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mutLBSgeneDB |
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| Gene summary for GRK5 |
 Gene summary |
| Basic gene Info. | Gene symbol | GRK5 |
| Gene name | G protein-coupled receptor kinase 5 | |
| Synonyms | GPRK5 | |
| Cytomap | UCSC genome browser: 10q26.11 | |
| Type of gene | protein-coding | |
| RefGenes | NM_005308.2, | |
| Description | FP2025g protein-coupled receptor kinase GRK5 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 600870 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000198873 | ||
| HPRD : 02926 | ||
| Vega : OTTHUMG00000019149 | ||
| Protein | UniProt: P34947 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_GRK5 | |
| BioGPS: 2869 | ||
| Pathway | NCI Pathway Interaction Database: GRK5 | |
| KEGG: GRK5 | ||
| REACTOME: GRK5 | ||
| Pathway Commons: GRK5 | ||
| Context | iHOP: GRK5 | |
| ligand binding site mutation search in PubMed: GRK5 | ||
| UCL Cancer Institute: GRK5 | ||
| Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0007217 | tachykinin receptor signaling pathway | 17986524 | GO:0043066 | negative regulation of apoptotic process | 20124405 | GO:0046777 | protein autophosphorylation | 14976207 |
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| Ligand binding site mutations for GRK5 |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | L192 | V191M | BLCA | 1 | G196,V200 | G198V | LUSC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for GRK5 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | G196 | G198V | 0.20663744 | V200 | G198V | 0.20663744 | L192 | V191M | -1.0634702 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for GRK5 from PDB |
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| Differential gene expression and gene-gene network for GRK5 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for GRK5 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C0023895 | Liver Diseases | 1 | Biomarker |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for GRK5 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Gene-centered drug-gene interaction network |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of GRK5 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | ANP | AMP-PNP | 4tnd | A | G196 V200 | SGV | SANGIVAMYCIN | 4tnb | A | L192 V200 |
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| Conservation information for LBS of GRK5 |
| Multiple alignments for P34947 in multiple species |
| LBS | AA sequence | # species | Species | A213 | TGKMYACKRLE | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | A213 | SGKMYALKKLE | 1 | Caenorhabditis elegans | A213 | TGKMYACKKLE | 1 | Drosophila melanogaster | D270 | IMNGGDLKFHI | 5 | Homo sapiens, Drosophila melanogaster, Mus musculus, Rattus norvegicus, Bos taurus | D270 | LMNGGDLKFHL | 1 | Caenorhabditis elegans | D329 | HIRISDLGLAV | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | D329 | HVRISDLGLAV | 2 | Caenorhabditis elegans, Drosophila melanogaster | G193 | QYRVLGKGGFG | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | G193 | LYRVLGKGGFG | 1 | Caenorhabditis elegans | G193 | MYRVLGKGGFG | 1 | Drosophila melanogaster | G195 | RVLGKGGFGEV | 6 | Homo sapiens, Caenorhabditis elegans, Drosophila melanogaster, Mus musculus, Rattus norvegicus, Bos taurus | G196 | VLGKGGFGEVC | 6 | Homo sapiens, Caenorhabditis elegans, Drosophila melanogaster, Mus musculus, Rattus norvegicus, Bos taurus | K215 | KMYACKRLEKK | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | K215 | KMYALKKLEKK | 1 | Caenorhabditis elegans | K215 | KMYACKKLEKK | 1 | Drosophila melanogaster | L192 | RQYRVLGKGGF | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | L192 | RLYRVLGKGGF | 1 | Caenorhabditis elegans | L192 | RMYRVLGKGGF | 1 | Drosophila melanogaster | L263 | ALCLVLTIMNG | 5 | Homo sapiens, Drosophila melanogaster, Mus musculus, Rattus norvegicus, Bos taurus | L263 | ALCLVLTLMNG | 1 | Caenorhabditis elegans | L318 | KPENILLDDYG | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | L318 | KPENILLDDFG | 1 | Caenorhabditis elegans | L318 | KPENILLDDHG | 1 | Drosophila melanogaster | M266 | LVLTIMNGGDL | 5 | Homo sapiens, Drosophila melanogaster, Mus musculus, Rattus norvegicus, Bos taurus | M266 | LVLTLMNGGDL | 1 | Caenorhabditis elegans | R470 | FVPDPRAVYCK | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | R470 | FCPDPRAVYAK | 1 | Caenorhabditis elegans | R470 | FVPDPHAVYAK | 1 | Drosophila melanogaster | S328 | GHIRISDLGLA | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | S328 | GHVRISDLGLA | 2 | Caenorhabditis elegans, Drosophila melanogaster | T264 | LCLVLTIMNGG | 5 | Homo sapiens, Drosophila melanogaster, Mus musculus, Rattus norvegicus, Bos taurus | T264 | LCLVLTLMNGG | 1 | Caenorhabditis elegans | V200 | GGFGEVCACQV | 6 | Homo sapiens, Caenorhabditis elegans, Drosophila melanogaster, Mus musculus, Rattus norvegicus, Bos taurus |
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