mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for HMOX1
Gene summary
Basic gene Info.Gene symbolHMOX1
Gene nameheme oxygenase (decycling) 1
SynonymsHMOX1D|HO-1|HSP32|bK286B10
CytomapUCSC genome browser: 22q13.1
Type of geneprotein-coding
RefGenesNM_002133.2,
Descriptionheat shock protein, 32-kDheme oxygenase 1
Modification date20141222
dbXrefs MIM : 141250
HGNC : HGNC
Ensembl : ENSG00000100292
HPRD : 00782
Vega : OTTHUMG00000150960
ProteinUniProt: P09601
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_HMOX1
BioGPS: 3162
PathwayNCI Pathway Interaction Database: HMOX1
KEGG: HMOX1
REACTOME: HMOX1
Pathway Commons: HMOX1
ContextiHOP: HMOX1
ligand binding site mutation search in PubMed: HMOX1
UCL Cancer Institute: HMOX1
Assigned class in mutLBSgeneDBB: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0006788heme oxidation17915953
GO:0035094response to nicotine18205746
GO:0042167heme catabolic process17915953
GO:0048661positive regulation of smooth muscle cell proliferation17600318
GO:0048662negative regulation of smooth muscle cell proliferation17600318
GO:0051260protein homooligomerization19556236
GO:0055072iron ion homeostasis17915953


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Ligand binding site mutations for HMOX1
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
 : non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
R183R185CSKCM1
A206A206VUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for HMOX1
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
A206A206V0.19171299
R183R185C-1.0653565
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for HMOX1 from PDB

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Differential gene expression and gene-gene network for HMOX1
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of HMOX1 and the right PPI network was created from samples without mutations in the LBS of HMOX1. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for HMOX1
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0022116Ischemia19Biomarker, Therapeutic
umls:C1956346Coronary Artery Disease17AlteredExpression, Biomarker, GeneticVariation
umls:C0020538Hypertension14Biomarker, GeneticVariation, Therapeutic
umls:C0024117Pulmonary Disease, Chronic Obstructive12Biomarker, GeneticVariation
umls:C0002395Alzheimer Disease11AlteredExpression, Biomarker, GeneticVariation
umls:C0011860Diabetes Mellitus, Type 211Biomarker, GeneticVariation, Therapeutic
umls:C0035126Reperfusion Injury9AlteredExpression, Biomarker, Therapeutic
umls:C0023903Liver Neoplasms8Biomarker, Therapeutic
umls:C0021368Inflammation7AlteredExpression, Biomarker
umls:C0524851Neurodegenerative Diseases7Biomarker
umls:C0009319Colitis6Biomarker, Therapeutic
umls:C0030567Parkinson Disease6AlteredExpression, Biomarker, GeneticVariation
umls:C0023895Liver Diseases6Biomarker, Therapeutic
umls:C0011853Diabetes Mellitus, Experimental5Biomarker, Therapeutic
umls:C0028754Obesity5Biomarker, GeneticVariation
umls:C0151744Myocardial Ischemia4Biomarker, GeneticVariation
umls:C0004096Asthma4Biomarker, GeneticVariation
umls:C0023893Liver Cirrhosis, Experimental3Biomarker, Therapeutic
umls:C0017661Glomerulonephritis, IGA3Biomarker, GeneticVariation
umls:C1458155Breast Neoplasms3AlteredExpression, Biomarker, GeneticVariation
umls:C0034067Pulmonary Emphysema3Biomarker
umls:C0018801Heart Failure3Biomarker
umls:C0038356Stomach Neoplasms2Biomarker, GeneticVariation
umls:C0032285Pneumonia2Biomarker, GeneticVariation
umls:C0016059Fibrosis2AlteredExpression, Therapeutic
umls:C0020507Hyperplasia2Biomarker, Therapeutic
umls:C0043251Wounds and Injuries2Biomarker
umls:C0011875Diabetic Angiopathies2GeneticVariation, Therapeutic
umls:C0007273Carotid Artery Diseases2Biomarker
umls:C0034069Pulmonary Fibrosis2Biomarker
umls:C0860207Drug-Induced Liver Injury2Biomarker, Therapeutic
umls:C0021655Insulin Resistance2Biomarker, Therapeutic
umls:C0024121Lung Neoplasms2Biomarker
umls:C0038220Status Epilepticus1Biomarker
umls:C0019212Hepatorenal Syndrome1Biomarker
umls:C2609414Acute Kidney Injury1Therapeutic
umls:C0162309Adrenoleukodystrophy1Biomarker
umls:C0002878Anemia, Hemolytic1Biomarker
umls:C0005779Blood Coagulation Disorders1Biomarker
umls:C0018800Cardiomegaly1Therapeutic
umls:C2937358Cerebral Hemorrhage1Biomarker
umls:C3658338Drug-Related Side Effects and Adverse Reactions1Biomarker
umls:C0152020Gastroparesis1Therapeutic
umls:C0018273Growth Disorders1Biomarker
umls:C0019158Hepatitis1Therapeutic
umls:C0020459Hyperinsulinism1Therapeutic
umls:C0012715Iron Metabolism Disorders1Biomarker
umls:C0023186Learning Disorders1Biomarker
umls:C0273115Lung Injury1Biomarker
umls:C0024668Mammary Neoplasms, Experimental1Therapeutic
umls:C0221013Mastocytosis, Systemic1Biomarker
umls:C0030286Pancreatic Diseases1Therapeutic
umls:C0032914Pre-Eclampsia1Biomarker
umls:C1846707Spinocerebellar Ataxia 171Biomarker
umls:C0040053Thrombosis1Therapeutic
umls:C0178324Vascular System Injuries1Therapeutic

