mutLBSgeneDB |
Gene summary for GSTA3 |
Gene summary |
Basic gene Info. | Gene symbol | GSTA3 |
Gene name | glutathione S-transferase alpha 3 | |
Synonyms | GSTA3-3|GTA3 | |
Cytomap | UCSC genome browser: 6p12.1 | |
Type of gene | protein-coding | |
RefGenes | NM_000847.4, | |
Description | GST class-alpha member 3S-(hydroxyalkyl)glutathione lyase A3glutathione S-alkyltransferase A3glutathione S-aralkyltransferase A3glutathione S-aryltransferase A3glutathione S-transferase A3glutathione S-transferase A3-3 | |
Modification date | 20141207 | |
dbXrefs | MIM : 605449 | |
HGNC : HGNC | ||
Ensembl : ENSG00000174156 | ||
HPRD : 07290 | ||
Vega : OTTHUMG00000014865 | ||
Protein | UniProt: Q16772 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_GSTA3 | |
BioGPS: 2940 | ||
Pathway | NCI Pathway Interaction Database: GSTA3 | |
KEGG: GSTA3 | ||
REACTOME: GSTA3 | ||
Pathway Commons: GSTA3 | ||
Context | iHOP: GSTA3 | |
ligand binding site mutation search in PubMed: GSTA3 | ||
UCL Cancer Institute: GSTA3 | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO Term | PubMed ID |
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Ligand binding site mutations for GSTA3 |
Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.) : non-synonymous mutation on LBS, Circle size denotes number of samples. |
Cancer type specific mutLBS sorted by frequency |
LBS | AAchange of nsSNV | Cancer type | # samples | F220,A216 | K218N | COAD | 2 | R131 | R131H | COAD | 1 | R45 | K43T | COAD | 1 | L107 | M105I | SKCM | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for GSTA3 |
Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
: nsSNV at non-LBS: nsSNV at LBS |
nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | R131 | R131H | -1.7004863 | L107 | M105I | -0.75237548 | R45 | K43T | -0.72027878 | F220 | K218N | -0.65559136 | A216 | K218N | -0.65559136 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
Structure image for GSTA3 from PDB |
PDB ID | PDB title | PDB structure | 1TDI | Crystal Structure of hGSTA3-3 in Complex with Glutathione |
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Differential gene expression and gene-gene network for GSTA3 |
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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Phenotype information for GSTA3 |
Gene level disease information (DisGeNet) |
Disease ID | Disease name | # PubMed | Association type |
Mutation level pathogenic information (ClinVar annotation) |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for GSTA3 |
Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
Gene-centered drug-gene interaction network |
Drug information targeting mutLBSgene (Approved drugs only) |
Drug status | DrugBank ID | Name | Type | Drug structure |
Approved|nutraceutical | DB00143 | Glutathione | Small molecule | |
Experimental | DB04521 | GSHNA | Small molecule |
Gene-centered ligand-gene interaction network |
Ligands binding to mutated ligand binding site of GSTA3 go to BioLip |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | ASD | ANDROST-4-ENE-3,17-DIONE | 2vcv | E | A216 | ASD | ANDROST-4-ENE-3,17-DIONE | 2vcv | A | A216 F220 | ASD | ANDROST-4-ENE-3,17-DIONE | 2vcv | L | A216 F220 | GSH | GLUTATHIONATE(1-) | 2vcv | B | F220 | ASD | ANDROST-4-ENE-3,17-DIONE | 2vcv | F | L107 A216 | ASD | ANDROST-4-ENE-3,17-DIONE | 2vcv | G | L107 A216 | ASD | ANDROST-4-ENE-3,17-DIONE | 2vcv | H | L107 A216 | ASD | ANDROST-4-ENE-3,17-DIONE | 2vcv | I | L107 A216 | ASD | ANDROST-4-ENE-3,17-DIONE | 2vcv | B | L107 A216 F220 | ASD | ANDROST-4-ENE-3,17-DIONE | 2vcv | D | L107 A216 F220 | ASD | ANDROST-4-ENE-3,17-DIONE | 2vcv | K | L107 A216 F220 | ASD | ANDROST-4-ENE-3,17-DIONE | 2vcv | P | L107 A216 F220 | GSH | GLUTATHIONATE(1-) | 1tdi | A | R131 | GSH | GLUTATHIONATE(1-) | 1tdi | B | R131 | GSH | GLUTATHIONATE(1-) | 2vcv | A | R131 | GSH | GLUTATHIONATE(1-) | 2vcv | B | R131 | GSH | GLUTATHIONATE(1-) | 2vcv | C | R131 | GSH | GLUTATHIONATE(1-) | 2vcv | D | R131 | GSH | GLUTATHIONATE(1-) | 2vcv | E | R131 | GSH | GLUTATHIONATE(1-) | 2vcv | F | R131 | GSH | GLUTATHIONATE(1-) | 2vcv | G | R131 | GSH | GLUTATHIONATE(1-) | 2vcv | H | R131 | GSH | GLUTATHIONATE(1-) | 2vcv | I | R131 | GSH | GLUTATHIONATE(1-) | 2vcv | J | R131 | GSH | GLUTATHIONATE(1-) | 2vcv | K | R131 | GSH | GLUTATHIONATE(1-) | 2vcv | L | R131 | GSH | GLUTATHIONATE(1-) | 2vcv | M | R131 | GSH | GLUTATHIONATE(1-) | 2vcv | N | R131 | GSH | GLUTATHIONATE(1-) | 2vcv | O | R131 | GSH | GLUTATHIONATE(1-) | 2vcv | P | R131 | GSH | GLUTATHIONATE(1-) | 1tdi | A | R45 | GSH | GLUTATHIONATE(1-) | 2vcv | C | R45 | GSH | GLUTATHIONATE(1-) | 2vcv | H | R45 | GSH | GLUTATHIONATE(1-) | 2vcv | J | R45 | GSH | GLUTATHIONATE(1-) | 2vcv | N | R45 | GSH | GLUTATHIONATE(1-) | 1tdi | B | R45 F220 | GSH | GLUTATHIONATE(1-) | 2vcv | A | R45 F220 | GSH | GLUTATHIONATE(1-) | 2vcv | D | R45 F220 | GSH | GLUTATHIONATE(1-) | 2vcv | E | R45 F220 | GSH | GLUTATHIONATE(1-) | 2vcv | F | R45 F220 | GSH | GLUTATHIONATE(1-) | 2vcv | G | R45 F220 | GSH | GLUTATHIONATE(1-) | 2vcv | I | R45 F220 | GSH | GLUTATHIONATE(1-) | 2vcv | K | R45 F220 | GSH | GLUTATHIONATE(1-) | 2vcv | L | R45 F220 | GSH | GLUTATHIONATE(1-) | 2vcv | M | R45 F220 | GSH | GLUTATHIONATE(1-) | 2vcv | O | R45 F220 | GSH | GLUTATHIONATE(1-) | 2vcv | P | R45 F220 |
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Conservation information for LBS of GSTA3 |
Multiple alignments for Q16772 in multiple species |
LBS | AA sequence | # species | Species | A208 | PRKPPADAKAL | 1 | Homo sapiens | A208 | QRKPFDDAKCV | 1 | Mus musculus | A208 | QRKPFDDEKCV | 1 | Rattus norvegicus | A212 | PADAKALEEAR | 1 | Homo sapiens | A212 | FDDAKCVESAK | 1 | Mus musculus | A212 | FDDEKCVESAK | 1 | Rattus norvegicus | A216 | KCVESAKKIFS | 2 | Mus musculus, Rattus norvegicus | A216 | KALEEARKIFR | 1 | Homo sapiens | D101 | TEGMADLNEMI | 1 | Homo sapiens | D101 | TEGVADLEIMI | 1 | Mus musculus | D101 | AEGVADLELMV | 1 | Rattus norvegicus | F10 | PVLHYFDGRGR | 2 | Mus musculus, Rattus norvegicus | F10 | PKLHYFNGRGR | 1 | Homo sapiens | F220 | SAKKIFS- | 2 | Mus musculus, Rattus norvegicus | F220 | EARKIFRF | 1 | Homo sapiens | L107 | LNEMILLLPLC | 1 | Homo sapiens | L107 | LEIMILYYPHM | 1 | Mus musculus | L107 | LELMVLYYPYM | 1 | Rattus norvegicus | L108 | NEMILLLPLCR | 1 | Homo sapiens | L108 | EIMILYYPHMP | 1 | Mus musculus | L108 | ELMVLYYPYMP | 1 | Rattus norvegicus | L111 | ILLLPLCRPEE | 1 | Homo sapiens | L111 | ILYYPHMPPEE | 1 | Mus musculus | L111 | VLYYPYMPPGE | 1 | Rattus norvegicus | L213 | ADAKALEEARK | 1 | Homo sapiens | L213 | DDAKCVESAKK | 1 | Mus musculus | L213 | DDEKCVESAKK | 1 | Rattus norvegicus | P110 | MILLLPLCRPE | 1 | Homo sapiens | P110 | MILYYPHMPPE | 1 | Mus musculus | P110 | MVLYYPYMPPG | 1 | Rattus norvegicus | P56 | MFQQVPMVEID | 2 | Homo sapiens, Mus musculus | P56 | MFEQVPMVEID | 1 | Rattus norvegicus | Q54 | SLMFQQVPMVE | 2 | Homo sapiens, Mus musculus | Q54 | SLMFEQVPMVE | 1 | Rattus norvegicus | Q67 | GMKLVQTKAIL | 2 | Mus musculus, Rattus norvegicus | Q67 | GMKLVQTRAIL | 1 | Homo sapiens | R131 | EKTKSRYFPAF | 1 | Homo sapiens | R131 | EQTRNRYFPAF | 1 | Mus musculus | R131 | DKARNRYFPAY | 1 | Rattus norvegicus | R15 | FDGRGRMEPIR | 2 | Mus musculus, Rattus norvegicus | R15 | FNGRGRMEPIR | 1 | Homo sapiens | R45 | DLARLRSDGSL | 2 | Mus musculus, Rattus norvegicus | R45 | DLGKLRNDGSL | 1 | Homo sapiens | T68 | MKLVQTKAILN | 2 | Mus musculus, Rattus norvegicus | T68 | MKLVQTRAILN | 1 | Homo sapiens | V55 | LMFQQVPMVEI | 2 | Homo sapiens, Mus musculus | V55 | LMFEQVPMVEI | 1 | Rattus norvegicus | Y9 | KPVLHYFDGRG | 2 | Mus musculus, Rattus norvegicus | Y9 | KPKLHYFNGRG | 1 | Homo sapiens |
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