mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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	Gene Summary
	Ligand Binding Site Mutation Information
	Protein Structure Related Information
	Gene Expression and Gene-Gene Network
	Phenotype Information
	Pharmacological Information
	Conservation Information for LBS

Gene summary for HSD17B4

Gene summary

Basic gene Info.	Gene symbol	HSD17B4
	Gene name	hydroxysteroid (17-beta) dehydrogenase 4
	Synonyms	DBP\|MFE-2\|MPF-2\|PRLTS1\|SDR8C1
	Cytomap	UCSC genome browser: 5q21
	Type of gene	protein-coding
	RefGenes	NM_001199291.2, NM_001292027.1,NM_001292028.1,NM_000414.3,NM_001199292.1,
	Description	17-beta-HSD 417-beta-HSD IV17-beta-hydroxysteroid dehydrogenase 417beta-estradiol dehydrogenase type IV3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydrataseD-3-hydroxyacyl-CoA dehydrataseD-bifunctional protein, peroxisomalbeta-h
	Modification date	20141207
dbXrefs	MIM : 601860
	HGNC : HGNC
	Ensembl : ENSG00000133835
	HPRD : 03514
	Vega : OTTHUMG00000128899
Protein	UniProt: P51659 go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_HSD17B4
	BioGPS: 3295
Pathway	NCI Pathway Interaction Database: HSD17B4
	KEGG: HSD17B4
	REACTOME: HSD17B4
	Pathway Commons: HSD17B4
Context	iHOP: HSD17B4
	ligand binding site mutation search in PubMed: HSD17B4
	UCL Cancer Institute: HSD17B4
Assigned class in mutLBSgeneDB	C: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

GO ID	GO Term	PubMed ID
GO:0001649	osteoblast differentiation	16210410
GO:0006635	fatty acid beta-oxidation	10400999
GO:0008152	metabolic process	9089413
GO:0008209	androgen metabolic process	7487879
GO:0008210	estrogen metabolic process	7487879
GO:0036111	very long-chain fatty-acyl-CoA metabolic process	9482850
GO:0036112	medium-chain fatty-acyl-CoA metabolic process	9089413
GO:0055114	oxidation-reduction process	9089413

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Ligand binding site mutations for HSD17B4

Cancer type specific mutLBS sorted by frequency

LBS	AAchange of nsSNV	Cancer type	# samples
A196	A196G	BRCA	1
H123	H123Y	SKCM	1
W652	H653Y	UCEC	1
F695	E693A	UCEC	1
V122	R121K	UCEC	1
L730	I729V	UCEC	1
V122	R121I	UCEC	1

cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

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Protein structure related information for HSD17B4

Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
(ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)

: nsSNV at non-LBS

: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.

LBS	AAchange of nsSNV	Relative stability change
F695	E693A	-1.6209907
L730	I729V	-1.3885674
V122	R121K	-0.73629955
W652	H653Y	-0.34587995
V122	R121I	-0.33241025
A196	A196G	-0.28826226
H123	H123Y	-0.25963493

(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for HSD17B4 from PDB

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Differential gene expression and gene-gene network for HSD17B4

Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)

* Left PPI network was created from samples with mutations in the LBS of HSD17B4 and the right PPI network was created from samples without mutations in the LBS of HSD17B4. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.

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Phenotype information for HSD17B4

Gene level disease information (DisGeNet)

Disease ID	Disease name	# PubMed	Association type
umls:C0282528	Peroxisomal Disorders	4	Biomarker
umls:C0685838	Gonadal dysgenesis XX type deafness	3	Biomarker, GeneticVariation
umls:C0043459	Zellweger Syndrome	3	Biomarker
umls:C0037769	Spasms, Infantile	1	Biomarker

Mutation level pathogenic information (ClinVar annotation)

Allele ID

AA change

Clinical significance

Origin

Phenotype IDs

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Pharmacological information for HSD17B4

Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network

Drug information targeting mutLBSgene (Approved drugs only)

Drug status	DrugBank ID	Name	Type	Drug structure
Nutraceutical	DB00157	NADH	Small molecule
Experimental	DB03192	3r-Hydroxydecanoyl-Coa	Small molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of HSD17B4 go to BioLip

