mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

Home

Download

 Statistics

Help

About Us
Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for XIAP
Gene summary
Basic gene Info.Gene symbolXIAP
Gene nameX-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
SynonymsAPI3|BIRC4|IAP-3|ILP1|MIHA|XLP2|hIAP-3|hIAP3
CytomapUCSC genome browser: Xq25
Type of geneprotein-coding
RefGenesNM_001167.3,
NM_001204401.1,NR_037916.1,
DescriptionE3 ubiquitin-protein ligase XIAPIAP-like proteinX-linked IAPbaculoviral IAP repeat-containing protein 4inhibitor of apoptosis protein 3
Modification date20141221
dbXrefs MIM : 300079
HGNC : HGNC
Ensembl : ENSG00000101966
HPRD : 02094
Vega : OTTHUMG00000022336
ProteinUniProt: P98170
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_XIAP
BioGPS: 331
PathwayNCI Pathway Interaction Database: XIAP
KEGG: XIAP
REACTOME: XIAP
Pathway Commons: XIAP
ContextiHOP: XIAP
ligand binding site mutation search in PubMed: XIAP
UCL Cancer Institute: XIAP
Assigned class in mutLBSgeneDBA: This gene has a literature evidence and it belongs to targetable_mutLBSgenes.
References showing study about ligand binding site mutation for XIAP.1. "Rigaud S, Lopez-Granados E, Sibéril S, Gloire G, Lambert N, Lenoir C, Synaeve C, Stacey M, Fugger L, Stephan JL, Fischer A, Picard C, Durandy A, Chapel H, Latour S. Human X-linked variable immunodeficiency caused by a hypomorphic mutation in XIAP in association with a rare polymorphism in CD40LG. Blood. 2011 Jul 14;118(2):252-61. doi: 10.1182/blood-2011-01-328849. Epub 2011 May 4." 21543760

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0016567protein ubiquitination19473982
GO:0031398positive regulation of protein ubiquitination21931591
GO:0043154negative regulation of cysteine-type endopeptidase activity involved in apoptotic process11583623
GO:1902530positive regulation of protein linear polyubiquitination21931591


Top
Ligand binding site mutations for XIAP
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
 : non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
R258L256ICOAD1
L292A291VKIRC1
R258N259SKIRC1
H83R84SLUAD1
H83H83QLUAD1
C471K472RLUSC1
C63F64LSTAD1
C450L449FUCEC1
I339I339TUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


Top
