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mutLBSgeneDB |
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| Gene summary for GRB7 |
 Gene summary |
| Basic gene Info. | Gene symbol | GRB7 |
| Gene name | growth factor receptor-bound protein 7 | |
| Synonyms | - | |
| Cytomap | UCSC genome browser: 17q12 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001030002.2, NM_001242442.1,NM_001242443.1,NM_005310.3, | |
| Description | B47GRB7 adapter proteinepidermal growth factor receptor GRB-7 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 601522 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000141738 | ||
| HPRD : 03311 | ||
| Vega : OTTHUMG00000133253 | ||
| Protein | UniProt: Q14451 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_GRB7 | |
| BioGPS: 2886 | ||
| Pathway | NCI Pathway Interaction Database: GRB7 | |
| KEGG: GRB7 | ||
| REACTOME: GRB7 | ||
| Pathway Commons: GRB7 | ||
| Context | iHOP: GRB7 | |
| ligand binding site mutation search in PubMed: GRB7 | ||
| UCL Cancer Institute: GRB7 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0030335 | positive regulation of cell migration | 10893408 |
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| Ligand binding site mutations for GRB7 |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | S437 | S437P | SKCM | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for GRB7 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | S437 | S437P | -0.59407762 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for GRB7 from PDB |
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| Differential gene expression and gene-gene network for GRB7 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for GRB7 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C1458155 | Breast Neoplasms | 5 | AlteredExpression, Biomarker, Therapeutic |
| umls:C0001418 | Adenocarcinoma | 1 | Biomarker |
| umls:C0007134 | Carcinoma, Renal Cell | 1 | Biomarker |
| umls:C0024121 | Lung Neoplasms | 1 | Biomarker |
| umls:C0033578 | Prostatic Neoplasms | 1 | Biomarker |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for GRB7 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of GRB7 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
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| Conservation information for LBS of GRB7 |
| Multiple alignments for Q14451 in multiple species |
| LBS | AA sequence | # species | Species | D496 | LYFSMDDGQTR | 2 | Homo sapiens, Rattus norvegicus | D496 | LYFSMDDGLTR | 1 | Bos taurus | D496 | LYFSMDEGQTR | 1 | Mus musculus | D497 | YFSMDDGQTRF | 2 | Homo sapiens, Rattus norvegicus | D497 | YFSMDDGLTRF | 1 | Bos taurus | D497 | YFSMDEGQTRF | 1 | Mus musculus | E439 | GRISREESQRL | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | E459 | LFLVRESQRNP | 2 | Homo sapiens, Bos taurus | E459 | VFLVRESQRNP | 2 | Mus musculus, Rattus norvegicus | F493 | EGRLYFSMDDG | 2 | Homo sapiens, Bos taurus | F493 | EGCLYFSMDEG | 1 | Mus musculus | F493 | EGCLYFSMDDG | 1 | Rattus norvegicus | H479 | LQKVKHYLILP | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | H479 | VQKVKHYLILP | 1 | Bos taurus | I482 | VKHYLILPSEE | 2 | Homo sapiens, Bos taurus | I482 | VKHYLILPSED | 2 | Mus musculus, Rattus norvegicus | I518 | QLNRGILPCLL | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | K478 | HLQKVKHYLIL | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | K478 | HVQKVKHYLIL | 1 | Bos taurus | L481 | KVKHYLILPSE | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | M495 | RLYFSMDDGQT | 1 | Homo sapiens | M495 | RLYFSMDDGLT | 1 | Bos taurus | M495 | CLYFSMDEGQT | 1 | Mus musculus | M495 | CLYFSMDDGQT | 1 | Rattus norvegicus | N463 | RESQRNPQGFV | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | Q442 | SREESQRLIGQ | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | Q442 | SREESQRLIRQ | 1 | Bos taurus | Q461 | LVRESQRNPQG | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | Q499 | SMDDGQTRFTD | 2 | Homo sapiens, Rattus norvegicus | Q499 | SMDDGLTRFTD | 1 | Bos taurus | Q499 | SMDEGQTRFTD | 1 | Mus musculus | R438 | HGRISREESQR | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | R458 | GLFLVRESQRN | 2 | Homo sapiens, Bos taurus | R458 | GVFLVRESQRN | 2 | Mus musculus, Rattus norvegicus | S437 | FHGRISREESQ | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | S460 | FLVRESQRNPQ | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | S494 | GRLYFSMDDGQ | 1 | Homo sapiens | S494 | GRLYFSMDDGL | 1 | Bos taurus | S494 | GCLYFSMDEGQ | 1 | Mus musculus | S494 | GCLYFSMDDGQ | 1 | Rattus norvegicus | V468 | NPQGFVLSLCH | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | Y480 | QKVKHYLILPS | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | Y492 | EEGRLYFSMDD | 2 | Homo sapiens, Bos taurus | Y492 | DEGCLYFSMDE | 1 | Mus musculus | Y492 | DEGCLYFSMDD | 1 | Rattus norvegicus |
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