mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for GSK3B
Gene summary
Basic gene Info.Gene symbolGSK3B
Gene nameglycogen synthase kinase 3 beta
Synonyms-
CytomapUCSC genome browser: 3q13.3
Type of geneprotein-coding
RefGenesNM_001146156.1,
NM_002093.3,
DescriptionGSK-3 betaGSK3beta isoformglycogen synthase kinase-3 betaserine/threonine-protein kinase GSK3B
Modification date20141222
dbXrefs MIM : 605004
HGNC : HGNC
Ensembl : ENSG00000082701
HPRD : 05418
Vega : OTTHUMG00000133765
ProteinUniProt: P49841
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_GSK3B
BioGPS: 2932
PathwayNCI Pathway Interaction Database: GSK3B
KEGG: GSK3B
REACTOME: GSK3B
Pathway Commons: GSK3B
ContextiHOP: GSK3B
ligand binding site mutation search in PubMed: GSK3B
UCL Cancer Institute: GSK3B
Assigned class in mutLBSgeneDBB: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0005977glycogen metabolic process8638126
GO:0006468protein phosphorylation11035810
GO:0006983ER overload response14744935
GO:0018105peptidyl-serine phosphorylation11104755
GO:0031334positive regulation of protein complex assembly8638126
GO:0032091negative regulation of protein binding16890161
GO:0035556intracellular signal transduction14749367
GO:0043066negative regulation of apoptotic process14744935
GO:0046827positive regulation of protein export from nucleus14744935
GO:0060070canonical Wnt signaling pathway18787224


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Ligand binding site mutations for GSK3B
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
 
: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
A83A83TCOAD2
S237I238TCOAD1
S35G34SCOAD1
S261G259WLUAD1
Q295Q295ELUAD1
S261G259VLUSC1
M101R102KSKCM1
V214,Y216S215LSTAD1
G68G68VSTAD1
F115F115LUCEC1
R96R96QUCEC1
R180R180QUCEC1
R180H179NUCEC1
V110R111QUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Clinical information for GSK3B from My Cancer Genome.
Glycogen synthase kinase 3 beta (GSK3B) is a gene that encodes a protein that functions as a serine/threonine kinase. The protein is involved in processes such as metabolic regulation, neuronal cell development, and body pattern formation. Missense, nonsense, and silent mutations are observed in cancers such as endometrial cancer, intestinal cancer, and stomach cancer.Related Pathways: β-catenin/Wnt signaling. Modified: December 4, 2015

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Protein structure related information for GSK3B
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
S261G259V0.017873503
S261G259W0.006601174
S237I238T-1.8400983
M101R102K-1.2803589
S35G34S-1.169063
R180H179N-1.0763669
V110R111Q-0.93436867
F115F115L-0.82687409
R180R180Q-0.76981431
A83A83T-0.72589859
G68G68V-0.58910379
V214S215L-0.48887976
Y216S215L-0.48887976
Q295Q295E-0.30328986
R96R96Q-0.27069703
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for GSK3B from PDB