Protein structure related information for XIAP
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
I339I339T-1.7850906
C450L449F-1.4732705
H83R84S-1.1891729
R258L256I-0.85796096
R258N259S-0.85556476
C63F64L-0.80058646
H83H83Q-0.67079396
L292A291V-0.60299314
C471K472R-0.5827517
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for XIAP from PDB

Top
Differential gene expression and gene-gene network for XIAP
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of XIAP and the right PPI network was created from samples without mutations in the LBS of XIAP. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Top

Top
Phenotype information for XIAP
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C1845076Lymphoproliferative Syndrome, X-Linked, 26Biomarker, GeneticVariation
umls:C0919267Ovarian Neoplasms2Biomarker
umls:C1862939Amyotrophic lateral sclerosis 12Biomarker
umls:C0014859Esophageal Neoplasms1AlteredExpression, Biomarker
umls:C0024668Mammary Neoplasms, Experimental1Therapeutic
umls:C0027055Myocardial Reperfusion Injury1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Top
Pharmacological information for XIAP
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
ExperimentalDB026281-[3,3-Dimethyl-2-(2-Methylamino-Propionylamino)-Butyryl]-Pyrrolidine-2-Carboxylic Acid(1,2,3,4-Tetrahydro-Naphthalen-1-Yl)-AmideSmall molecule
ExperimentalDB04612N-METHYLALANYL-3-METHYLVALYL-4-PHENOXY-N-(1,2,3,4-TETRAHYDRONAPHTHALEN-1-YL)PROLINAMIDESmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of XIAP go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
ZNZINC(2+)4ic2AC450 C471
ZNZINC(2+)4ic2BC450 C471
ZNZINC(2+)4ic3AC450 C471
ZNZINC(2+)4ic3BC450 C471
ZNZINC(2+)2poiAC63 H83
ZNZINC(2+)2qraAC63 H83
ZNZINC(2+)4mtzAC63 H83
ZNZINC(2+)4oxcAC63 H83
ZNZINC(2+)4oxcBC63 H83
ZNZINC(2+)4oxcCC63 H83
ZNZINC(2+)4oxcDC63 H83
X222(S),3(S),6(S),7(S),9A(S) 6-(2-AMINO-BUTYRYLAMINO)-7-HYDROXYMETHYL-5-OXO-OCTAHYDRO-PYRROLO[1,2-A]AZEPINE-3-CARBOXYLIC ACID BENZHYDRYL-AMIDE3clxCI339
BI6(3S,6S,7Z,10AS)-N-(DIPHENYLMETHYL)-6-{[(2S)-2-(METHYLIDENEAMINO)BUTANOYL]AMINO}-5-OXO-1,2,3,5,6,9,10,10A-OCTAHYDROPYRROLO[1,2-A]AZOCINE-3-CARBOXAMIDE2jk7AL292
CO91-({2-[(1S)-1-AMINOETHYL]-1,3-OXAZOL-4-YL}CARBONYL)-L-PROLYL-L-TRYPTOPHAN2opyAL292