Ligand ID	Ligand short name	Ligand long name	PDB ID	PDB name	mutLBS
NAD		NAD ZWITTERION	1zbq	A	H123 A196
NAD		NAD ZWITTERION	1zbq	C	H123 A196
NAD		NAD ZWITTERION	1zbq	E	H123 A196
NAD		NAD ZWITTERION	1zbq	B	V122 H123 A196
NAD		NAD ZWITTERION	1zbq	D	V122 H123 A196
NAD		NAD ZWITTERION	1zbq	F	V122 H123 A196

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Conservation information for LBS of HSD17B4

Multiple alignments for P51659 in multiple species

LBS	AA sequence	# species	Species
A100	VVVNNAGILRD	3	Homo sapiens, Mus musculus, Rattus norvegicus
A100	-----------	1	Arabidopsis thaliana
A100	ILVNNAGILRD	1	Drosophila melanogaster
A100	VLINNAGILRD	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A100	ILINNAGILRD	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
A19	VTGAGGGLGRA	2	Mus musculus, Rattus norvegicus
A19	VTGAGAGLGRA	1	Homo sapiens
A19	-----------	1	Arabidopsis thaliana
A19	VTGAGAGLGRE	1	Drosophila melanogaster
A19	ITGAGGGLGKV	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A19	VTGAGGGLGKA	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
A196	TIAPNAGSRMT	3	Homo sapiens, Mus musculus, Rattus norvegicus
A196	-----------	1	Arabidopsis thaliana
A196	VIVPTAASRMT	1	Drosophila melanogaster
A196	SIAPLARSRMT	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A196	VIAPIAASRMT	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
D40	LVVVNDLGGDF	2	Homo sapiens, Rattus norvegicus
D40	-----------	1	Arabidopsis thaliana
D40	KVVVNDLGGTH	1	Drosophila melanogaster
D40	LVIVNDLGGDF	1	Mus musculus
D40	KVVVNDLGGTL	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D40	SVVVNDLGASF	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
F695	-----------	4	Arabidopsis thaliana, Drosophila melanogaster, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
F695	LSDEDFMEVVL	1	Homo sapiens
F695	ISDEDFMEVVF	1	Mus musculus
F695	ISDEDFMEVVL	1	Rattus norvegicus
F709	-----------	4	Arabidopsis thaliana, Drosophila melanogaster, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
F709	DPQKAFFSGRL	2	Homo sapiens, Mus musculus
F709	NPQNAFFSGRL	1	Rattus norvegicus
G101	VVNNAGILRDR	3	Homo sapiens, Mus musculus, Rattus norvegicus
G101	-----------	1	Arabidopsis thaliana
G101	LVNNAGILRDR	1	Drosophila melanogaster
G101	LINNAGILRDV	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G101	LINNAGILRDI	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
G16	VVLVTGAGGGL	2	Mus musculus, Rattus norvegicus
G16	VVLVTGAGAGL	1	Homo sapiens
G16	-----------	1	Arabidopsis thaliana
G16	VAVVTGAGAGL	1	Drosophila melanogaster
G16	VVVITGAGGGL	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G16	VVVVTGAGGGL	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
G20	TGAGGGLGRAY	2	Mus musculus, Rattus norvegicus
G20	TGAGAGLGRAY	1	Homo sapiens
G20	-----------	1	Arabidopsis thaliana
G20	TGAGAGLGREY	1	Drosophila melanogaster
G20	TGAGGGLGKVY	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G20	TGAGGGLGKAY	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
H123	IIHRVHLRGSF	2	Homo sapiens, Mus musculus
H123	-----------	1	Arabidopsis thaliana
H123	LVNDVHLKGSF	1	Drosophila melanogaster
H123	IIQRVHLRGSF	1	Rattus norvegicus
H123	SVVDVHLTGGY	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H123	LIFKVHVKGSY	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
I102	VNNAGILRDRS	4	Homo sapiens, Drosophila melanogaster, Mus musculus, Rattus norvegicus
I102	-----------	1	Arabidopsis thaliana
I102	INNAGILRDVS	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I102	INNAGILRDIS	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
K168	NYSAAKLGLLG	2	Homo sapiens, Rattus norvegicus
K168	-----------	1	Arabidopsis thaliana
K168	NYTAAKMGLIG	1	Drosophila melanogaster