PDB IDPDB titlePDB structure
1H8FGLYCOGEN SYNTHASE KINASE 3 BETA.

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Differential gene expression and gene-gene network for GSK3B
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of GSK3B and the right PPI network was created from samples without mutations in the LBS of GSK3B. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for GSK3B
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0036341Schizophrenia16Biomarker, GeneticVariation
umls:C0005586Bipolar Disorder16Biomarker, GeneticVariation
umls:C0002395Alzheimer Disease15AlteredExpression, Biomarker, GeneticVariation
umls:C0033578Prostatic Neoplasms5AlteredExpression, Biomarker, PostTranslationalModification
umls:C0011581Depressive Disorder3Biomarker, GeneticVariation
umls:C0334634Lymphoma, Mantle-Cell1AlteredExpression, Biomarker
umls:C0000772Abnormalities, Multiple1Biomarker
umls:C2609414Acute Kidney Injury1Biomarker
umls:C0993582Arthritis, Experimental1Biomarker
umls:C0018800Cardiomegaly1Biomarker
umls:C0018801Heart Failure1Biomarker
umls:C0026846Muscular Atrophy1Therapeutic
umls:C0027051Myocardial Infarction1Biomarker
umls:C0031154Peritonitis1Biomarker
umls:C0032343Poisoning1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for GSK3B
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
ApprovedDB01356LithiumSmall molecule
ExperimentalDB017723-[3-(2,3-Dihydroxy-Propylamino)-Phenyl]-4-(5-Fluoro-1-Methyl-1h-Indol-3-Yl)-Pyrrole-2,5-DioneSmall molecule
ExperimentalDB01793I-5Small molecule
ExperimentalDB01950N-(4-Methoxybenzyl)-N'-(5-Nitro-1,3-Thiazol-2-Yl)UreaSmall molecule
ExperimentalDB02010StaurosporineSmall molecule
ExperimentalDB02052Indirubin-3'-MonoximeSmall molecule
ExperimentalDB03444(3e)-6'-Bromo-2,3'-Biindole-2',3(1h,1'h)-Dione 3-OximeSmall molecule
ExperimentalDB04014AlsterpaulloneSmall molecule
ExperimentalDB04395Phosphoaminophosphonic Acid-Adenylate EsterSmall molecule
ExperimentalDB070142-(1,3-benzodioxol-5-yl)-5-[(3-fluoro-4-methoxybenzyl)sulfanyl]-1,3,4-oxadiazoleSmall molecule
ExperimentalDB070585-[1-(4-methoxyphenyl)-1H-benzimidazol-6-yl]-1,3,4-oxadiazole-2(3H)-thioneSmall molecule
ExperimentalDB07149(7S)-2-(2-aminopyrimidin-4-yl)-7-(2-fluoroethyl)-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-oneSmall molecule
ExperimentalDB07584N-[2-(5-methyl-4H-1,2,4-triazol-3-yl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amineSmall molecule
ExperimentalDB075855-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridineSmall molecule
ExperimentalDB076763-({[(3S)-3,4-dihydroxybutyl]oxy}amino)-1H,2'H-2,3'-biindol-2'-oneSmall molecule
ExperimentalDB07812N-[(1S)-2-amino-1-phenylethyl]-5-(1H-pyrrolo[2,3-b]pyridin-4-yl)thiophene-2-carboxamideSmall molecule
ExperimentalDB078594-(4-CHLOROPHENYL)-4-[4-(1H-PYRAZOL-4-YL)PHENYL]PIPERIDINESmall molecule
ExperimentalDB07947ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY)ETHYLAMINO)ETHYL)AMIDESmall molecule
