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mutLBSgeneDB |
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| Gene summary for HNRNPA1 |
 Gene summary |
| Basic gene Info. | Gene symbol | HNRNPA1 |
| Gene name | heterogeneous nuclear ribonucleoprotein A1 | |
| Synonyms | ALS19|ALS20|HNRPA1|HNRPA1L3|IBMPFD3|hnRNP A1|hnRNP-A1 | |
| Cytomap | UCSC genome browser: 12q13.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_002136.2, NM_031157.2, | |
| Description | Putative heterogeneous nuclear ribonucleoprotein A1-like 3helix-destabilizing proteinheterogeneous nuclear ribonucleoprotein A1B proteinheterogeneous nuclear ribonucleoprotein B2 proteinheterogeneous nuclear ribonucleoprotein core protein A1hnRNP A1- | |
| Modification date | 20141222 | |
| dbXrefs | MIM : 164017 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000135486 | ||
| HPRD : 01242 | ||
| Vega : OTTHUMG00000169702 | ||
| Protein | UniProt: P09651 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_HNRNPA1 | |
| BioGPS: 3178 | ||
| Pathway | NCI Pathway Interaction Database: HNRNPA1 | |
| KEGG: HNRNPA1 | ||
| REACTOME: HNRNPA1 | ||
| Pathway Commons: HNRNPA1 | ||
| Context | iHOP: HNRNPA1 | |
| ligand binding site mutation search in PubMed: HNRNPA1 | ||
| UCL Cancer Institute: HNRNPA1 | ||
| Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0051168 | nuclear export | 8521471 | GO:0051170 | nuclear import | 8521471 |
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| Ligand binding site mutations for HNRNPA1 |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | R55 | S54C | BLCA | 1 | D42 | D42N | COAD | 1 | F59 | V60L | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for HNRNPA1 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | F59 | V60L | 0.12933986 | D42 | D42N | -1.1486889 | R55 | S54C | -0.85843172 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for HNRNPA1 from PDB |
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| Differential gene expression and gene-gene network for HNRNPA1 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for HNRNPA1 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C0007097 | Carcinoma | 1 | Biomarker |
| umls:C0024667 | Mammary Neoplasms, Animal | 1 | Biomarker |
| umls:C0024668 | Mammary Neoplasms, Experimental | 1 | Biomarker |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for HNRNPA1 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Gene-centered drug-gene interaction network |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of HNRNPA1 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | NUC | Nucleic Acids | 1pgz | A | D42 R55 F59 | NUC | Nucleic Acids | 1po6 | A | D42 R55 F59 | NUC | Nucleic Acids | 1u1k | A | D42 R55 F59 | NUC | Nucleic Acids | 1u1l | A | D42 R55 F59 | NUC | Nucleic Acids | 1u1m | A | D42 R55 F59 | NUC | Nucleic Acids | 1u1n | A | D42 R55 F59 | NUC | Nucleic Acids | 1u1o | A | D42 R55 F59 | NUC | Nucleic Acids | 1u1p | A | D42 R55 F59 | NUC | Nucleic Acids | 1u1q | A | D42 R55 F59 | NUC | Nucleic Acids | 1u1r | A | D42 R55 F59 | NUC | Nucleic Acids | 2up1 | A | D42 R55 F59 | NUC | Nucleic Acids | 4yoe | A | R55 F59 |
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| Conservation information for LBS of HNRNPA1 |
