mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for HOXC9
Gene summary
Basic gene Info.Gene symbolHOXC9
Gene namehomeobox C9
SynonymsHOX3|HOX3B
CytomapUCSC genome browser: 12q13.3
Type of geneprotein-coding
RefGenesNM_006897.1,
Descriptionhomeo box C9homeobox protein Hox-3Bhomeobox protein Hox-C9
Modification date20141207
dbXrefs MIM : 142971
HGNC : HGNC
Ensembl : ENSG00000180806
HPRD : 00857
Vega : OTTHUMG00000160033
ProteinUniProt: P31274
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_HOXC9
BioGPS: 3225
PathwayNCI Pathway Interaction Database: HOXC9
KEGG: HOXC9
REACTOME: HOXC9
Pathway Commons: HOXC9
ContextiHOP: HOXC9
ligand binding site mutation search in PubMed: HOXC9
UCL Cancer Institute: HOXC9
Assigned class in mutLBSgeneDBB: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID


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Ligand binding site mutations for HOXC9

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
R234R234WCOAD1
R196R196CCOAD1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for HOXC9
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
R234R234W-1.0170059
R196R196C-0.95339857
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for HOXC9 from PDB

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Differential gene expression and gene-gene network for HOXC9
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of HOXC9 and the right PPI network was created from samples without mutations in the LBS of HOXC9. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for HOXC9
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for HOXC9
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of HOXC9 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS


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Conservation information for LBS of HOXC9
Multiple alignments for P31274 in multiple species
LBSAA sequence# speciesSpecies


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