ExperimentalDB08073(2S)-1-(1H-INDOL-3-YL)-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINESmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of GSK3B go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
STUSTAUROSPORINE1q3dAA83
STUSTAUROSPORINE1q3dBA83
IXMINDIRUBIN-3'-MONOXIME1q41AA83
IXMINDIRUBIN-3'-MONOXIME1q41BA83
679I-51q4lBA83
TMUN-(4-METHOXYBENZYL)-N'-(5-NITRO-1,3-THIAZOL-2-YL)UREA1q5kAA83
TMUN-(4-METHOXYBENZYL)-N'-(5-NITRO-1,3-THIAZOL-2-YL)UREA1q5kBA83
BRW6-BROMOINDIRUBIN-3-OXIME1uv5AA83
AG1RUTHENIUM PYRIDOCARBAZOLE2jldAA83
AG1RUTHENIUM PYRIDOCARBAZOLE2jldBA83
HBM2-(2,4-DICHLOROPHENYL)-4-HYDROXY-N-(2-{4-[(METHYLSULFONYL)AMINO]PHENYL}ETHYL)-1H-BENZIMIDAZOLE-7-CARBOXAMIDE2o5kAA83
BIMBIS-(INDOLE)MALEIMIDE PYRIDINOPHANE2ow3AA83
BIMBIS-(INDOLE)MALEIMIDE PYRIDINOPHANE2ow3BA83
553(7S)-2-(2-AMINOPYRIMIDIN-4-YL)-7-(2-FLUOROETHYL)-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE3du8AA83
553(7S)-2-(2-AMINOPYRIMIDIN-4-YL)-7-(2-FLUOROETHYL)-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE3du8BA83
3HT5-[1-(4-METHOXYPHENYL)-1H-BENZIMIDAZOL-6-YL]-1,3,4-OXADIAZOLE-2(3H)-THIONE3f88AA83
3HT5-[1-(4-METHOXYPHENYL)-1H-BENZIMIDAZOL-6-YL]-1,3,4-OXADIAZOLE-2(3H)-THIONE3f88BA83
G3B2-METHYL-5-(3-{4-[(S)-METHYLSULFINYL]PHENYL}-1-BENZOFURAN-5-YL)-1,3,4-OXADIAZOLE3gb2AA83
DW1RUTHENIUM PYRIDOCARBAZOLE3m1sBA83
OS1RUTHENIUM OCTASPORINE3pupAA83
OS1RUTHENIUM OCTASPORINE3pupBA83
OFT(3Z)-N,N-DIETHYL-3-[(3E)-3-(HYDROXYIMINO)-1,3-DIHYDRO- 2H-INDOL-2-YLIDENE]-2-OXO-2,3-DIHYDRO-1H-INDOLE-5- SULFONAMIDE3sayAA83
OFT(3Z)-N,N-DIETHYL-3-[(3E)-3-(HYDROXYIMINO)-1,3-DIHYDRO- 2H-INDOL-2-YLIDENE]-2-OXO-2,3-DIHYDRO-1H-INDOLE-5- SULFONAMIDE3sayBA83
ZRK2-(4-PYRIDINYL)FURO[3,2-C]PYRIDIN-4(5H)-ONE3zrkAA83
ZRK2-(4-PYRIDINYL)FURO[3,2-C]PYRIDIN-4(5H)-ONE3zrkBA83
ZRL7-BROMO-2-PYRIDIN-4-YL-5H-THIENO[3,2-C]PYRIDIN-4-ONE3zrlAA83
ZRL7-BROMO-2-PYRIDIN-4-YL-5H-THIENO[3,2-C]PYRIDIN-4-ONE3zrlBA83
ZRM7-(4-HYDROXYPHENYL)-2-PYRIDIN-4-YL-5H-THIENO[3,2-C]PYRIDIN-4-ONE3zrmAA83
ZRM7-(4-HYDROXYPHENYL)-2-PYRIDIN-4-YL-5H-THIENO[3,2-C]PYRIDIN-4-ONE3zrmBA83
7YG3-AMINO-6-(4-{[2-(DIMETHYLAMINO)ETHYL]SULFAMOYL}PHENYL)-N-PYRIDIN-3-YLPYRAZINE-2-CARBOXAMIDE4accAA83
KDI3-AMINO-N-(3-METHOXYPROPYL)-6-{4-[(4-METHYLPIPERAZIN-1-YL)SULFONYL]PHENYL}PYRAZINE-2-CARBOXAMIDE4achAA83
SJJ5-(4-METHOXYPHENYL)-N-(PYRIDIN-4-YLMETHYL)-1,3-OXAZOLE-4-CARBOXAMIDE4afjAA83
SJJ5-(4-METHOXYPHENYL)-N-(PYRIDIN-4-YLMETHYL)-1,3-OXAZOLE-4-CARBOXAMIDE4afjBA83
CWTLEUCETTINE L4(5Z)-5-(1,3-BENZODIOXOL-5-YLMETHYLIDENE)-3- METHYL-2-(PROPAN-2-YLAMINO)IMIDAZOL-4-ONE4b7tAA83
IQ66-CHLORO-N-CYCLOHEXYL-4-(1H-PYRROLO[2,3-B]PYRIDIN-3- YL)PYRIDIN-2-AMINE4iq6AA83
2WE2-{2-[(CYCLOPROPYLCARBONYL)AMINO]PYRIDIN-4-YL}-4-OXO- 4H-1LAMBDA~4~,3-THIAZOLE-5-CARBOXAMIDE4ptcAA83
2WE2-{2-[(CYCLOPROPYLCARBONYL)AMINO]PYRIDIN-4-YL}-4-OXO- 4H-1LAMBDA~4~,3-THIAZOLE-5-CARBOXAMIDE4ptcBA83