| Multiple alignments for P09651 in multiple species |
| LBS | AA sequence | # species | Species | A89 | VEPKRAVSRED | 7 | Homo sapiens, Macaca mulatta, Pan troglodytes, Pan troglodytes, Pan troglodytes, Bos taurus, Rattus norvegicus | D42 | WGTLTDCVVMR | 7 | Homo sapiens, Macaca mulatta, Pan troglodytes, Pan troglodytes, Pan troglodytes, Bos taurus, Rattus norvegicus | E85 | DGRVVEPKRAV | 7 | Homo sapiens, Macaca mulatta, Pan troglodytes, Pan troglodytes, Pan troglodytes, Bos taurus, Rattus norvegicus | F17 | QLRKLFIGGLS | 7 | Homo sapiens, Macaca mulatta, Pan troglodytes, Pan troglodytes, Pan troglodytes, Bos taurus, Rattus norvegicus | F57 | KRSRGFGFVTY | 7 | Homo sapiens, Macaca mulatta, Pan troglodytes, Pan troglodytes, Pan troglodytes, Bos taurus, Rattus norvegicus | F59 | SRGFGFVTYAT | 7 | Homo sapiens, Macaca mulatta, Pan troglodytes, Pan troglodytes, Pan troglodytes, Bos taurus, Rattus norvegicus | G19 | RKLFIGGLSFE | 7 | Homo sapiens, Macaca mulatta, Pan troglodytes, Pan troglodytes, Pan troglodytes, Bos taurus, Rattus norvegicus | G20 | KLFIGGLSFET | 7 | Homo sapiens, Macaca mulatta, Pan troglodytes, Pan troglodytes, Pan troglodytes, Bos taurus, Rattus norvegicus | G56 | TKRSRGFGFVT | 7 | Homo sapiens, Macaca mulatta, Pan troglodytes, Pan troglodytes, Pan troglodytes, Bos taurus, Rattus norvegicus | H101 | QRPGAHLTVKK | 7 | Homo sapiens, Macaca mulatta, Pan troglodytes, Pan troglodytes, Pan troglodytes, Bos taurus, Rattus norvegicus | K15 | PEQLRKLFIGG | 7 | Homo sapiens, Macaca mulatta, Pan troglodytes, Pan troglodytes, Pan troglodytes, Bos taurus, Rattus norvegicus | K87 | RVVEPKRAVSR | 7 | Homo sapiens, Macaca mulatta, Pan troglodytes, Pan troglodytes, Pan troglodytes, Bos taurus, Rattus norvegicus | M46 | TDCVVMRDPNT | 7 | Homo sapiens, Macaca mulatta, Pan troglodytes, Pan troglodytes, Pan troglodytes, Bos taurus, Rattus norvegicus | Q12 | PKEPEQLRKLF | 7 | Homo sapiens, Macaca mulatta, Pan troglodytes, Pan troglodytes, Pan troglodytes, Bos taurus, Rattus norvegicus | R55 | NTKRSRGFGFV | 7 | Homo sapiens, Macaca mulatta, Pan troglodytes, Pan troglodytes, Pan troglodytes, Bos taurus, Rattus norvegicus | R82 | HKVDGRVVEPK | 7 | Homo sapiens, Macaca mulatta, Pan troglodytes, Pan troglodytes, Pan troglodytes, Bos taurus, Rattus norvegicus | R88 | VVEPKRAVSRE | 7 | Homo sapiens, Macaca mulatta, Pan troglodytes, Pan troglodytes, Pan troglodytes, Bos taurus, Rattus norvegicus | R92 | KRAVSREDSQR | 7 | Homo sapiens, Macaca mulatta, Pan troglodytes, Pan troglodytes, Pan troglodytes, Bos taurus, Rattus norvegicus | S91 | PKRAVSREDSQ | 7 | Homo sapiens, Macaca mulatta, Pan troglodytes, Pan troglodytes, Pan troglodytes, Bos taurus, Rattus norvegicus | S95 | VSREDSQRPGA | 7 | Homo sapiens, Macaca mulatta, Pan troglodytes, Pan troglodytes, Pan troglodytes, Bos taurus, Rattus norvegicus | V44 | TLTDCVVMRDP | 7 | Homo sapiens, Macaca mulatta, Pan troglodytes, Pan troglodytes, Pan troglodytes, Bos taurus, Rattus norvegicus | V90 | EPKRAVSREDS | 7 | Homo sapiens, Macaca mulatta, Pan troglodytes, Pan troglodytes, Pan troglodytes, Bos taurus, Rattus norvegicus |
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