|
mutLBSgeneDB |
| |
| |
| |
| |
| |
| |
|
| Gene summary for DCPS |
 Gene summary |
| Basic gene Info. | Gene symbol | DCPS |
| Gene name | decapping enzyme, scavenger | |
| Synonyms | DCS1|HINT-5|HINT5|HSL1 | |
| Cytomap | UCSC genome browser: 11q24.2 | |
| Type of gene | protein-coding | |
| RefGenes | NM_014026.4, | |
| Description | decapping scavenger enzymeheat shock-like protein 1hint-related 7meGMP-directed hydrolasehistidine triad nucleotide-binding protein 5histidine triad protein member 5homolog of C. elegans 7meGMP-directed hydrolase dcs-1m7GpppX diphosphatasemRNA deca | |
| Modification date | 20141222 | |
| dbXrefs | MIM : 610534 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000110063 | ||
| HPRD : 16787 | ||
| Vega : OTTHUMG00000165829 | ||
| Protein | UniProt: Q96C86 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_DCPS | |
| BioGPS: 28960 | ||
| Pathway | NCI Pathway Interaction Database: DCPS | |
| KEGG: DCPS | ||
| REACTOME: DCPS | ||
| Pathway Commons: DCPS | ||
| Context | iHOP: DCPS | |
| ligand binding site mutation search in PubMed: DCPS | ||
| UCL Cancer Institute: DCPS | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0036245 | cellular response to menadione | 16140270 | GO:0043069 | negative regulation of programmed cell death | 16140270 | GO:0045292 | mRNA cis splicing, via spliceosome | 18426921 |
| Top |
| Ligand binding site mutations for DCPS |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
 |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | I219 | A220T | COAD | 2 | I83 | V81I | BLCA | 1 | R322 | D324N | BLCA | 1 | R145 | R145H | COAD | 1 | D59,I61 | K60I | LUAD | 1 | R188 | R188Q | LUSC | 1 | H279 | H279N | OV | 1 | I219 | A220T | STAD | 1 | R145 | R145H | THCA | 1 | F63 | F63V | UCEC | 1 | R145 | R145H | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
| Top |
| Protein structure related information for DCPS |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
 |
| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | R322 | D324N | -1.2097326 | F63 | F63V | -1.0918922 | R188 | R188Q | -0.98254347 | I219 | A220T | -0.97507558 | I83 | V81I | -0.97139312 | R145 | R145H | -0.91741633 | H279 | H279N | -0.69169563 | D59 | K60I | -0.27710142 | I61 | K60I | -0.27710142 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for DCPS from PDB |
| PDB ID | PDB title | PDB structure | 1XML | Structure of human Dcps |  |
| Top |
| Differential gene expression and gene-gene network for DCPS |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
| Top |
| Top |
| Phenotype information for DCPS |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
| Top |
| Pharmacological information for DCPS |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
 |
| Gene-centered drug-gene interaction network |
 |
| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Experimental | DB01649 | 7-Methyl-Gpppa | Small molecule |  |
| Experimental | DB01960 | 7n-Methyl-8-Hydroguanosine-5'-Diphosphate | Small molecule |  |
| Experimental | DB03593 | N7-Methyl-Guanosine-5'-Monophosphate | Small molecule |  |
| Experimental | DB03958 | 7-methyl-guanosine-5'-triphosphate-5'-guanosine | Small molecule |  |
| Experimental | DB07642 | 5-{[1-(2-fluorobenzyl)piperidin-4-yl]methoxy}quinazoline-2,4-diamine | Small molecule |  |
| Experimental | DB07643 | 5-{[1-(2,3-dichlorobenzyl)piperidin-4-yl]methoxy}quinazoline-2,4-diamine | Small molecule |  |
| Experimental | DB07644 | 5-[(1S)-1-(3-chlorophenyl)ethoxy]quinazoline-2,4-diamine | Small molecule |  |
| Gene-centered ligand-gene interaction network |
 |
| Ligands binding to mutated ligand binding site of DCPS go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | GTG | 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE-5'-GUANOSINE | 1st0 | A | D59 I61 I219 H279 | DD2 | 5-{[1-(2,3-DICHLOROBENZYL)PIPERIDIN-4-YL]METHOXY}QUINAZOLINE-2,4-DIAMINE | 3bl9 | A | F63 | M7G | 7-METHYL-7,8-DIHYDROGUANOSINE-5'-DIPHOSPHATE | 1xmm | D | H279 | G7M | 7-METHYLGUANOSINE 5'-PHOSPHATE | 1xmm | C | I219 | DD1 | 5-{[1-(2-FLUOROBENZYL)PIPERIDIN-4-YL]METHOXY}QUINAZOLINE-2,4-DIAMINE | 3bl7 | A | I219 | 31G | 3-{[(2,4-DIAMINOQUINAZOLIN-5-YL) OXY]METHYL}BENZENESULFONIC ACID | 4qeb | A | I219 | M7G | 7-METHYL-7,8-DIHYDROGUANOSINE-5'-DIPHOSPHATE | 1xmm | A | I219 H279 | GTA | P1-7-METHYLGUANOSINE-P3-ADENOSINE-5',5'-TRIPHOSPHATE | 1st4 | A | I61 F63 I83 H279 | DD3 | 5-[(1S)-1-(3-CHLOROPHENYL)ETHOXY]QUINAZOLINE-2,4-DIAMINE | 3bla | A | I83 R188 I219 | GTA | P1-7-METHYLGUANOSINE-P3-ADENOSINE-5',5'-TRIPHOSPHATE | 1st4 | B | R145 H279 R322 | GTG | 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE-5'-GUANOSINE | 1st0 | B | R145 R188 I219 H279 R322 | G7M | 7-METHYLGUANOSINE 5'-PHOSPHATE | 1xmm | B | R188 | DD3 | 5-[(1S)-1-(3-CHLOROPHENYL)ETHOXY]QUINAZOLINE-2,4-DIAMINE | 3bla | B | R188 | 30U | 4-{[(2,4-DIAMINOQUINAZOLIN-5-YL) OXY]METHYL}BENZENESULFONIC ACID | 4qdv | D | R188 | 30U | 4-{[(2,4-DIAMINOQUINAZOLIN-5-YL) OXY]METHYL}BENZENESULFONIC ACID | 4qdv | A | R188 I219 |