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for HMOX1
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
NutraceuticalDB00157NADHSmall molecule
ExperimentalDB01942Formic AcidSmall molecule
ExperimentalDB02073Biliverdine Ix AlphaSmall molecule
ExperimentalDB0246812-PhenylhemeSmall molecule
ExperimentalDB039062-PhenylhemeSmall molecule
ExperimentalDB04803VerdohemeSmall molecule
InvestigationalDB04912StannsoporfinSmall molecule
ExperimentalDB069141-({2-[2-(4-CHLOROPHENYL)ETHYL]-1,3-DIOXOLAN-2-YL}METHYL)-1H-IMIDAZOLESmall molecule
ExperimentalDB073421-(adamantan-1-yl)-2-(1H-imidazol-1-yl)ethanoneSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of HMOX1 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
BLABILIVERDIN1s8cAA206
HEMHEME B1n45AR183
HEMHEME B1n45BR183
HEMHEME B1oykAR183
HEMHEME B1oykBR183
HEMHEME B1oylAR183
HEMHEME B1oylBR183
HEMHEME B1ozeAR183
HEMHEME B1ozeBR183
HEMHEME B1ozlAR183
HEMHEME B1ozlBR183
HEMHEME B1ozrAR183
HEMHEME B1ozrBR183
HEMHEME B1ozwAR183
HEMHEME B1ozwBR183
2FH2-PHENYLHEME1s13AR183
2FH2-PHENYLHEME1s13BR183
1FH12-PHENYLHEME1t5pAR183
1FH12-PHENYLHEME1t5pBR183
VERVERDOHEME1twnAR183
VERVERDOHEME1twnBR183
VERVERDOHEME1twrAR183
HEMHEME B1xjzAR183
HEMHEME B1xjzBR183
HEMHEME B3czyAR183
HEMHEME B3czyBR183
HEMHEME B3hokAR183
HEMHEME B3hokBR183
HEMHEME B3k4fAR183
HEMHEME B3k4fBR183
HEMHEME B3tgmAR183
HEMHEME B3tgmBR183
HEMHEME B4wd4AR183
HEMHEME B4wd4BR183
HEMHEME B4wd4CR183


