mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for USP21
Gene summary
Basic gene Info.Gene symbolUSP21
Gene nameubiquitin specific peptidase 21
SynonymsUSP16|USP23
CytomapUCSC genome browser: 1q22
Type of geneprotein-coding
RefGenesNM_001014443.2,
NM_012475.4,
DescriptionNEDD8-specific proteasedeubiquitinating enzyme 21ubiquitin carboxyl-terminal hydrolase 21ubiquitin specific protease 21ubiquitin thioesterase 21ubiquitin thiolesterase 21ubiquitin-specific processing protease 21ubiquitin-specific protease 16ubiqui
Modification date20141207
dbXrefs MIM : 604729
HGNC : HGNC
Ensembl : ENSG00000143258
HPRD : 05291
Vega : OTTHUMG00000033154
ProteinUniProt: Q9UK80
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_USP21
BioGPS: 27005
PathwayNCI Pathway Interaction Database: USP21
KEGG: USP21
REACTOME: USP21
Pathway Commons: USP21
ContextiHOP: USP21
ligand binding site mutation search in PubMed: USP21
UCL Cancer Institute: USP21
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID


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Ligand binding site mutations for USP21

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
C221F222SCOAD1
C440R441WSKCM1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for USP21
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
C221F222S-1.4275731
C440R441W-0.84343062
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for USP21 from PDB

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Differential gene expression and gene-gene network for USP21
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of USP21 and the right PPI network was created from samples without mutations in the LBS of USP21. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for USP21
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for USP21
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of USP21 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
NEHETHYLAMINE3i3tAC221
NEHETHYLAMINE3i3tCC221
NEHETHYLAMINE3i3tEC221
NEHETHYLAMINE3i3tGC221
ZNZINC(2+)2y5bAC440
ZNZINC(2+)2y5bEC440
ZNZINC(2+)3i3tAC440
ZNZINC(2+)3i3tCC440
ZNZINC(2+)3i3tEC440
ZNZINC(2+)3i3tGC440
ZNZINC(2+)3mtnAC440
ZNZINC(2+)3mtnCC440


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Conservation information for LBS of USP21
Multiple alignments for Q9UK80 in multiple species
LBSAA sequence# speciesSpecies
C221NLGNTCFLNAV3Homo sapiens, Mus musculus, Rattus norvegicus
C221NLGNTCFLNAL1Bos taurus
C384KSCLKCQACGY4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
C387LKCQACGYRST4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
C437ENAPVCDRCRQ4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
C440PVCDRCRQKTR4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
G517GSVHYGHYTAL4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
H518SVHYGHYTALC4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
N219LRNLGNTCFLN4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
Q299FSGYSQQDAQE4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus


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