	QVVSVRVCRDM	1	Arabidopsis thaliana
R41	TVVTVRVCRDL	1	Arabidopsis thaliana
R44	SIRVCRDMITR	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
R44	SVRVCRDMTTR	1	Arabidopsis thaliana
R44	TVRVCRDLVTR	1	Arabidopsis thaliana
R49	RDMITRRSLGY	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
R49	RDMTTRRSLGY	1	Arabidopsis thaliana
R49	RDLVTRRSLGY	1	Arabidopsis thaliana
R83	KGKPVRIMWSQ	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
R83	NGRAIRVMYSV	1	Arabidopsis thaliana
R83	YGKPIRVMYSH	1	Arabidopsis thaliana
R89	IMWSQRDPSLR	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
R89	VMYSVRDPSLR	1	Arabidopsis thaliana
R89	VMYSHRDPSVR	1	Arabidopsis thaliana
R94	RDPSLRKSGVG	5	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Arabidopsis thaliana
R94	RDPSVRRSGAG	1	Arabidopsis thaliana
S12	SYPMASLYVGD	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
S12	QQGTTSLYVGD	1	Arabidopsis thaliana
S12	QFGNTSLYVGD	1	Arabidopsis thaliana
S127	FGNILSCKVVC	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
S127	FGPILSCKVAV	1	Arabidopsis thaliana
S127	FGNIVSCKVAV	1	Arabidopsis thaliana
S175	VGRFKSRKERE	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
S175	VGPFVHKLQRD	1	Arabidopsis thaliana
S175	VGPFLRRQERD	1	Arabidopsis thaliana
S4	--MNPSAPSYP	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
S4	AAAAAGAAQQG	1	Arabidopsis thaliana
S4	TSGGATATQFG	1	Arabidopsis thaliana
S605	PESLRSKVDEA	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
S605	PEALKAKVTEA	1	Arabidopsis thaliana
S605	PEALKAKVAEA	1	Arabidopsis thaliana
S87	VRIMWSQRDPS	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
S87	IRVMYSVRDPS	1	Arabidopsis thaliana
S87	IRVMYSHRDPS	1	Arabidopsis thaliana
T118	KALYDTFSAFG	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
T118	KALHETFSAFG	1	Arabidopsis thaliana
T118	KALHDTFSSFG	1	Arabidopsis thaliana
T582	LAGKITGMLLE	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
T582	SAAKVTGMLLE	2	Arabidopsis thaliana, Arabidopsis thaliana
V42	ILSIRVCRDMI	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
V42	VVSVRVCRDMT	1	Arabidopsis thaliana
V42	VVTVRVCRDLV	1	Arabidopsis thaliana
V607	SLRSKVDEAVA	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
V607	ALKAKVTEAMD	1	Arabidopsis thaliana
V607	ALKAKVAEAMD	1	Arabidopsis thaliana
V613	DEAVAVLQAH-	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
V613	TEAMDVLRSVA	1	Arabidopsis thaliana
V613	AEAMDVLRSV-	1	Arabidopsis thaliana
W86	PVRIMWSQRDP	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
W86	AIRVMYSVRDP	1	Arabidopsis thaliana
W86	PIRVMYSHRDP	1	Arabidopsis thaliana
Y14	PMASLYVGDLH	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
Y14	GTTSLYVGDLD	1	Arabidopsis thaliana
Y14	GNTSLYVGDLD	1	Arabidopsis thaliana
Y140	G-SKGYGFVHF	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
Y140	GQSKGYGFVQY	2	Arabidopsis thaliana, Arabidopsis thaliana
Y54	RRSLGYAYVNF	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
Y54	RRSLGYGYVNY	1	Arabidopsis thaliana
Y54	RRSLGYGYVNF	1	Arabidopsis thaliana
Y56	SLGYAYVNFQQ	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
Y56	SLGYGYVNYAT	1	Arabidopsis thaliana
Y56	SLGYGYVNFTN	1	Arabidopsis thaliana