| Top |
| Conservation information for LBS of DCPS |
| Multiple alignments for Q96C86 in multiple species |
| LBS | AA sequence | # species | Species | D205 | FVLIPDLKWNQ | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | D205 | FVLLQDIKWDG | 1 | Caenorhabditis elegans | D205 | FIVIPDLKWDR | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | D59 | RESARDKIIFL | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | D59 | GADSSHKSLFV | 1 | Caenorhabditis elegans | D59 | KDDTKSKIITL | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | E185 | LDKKAEADRIV | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | E185 | LEKRSEVDKIV | 1 | Caenorhabditis elegans | E185 | LTHKAEAERIV | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | E85 | AVVILEKTPFQ | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | E85 | GILLANKSPFS | 1 | Caenorhabditis elegans | E85 | ALLLLEKTAFD | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | F108 | ELKLQFSNDIY | 2 | Mus musculus, Rattus norvegicus | F108 | ELQLQFSNDIY | 1 | Homo sapiens | F108 | QLQEISRNDIF | 1 | Caenorhabditis elegans | F108 | DTKLVENNDVF | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | F63 | RDKIIFLHGKV | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | F63 | SHKSLFVLLSH | 1 | Caenorhabditis elegans | F63 | KSKIITLYGKI | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | G289 | FEA-PGSGVER | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | G289 | YDA-PASTTMS | 1 | Caenorhabditis elegans | G289 | HETGDGSAVGR | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | H139 | PATEKHLQKYL | 1 | Homo sapiens | H139 | PINDRLIAKYR | 1 | Caenorhabditis elegans | H139 | PASETHVRKYS | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | H139 | PATEKHLQKYM | 1 | Mus musculus | H139 | PASEKHLQKYM | 1 | Rattus norvegicus | H268 | LRVYLHYLPSY | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | H268 | IKCYFHYQPSF | 1 | Caenorhabditis elegans | H268 | LKMFVHYLPSY | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | H277 | SYYHLHVHFTA | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | H277 | SFYHLHVHFIN | 1 | Caenorhabditis elegans | H277 | SYYHLHVHILH | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | H279 | YHLHVHFTALG | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | H279 | YHLHVHFINLK | 1 | Caenorhabditis elegans | H279 | YHLHVHILHVD | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | I179 | QWVYNILDKKA | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | I179 | NWVYNCLEKRS | 1 | Caenorhabditis elegans | I179 | QWVENILTHKA | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | I203 | DGFVLIPDLKW | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | I203 | NGFVLLQDIKW | 1 | Caenorhabditis elegans | I203 | NGFIVIPDLKW | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | I219 | DDLYLIAICHR | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | I219 | ENLYVLAICHR | 1 | Caenorhabditis elegans | I219 | SALNLMAIVHA | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | I61 | SARDKIIFLHG | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | I61 | DSSHKSLFVLL | 1 | Caenorhabditis elegans | I61 | DTKSKIITLYG | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | I83 | EDAVVILEKTP | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | I83 | SQGILLANKSP | 1 | Caenorhabditis elegans | I83 | EVALLLLEKTA | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | K128 | HLSDIKTTVVY | 2 | Mus musculus, Rattus norvegicus | K128 | QLNDVKTTVVY | 1 | Homo sapiens | K128 | KLNLLKSQLIY | 1 | Caenorhabditis elegans | K128 | TLPSVKSTLIW | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | K142 | EKHLQKYMRQD | 2 | Mus musculus, Rattus norvegicus | K142 | EKHLQKYLRQD | 1 | Homo sapiens | K142 | DRLIAKYRQEE | 1 | Caenorhabditis elegans | K142 | ETHVRKYSSQK | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | K207 | LIPDLKWNQQQ | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | K207 | LLQDIKWDGKT | 1 | Caenorhabditis elegans | K207 | VIPDLKWDRQT | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | L171 | ESQ-SLSIQWV | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | L171 | EKY-QLNLNWV | 1 | Caenorhabditis elegans | L171 | ETQRGPQIQWV | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | L206 | VLIPDLKWNQQ | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | L206 | VLLQDIKWDGK | 1 | Caenorhabditis elegans | L206 | IVIPDLKWDRQ | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | N110 | KLQFSNDIYST | 2 | Mus musculus, Rattus norvegicus | N110 | QLQFSNDIYST | 1 | Homo sapiens | N110 | QEISRNDIFGS | 1 | Caenorhabditis elegans | N110 | KLVENNDVFHW | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | P204 | GFVLIPDLKWN | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | P204 | GFVLLQDIKWD | 1 | Caenorhabditis elegans | P204 | GFIVIPDLKWD | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | P271 | YLHYLPSYYHL | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | P271 | YFHYQPSFYHL | 1 | Caenorhabditis elegans | P271 | FVHYLPSYYHL | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | P288 | GFEA-PGSGVE | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | P288 | KYDA-PASTTM | 1 | Caenorhabditis elegans | P288 | DHETGDGSAVG | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | Q146 | QKYMRQDLRLI | 2 | Mus musculus, Rattus norvegicus | Q146 | QKYLRQDLRLI | 1 | Homo sapiens | Q146 | AKYRQEEKFVI | 1 | Caenorhabditis elegans | Q146 | RKYSSQKKRMV | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | R145 | LQKYMRQDLRL | 2 | Mus musculus, Rattus norvegicus | R145 | LQKYLRQDLRL | 1 | Homo sapiens | R145 | IAKYRQEEKFV | 1 | Caenorhabditis elegans | R145 | VRKYSSQKKRM | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | R188 | KAEADRIVFEN | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | R188 | RSEVDKIVFED | 1 | Caenorhabditis elegans | R188 | KAEAERIVVED | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | R294 | GSGVERAHLLA | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | R294 | ASTTMSAILLD | 1 | Caenorhabditis elegans | R294 | GSAVGRAILLD | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | R322 | LTFALRTDDPL | 2 | Mus musculus, Rattus norvegicus | R322 | LTFALRADDPL | 1 | Homo sapiens | R322 | LTFTRKNGDKL | 1 | Caenorhabditis elegans | R322 | ITFNIGEQHFL | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | R54 | VQKVLRESARD | 2 | Mus musculus, Rattus norvegicus | R54 | LQKVLRESARD | 1 | Homo sapiens | R54 | FQEILGADSSH | 1 | Caenorhabditis elegans | R54 | FEKILKDDTKS | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | S272 | LHYLPSYYHLH | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | S272 | FHYQPSFYHLH | 1 | Caenorhabditis elegans | S272 | VHYLPSYYHLH | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | T130 | SDIKTTVVYPA | 2 | Mus musculus, Rattus norvegicus | T130 | NDVKTTVVYPA | 1 | Homo sapiens | T130 | NLLKSQLIYPI | 1 | Caenorhabditis elegans | T130 | PSVKSTLIWPA | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | V132 | VKTTVVYPATE | 1 | Homo sapiens | V132 | LKSQLIYPIND | 1 | Caenorhabditis elegans | V132 | VKSTLIWPASE | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | V132 | IKTTVVYPATE | 1 | Mus musculus | V132 | IKTTVVYPASE | 1 | Rattus norvegicus | W175 | SLSIQWVYNIL | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | W175 | QLNLNWVYNCL | 1 | Caenorhabditis elegans | W175 | GPQIQWVENIL | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | Y113 | FSNDIYSTY-- | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | Y113 | SRNDIFGSY-- | 1 | Caenorhabditis elegans | Y113 | ENNDVFHWFLS | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | Y143 | KHLQKYMRQDL | 2 | Mus musculus, Rattus norvegicus | Y143 | KHLQKYLRQDL | 1 | Homo sapiens | Y143 | RLIAKYRQEEK | 1 | Caenorhabditis elegans | Y143 | THVRKYSSQKK | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | Y273 | HYLPSYYHLHV | 4 | Homo sapiens, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Mus musculus, Rattus norvegicus | Y273 | HYQPSFYHLHV | 1 | Caenorhabditis elegans |
 |
Copyright © 2016-Present - The University of Texas Health Science Center at Houston |