mutLBSgeneDB |
Gene summary for HK2 |
Gene summary |
Basic gene Info. | Gene symbol | HK2 |
Gene name | hexokinase 2 | |
Synonyms | HKII|HXK2 | |
Cytomap | UCSC genome browser: 2p13 | |
Type of gene | protein-coding | |
RefGenes | NM_000189.4, | |
Description | HK IIhexokinase type IIhexokinase-2hexokinase-2, musclemuscle form hexokinase | |
Modification date | 20141207 | |
dbXrefs | MIM : 601125 | |
HGNC : HGNC | ||
Ensembl : ENSG00000159399 | ||
HPRD : 03080 | ||
Vega : OTTHUMG00000129972 | ||
Protein | UniProt: P52789 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_HK2 | |
BioGPS: 3099 | ||
Pathway | NCI Pathway Interaction Database: HK2 | |
KEGG: HK2 | ||
REACTOME: HK2 | ||
Pathway Commons: HK2 | ||
Context | iHOP: HK2 | |
ligand binding site mutation search in PubMed: HK2 | ||
UCL Cancer Institute: HK2 | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO Term | PubMed ID | GO:0008637 | apoptotic mitochondrial changes | 18350175 |
Top |
Ligand binding site mutations for HK2 |
Cancer type specific mutLBS sorted by frequency |
LBS | AAchange of nsSNV | Cancer type | # samples | P157 | H159Y | BRCA | 1 | D861 | D861Y | COAD | 1 | P157 | P157L | SKCM | 1 | N235 | A236T | STAD | 1 | I229 | I229T | STAD | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
Top |
Protein structure related information for HK2 |
Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
: nsSNV at non-LBS: nsSNV at LBS |
nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | D861 | D861Y | 0.27491011 | I229 | I229T | -1.1066315 | N235 | A236T | -0.55471408 | P157 | P157L | -0.49758909 | P157 | H159Y | -0.46952274 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
Structure image for HK2 from PDB |
Top |
Differential gene expression and gene-gene network for HK2 |
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
Top |
Top |
Phenotype information for HK2 |
Gene level disease information (DisGeNet) |
Disease ID | Disease name | # PubMed | Association type |
umls:C0028754 | Obesity | 4 | Biomarker |
umls:C0151744 | Myocardial Ischemia | 1 | Biomarker |
Mutation level pathogenic information (ClinVar annotation) |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
Top |
Pharmacological information for HK2 |
Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
Drug information targeting mutLBSgene (Approved drugs only) |
Drug status | DrugBank ID | Name | Type | Drug structure |
Gene-centered ligand-gene interaction network |
Ligands binding to mutated ligand binding site of HK2 go to BioLip |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | BG6 | BETA-D-GLUCOSE 6-PHOSPHATE | 2nzt | A | D861 | BG6 | BETA-D-GLUCOSE 6-PHOSPHATE | 2nzt | B | D861 | BG6 | BETA-D-GLUCOSE 6-PHOSPHATE | 2nzt | A | I229 | BG6 | BETA-D-GLUCOSE 6-PHOSPHATE | 2nzt | B | I229 | GLC | ALPHA-D-GLUCOSE | 2nzt | A | P157 I229 N235 | GLC | ALPHA-D-GLUCOSE | 2nzt | B | P157 I229 N235 |
Top |
Conservation information for LBS of HK2 |
Multiple alignments for P52789 in multiple species |
LBS | AA sequence | # species | Species | D209 | VAVVNDTVGTM | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | D413 | STIGVDGSVYK | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | D84 | EFLALDLGGTN | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | D861 | VTVGVDGTLYK | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | E260 | MCINMEWGAFG | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | E294 | GKQLFEKMISG | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | F156 | GFTFSFPCHQT | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | G231 | IGLIVGTGSNA | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | G233 | LIVGTGSNACY | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | G414 | TIGVDGSVYKK | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | G448 | LRSEDGSGKGA | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | G862 | TVGVDGTLYKL | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | G87 | ALDLGGTNFRV | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | I229 | CEIGLIVGTGS | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | K173 | LVSWTKGFKSS | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | N208 | IVAVVNDTVGT | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | N235 | VGTGSNACYME | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | P157 | FTFSFPCHQTK | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | Q291 | LNPGKQLFEKM | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | S155 | LGFTFSFPCHQ | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | S234 | IVGTGSNACYM | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | S415 | IGVDGSVYKKH | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | S449 | RSEDGSGKGAA | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | S603 | LGFTFSFPCQQ | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | T153 | LPLGFTFSFPC | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | T172 | FLVSWTKGFKS | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | T210 | AVVNDTVGTMM | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | T232 | GLIVGTGSNAC | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | T863 | VGVDGTLYKLH | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | T88 | LDLGGTNFRVL | 3 | Homo sapiens, Mus musculus, Rattus norvegicus |
Copyright © 2016-Present - The University of Texas Health Science Center at Houston |