K168	NYSAAKLGILG	1	Mus musculus
K168	NYSAAKMGLVG	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K168	NYSAAKLGMVG	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
L21	GAGGGLGRAYA	2	Mus musculus, Rattus norvegicus
L21	GAGAGLGRAYA	1	Homo sapiens
L21	-----------	1	Arabidopsis thaliana
L21	GAGAGLGREYA	1	Drosophila melanogaster
L21	GAGGGLGKVYA	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L21	GAGGGLGKAYC	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
L41	VVVNDLGGDFK	2	Homo sapiens, Rattus norvegicus
L41	-----------	1	Arabidopsis thaliana
L41	VVVNDLGGTHS	1	Drosophila melanogaster
L41	VIVNDLGGDFK	1	Mus musculus
L41	VVVNDLGGTLG	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L41	VVVNDLGASFK	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
L730	KLQMILKDYAK	3	Homo sapiens, Mus musculus, Rattus norvegicus
L730	---------SS	1	Arabidopsis thaliana
L730	---------AK	1	Drosophila melanogaster
L730	---------SK	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L730	-----------	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
M200	NAGSRMTQTVM	1	Homo sapiens
M200	-----------	1	Arabidopsis thaliana
M200	TAASRMTEGIL	1	Drosophila melanogaster
M200	NAGSRMTETVL	1	Mus musculus
M200	NAGSRMTETVM	1	Rattus norvegicus
M200	LARSRMTENVL	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
M200	IAASRMTETVM	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
M721	-----------	4	Arabidopsis thaliana, Drosophila melanogaster, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
M721	ARGNIMLSQKL	3	Homo sapiens, Mus musculus, Rattus norvegicus
N195	NTIAPNAGSRM	3	Homo sapiens, Mus musculus, Rattus norvegicus
N195	-----------	1	Arabidopsis thaliana
N195	NVIVPTAASRM	1	Drosophila melanogaster
N195	NSIAPLARSRM	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N195	NVIAPIAASRM	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
N39	ALVVVNDLGGD	2	Homo sapiens, Rattus norvegicus
N39	AKVVVNDLGGT	2	Drosophila melanogaster, Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N39	-----------	1	Arabidopsis thaliana
N39	ALVIVNDLGGD	1	Mus musculus
N39	ASVVVNDLGAS	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
N99	DVVVNNAGILR	3	Homo sapiens, Mus musculus, Rattus norvegicus
N99	-----------	1	Arabidopsis thaliana
N99	DILVNNAGILR	1	Drosophila melanogaster
N99	DVLINNAGILR	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N99	DILINNAGILR	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
P194	CNTIAPNAGSR	3	Homo sapiens, Mus musculus, Rattus norvegicus
P194	-----------	1	Arabidopsis thaliana
P194	CNVIVPTAASR	1	Drosophila melanogaster
P194	VNSIAPLARSR	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P194	SNVIAPIAASR	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
P705	-----------	4	Arabidopsis thaliana, Drosophila melanogaster, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
P705	LGKLDPQKAFF	1	Homo sapiens
P705	FGKLDPQKAFF	1	Mus musculus
P705	LGKLNPQNAFF	1	Rattus norvegicus
Q706	-----------	4	Arabidopsis thaliana, Drosophila melanogaster, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Q706	GKLDPQKAFFS	2	Homo sapiens, Mus musculus
Q706	GKLNPQNAFFS	1	Rattus norvegicus
Q724	-----------	4	Arabidopsis thaliana, Drosophila melanogaster, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Q724	NIMLSQKLQMI	3	Homo sapiens, Mus musculus, Rattus norvegicus
Q727	-----------	4	Arabidopsis thaliana, Drosophila melanogaster, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Q727	LSQKLQMILKD	3	Homo sapiens, Mus musculus, Rattus norvegicus
R199	PNAGSRMTETV	2	Mus musculus, Rattus norvegicus
R199	PNAGSRMTQTV	1	Homo sapiens
R199	-----------	1	Arabidopsis thaliana
R199	PTAASRMTEGI	1	Drosophila melanogaster
