mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for GLO1
Gene summary
Basic gene Info.Gene symbolGLO1
Gene nameglyoxalase I
CytomapUCSC genome browser: 6p21.3-p21.1
Type of geneprotein-coding
DescriptionS-D-lactoylglutathione methylglyoxal lyasealdoketomutaseepididymis secretory protein Li 74glx Iglyoxalase domain containing 1ketone-aldehyde mutaselactoyl glutathione lyaselactoylglutathione lyasemethylglyoxalase
Modification date20141207
dbXrefs MIM : 138750
Ensembl : ENSG00000124767
HPRD : 00730
Vega : OTTHUMG00000014636
ProteinUniProt: Q04760
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_GLO1
BioGPS: 2739
PathwayNCI Pathway Interaction Database: GLO1
Pathway Commons: GLO1
ContextiHOP: GLO1
ligand binding site mutation search in PubMed: GLO1
UCL Cancer Institute: GLO1
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO:0043066negative regulation of apoptotic process11489834

Ligand binding site mutations for GLO1

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for GLO1
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for GLO1 from PDB

Differential gene expression and gene-gene network for GLO1
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of GLO1 and the right PPI network was created from samples without mutations in the LBS of GLO1. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for GLO1
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0004352Autistic Disorder5Biomarker, GeneticVariation
umls:C0003469Anxiety Disorders4Biomarker
umls:C0011581Depressive Disorder1Biomarker
umls:C0279626Esophageal Squamous Cell Carcinoma1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for GLO1
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
Approved|nutraceuticalDB00143GlutathioneSmall molecule
Approved|investigationalDB00328IndomethacinSmall molecule
ExperimentalDB03130S-P-NitrobenzyloxycarbonylglutathioneSmall molecule
ExperimentalDB03330S-(N-Hydroxy-N-Iodophenylcarbamoyl)GlutathioneSmall molecule
ExperimentalDB03345Beta-MercaptoethanolSmall molecule
ExperimentalDB03602S-Benzyl-GlutathioneSmall molecule
ExperimentalDB04132S-HexylglutathioneSmall molecule
ExperimentalDB08179methyl 4-(2,3-dihydroxy-5-methylphenoxy)-2-hydroxy-6-methylbenzoateSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of GLO1 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS

Conservation information for LBS of GLO1
Multiple alignments for Q04760 in multiple species
LBSAA sequence# speciesSpecies
A181NPNKMATLM--1Homo sapiens
A181DLKTIGTTTVN1Arabidopsis thaliana
A181NPNKIATII--1Mus musculus
A181NPNKMATII--1Rattus norvegicus
A181EQK--------1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A181PHGLIA-----1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A97ALSRKATLELT1Homo sapiens
A97TFGQPATIELT1Arabidopsis thaliana
A97TFSRKATLELT1Mus musculus
A97AFSRKATLELT1Rattus norvegicus
A97---REGLLELT1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A97VFSCESVLELT1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
C61TLIQKCDFPIM1Homo sapiens
C61SLLKRLDFSEM1Arabidopsis thaliana
C61TLLQKLDFPAM1Mus musculus
C61TLLQKLDFPSM1Rattus norvegicus
C61KVIDKADHPNG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C61KLLRTSEHESA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E100RKATLELTHNW3Homo sapiens, Mus musculus, Rattus norvegicus
E100QPATIELTHNW1Arabidopsis thaliana
E100REGLLELTHNW1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E100CESVLELTHNW1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E173DGYWIEILNPN3Homo sapiens, Mus musculus, Rattus norvegicus
E173DGYWIEIFDLK1Arabidopsis thaliana
E173DNYWVEVIEQK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E173DGYSIEVVPHG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F163MKGLAFIQDPD2Homo sapiens, Mus musculus
F163MKNIAFIKDPD1Arabidopsis thaliana
F163MKGLAFVQDPD1Rattus norvegicus
F163MKDIAFLLDPD1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F163MKNIAFLKDPD1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F63IQKCDFPIMKF1Homo sapiens
F63LKRLDFSEMKF1Arabidopsis thaliana
F63LQKLDFPAMKF1Mus musculus
F63LQKLDFPSMKF1Rattus norvegicus
F63IDKADHPNGKF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F63LRTSEHESAKF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F68FPIMKFSLYFL1Homo sapiens
F68FSEMKFSLYFL1Arabidopsis thaliana
F68FPAMKFSLYFL1Mus musculus
F68FPSMKFSLYFL1Rattus norvegicus
F68HPNGKFTNYFL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F68HESAKFTLYFL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F72KFSLYFLAYED3Homo sapiens, Mus musculus, Rattus norvegicus
F72KFSLYFLGYED1Arabidopsis thaliana
F72KFTNYFLAY--1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F72KFTLYFLGY--1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G156KKPDDGKMKGL3Homo sapiens, Mus musculus, Rattus norvegicus
G156KKPNDGKMKNI1Arabidopsis thaliana
G156KKLTDGRMKDI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G156PKFNQGRMKNI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H127PRGFGHIGIAV3Homo sapiens, Mus musculus, Rattus norvegicus
H127PRGFGHIGVTV1Arabidopsis thaliana
H127EKGYGHVCISV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H127PQGYGHICISC1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I89EKDEKIAWALS1Homo sapiens
I89DPTERTVWTFG1Arabidopsis thaliana
I89DKSEKTAWTFS1Mus musculus
I89DKTERTAWAFS1Rattus norvegicus
I89HD---------1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I89TDS-----VFS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K151-VKFVKKPDDG3Homo sapiens, Mus musculus, Rattus norvegicus
K151-VEFAKKPNDG1Arabidopsis thaliana
K151-LPFKKKLTDG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K151KIQWSPKFNQG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K157KPDDGKMKGLA3Homo sapiens, Mus musculus, Rattus norvegicus
K157KPNDGKMKNIA1Arabidopsis thaliana
K157KLTDGRMKDIA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K157KFNQGRMKNIA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L11-----LTDEAA2Homo sapiens, Rattus norvegicus
L11-----LSTN--1Arabidopsis thaliana
L11-----LTDETA1Mus musculus
L11FGHICFTVDNI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L11FGHICFSVSDI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L161GKMKGLAFIQD2Homo sapiens, Mus musculus
L161GKMKNIAFIKD1Arabidopsis thaliana
L161GKMKGLAFVQD1Rattus norvegicus
L161GRMKDIAFLLD1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L161GRMKNIAFLKD1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L183NKMATLM----1Homo sapiens
L183KTIGTTTVNAA1Arabidopsis thaliana
L183NKIATII----1Mus musculus
L183NKMATII----1Rattus norvegicus
L183K----------1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L183GLIA-------1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L70IMKFSLYFLAY1Homo sapiens
L70EMKFSLYFLGY1Arabidopsis thaliana
L70AMKFSLYFLAY1Mus musculus
L70SMKFSLYFLAY1Rattus norvegicus
L70NGKFTNYFLAY1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L70SAKFTLYFLGY1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L93KIAWALSRKAT1Homo sapiens
L93RTVWTFGQPAT1Arabidopsis thaliana
L93KTAWTFSRKAT1Mus musculus
L93RTAWAFSRKAT1Rattus norvegicus
L93-------REGL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L93----VFSCESV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
M1-----MAEPQP3Homo sapiens, Mus musculus, Rattus norvegicus
M1--MASEARESP1Arabidopsis thaliana
M1YNFGTEKKEGP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M1HNWGTEKNPDY1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
M158PDDGKMKGLAF3Homo sapiens, Mus musculus, Rattus norvegicus
M158PNDGKMKNIAF1Arabidopsis thaliana
M158LTDGRMKDIAF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M158FNQGRMKNIAF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
M180LNPNKMATLM-1Homo sapiens
M180FDLKTIGTTTV1Arabidopsis thaliana
M180LNPNKIATII-1Mus musculus
M180LNPNKMATII-1Rattus norvegicus
M180IEQK-------1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M180VPHGLIA----1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
M36LLQQTMLRIKD2Mus musculus, Rattus norvegicus
M36LLQQTMLRVKD1Homo sapiens
M36IMQQTMFRIKD1Arabidopsis thaliana
M36RFNHTMVRVKD1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M36KFNHTMIRIKN1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
M66CDFPIMKFSLY1Homo sapiens
M66LDFSEMKFSLY1Arabidopsis thaliana
M66LDFPAMKFSLY1Mus musculus
M66LDFPSMKFSLY1Rattus norvegicus
M66ADHPNGKFTNY1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M66SEHESAKFTLY1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N104LELTHNWGTED3Homo sapiens, Mus musculus, Rattus norvegicus
N104IELTHNWGTES1Arabidopsis thaliana
N104LELTHNWGTEK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N104LELTHNWGTEN1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q34DFLLQQTMLRI2Mus musculus, Rattus norvegicus
Q34DFLLQQTMLRV1Homo sapiens
Q34GYIMQQTMFRI1Arabidopsis thaliana
Q34NFRFNHTMVRV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q34N-KFNHTMIRI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q59GLTLLQKLDFP2Mus musculus, Rattus norvegicus
Q59GMTLIQKCDFP1Homo sapiens
Q59GMSLLKRLDFS1Arabidopsis thaliana
Q59GMKVIDKADHP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q59GMKLLRTSEHE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R123N-SDPRGFGHI3Homo sapiens, Mus musculus, Rattus norvegicus
R123N-SEPRGFGHI1Arabidopsis thaliana
R123NDGDEKGYGHV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R123N-SEPQGYGHI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R38QQTMLRIKDPK2Mus musculus, Rattus norvegicus
R38QQTMLRVKDPK1Homo sapiens
R38QQTMFRIKDPK1Arabidopsis thaliana
R38NHTMVRVKDPE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R38NHTMIRIKNPT1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T102ATLELTHNWGT3Homo sapiens, Mus musculus, Rattus norvegicus
T102ATIELTHNWGT1Arabidopsis thaliana
T102GLLELTHNWGT1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T102SVLELTHNWGT1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V150--VKFVKKPDD3Homo sapiens, Mus musculus, Rattus norvegicus
V150--VEFAKKPND1Arabidopsis thaliana
V150--LPFKKKLTD1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V150DKIQWSPKFNQ1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
W171DPDGYWIEILN3Homo sapiens, Mus musculus, Rattus norvegicus
W171DPDGYWIEIFD1Arabidopsis thaliana
W171DPDNYWVEVIE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
W171DPDGYSIEVVP1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)

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