mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for GLP1R
Gene summary
Basic gene Info.Gene symbolGLP1R
Gene nameglucagon-like peptide 1 receptor
Synonyms-
CytomapUCSC genome browser: 6p21
Type of geneprotein-coding
RefGenesNM_002062.3,
DescriptionGLP-1 receptorGLP-1-RGLP-1R
Modification date20141207
dbXrefs MIM : 138032
HGNC : HGNC
Ensembl : ENSG00000112164
HPRD : 00677
Vega : OTTHUMG00000014638
ProteinUniProt: P43220
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_GLP1R
BioGPS: 2740
PathwayNCI Pathway Interaction Database: GLP1R
KEGG: GLP1R
REACTOME: GLP1R
Pathway Commons: GLP1R
ContextiHOP: GLP1R
ligand binding site mutation search in PubMed: GLP1R
UCL Cancer Institute: GLP1R
Assigned class in mutLBSgeneDBB: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0007204positive regulation of cytosolic calcium ion concentration7589461
GO:0019933cAMP-mediated signaling7589461


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Ligand binding site mutations for GLP1R
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
 
: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
D122D122NSKCM1
F80S79LSKCM1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for GLP1R
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
D122D122N-0.58358269
F80S79L-0.5074715
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for GLP1R from PDB

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Differential gene expression and gene-gene network for GLP1R
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of GLP1R and the right PPI network was created from samples without mutations in the LBS of GLP1R. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for GLP1R
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0020538Hypertension2Biomarker
umls:C0020507Hyperplasia1Biomarker
umls:C0027651Neoplasms1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for GLP1R
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
ApprovedDB00040Glucagon recombinantBiotech
Approved|investigationalDB01276ExenatideBiotech
InvestigationalDB05162GSK716155Small molecule
ApprovedDB06655LiraglutideBiotech
ApprovedDB09043AlbiglutideBiotech
ApprovedDB09045DulaglutideBiotech

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of GLP1R go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
10MN-DECYL-BETA-D-THIOMALTOSIDE3iolAD122
10MN-DECYL-BETA-D-THIOMALTOSIDE3c59AF80
10MN-DECYL-BETA-D-THIOMALTOSIDE3c5tAF80


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Conservation information for LBS of GLP1R
Multiple alignments for P43220 in multiple species
LBSAA sequence# speciesSpecies
A28PRPQGATVSLW1Homo sapiens
A28PRPQGTTVSLS1Mus musculus
A28PRPQGATVSLS1Rattus norvegicus
D122SLPWRDLSECE3Homo sapiens, Mus musculus, Rattus norvegicus
E127DLSECEESKRG2Homo sapiens, Mus musculus
E127DLSECEESKQG1Rattus norvegicus
E128LSECEESKRGE2Homo sapiens, Mus musculus
E128LSECEESKQGE1Rattus norvegicus
E34TVSLSETVQKW2Mus musculus, Rattus norvegicus
E34TVSLWETVQKW1Homo sapiens
E68NRTFDDYACWP2Mus musculus, Rattus norvegicus
E68NRTFDEYACWP1Homo sapiens
F80GPPGSFVNVSC2Mus musculus, Rattus norvegicus
F80GEPGSFVNVSC1Homo sapiens
H99SVLQGHVYRFC2Mus musculus, Rattus norvegicus
H99SVPQGHVYRFC1Homo sapiens
L111AEGLWLQKDNS1Homo sapiens
L111AEGLWLHKDNS1Mus musculus
L111AEGIWLHKDNS1Rattus norvegicus
L123LPWRDLSECEE3Homo sapiens, Mus musculus, Rattus norvegicus
L32GATVSLWETVQ1Homo sapiens
L32GTTVSLSETVQ1Mus musculus
L32GATVSLSETVQ1Rattus norvegicus
L89SCPWYLPWASS3Homo sapiens, Mus musculus, Rattus norvegicus
N82PGSFVNVSCPW3Homo sapiens, Mus musculus, Rattus norvegicus
P90CPWYLPWASSV3Homo sapiens, Mus musculus, Rattus norvegicus
R121SSLPWRDLSEC3Homo sapiens, Mus musculus, Rattus norvegicus
S31QGATVSLWETV1Homo sapiens
S31QGTTVSLSETV1Mus musculus
S31QGATVSLSETV1Rattus norvegicus
T29RPQGATVSLWE1Homo sapiens
T29RPQGTTVSLSE1Mus musculus
T29RPQGATVSLSE1Rattus norvegicus
T35VSLSETVQKWR2Mus musculus, Rattus norvegicus
T35VSLWETVQKWR1Homo sapiens
V30PQGATVSLWET1Homo sapiens
V30PQGTTVSLSET1Mus musculus
V30PQGATVSLSET1Rattus norvegicus
V36SLSETVQKWRE2Mus musculus, Rattus norvegicus
V36SLWETVQKWRE1Homo sapiens
W120NSSLPWRDLSE3Homo sapiens, Mus musculus, Rattus norvegicus
W39ETVQKWREYRR2Homo sapiens, Mus musculus
W39ETVQKWREYRH1Rattus norvegicus
W91PWYLPWASSVL2Mus musculus, Rattus norvegicus
W91PWYLPWASSVP1Homo sapiens
Y101LQGHVYRFCTA2Mus musculus, Rattus norvegicus
Y101PQGHVYRFCTA1Homo sapiens
Y69RTFDDYACWPD2Mus musculus, Rattus norvegicus
Y69RTFDEYACWPD1Homo sapiens
Y88VSCPWYLPWAS3Homo sapiens, Mus musculus, Rattus norvegicus


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