IIIPeptide ligand (ALA,VAL,PRO,PHE)2opzAL292
IIIPeptide ligand (ALA,VAL,PRO,PHE)2opzBL292
IIIPeptide ligand (ALA,VAL,PRO,PHE)2opzCL292
IIIPeptide ligand (ALA,VAL,PRO,PHE)2opzDL292
IIIPeptide ligand (ALA,LYS,PRO,PHE)2vslAL292
X222(S),3(S),6(S),7(S),9A(S) 6-(2-AMINO-BUTYRYLAMINO)-7-HYDROXYMETHYL-5-OXO-OCTAHYDRO-PYRROLO[1,2-A]AZEPINE-3-CARBOXYLIC ACID BENZHYDRYL-AMIDE3clxBL292
X222(S),3(S),6(S),7(S),9A(S) 6-(2-AMINO-BUTYRYLAMINO)-7-HYDROXYMETHYL-5-OXO-OCTAHYDRO-PYRROLO[1,2-A]AZEPINE-3-CARBOXYLIC ACID BENZHYDRYL-AMIDE3clxCL292
X232(S),3(S),6(S),7(S),9A(S) 6-(2-AMINO-BUTYRYLAMINO)-7-AMINOMETHYL-5-OXO-OCTAHYDRO-PYRROLO[1,2-A]AZEPINE-3-CARBOXYLIC ACID BENZHYDRYL-AMIDE3cm2DL292
X232(S),3(S),6(S),7(S),9A(S) 6-(2-AMINO-BUTYRYLAMINO)-7-AMINOMETHYL-5-OXO-OCTAHYDRO-PYRROLO[1,2-A]AZEPINE-3-CARBOXYLIC ACID BENZHYDRYL-AMIDE3cm2AL292
X232(S),3(S),6(S),7(S),9A(S) 6-(2-AMINO-BUTYRYLAMINO)-7-AMINOMETHYL-5-OXO-OCTAHYDRO-PYRROLO[1,2-A]AZEPINE-3-CARBOXYLIC ACID BENZHYDRYL-AMIDE3cm2BL292
X232(S),3(S),6(S),7(S),9A(S) 6-(2-AMINO-BUTYRYLAMINO)-7-AMINOMETHYL-5-OXO-OCTAHYDRO-PYRROLO[1,2-A]AZEPINE-3-CARBOXYLIC ACID BENZHYDRYL-AMIDE3cm2CL292
X232(S),3(S),6(S),7(S),9A(S) 6-(2-AMINO-BUTYRYLAMINO)-7-AMINOMETHYL-5-OXO-OCTAHYDRO-PYRROLO[1,2-A]AZEPINE-3-CARBOXYLIC ACID BENZHYDRYL-AMIDE3cm2EL292
X232(S),3(S),6(S),7(S),9A(S) 6-(2-AMINO-BUTYRYLAMINO)-7-AMINOMETHYL-5-OXO-OCTAHYDRO-PYRROLO[1,2-A]AZEPINE-3-CARBOXYLIC ACID BENZHYDRYL-AMIDE3cm2FL292
X232(S),3(S),6(S),7(S),9A(S) 6-(2-AMINO-BUTYRYLAMINO)-7-AMINOMETHYL-5-OXO-OCTAHYDRO-PYRROLO[1,2-A]AZEPINE-3-CARBOXYLIC ACID BENZHYDRYL-AMIDE3cm2GL292
X232(S),3(S),6(S),7(S),9A(S) 6-(2-AMINO-BUTYRYLAMINO)-7-AMINOMETHYL-5-OXO-OCTAHYDRO-PYRROLO[1,2-A]AZEPINE-3-CARBOXYLIC ACID BENZHYDRYL-AMIDE3cm2HL292
X232(S),3(S),6(S),7(S),9A(S) 6-(2-AMINO-BUTYRYLAMINO)-7-AMINOMETHYL-5-OXO-OCTAHYDRO-PYRROLO[1,2-A]AZEPINE-3-CARBOXYLIC ACID BENZHYDRYL-AMIDE3cm2IL292
X232(S),3(S),6(S),7(S),9A(S) 6-(2-AMINO-BUTYRYLAMINO)-7-AMINOMETHYL-5-OXO-OCTAHYDRO-PYRROLO[1,2-A]AZEPINE-3-CARBOXYLIC ACID BENZHYDRYL-AMIDE3cm2JL292
X222(S),3(S),6(S),7(S),9A(S) 6-(2-AMINO-BUTYRYLAMINO)-7-HYDROXYMETHYL-5-OXO-OCTAHYDRO-PYRROLO[1,2-A]AZEPINE-3-CARBOXYLIC ACID BENZHYDRYL-AMIDE3cm7DL292
SMK(3S,6S,7R,9AS)-6-{[(2S)-2-AMINOBUTANOYL]AMINO}-7-(2-AMINOETHYL)-N-(DIPHENYLMETHYL)-5-OXOOCTAHYDRO-1H-PYRROLO[1,2-A]AZEPINE-3-CARBOXAMIDE3eylAL292
