mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for GSTA3
Gene summary
Basic gene Info.Gene symbolGSTA3
Gene nameglutathione S-transferase alpha 3
SynonymsGSTA3-3|GTA3
CytomapUCSC genome browser: 6p12.1
Type of geneprotein-coding
RefGenesNM_000847.4,
DescriptionGST class-alpha member 3S-(hydroxyalkyl)glutathione lyase A3glutathione S-alkyltransferase A3glutathione S-aralkyltransferase A3glutathione S-aryltransferase A3glutathione S-transferase A3glutathione S-transferase A3-3
Modification date20141207
dbXrefs MIM : 605449
HGNC : HGNC
Ensembl : ENSG00000174156
HPRD : 07290
Vega : OTTHUMG00000014865
ProteinUniProt: Q16772
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_GSTA3
BioGPS: 2940
PathwayNCI Pathway Interaction Database: GSTA3
KEGG: GSTA3
REACTOME: GSTA3
Pathway Commons: GSTA3
ContextiHOP: GSTA3
ligand binding site mutation search in PubMed: GSTA3
UCL Cancer Institute: GSTA3
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID


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Ligand binding site mutations for GSTA3
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
 
: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
F220,A216K218NCOAD2
R131R131HCOAD1
R45K43TCOAD1
L107M105ISKCM1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for GSTA3
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
R131R131H-1.7004863
L107M105I-0.75237548
R45K43T-0.72027878
F220K218N-0.65559136
A216K218N-0.65559136
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for GSTA3 from PDB
PDB IDPDB titlePDB structure
1TDICrystal Structure of hGSTA3-3 in Complex with Glutathione

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Differential gene expression and gene-gene network for GSTA3
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of GSTA3 and the right PPI network was created from samples without mutations in the LBS of GSTA3. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for GSTA3
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for GSTA3
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
Approved|nutraceuticalDB00143GlutathioneSmall molecule
ExperimentalDB04521GSHNASmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of GSTA3 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
ASDANDROST-4-ENE-3,17-DIONE2vcvEA216
ASDANDROST-4-ENE-3,17-DIONE2vcvAA216 F220
ASDANDROST-4-ENE-3,17-DIONE2vcvLA216 F220
GSHGLUTATHIONATE(1-)2vcvBF220
ASDANDROST-4-ENE-3,17-DIONE2vcvFL107 A216
ASDANDROST-4-ENE-3,17-DIONE2vcvGL107 A216
ASDANDROST-4-ENE-3,17-DIONE2vcvHL107 A216
ASDANDROST-4-ENE-3,17-DIONE2vcvIL107 A216
ASDANDROST-4-ENE-3,17-DIONE2vcvBL107 A216 F220
ASDANDROST-4-ENE-3,17-DIONE2vcvDL107 A216 F220
ASDANDROST-4-ENE-3,17-DIONE2vcvKL107 A216 F220
ASDANDROST-4-ENE-3,17-DIONE2vcvPL107 A216 F220
GSHGLUTATHIONATE(1-)1tdiAR131
GSHGLUTATHIONATE(1-)1tdiBR131
GSHGLUTATHIONATE(1-)2vcvAR131
GSHGLUTATHIONATE(1-)2vcvBR131
GSHGLUTATHIONATE(1-)2vcvCR131
GSHGLUTATHIONATE(1-)2vcvDR131
GSHGLUTATHIONATE(1-)2vcvER131
GSHGLUTATHIONATE(1-)2vcvFR131
GSHGLUTATHIONATE(1-)2vcvGR131
GSHGLUTATHIONATE(1-)2vcvHR131
GSHGLUTATHIONATE(1-)2vcvIR131
GSHGLUTATHIONATE(1-)2vcvJR131
GSHGLUTATHIONATE(1-)2vcvKR131
GSHGLUTATHIONATE(1-)2vcvLR131
GSHGLUTATHIONATE(1-)2vcvMR131
GSHGLUTATHIONATE(1-)2vcvNR131
GSHGLUTATHIONATE(1-)2vcvOR131
GSHGLUTATHIONATE(1-)2vcvPR131
GSHGLUTATHIONATE(1-)1tdiAR45
GSHGLUTATHIONATE(1-)2vcvCR45
GSHGLUTATHIONATE(1-)2vcvHR45
GSHGLUTATHIONATE(1-)2vcvJR45
GSHGLUTATHIONATE(1-)2vcvNR45
GSHGLUTATHIONATE(1-)1tdiBR45 F220
GSHGLUTATHIONATE(1-)2vcvAR45 F220
GSHGLUTATHIONATE(1-)2vcvDR45 F220
GSHGLUTATHIONATE(1-)2vcvER45 F220
GSHGLUTATHIONATE(1-)2vcvFR45 F220
GSHGLUTATHIONATE(1-)2vcvGR45 F220
GSHGLUTATHIONATE(1-)2vcvIR45 F220
GSHGLUTATHIONATE(1-)2vcvKR45 F220
GSHGLUTATHIONATE(1-)2vcvLR45 F220
GSHGLUTATHIONATE(1-)2vcvMR45 F220
GSHGLUTATHIONATE(1-)2vcvOR45 F220
GSHGLUTATHIONATE(1-)2vcvPR45 F220


