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mutLBSgeneDB |
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| Gene summary for GPC1 |
 Gene summary |
| Basic gene Info. | Gene symbol | GPC1 |
| Gene name | glypican 1 | |
| Synonyms | glypican | |
| Cytomap | UCSC genome browser: 2q35-q37 | |
| Type of gene | protein-coding | |
| RefGenes | NM_002081.2, | |
| Description | glypican proteoglycan 1glypican-1 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 600395 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000063660 | ||
| HPRD : 02671 | ||
| Vega : OTTHUMG00000133349 | ||
| Protein | UniProt: P35052 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_GPC1 | |
| BioGPS: 2817 | ||
| Pathway | NCI Pathway Interaction Database: GPC1 | |
| KEGG: GPC1 | ||
| REACTOME: GPC1 | ||
| Pathway Commons: GPC1 | ||
| Context | iHOP: GPC1 | |
| ligand binding site mutation search in PubMed: GPC1 | ||
| UCL Cancer Institute: GPC1 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0030200 | heparan sulfate proteoglycan catabolic process | 12732622 |
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| Ligand binding site mutations for GPC1 |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | I437 | Q436H | BLCA | 1 | D388 | D388N | COAD | 1 | E443 | E441K | SKCM | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for GPC1 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | D388 | D388N | -1.2619239 | E443 | E441K | -1.2222848 | I437 | Q436H | -0.71586415 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for GPC1 from PDB |
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| Differential gene expression and gene-gene network for GPC1 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for GPC1 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for GPC1 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of GPC1 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | CA | CALCIUM(2+) | 4bwe | A | D388 | CA | CALCIUM(2+) | 4bwe | B | D388 | CA | CALCIUM(2+) | 4bwe | C | D388 | CA | CALCIUM(2+) | 4bwe | D | D388 | CA | CALCIUM(2+) | 4bwe | A | I437 E443 | CA | CALCIUM(2+) | 4bwe | B | I437 E443 | CA | CALCIUM(2+) | 4bwe | C | I437 E443 | CA | CALCIUM(2+) | 4bwe | D | I437 E443 |
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| Conservation information for LBS of GPC1 |
| Multiple alignments for P35052 in multiple species |
| LBS | AA sequence | # species | Species | D388 | KAQLRDVQDFW | 1 | Homo sapiens | D388 | YSKLKEMQLYW | 1 | Danio rerio | D388 | KGILSDIQDYW | 1 | Xenopus tropicalis | D388 | KAQLRDIQDFW | 1 | Mus musculus | D388 | KAQLRDIQDYW | 1 | Rattus norvegicus | D391 | LRDVQDFWISL | 1 | Homo sapiens | D391 | LKEMQLYWIQL | 1 | Danio rerio | D391 | LSDIQDYWVSL | 1 | Xenopus tropicalis | D391 | LRDIQDFWISL | 1 | Mus musculus | D391 | LRDIQDYWISL | 1 | Rattus norvegicus | D48 | GFSLSDVPQAE | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | D48 | GFTLNGVPQSE | 1 | Danio rerio | D48 | GFSLNGAPQSE | 1 | Xenopus tropicalis | E443 | NNPEVEVDITK | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | E443 | NNPEVEIDITK | 1 | Danio rerio | E443 | NNPEVDVDITK | 1 | Xenopus tropicalis | E72 | TCCTSEMEENL | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | E72 | TCCTSAMEETL | 1 | Danio rerio | E72 | TCCTSEMEENF | 1 | Xenopus tropicalis | I437 | GLANQINNPEV | 5 | Homo sapiens, Danio rerio, Xenopus tropicalis, Mus musculus, Rattus norvegicus |
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