CZ31,1'-{HEXA-2,4-DIYNE-1,6-DIYLBIS[OXY{(2S,3R)-2-[(N-METHYL-L-ALANYL)AMINO]-1-OXOBUTANE-3,1-DIYL}(2S)PYRROLIDINE-1,2-DIYLMETHANEDIYL]}BIS[5-(PHENYLSULFANYL)-1H-TETRAZOLE]3g76AL292
CZ31,1'-{HEXA-2,4-DIYNE-1,6-DIYLBIS[OXY{(2S,3R)-2-[(N-METHYL-L-ALANYL)AMINO]-1-OXOBUTANE-3,1-DIYL}(2S)PYRROLIDINE-1,2-DIYLMETHANEDIYL]}BIS[5-(PHENYLSULFANYL)-1H-TETRAZOLE]3g76BL292
CZ31,1'-{HEXA-2,4-DIYNE-1,6-DIYLBIS[OXY{(2S,3R)-2-[(N-METHYL-L-ALANYL)AMINO]-1-OXOBUTANE-3,1-DIYL}(2S)PYRROLIDINE-1,2-DIYLMETHANEDIYL]}BIS[5-(PHENYLSULFANYL)-1H-TETRAZOLE]3g76CL292
CZ31,1'-{HEXA-2,4-DIYNE-1,6-DIYLBIS[OXY{(2S,3R)-2-[(N-METHYL-L-ALANYL)AMINO]-1-OXOBUTANE-3,1-DIYL}(2S)PYRROLIDINE-1,2-DIYLMETHANEDIYL]}BIS[5-(PHENYLSULFANYL)-1H-TETRAZOLE]3g76DL292
CZ31,1'-{HEXA-2,4-DIYNE-1,6-DIYLBIS[OXY{(2S,3R)-2-[(N-METHYL-L-ALANYL)AMINO]-1-OXOBUTANE-3,1-DIYL}(2S)PYRROLIDINE-1,2-DIYLMETHANEDIYL]}BIS[5-(PHENYLSULFANYL)-1H-TETRAZOLE]3g76EL292
0O6(3S,6S,7S,9AS,3'S,6'S,7'S,9A'S)-N,N'-(BENZENE-1,4- DIYLBIS{BUTANE-4,1-DIYL-1H-1,2,3-TRIAZOLE-1,4- DIYL[(S)-PHENYLMETHANEDIYL]})BIS[7-(HYDROXYMETHYL)-6- {[(2S)-2-(METHYLAMINO)BUTANOYL]AMINO}-5-OXOOCTAHYDRO- 1H-PYRROLO[1,2-A]AZEPINE-3-CARBOXAMIDE]4ec4AL292
0O6(3S,6S,7S,9AS,3'S,6'S,7'S,9A'S)-N,N'-(BENZENE-1,4- DIYLBIS{BUTANE-4,1-DIYL-1H-1,2,3-TRIAZOLE-1,4- DIYL[(S)-PHENYLMETHANEDIYL]})BIS[7-(HYDROXYMETHYL)-6- {[(2S)-2-(METHYLAMINO)BUTANOYL]AMINO}-5-OXOOCTAHYDRO- 1H-PYRROLO[1,2-A]AZEPINE-3-CARBOXAMIDE]4ec4BL292
0O6(3S,6S,7S,9AS,3'S,6'S,7'S,9A'S)-N,N'-(BENZENE-1,4- DIYLBIS{BUTANE-4,1-DIYL-1H-1,2,3-TRIAZOLE-1,4- DIYL[(S)-PHENYLMETHANEDIYL]})BIS[7-(HYDROXYMETHYL)-6- {[(2S)-2-(METHYLAMINO)BUTANOYL]AMINO}-5-OXOOCTAHYDRO- 1H-PYRROLO[1,2-A]AZEPINE-3-CARBOXAMIDE]4ec4CL292
0O6(3S,6S,7S,9AS,3'S,6'S,7'S,9A'S)-N,N'-(BENZENE-1,4- DIYLBIS{BUTANE-4,1-DIYL-1H-1,2,3-TRIAZOLE-1,4- DIYL[(S)-PHENYLMETHANEDIYL]})BIS[7-(HYDROXYMETHYL)-6- {[(2S)-2-(METHYLAMINO)BUTANOYL]AMINO}-5-OXOOCTAHYDRO- 1H-PYRROLO[1,2-A]AZEPINE-3-CARBOXAMIDE]4ec4EL292
0O6(3S,6S,7S,9AS,3'S,6'S,7'S,9A'S)-N,N'-(BENZENE-1,4- DIYLBIS{BUTANE-4,1-DIYL-1H-1,2,3-TRIAZOLE-1,4- DIYL[(S)-PHENYLMETHANEDIYL]})BIS[7-(HYDROXYMETHYL)-6- {[(2S)-2-(METHYLAMINO)BUTANOYL]AMINO}-5-OXOOCTAHYDRO- 1H-PYRROLO[1,2-A]AZEPINE-3-CARBOXAMIDE]4ec4FL292