2WFN-[4-(ISOQUINOLIN-7-YL)PYRIDIN-2- YL]CYCLOPROPANECARBOXAMIDE4pteAA83
2WFN-[4-(ISOQUINOLIN-7-YL)PYRIDIN-2- YL]CYCLOPROPANECARBOXAMIDE4pteBA83
2WG2-{2-[(CYCLOPROPYLCARBONYL)AMINO]PYRIDIN-4-YL}-4- METHOXYPYRIMIDINE-5-CARBOXAMIDE4ptgAA83
2WG2-{2-[(CYCLOPROPYLCARBONYL)AMINO]PYRIDIN-4-YL}-4- METHOXYPYRIMIDINE-5-CARBOXAMIDE4ptgBA83
IQ66-CHLORO-N-CYCLOHEXYL-4-(1H-PYRROLO[2,3-B]PYRIDIN-3- YL)PYRIDIN-2-AMINE4iq6BA83 M101 V110
ANPAMP-PNP1j1bAA83 V110
ADPADP1j1cAA83 V110
ADZ9-METHYL-9H-PURIN-6-AMINE1o9uAA83 V110
ANPAMP-PNP1pyxAA83 V110
ANPAMP-PNP1pyxBA83 V110
679I-51q4lAA83 V110
DFN3-[3-(2,3-DIHYDROXY-PROPYLAMINO)-PHENYL]-4-(5-FLUORO-1-METHYL-1H-INDOL-3-YL)-PYRROLE-2,5-DIONE1r0eAA83 V110
DFN3-[3-(2,3-DIHYDROXY-PROPYLAMINO)-PHENYL]-4-(5-FLUORO-1-METHYL-1H-INDOL-3-YL)-PYRROLE-2,5-DIONE1r0eBA83 V110
34O2-(1,3-BENZODIOXOL-5-YL)-5-[(3-FLUORO-4-METHOXYBENZYL)SULFANYL]-1,3,4-OXADIAZOLE3f7zAA83 V110
34O2-(1,3-BENZODIOXOL-5-YL)-5-[(3-FLUORO-4-METHOXYBENZYL)SULFANYL]-1,3,4-OXADIAZOLE3f7zBA83 V110
Z92(4Z)-4-[(4-CHLOROPHENYL)HYDRAZONO]-5-(3,4-DIMETHOXYPHENYL)-2H-PYRAZOL-3-ONE3l1sAA83 V110
Z92(4Z)-4-[(4-CHLOROPHENYL)HYDRAZONO]-5-(3,4-DIMETHOXYPHENYL)-2H-PYRAZOL-3-ONE3l1sBA83 V110
DW1RUTHENIUM PYRIDOCARBAZOLE3m1sAA83 V110
55E4-(4-HYDROXY-3-METHYLPHENYL)-6-PHENYLPYRIMIDIN-2(5H)-ONE3q3bAA83 V110
55E4-(4-HYDROXY-3-METHYLPHENYL)-6-PHENYLPYRIMIDIN-2(5H)-ONE3q3bBA83 V110
TSK3-(5-FLUORO-6-IODO-1-METHYL-1H-INDOL-3-YL)-4-(7-METHOXY-1-BENZOFURAN-3-YL)-1H-PYRROLE-2,5-DIONE3sd0AA83 V110
7YG3-AMINO-6-(4-{[2-(DIMETHYLAMINO)ETHYL]SULFAMOYL}PHENYL)-N-PYRIDIN-3-YLPYRAZINE-2-CARBOXAMIDE4accBA83 V110
GR93-AMINO-6-{4-[(4-METHYLPIPERAZIN-1-YL)SULFONYL]PHENYL}-N-PYRIDIN-3-YLPYRAZINE-2-CARBOXAMIDE4acdAA83 V110
GR93-AMINO-6-{4-[(4-METHYLPIPERAZIN-1-YL)SULFONYL]PHENYL}-N-PYRIDIN-3-YLPYRAZINE-2-CARBOXAMIDE4acdBA83 V110
6LQ2-AMINO-5-{4-[(4-METHYLPIPERAZIN-1-YL)SULFONYL]PHENYL}-N-[4-(PYRROLIDIN-1-YLMETHYL)PYRIDIN-3-YL]PYRIDINE-3-CARBOXAMIDE4acgAA83 V110
6LQ2-AMINO-5-{4-[(4-METHYLPIPERAZIN-1-YL)SULFONYL]PHENYL}-N-[4-(PYRROLIDIN-1-YLMETHYL)PYRIDIN-3-YL]PYRIDINE-3-CARBOXAMIDE4acgBA83 V110
KDI3-AMINO-N-(3-METHOXYPROPYL)-6-{4-[(4-METHYLPIPERAZIN-1-YL)SULFONYL]PHENYL}PYRAZINE-2-CARBOXAMIDE4achBA83 V110
0KDN-(PYRIDIN-3-YL)-2-(THIOPHEN-3-YL)-3H-IMIDAZO[4,5-B]PYRIDINE-7-CARBOXAMIDE4ditAA83 V110
ADPADP4nm0AA83 V110
ADPADP4nm3AA83 V110
Z48N-[(1S)-2-HYDROXY-1-PHENYLETHYL]-4-[5-METHYL-2-(PHENYLAMINO)PYRIMIDIN-4-YL]-1H-PYRROLE-2-CARBOXAMIDE3i4bAG68 A83
Z48N-[(1S)-2-HYDROXY-1-PHENYLETHYL]-4-[5-METHYL-2-(PHENYLAMINO)PYRIMIDIN-4-YL]-1H-PYRROLE-2-CARBOXAMIDE3i4bBG68 A83
IIIPeptide ligand (VAL,GLU,PRO,GLN,LYS,PHE,ALA,GLU,GLU,LEU,ILE,HIS,ARG,LEU,GLU,ALA,VAL,GLN)1o9uAQ295
IIIPeptide ligand (VAL,GLU,PRO,GLN,LYS,PHE,ALA,GLU,GLU,LEU,ILE,HIS,ARG,LEU,GLU,ALA,VAL,GLN)4b7tAQ295
IIIPeptide ligand (ILE,LEU,VAL,GLU,PRO,GLN,LYS,PHE,ALA,GLU,GLU,LEU,ILE,HIS,ARG,LEU,GLU,ALA,VAL,GLN,ARG)4nm0AQ295
IIIPeptide ligand (VAL,GLU,PRO,GLN,LYS,PHE,ALA,GLU,GLU,LEU,ILE,HIS,ARG,LEU,GLU,ALA,VAL,GLN,ARG)4nm3AQ295