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Conservation information for LBS of HMOX1
Multiple alignments for P09601 in multiple species
LBSAA sequence# speciesSpecies
A206EEAKTAFLLNI3Homo sapiens, Mus musculus, Rattus norvegicus
A206EEAKKAFLLNI1Gallus gallus
A206DEAKTAFLLNI1Bos taurus
A28EVHTQAENAEF2Homo sapiens, Bos taurus
A28EVHEQAENTPF1Gallus gallus
A28EVHIQAENAEF1Mus musculus
A28EVHIRAENSEF1Rattus norvegicus
A31TQAENAEFMRN1Homo sapiens
A31EQAENTPFMKN1Gallus gallus
A31IQAENAEFMKN1Mus musculus
A31IRAENSEFMRN1Rattus norvegicus
A31TQAENAEFMKN1Bos taurus
D140TRYLGDLSGGQ5Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
E25Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
E215NIQLFEELQEL1Homo sapiens
E215NIQVFEALQKL1Gallus gallus
E215NIELFEELQVM1Mus musculus
E215NIELFEELQAL1Rattus norvegicus
E215NIQLFEELQGL1Bos taurus
E29VHTQAENAEFM2Homo sapiens, Bos taurus
E29VHEQAENTPFM1Gallus gallus
E29VHIQAENAEFM1Mus musculus
E29VHIRAENSEFM1Rattus norvegicus
E32QAENAEFMKNF2Mus musculus, Bos taurus
E32QAENAEFMRNF1Homo sapiens
E32QAENTPFMKNF1Gallus gallus
E32RAENSEFMRNF1Rattus norvegicus
F166GEGLAFFTFPN3Homo sapiens, Mus musculus, Bos taurus
F166GEGLAFFTFDG1Gallus gallus
F166GEGLAFFTFPS1Rattus norvegicus
F167EGLAFFTFPNI3Homo sapiens, Mus musculus, Bos taurus
F167EGLAFFTFDGV1Gallus gallus
F167EGLAFFTFPSI1Rattus norvegicus
F207EAKTAFLLNIQ2Homo sapiens, Bos taurus
F207EAKTAFLLNIE2Mus musculus, Rattus norvegicus
F207EAKKAFLLNIQ1Gallus gallus
F214LNIQLFEELQE1Homo sapiens
F214LNIQVFEALQK1Gallus gallus
F214LNIELFEELQV1Mus musculus
F214LNIELFEELQA1Rattus norvegicus
F214LNIQLFEELQG1Bos taurus
F37EFMRNFQKGQV2Homo sapiens, Rattus norvegicus
F37PFMKNFQKGQV1Gallus gallus
F37EFMKNFQKGQV1Mus musculus
F37EFMKNFQKGEL1Bos taurus
F47VSREGFKLVMA2Mus musculus, Rattus norvegicus
F47VTRDGFKLVMA1Homo sapiens
F47VSLHEFKLVTA1Gallus gallus
F47LTQEGFKLVMA1Bos taurus
G139YTRYLGDLSGG5Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
G143LGDLSGGQVLK5Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
G144GDLSGGQVLKK5Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
H25ATKEVHTQAEN2Homo sapiens, Bos taurus
H25ATKEVHEQAEN1Gallus gallus
H25ATKEVHIQAEN1Mus musculus
H25ATKEVHIRAEN1Rattus norvegicus
I57ASLYHIYVALE2Homo sapiens, Bos taurus
I57ASLYHIYTALE2Mus musculus, Rattus norvegicus
I57ASLYFIYSALE1Gallus gallus
K179SATKFKQLYRS2Homo sapiens, Bos taurus
K179NATKFKQLYRS1Gallus gallus
K179SPTKFKQLYRA1Mus musculus
K179NPTKFKQLYRA1Rattus norvegicus
K18LSEALKEATKE4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
K18LSELLKEATKE1Gallus gallus
L138AYTRYLGDLSG5Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
L147SGGQVLKKIAQ5Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
L213LLNIQLFEELQ2Homo sapiens, Bos taurus
L213LLNIELFEELQ2Mus musculus, Rattus norvegicus
L213LLNIQVFEALQ1Gallus gallus
L217QLFEELQELLT1Homo sapiens
L217QVFEALQKLVS1Gallus gallus
L217ELFEELQVMLT1Mus musculus
L217ELFEELQALLT1Rattus norvegicus
L217QLFEELQGLLT1Bos taurus
L54LVMASLYHIYV2Homo sapiens, Bos taurus
L54LVMASLYHIYT2Mus musculus, Rattus norvegicus
L54LVTASLYFIYS1Gallus gallus
M34ENAEFMKNFQK2Mus musculus, Bos taurus
M34ENAEFMRNFQK1Homo sapiens
M34ENTPFMKNFQK1Gallus gallus
M34ENSEFMRNFQK1Rattus norvegicus
M9D---SMPQDLS2Homo sapiens, Mus musculus
M9HNAESMSQDLS1Gallus gallus
M9D---SMSQDLS1Rattus norvegicus
M9DS--SMPQDLS1Bos taurus
N210TAFLLNIQLFE2Homo sapiens, Bos taurus
N210TAFLLNIELFE2Mus musculus, Rattus norvegicus
N210KAFLLNIQVFE1Gallus gallus
P45Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
Q11--SMPQDLSEA3Homo sapiens, Mus musculus, Bos taurus
Q11AESMSQDLSEL1Gallus gallus
Q11--SMSQDLSEA1Rattus norvegicus
Q27KEVHTQAENAE2Homo sapiens, Bos taurus
Q27KEVHEQAENTP1Gallus gallus
Q27KEVHIQAENAE1Mus musculus
Q27KEVHIRAENSE1Rattus norvegicus
Q38FMKNFQKGQVS2Gallus gallus, Mus musculus
Q38FMRNFQKGQVT1Homo sapiens
Q38FMRNFQKGQVS1Rattus norvegicus
Q38FMKNFQKGELT1Bos taurus
Q55Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
R136AHAYTRYLGDL5Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
R183FKQLYRARMNT2Mus musculus, Rattus norvegicus
R183FKQLYRSRMNS1Homo sapiens
R183FKQLYRSRMNA1Gallus gallus
R183FKQLYRSRMNT1Bos taurus
R35NAEFMKNFQKG2Mus musculus, Bos taurus
R35NAEFMRNFQKG1Homo sapiens
R35NTPFMKNFQKG1Gallus gallus
R35NSEFMRNFQKG1Rattus norvegicus
S142YLGDLSGGQVL5Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
S53KLVMASLYHIY4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
S53KLVTASLYFIY1Gallus gallus
S8PD---SMPQDL2Homo sapiens, Mus musculus
S8PHNAESMSQDL1Gallus gallus
S8LD---SMSQDL1Rattus norvegicus
S8PDS--SMPQDL1Bos taurus
T135VAHAYTRYLGD5Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
V146LSGGQVLKKIA5Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
V50EGFKLVMASLY3Mus musculus, Rattus norvegicus, Bos taurus
V50DGFKLVMASLY1Homo sapiens
V50HEFKLVTASLY1Gallus gallus
Y134LVAHAYTRYLG5Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus


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