0O6(3S,6S,7S,9AS,3'S,6'S,7'S,9A'S)-N,N'-(BENZENE-1,4- DIYLBIS{BUTANE-4,1-DIYL-1H-1,2,3-TRIAZOLE-1,4- DIYL[(S)-PHENYLMETHANEDIYL]})BIS[7-(HYDROXYMETHYL)-6- {[(2S)-2-(METHYLAMINO)BUTANOYL]AMINO}-5-OXOOCTAHYDRO- 1H-PYRROLO[1,2-A]AZEPINE-3-CARBOXAMIDE]4ec4GL292
0O6(3S,6S,7S,9AS,3'S,6'S,7'S,9A'S)-N,N'-(BENZENE-1,4- DIYLBIS{BUTANE-4,1-DIYL-1H-1,2,3-TRIAZOLE-1,4- DIYL[(S)-PHENYLMETHANEDIYL]})BIS[7-(HYDROXYMETHYL)-6- {[(2S)-2-(METHYLAMINO)BUTANOYL]AMINO}-5-OXOOCTAHYDRO- 1H-PYRROLO[1,2-A]AZEPINE-3-CARBOXAMIDE]4ec4KL292
1AQ(3S,7R,8AR)-2-{(2S)-2-(4,4-DIFLUOROCYCLOHEXYL)-2-[(N- METHYL-L-ALANYL)AMINO]ACETYL}-N-[(4R)-3,4-DIHYDRO-2H- CHROMEN-4-YL]-7-ETHOXYOCTAHYDROPYRROLO[1,2-A]PYRAZINE- 3-CARBOXAMIDE4hy0AL292
1AQ(3S,7R,8AR)-2-{(2S)-2-(4,4-DIFLUOROCYCLOHEXYL)-2-[(N- METHYL-L-ALANYL)AMINO]ACETYL}-N-[(4R)-3,4-DIHYDRO-2H- CHROMEN-4-YL]-7-ETHOXYOCTAHYDROPYRROLO[1,2-A]PYRAZINE- 3-CARBOXAMIDE4hy0CL292
1AQ(3S,7R,8AR)-2-{(2S)-2-(4,4-DIFLUOROCYCLOHEXYL)-2-[(N- METHYL-L-ALANYL)AMINO]ACETYL}-N-[(4R)-3,4-DIHYDRO-2H- CHROMEN-4-YL]-7-ETHOXYOCTAHYDROPYRROLO[1,2-A]PYRAZINE- 3-CARBOXAMIDE4hy0EL292
1AQ(3S,7R,8AR)-2-{(2S)-2-(4,4-DIFLUOROCYCLOHEXYL)-2-[(N- METHYL-L-ALANYL)AMINO]ACETYL}-N-[(4R)-3,4-DIHYDRO-2H- CHROMEN-4-YL]-7-ETHOXYOCTAHYDROPYRROLO[1,2-A]PYRAZINE- 3-CARBOXAMIDE4hy0FL292
1AQ(3S,7R,8AR)-2-{(2S)-2-(4,4-DIFLUOROCYCLOHEXYL)-2-[(N- METHYL-L-ALANYL)AMINO]ACETYL}-N-[(4R)-3,4-DIHYDRO-2H- CHROMEN-4-YL]-7-ETHOXYOCTAHYDROPYRROLO[1,2-A]PYRAZINE- 3-CARBOXAMIDE4hy0GL292
GT6(2S,2'S)-N,N'-[(6,6'-DIFLUORO-1H,1'H-2,2'-BIINDOLE-3, 3'-DIYL)BIS{METHANEDIYL[(2R,4S)-4-HYDROXYPYRROLIDINE- 2,1-DIYL][(2S)-1-OXOBUTANE-1,2-DIYL]}]BIS[2- (METHYLAMINO)PROPANAMIDE]4kmpBL292
4YN(2R,5R)-4-[2-(6-BENZYL-3,3-DIMETHYL-2,3-DIHYDRO-1H- PYRROLO[3,2-C]PYRIDIN-1-YL)-2-OXOETHYL]-5- (METHOXYMETHYL)-2-METHYLPIPERAZIN-1-IUM5c83AL292
X222(S),3(S),6(S),7(S),9A(S) 6-(2-AMINO-BUTYRYLAMINO)-7-HYDROXYMETHYL-5-OXO-OCTAHYDRO-PYRROLO[1,2-A]AZEPINE-3-CARBOXYLIC ACID BENZHYDRYL-AMIDE3cm7DR258


Top
Conservation information for LBS of XIAP
Multiple alignments for P98170 in multiple species
LBSAA sequence# speciesSpecies
C203VQCFCCGGKLK3Homo sapiens, Mus musculus, Rattus norvegicus
C203VKCFCCGGKLM1Xenopus tropicalis
C227RHFPNCFFVLG3Homo sapiens, Mus musculus, Rattus norvegicus
