mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for GSTA4
Gene summary
Basic gene Info.Gene symbolGSTA4
Gene nameglutathione S-transferase alpha 4
CytomapUCSC genome browser: 6p12.1
Type of geneprotein-coding
DescriptionGST class-alpha member 4S-(hydroxyalkyl)glutathione lyase A4glutathione S-alkyltransferase A4glutathione S-aralkyltransferase A4glutathione S-aryltransferase A4glutathione S-transferase A4glutathione S-transferase A4-4glutathione transferase A4-4
Modification date20141207
dbXrefs MIM : 605450
Ensembl : ENSG00000170899
HPRD : 06899
Vega : OTTHUMG00000014868
ProteinUniProt: O15217
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_GSTA4
BioGPS: 2941
PathwayNCI Pathway Interaction Database: GSTA4
Pathway Commons: GSTA4
ContextiHOP: GSTA4
ligand binding site mutation search in PubMed: GSTA4
UCL Cancer Institute: GSTA4
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO:0006749glutathione metabolic process10329152
GO:0006805xenobiotic metabolic process10329152

Ligand binding site mutations for GSTA4
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for GSTA4
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for GSTA4 from PDB

Differential gene expression and gene-gene network for GSTA4
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of GSTA4 and the right PPI network was created from samples without mutations in the LBS of GSTA4. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for GSTA4
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0030567Parkinson Disease2Biomarker, GeneticVariation
umls:C0003850Arteriosclerosis2Biomarker, Therapeutic
umls:C0032927Precancerous Conditions1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for GSTA4
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
Approved|nutraceuticalDB00143GlutathioneSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of GSTA4 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
IIIPeptide ligand (GGL,CYS,GLY)1gulAQ45
IIIPeptide ligand (GGL,CYS,GLY)1gulBQ45
IIIPeptide ligand (GGL,CYS,GLY)1gulCQ45
IIIPeptide ligand (GGL,CYS,GLY)1gulDQ45
IIIPeptide ligand (GGL,CYS,GLY)1gulEQ45
IIIPeptide ligand (GGL,CYS,GLY)1gulFQ45
IIIPeptide ligand (GGL,CYS,GLY)1gulGQ45
IIIPeptide ligand (GGL,CYS,GLY)1gulHQ45

Conservation information for LBS of GSTA4
Multiple alignments for O15217 in multiple species
LBSAA sequence# speciesSpecies

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