SO4SULFATE1gngAR96 R180 V214
SO4SULFATE1gngBR96 R180 V214
PO4PHOSPHATE ION1i09AR96 R180 V214
PO4PHOSPHATE ION1i09BR96 R180 V214
PO4PHOSPHATE ION1i09AS237
IIIPeptide ligand (ASP,PRO,HIS,ARG,LEU,LEU,GLN,GLN,LEU,VAL,LEU,SER,GLY,ASN,LEU,ILE,LYS,GLU,ALA,VAL,ARG,ARG,LEU,HIS,SER)1gngAS261
IIIPeptide ligand (ASP,PRO,HIS,ARG,LEU,LEU,GLN,GLN,LEU,VAL,LEU,SER,GLY,ASN,LEU,ILE,LYS,GLU,ALA,VAL,ARG,ARG,LEU,HIS,SER)1gngBS261
IIIPeptide ligand (PRO,HIS,ARG,LEU,LEU,GLN,GLN,LEU,VAL,LEU,SER,GLY,ASN,LEU,ILE,LYS,GLU,ALA,VAL,ARG,ARG,LEU,HIS)3zrmAS261
IIIPeptide ligand (ALA,GLY,GLY,ALA,ALA,ALA,ALA,ALA)2jldAS35 F115
TSK3-(5-FLUORO-6-IODO-1-METHYL-1H-INDOL-3-YL)-4-(7-METHOXY-1-BENZOFURAN-3-YL)-1H-PYRROLE-2,5-DIONE3sd0BV110
I5R(2R)-2-(1H-INDOL-3-YLMETHYL)-1,4-DIHYDROPYRIDO[2,3- B]PYRAZIN-3(2H)-ONE4j1rAV110
I5R(2R)-2-(1H-INDOL-3-YLMETHYL)-1,4-DIHYDROPYRIDO[2,3- B]PYRAZIN-3(2H)-ONE4j1rBV110
I5R(2R)-2-(1H-INDOL-3-YLMETHYL)-1,4-DIHYDROPYRIDO[2,3- B]PYRAZIN-3(2H)-ONE4j1rCV110
I5R(2R)-2-(1H-INDOL-3-YLMETHYL)-1,4-DIHYDROPYRIDO[2,3- B]PYRAZIN-3(2H)-ONE4j1rDV110
1JX(2R)-2-METHYL-1,4-DIHYDROPYRIDO[2,3-B]PYRAZIN-3(2H)-ONE4j71AV110
1JX(2R)-2-METHYL-1,4-DIHYDROPYRIDO[2,3-B]PYRAZIN-3(2H)-ONE4j71BV110
IIIPeptide ligand (HIS,ARG,LEU,LEU,GLN,GLN,LEU,VAL,LEU,SER,GLY,ASN,LEU,ILE,LYS,GLU,ALA,VAL,ARG,ARG,LEU,HIS,SER)4afjAY216
IIIPeptide ligand (PRO,HIS,ARG,LEU,LEU,GLN,GLN,LEU,VAL,LEU,SER,GLY,ASN,LEU,ILE,LYS,GLU,ALA,VAL,ARG,ARG,LEU,HIS,SER)3zrkAY216 S261
IIIPeptide ligand (PRO,HIS,ARG,LEU,LEU,GLN,GLN,LEU,VAL,LEU,SER,GLY,ASN,LEU,ILE,LYS,GLU,ALA,VAL,ARG,ARG,LEU,HIS)3zrlAY216 S261


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Conservation information for LBS of GSK3B
Multiple alignments for P49841 in multiple species
LBSAA sequence# speciesSpecies
A83SGELVAIKKVL3Homo sapiens, Mus musculus, Rattus norvegicus
A83TGETVAIKKVL1Arabidopsis thaliana
A83TNEMVAIKKVL1Caenorhabditis elegans
C199AVLKLCDFGSA3Homo sapiens, Mus musculus, Rattus norvegicus
C199HQVKLCDFGSA1Arabidopsis thaliana
C199GVLKLCDFGSA1Caenorhabditis elegans
D133LNLVLDYVPET3Homo sapiens, Mus musculus, Rattus norvegicus
D133LNLVLEYVPET1Arabidopsis thaliana
D133LNLILEYVPET1Caenorhabditis elegans
D181GICHRDIKPQN4Homo sapiens, Caenorhabditis elegans, Mus musculus, Rattus norvegicus
D181GVCHRDIKPQN1Arabidopsis thaliana
D200VLKLCDFGSAK4Homo sapiens, Caenorhabditis elegans, Mus musculus, Rattus norvegicus
D200QVKLCDFGSAK1Arabidopsis thaliana
D264GDSGVDQLVEI4Homo sapiens, Caenorhabditis elegans, Mus musculus, Rattus norvegicus
D264GESGVDQLVEI1Arabidopsis thaliana
E137LDYVPETVYRV3Homo sapiens, Mus musculus, Rattus norvegicus
E137LEYVPETVYRV2Arabidopsis thaliana, Caenorhabditis elegans
E290NPNYTEFKFPQ4Homo sapiens, Arabidopsis thaliana, Mus musculus, Rattus norvegicus
E290NPNYKEFKFPQ1Caenorhabditis elegans
E97RFKNRELQIMR4Homo sapiens, Caenorhabditis elegans, Mus musculus, Rattus norvegicus