C227KHFPECYFVLG1Xenopus tropicalis
C300GDKVKCFHCGG3Homo sapiens, Mus musculus, Rattus norvegicus
C300GDATKCFHCGG1Xenopus tropicalis
C303VKCFHCGGGLT3Homo sapiens, Mus musculus, Rattus norvegicus
C303TKCFHCGGVLN1Xenopus tropicalis
C327KWYPGCKYLLD2Mus musculus, Rattus norvegicus
C327KWYPGCKYLLE1Homo sapiens
C327KAYPGCKFLID1Xenopus tropicalis
C450QEEKLCKICMD3Homo sapiens, Mus musculus, Rattus norvegicus
C450EEEKICKVCMD1Xenopus tropicalis
C453KLCKICMDRNI3Homo sapiens, Mus musculus, Rattus norvegicus
C453KICKVCMDRRI1Xenopus tropicalis
C465IVFVPCGHLVT3Homo sapiens, Mus musculus, Rattus norvegicus
C465IVFIPCGHLVA1Xenopus tropicalis
C471GHLVTCKQCAE3Homo sapiens, Mus musculus, Rattus norvegicus
C471GHLVACAVCAD1Xenopus tropicalis
C474VTCKQCAEAVD3Homo sapiens, Mus musculus, Rattus norvegicus
C474VACAVCADVLD1Xenopus tropicalis
C481EAVDKCPMCYT2Homo sapiens, Mus musculus
C481DVLDKCPICCT1Xenopus tropicalis
C481EAVDKCPMCCT1Rattus norvegicus
C484DKCPMCYTVIT2Homo sapiens, Mus musculus
C484DKCPICCTIVE1Xenopus tropicalis
C484DKCPMCCTVIT1Rattus norvegicus
C63GDTVQCFSCHA2Mus musculus, Rattus norvegicus
C63GDTVRCFSCHA1Homo sapiens
C63GDRVKCFSCLA1Xenopus tropicalis
C66VRCFSCHAAVD1Homo sapiens
C66VKCFSCLAMVE1Xenopus tropicalis
C66VQCFSCHAAID1Mus musculus
C66VQCFSCHAAVD1Rattus norvegicus
C90RISPNCRFING2Mus musculus, Rattus norvegicus
C90KVSPNCRFING1Homo sapiens
C90KISPNCKFING1Xenopus tropicalis
D214NWEPCDRAWSE3Homo sapiens, Mus musculus, Rattus norvegicus
D214NWEPSDKAWTE1Xenopus tropicalis
D309GGGLTDWKPSE3Homo sapiens, Mus musculus, Rattus norvegicus
D309GGVLNCWSATD1Xenopus tropicalis
E219DRAWSEHRRHF3Homo sapiens, Mus musculus, Rattus norvegicus
E219DKAWTEHKKHF1Xenopus tropicalis
E314DWKPSEDPWEQ3Homo sapiens, Mus musculus, Rattus norvegicus
E314CWSATDDPWEE1Xenopus tropicalis
E337DEKGQEYINNI2Mus musculus, Rattus norvegicus
E337EQKGQEYINNI1Homo sapiens
E337DEKGQHFINHA1Xenopus tropicalis
F224EHRRHFPNCFF3Homo sapiens, Mus musculus, Rattus norvegicus
F224EHKKHFPECYF1Xenopus tropicalis
G304KCFHCGGGLTD3Homo sapiens, Mus musculus, Rattus norvegicus
G304KCFHCGGVLNC1Xenopus tropicalis
G305CFHCGGGLTDW3Homo sapiens, Mus musculus, Rattus norvegicus
G305CFHCGGVLNCW1Xenopus tropicalis
G306FHCGGGLTDWK3Homo sapiens, Mus musculus, Rattus norvegicus
G306FHCGGVLNCWS1Xenopus tropicalis
