|
mutLBSgeneDB |
| |
| |
| |
| |
| |
| |
|
| Gene summary for SULT1C4 |
 Gene summary |
| Basic gene Info. | Gene symbol | SULT1C4 |
| Gene name | sulfotransferase family, cytosolic, 1C, member 4 | |
| Synonyms | SULT1C|SULT1C2 | |
| Cytomap | UCSC genome browser: 2q12.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_006588.2, | |
| Description | ST1C4SULT1C#2sulfotransferase 1C2sulfotransferase 1C4sulfotransferase family, cytosolic, 1C, member 2sulfotransferase family, cytosolic, 1C, member C2 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 608357 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000198075 | ||
| HPRD : 07461 | ||
| Vega : OTTHUMG00000130958 | ||
| Protein | UniProt: O75897 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_SULT1C4 | |
| BioGPS: 27233 | ||
| Pathway | NCI Pathway Interaction Database: SULT1C4 | |
| KEGG: SULT1C4 | ||
| REACTOME: SULT1C4 | ||
| Pathway Commons: SULT1C4 | ||
| Context | iHOP: SULT1C4 | |
| ligand binding site mutation search in PubMed: SULT1C4 | ||
| UCL Cancer Institute: SULT1C4 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0051923 | sulfation | 20056724 |
| Top |
| Ligand binding site mutations for SULT1C4 |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | K113 | L112M | LUAD | 1 | T58 | T58K | LUAD | 1 | Y200 | E201K | LUAD | 1 | F88 | P87S | LUSC | 1 | K113 | L112M | OV | 1 | Y247 | S249L | SKCM | 1 | M255 | E253K | SKCM | 1 | Y247 | S249L | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
| Top |
| Protein structure related information for SULT1C4 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
 |
| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | Y247 | S249L | 0.10398527 | K113 | L112M | -1.3736132 | M255 | E253K | -1.3607009 | Y200 | E201K | -1.187781 | F88 | P87S | -1.0096668 | T58 | T58K | -0.75634878 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for SULT1C4 from PDB |
| Top |
| Differential gene expression and gene-gene network for SULT1C4 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
| Top |
| Top |
| Phenotype information for SULT1C4 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
| Top |
| Pharmacological information for SULT1C4 |
| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
 |
| Ligands binding to mutated ligand binding site of SULT1C4 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | PCI | PENTACHLOROPHENOL | 2gwh | A | F88 K113 Y247 M255 | PCI | PENTACHLOROPHENOL | 2gwh | B | F88 K113 Y247 M255 | A3P | ADENOSINE 3',5'-BISPHOSPHATE | 2gwh | A | T58 Y200 | A3P | ADENOSINE 3',5'-BISPHOSPHATE | 2gwh | B | T58 Y200 |
| Top |
| Conservation information for LBS of SULT1C4 |
| Multiple alignments for O75897 in multiple species |
| LBS | AA sequence | # species | Species |
 |
Copyright © 2016-Present - The University of Texas Health Science Center at Houston |