E97RYKNRELQTMR1Arabidopsis thaliana
F115VRLRYFFYSSG3Homo sapiens, Mus musculus, Rattus norvegicus
F115VSLKHCFFSTT1Arabidopsis thaliana
F115VKLKYFFYSSG1Caenorhabditis elegans
F229APELIFGATDY3Homo sapiens, Mus musculus, Rattus norvegicus
F229APELIFGATEY1Arabidopsis thaliana
F229APELIFGATNY1Caenorhabditis elegans
F291PNYTEFKFPQI4Homo sapiens, Arabidopsis thaliana, Mus musculus, Rattus norvegicus
F291PNYKEFKFPQI1Caenorhabditis elegans
F293YTEFKFPQIKA4Homo sapiens, Arabidopsis thaliana, Mus musculus, Rattus norvegicus
F293YKEFKFPQIKA1Caenorhabditis elegans
F67IGNGSFGVVYQ3Homo sapiens, Mus musculus, Rattus norvegicus
F67VGQGSFGIVFQ1Arabidopsis thaliana
F67IGNGSFGVVFL1Caenorhabditis elegans
G202KLCDFGSAKQL3Homo sapiens, Mus musculus, Rattus norvegicus
G202KLCDFGSAKVL1Arabidopsis thaliana
G202KLCDFGSAKYL1Caenorhabditis elegans
G262FPGDSGVDQLV4Homo sapiens, Caenorhabditis elegans, Mus musculus, Rattus norvegicus
G262FPGESGVDQLV1Arabidopsis thaliana
G63DTKVIGNGSFG3Homo sapiens, Mus musculus, Rattus norvegicus
G63AERIVGQGSFG1Arabidopsis thaliana
G63DQKVIGNGSFG1Caenorhabditis elegans
G65KVIGNGSFGVV4Homo sapiens, Caenorhabditis elegans, Mus musculus, Rattus norvegicus
G65RIVGQGSFGIV1Arabidopsis thaliana
G68GNGSFGVVYQA3Homo sapiens, Mus musculus, Rattus norvegicus
G68GQGSFGIVFQA1Arabidopsis thaliana
G68GNGSFGVVFLA1Caenorhabditis elegans
H173SLAYIHSF-GI3Homo sapiens, Mus musculus, Rattus norvegicus
H173ALAYIHGGVGV1Arabidopsis thaliana
H173SLAYIHSI-GI1Caenorhabditis elegans
I228RAPELIFGATD3Homo sapiens, Mus musculus, Rattus norvegicus
I228RAPELIFGATE1Arabidopsis thaliana
I228RAPELIFGATN1Caenorhabditis elegans
I270QLVEIIKVLGT5Homo sapiens, Arabidopsis thaliana, Caenorhabditis elegans, Mus musculus, Rattus norvegicus
I281PTREQIREMNP3Homo sapiens, Mus musculus, Rattus norvegicus
I281PTREEIKCMNP1Arabidopsis thaliana
I281PTREQIQSMNP1Caenorhabditis elegans
I296FKFPQIKAHPW5Homo sapiens, Arabidopsis thaliana, Caenorhabditis elegans, Mus musculus, Rattus norvegicus
I62TDTKVIGNGSF3Homo sapiens, Mus musculus, Rattus norvegicus
I62MAERIVGQGSF1Arabidopsis thaliana
I62YDQKVIGNGSF1Caenorhabditis elegans
K183CHRDIKPQNLL5Homo sapiens, Arabidopsis thaliana, Caenorhabditis elegans, Mus musculus, Rattus norvegicus
K205DFGSAKQLVRG3Homo sapiens, Mus musculus, Rattus norvegicus
K205DFGSAKVLVKG1Arabidopsis thaliana
K205DFGSAKYLVRN1Caenorhabditis elegans
K271LVEIIKVLGTP5Homo sapiens, Arabidopsis thaliana, Caenorhabditis elegans, Mus musculus, Rattus norvegicus
K292NYTEFKFPQIK4Homo sapiens, Arabidopsis thaliana, Mus musculus, Rattus norvegicus
K292NYKEFKFPQIK1Caenorhabditis elegans
K36--DGSKVTT--3Homo sapiens, Mus musculus, Rattus norvegicus
K36VVDGNGTETGH1Arabidopsis thaliana
K36--SGKQVTM--1Caenorhabditis elegans
K85ELVAIKKVLQD3Homo sapiens, Mus musculus, Rattus norvegicus
K85ETVAIKKVLQD1Arabidopsis thaliana
K85EMVAIKKVLQD1Caenorhabditis elegans
L132YLNLVLDYVPE3Homo sapiens, Mus musculus, Rattus norvegicus