H220RAWSEHRRHFP3Homo sapiens, Mus musculus, Rattus norvegicus
H220KAWTEHKKHFP1Xenopus tropicalis
H223SEHRRHFPNCF3Homo sapiens, Mus musculus, Rattus norvegicus
H223TEHKKHFPECY1Xenopus tropicalis
H320DPWEQHAKWYP3Homo sapiens, Mus musculus, Rattus norvegicus
H320DPWEEHAKAYP1Xenopus tropicalis
H343YINNIHLTHSL3Homo sapiens, Mus musculus, Rattus norvegicus
H343FINHAQLKRPI1Xenopus tropicalis
H346NIHLTHSLEEC1Homo sapiens
H346HAQLKRPILHK1Xenopus tropicalis
H346NIHLTHSLEES1Mus musculus
H346NIHLTHSLGES1Rattus norvegicus
H467FVPCGHLVTCK3Homo sapiens, Mus musculus, Rattus norvegicus
H467FIPCGHLVACA1Xenopus tropicalis
H67RCFSCHAAVDR1Homo sapiens
H67KCFSCLAMVEG1Xenopus tropicalis
H67QCFSCHAAIDR1Mus musculus
H67QCFSCHAAVDR1Rattus norvegicus
H83SAVGRHRRISP2Mus musculus, Rattus norvegicus
H83SAVGRHRKVSP1Homo sapiens
H83TAIGKHRKISP1Xenopus tropicalis
I339KGQEYINNIHL3Homo sapiens, Mus musculus, Rattus norvegicus
I339KGQHFINHAQL1Xenopus tropicalis
K206FCCGGKLKNWE3Homo sapiens, Mus musculus, Rattus norvegicus
K206FCCGGKLMNWE1Xenopus tropicalis
K208CGGKLKNWEPC3Homo sapiens, Mus musculus, Rattus norvegicus
K208CGGKLMNWEPS1Xenopus tropicalis
K297LGEGDKVKCFH3Homo sapiens, Mus musculus, Rattus norvegicus
K297IGDGDATKCFH1Xenopus tropicalis
K299EGDKVKCFHCG3Homo sapiens, Mus musculus, Rattus norvegicus
K299DGDATKCFHCG1Xenopus tropicalis
K311GLTDWKPSEDP3Homo sapiens, Mus musculus, Rattus norvegicus
K311VLNCWSATDDP1Xenopus tropicalis
K322WEQHAKWYPGC3Homo sapiens, Mus musculus, Rattus norvegicus
K322WEEHAKAYPGC1Xenopus tropicalis
L207CCGGKLKNWEP3Homo sapiens, Mus musculus, Rattus norvegicus
L207CCGGKLMNWEP1Xenopus tropicalis
L292AGFYALGEGDK3Homo sapiens, Mus musculus, Rattus norvegicus
L292AGFYSIGDGDA1Xenopus tropicalis
L307HCGGGLTDWKP3Homo sapiens, Mus musculus, Rattus norvegicus
L307HCGGVLNCWSA1Xenopus tropicalis
L344INNIHLTHSLE2Homo sapiens, Mus musculus
L344INHAQLKRPIL1Xenopus tropicalis
L344INNIHLTHSLG1Rattus norvegicus
L348HLTHSLEECLV1Homo sapiens
L348QLKRPILHK-A1Xenopus tropicalis
L348HLTHSLEESLG1Mus musculus
L348HLTHSLGESVV1Rattus norvegicus
N249VSSDRNFPNST3Homo sapiens, Mus musculus, Rattus norvegicus
N249THGGRRRGSEL1Xenopus tropicalis
N340GQEYINNIHLT3Homo sapiens, Mus musculus, Rattus norvegicus
N340GQHFINHAQLK1Xenopus tropicalis