R199	PLARSRMTENV	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R199	PIAASRMTETV	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
S150	RIIMTSSASGI	1	Homo sapiens
S150	-----------	1	Arabidopsis thaliana
S150	RIIMTSSNSGI	1	Drosophila melanogaster
S150	RILMTSSASGI	1	Mus musculus
S150	RIIMTASASGI	1	Rattus norvegicus
S150	RIINTASPAGL	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S150	RVINTASAAGL	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
S151	IIMTSSASGIY	1	Homo sapiens
S151	-----------	1	Arabidopsis thaliana
S151	IIMTSSNSGIY	1	Drosophila melanogaster
S151	ILMTSSASGIY	1	Mus musculus
S151	IIMTASASGIY	1	Rattus norvegicus
S151	IINTASPAGLF	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S151	VINTASAAGLF	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
S198	APNAGSRMTET	2	Mus musculus, Rattus norvegicus
S198	APNAGSRMTQT	1	Homo sapiens
S198	-----------	1	Arabidopsis thaliana
S198	VPTAASRMTEG	1	Drosophila melanogaster
S198	APLARSRMTEN	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S198	APIAASRMTET	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
S723	-----------	4	Arabidopsis thaliana, Drosophila melanogaster, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
S723	GNIMLSQKLQM	3	Homo sapiens, Mus musculus, Rattus norvegicus
S75	VANYDSV-EAG	2	Mus musculus, Rattus norvegicus
S75	VANYDSV-EEG	1	Homo sapiens
S75	-----------	1	Arabidopsis thaliana
S75	VADYNSV-IDG	1	Drosophila melanogaster
S75	VANYDSVNENG	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S75	VANYDSV-ENG	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
T149	GRIIMTSSASG	1	Homo sapiens
T149	-----------	1	Arabidopsis thaliana
T149	GRIIMTSSNSG	1	Drosophila melanogaster
T149	GRILMTSSASG	1	Mus musculus
T149	GRIIMTASASG	1	Rattus norvegicus
T149	GRIINTASPAG	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T149	GRVINTASAAG	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
T201	AGSRMTQTVMP	1	Homo sapiens
T201	-----------	1	Arabidopsis thaliana
T201	AASRMTEGILP	1	Drosophila melanogaster
T201	AGSRMTETVLP	1	Mus musculus
T201	AGSRMTETVMP	1	Rattus norvegicus
T201	ARSRMTENVLP	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T201	AASRMTETVMP	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
V122	DIIHRVHLRGS	2	Homo sapiens, Mus musculus
V122	N----------	1	Arabidopsis thaliana
V122	NLVNDVHLKGS	1	Drosophila melanogaster
V122	DIIQRVHLRGS	1	Rattus norvegicus
V122	ASVVDVHLTGG	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V122	DLIFKVHVKGS	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
V698	-----------	4	Arabidopsis thaliana, Drosophila melanogaster, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
V698	EDFMEVVLGKL	2	Homo sapiens, Rattus norvegicus
V698	EDFMEVVFGKL	1	Mus musculus
V699	-----------	4	Arabidopsis thaliana, Drosophila melanogaster, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
V699	DFMEVVLGKLD	1	Homo sapiens
V699	DFMEVVFGKLD	1	Mus musculus
V699	DFMEVVLGKLN	1	Rattus norvegicus
V76	ANYDSV-EAGE	2	Mus musculus, Rattus norvegicus
V76	ANYDSV-EEGE	1	Homo sapiens
V76	-----------	1	Arabidopsis thaliana
V76	ADYNSV-IDGA	1	Drosophila melanogaster
V76	ANYDSVNENGE	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V76	ANYDSV-ENGD	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
W652	-----------	4	Arabidopsis thaliana, Drosophila melanogaster, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
W652	NAVFEWHITKG	2	Homo sapiens, Mus musculus
W652	NAVFEWHITKN	1	Rattus norvegicus
Y164	FGQANYSAAKL	4	Homo sapiens, Mus musculus, Rattus norvegicus, Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Y164	-----------	1	Arabidopsis thaliana
Y164	FGQVNYTAAKM	1	Drosophila melanogaster
Y164	FGQANYSAAKM	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)