L132YLNLVLEYVPE1Arabidopsis thaliana
L132YLNLILEYVPE1Caenorhabditis elegans
L188KPQNLLLDPDT3Homo sapiens, Mus musculus, Rattus norvegicus
L188KPQNLLVNPHT1Arabidopsis thaliana
L188KPQNLLIDPES1Caenorhabditis elegans
L266SGVDQLVEIIK5Homo sapiens, Arabidopsis thaliana, Caenorhabditis elegans, Mus musculus, Rattus norvegicus
M101RELQIMRKLDH3Homo sapiens, Mus musculus, Rattus norvegicus
M101RELQTMRLLDH1Arabidopsis thaliana
M101RELQIMRKLNH1Caenorhabditis elegans
N186DIKPQNLLLDP3Homo sapiens, Mus musculus, Rattus norvegicus
N186DIKPQNLLVNP1Arabidopsis thaliana
N186DIKPQNLLIDP1Caenorhabditis elegans
N213VRGEPNVSYIC3Homo sapiens, Mus musculus, Rattus norvegicus
N213VKGEPNISYIC1Arabidopsis thaliana
N213VRNEPNVSYIC1Caenorhabditis elegans
N64TKVIGNGSFGV3Homo sapiens, Mus musculus, Rattus norvegicus
N64ERIVGQGSFGI1Arabidopsis thaliana
N64QKVIGNGSFGV1Caenorhabditis elegans
P136VLDYVPETVYR3Homo sapiens, Mus musculus, Rattus norvegicus
P136VLEYVPETVYR1Arabidopsis thaliana
P136ILEYVPETVYR1Caenorhabditis elegans
P276KVLGTPTREQI4Homo sapiens, Caenorhabditis elegans, Mus musculus, Rattus norvegicus
P276KVLGTPTREEI1Arabidopsis thaliana
P294TEFKFPQIKAH4Homo sapiens, Arabidopsis thaliana, Mus musculus, Rattus norvegicus
P294KEFKFPQIKAH1Caenorhabditis elegans
P331TARLTPLEACA3Homo sapiens, Mus musculus, Rattus norvegicus
P331NLRSTAMEAIV1Arabidopsis thaliana
P331TSRPTPQAACQ1Caenorhabditis elegans
Q185RDIKPQNLLLD3Homo sapiens, Mus musculus, Rattus norvegicus
Q185RDIKPQNLLVN1Arabidopsis thaliana
Q185RDIKPQNLLID1Caenorhabditis elegans
Q295EFKFPQIKAHP5Homo sapiens, Arabidopsis thaliana, Caenorhabditis elegans, Mus musculus, Rattus norvegicus
R141PETVYRVARHY4Homo sapiens, Caenorhabditis elegans, Mus musculus, Rattus norvegicus
R141PETVYRVSKHY1Arabidopsis thaliana
R180-GICHRDIKPQ4Homo sapiens, Caenorhabditis elegans, Mus musculus, Rattus norvegicus
R180VGVCHRDIKPQ1Arabidopsis thaliana
R220SYICSRYYRAP5Homo sapiens, Arabidopsis thaliana, Caenorhabditis elegans, Mus musculus, Rattus norvegicus
R96KRFKNRELQIM4Homo sapiens, Caenorhabditis elegans, Mus musculus, Rattus norvegicus
R96KRYKNRELQTM1Arabidopsis thaliana
S236ATDYTSSIDVW2Homo sapiens, Mus musculus
S236ATEYTTTIDIW1Arabidopsis thaliana
S236ATNYTNSIDVW1Caenorhabditis elegans
S236ATDYTSSIDMW1Rattus norvegicus
S237TDYTSSIDVWS2Homo sapiens, Mus musculus
S237TEYTTTIDIWS1Arabidopsis thaliana
S237TNYTNSIDVWS1Caenorhabditis elegans
S237TDYTSSIDMWS1Rattus norvegicus
S261IFPGDSGVDQL4Homo sapiens, Caenorhabditis elegans, Mus musculus, Rattus norvegicus
S261LFPGESGVDQL1Arabidopsis thaliana
S35---DGSKVTT-3Homo sapiens, Mus musculus, Rattus norvegicus
S35AVVDGNGTETG1Arabidopsis thaliana
S35---SGKQVTM-1Caenorhabditis elegans
S66VIGNGSFGVVY3Homo sapiens, Mus musculus, Rattus norvegicus
S66IVGQGSFGIVF1Arabidopsis thaliana
S66VIGNGSFGVVF1Caenorhabditis elegans
T138DYVPETVYRVA3Homo sapiens, Mus musculus, Rattus norvegicus