N89RRISPNCRFIN2Mus musculus, Rattus norvegicus
N89RKVSPNCRFIN1Homo sapiens
N89RKISPNCKFIN1Xenopus tropicalis
P251SDRNFPNSTNS2Mus musculus, Rattus norvegicus
P251SDRNFPNSTNL1Homo sapiens
P251GGRRRGSELAC1Xenopus tropicalis
P325HAKWYPGCKYL3Homo sapiens, Mus musculus, Rattus norvegicus
P325HAKAYPGCKFL1Xenopus tropicalis
P88HRRISPNCRFI2Mus musculus, Rattus norvegicus
P88HRKVSPNCRFI1Homo sapiens
P88HRKISPNCKFI1Xenopus tropicalis
Q197TGIGDQVQCFC1Homo sapiens
Q197TGINDQVKCFC1Xenopus tropicalis
Q197TGADDQVQCFC1Mus musculus
Q197TGIDDQVQCFC1Rattus norvegicus
Q319EDPWEQHAKWY3Homo sapiens, Mus musculus, Rattus norvegicus
Q319DDPWEEHAKAY1Xenopus tropicalis
Q336LDEKGQEYINN2Mus musculus, Rattus norvegicus
Q336LEQKGQEYINN1Homo sapiens
Q336IDEKGQHFINH1Xenopus tropicalis
R222WSEHRRHFPNC3Homo sapiens, Mus musculus, Rattus norvegicus
R222WTEHKKHFPEC1Xenopus tropicalis
R248-VSSDRNFPNS2Mus musculus, Rattus norvegicus
R248AVSSDRNFPNS1Homo sapiens
R248-THGGRRRGSE1Xenopus tropicalis
R258STNSPRNPAMA2Mus musculus, Rattus norvegicus
R258STNLPRNPSMA1Homo sapiens
R258ELAC---PAMN1Xenopus tropicalis
R62EGDTVQCFSCH2Mus musculus, Rattus norvegicus
R62EGDTVRCFSCH1Homo sapiens
R62DGDRVKCFSCL1Xenopus tropicalis
S347IHLTHSLEECL1Homo sapiens
S347AQLKRPILHK-1Xenopus tropicalis
S347IHLTHSLEESL1Mus musculus
S347IHLTHSLGESV1Rattus norvegicus
S87RHRRISPNCRF2Mus musculus, Rattus norvegicus
S87RHRKVSPNCRF1Homo sapiens
S87KHRKISPNCKF1Xenopus tropicalis
T308CGGGLTDWKPS3Homo sapiens, Mus musculus, Rattus norvegicus
T308CGGVLNCWSAT1Xenopus tropicalis
T345NNIHLTHSLEE2Homo sapiens, Mus musculus
T345NHAQLKRPILH1Xenopus tropicalis
T345NNIHLTHSLGE1Rattus norvegicus
V298GEGDKVKCFHC3Homo sapiens, Mus musculus, Rattus norvegicus
V298GDGDATKCFHC1Xenopus tropicalis
W310GGLTDWKPSED3Homo sapiens, Mus musculus, Rattus norvegicus
W310GVLNCWSATDD1Xenopus tropicalis
W323EQHAKWYPGCK3Homo sapiens, Mus musculus, Rattus norvegicus
W323EEHAKAYPGCK1Xenopus tropicalis
Y324QHAKWYPGCKY3Homo sapiens, Mus musculus, Rattus norvegicus
Y324EHAKAYPGCKF1Xenopus tropicalis
Y338EKGQEYINNIH2Mus musculus, Rattus norvegicus
Y338QKGQEYINNIH1Homo sapiens
Y338EKGQHFINHAQ1Xenopus tropicalis


Copyright © 2016-Present - The University of Texas Health Science Center at Houston
Site Policies | State of Texas