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Conservation information for LBS of GSTA3
Multiple alignments for Q16772 in multiple species
LBSAA sequence# speciesSpecies
A208PRKPPADAKAL1Homo sapiens
A208QRKPFDDAKCV1Mus musculus
A208QRKPFDDEKCV1Rattus norvegicus
A212PADAKALEEAR1Homo sapiens
A212FDDAKCVESAK1Mus musculus
A212FDDEKCVESAK1Rattus norvegicus
A216KCVESAKKIFS2Mus musculus, Rattus norvegicus
A216KALEEARKIFR1Homo sapiens
D101TEGMADLNEMI1Homo sapiens
D101TEGVADLEIMI1Mus musculus
D101AEGVADLELMV1Rattus norvegicus
F10PVLHYFDGRGR2Mus musculus, Rattus norvegicus
F10PKLHYFNGRGR1Homo sapiens
F220SAKKIFS-2Mus musculus, Rattus norvegicus
F220EARKIFRF1Homo sapiens
L107LNEMILLLPLC1Homo sapiens
L107LEIMILYYPHM1Mus musculus
L107LELMVLYYPYM1Rattus norvegicus
L108NEMILLLPLCR1Homo sapiens
L108EIMILYYPHMP1Mus musculus
L108ELMVLYYPYMP1Rattus norvegicus
L111ILLLPLCRPEE1Homo sapiens
L111ILYYPHMPPEE1Mus musculus
L111VLYYPYMPPGE1Rattus norvegicus
L213ADAKALEEARK1Homo sapiens
L213DDAKCVESAKK1Mus musculus
L213DDEKCVESAKK1Rattus norvegicus
P110MILLLPLCRPE1Homo sapiens
P110MILYYPHMPPE1Mus musculus
P110MVLYYPYMPPG1Rattus norvegicus
P56MFQQVPMVEID2Homo sapiens, Mus musculus
P56MFEQVPMVEID1Rattus norvegicus
Q54SLMFQQVPMVE2Homo sapiens, Mus musculus
Q54SLMFEQVPMVE1Rattus norvegicus
Q67GMKLVQTKAIL2Mus musculus, Rattus norvegicus
Q67GMKLVQTRAIL1Homo sapiens
R131EKTKSRYFPAF1Homo sapiens
R131EQTRNRYFPAF1Mus musculus
R131DKARNRYFPAY1Rattus norvegicus
R15FDGRGRMEPIR2Mus musculus, Rattus norvegicus
R15FNGRGRMEPIR1Homo sapiens
R45DLARLRSDGSL2Mus musculus, Rattus norvegicus
R45DLGKLRNDGSL1Homo sapiens
T68MKLVQTKAILN2Mus musculus, Rattus norvegicus
T68MKLVQTRAILN1Homo sapiens
V55LMFQQVPMVEI2Homo sapiens, Mus musculus
V55LMFEQVPMVEI1Rattus norvegicus
Y9KPVLHYFDGRG2Mus musculus, Rattus norvegicus
Y9KPKLHYFNGRG1Homo sapiens


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