T138EYVPETVYRVS1Arabidopsis thaliana
T138EYVPETVYRVA1Caenorhabditis elegans
T275IKVLGTPTREQ4Homo sapiens, Caenorhabditis elegans, Mus musculus, Rattus norvegicus
T275IKVLGTPTREE1Arabidopsis thaliana
T289MNPNYTEFKFP4Homo sapiens, Arabidopsis thaliana, Mus musculus, Rattus norvegicus
T289MNPNYKEFKFP1Caenorhabditis elegans
T330PTARLTPLEAC3Homo sapiens, Mus musculus, Rattus norvegicus
T330PNLRSTAMEAI1Arabidopsis thaliana
T330PTSRPTPQAAC1Caenorhabditis elegans
T38DGSKVTT---V3Homo sapiens, Mus musculus, Rattus norvegicus
T38DGNGTETGHII1Arabidopsis thaliana
T38SGKQVTM---V1Caenorhabditis elegans
T39GSKVTT---VV3Homo sapiens, Mus musculus, Rattus norvegicus
T39GNGTETGHIIV1Arabidopsis thaliana
T39GKQVTM---VV1Caenorhabditis elegans
T43--VVAT-PGQG3Homo sapiens, Mus musculus, Rattus norvegicus
T43HIIVTTIGGKN1Arabidopsis thaliana
T43--VVASVATDG1Caenorhabditis elegans
V110DHCNIVRLRYF3Homo sapiens, Mus musculus, Rattus norvegicus
V110DHPNVVSLKHC1Arabidopsis thaliana
V110NHPNIVKLKYF1Caenorhabditis elegans
V135LVLDYVPETVY3Homo sapiens, Mus musculus, Rattus norvegicus
V135LVLEYVPETVY1Arabidopsis thaliana
V135LILEYVPETVY1Caenorhabditis elegans
V214RGEPNVSYICS3Homo sapiens, Mus musculus, Rattus norvegicus
V214KGEPNISYICS1Arabidopsis thaliana
V214RNEPNVSYICS1Caenorhabditis elegans
V240TSSIDVWSAGC2Homo sapiens, Mus musculus
V240TTTIDIWSAGC1Arabidopsis thaliana
V240TNSIDVWSAGT1Caenorhabditis elegans
V240TSSIDMWSAGC1Rattus norvegicus
V263PGDSGVDQLVE4Homo sapiens, Caenorhabditis elegans, Mus musculus, Rattus norvegicus
V263PGESGVDQLVE1Arabidopsis thaliana
V267GVDQLVEIIKV5Homo sapiens, Arabidopsis thaliana, Caenorhabditis elegans, Mus musculus, Rattus norvegicus
V37-DGSKVTT---3Homo sapiens, Mus musculus, Rattus norvegicus
V37VDGNGTETGHI1Arabidopsis thaliana
V37-SGKQVTM---1Caenorhabditis elegans
V40TT---VVAT-P3Homo sapiens, Mus musculus, Rattus norvegicus
V40ETGHIIVTTIG1Arabidopsis thaliana
V40TM---VVASVA1Caenorhabditis elegans
V41T---VVAT-PG3Homo sapiens, Mus musculus, Rattus norvegicus
V41TGHIIVTTIGG1Arabidopsis thaliana
V41M---VVASVAT1Caenorhabditis elegans
V70GSFGVVYQAKL3Homo sapiens, Mus musculus, Rattus norvegicus
V70GSFGIVFQAKC1Arabidopsis thaliana
V70GSFGVVFLAKL1Caenorhabditis elegans
V87VAIKKVLQDKR5Homo sapiens, Arabidopsis thaliana, Caenorhabditis elegans, Mus musculus, Rattus norvegicus
Y134NLVLDYVPETV3Homo sapiens, Mus musculus, Rattus norvegicus
Y134NLVLEYVPETV1Arabidopsis thaliana
Y134NLILEYVPETV1Caenorhabditis elegans
Y140VPETVYRVARH4Homo sapiens, Caenorhabditis elegans, Mus musculus, Rattus norvegicus
Y140VPETVYRVSKH1Arabidopsis thaliana
Y216EPNVSYICSRY4Homo sapiens, Caenorhabditis elegans, Mus musculus, Rattus norvegicus
Y216EPNISYICSRY1Arabidopsis thaliana
Y288EMNPNYTEFKF3Homo sapiens, Mus musculus, Rattus norvegicus
Y288CMNPNYTEFKF1Arabidopsis thaliana
Y288SMNPNYKEFKF1Caenorhabditis elegans


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