mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for IFNA2
Gene summary
Basic gene Info.Gene symbolIFNA2
Gene nameinterferon, alpha 2
SynonymsIFN-alphaA|IFNA|IFNA2B|INFA2
CytomapUCSC genome browser: 9p22
Type of geneprotein-coding
RefGenesNM_000605.3,
DescriptionIFN-alpha-2alpha-2a interferoninterferon alpha 2ainterferon alpha 2binterferon alpha Ainterferon alpha-2leIF A
Modification date20141207
dbXrefs MIM : 147562
HGNC : HGNC
Ensembl : ENSG00000188379
HPRD : 00950
Vega : OTTHUMG00000019674
ProteinUniProt: P01563
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_IFNA2
BioGPS: 3440
PathwayNCI Pathway Interaction Database: IFNA2
KEGG: IFNA2
REACTOME: IFNA2
Pathway Commons: IFNA2
ContextiHOP: IFNA2
ligand binding site mutation search in PubMed: IFNA2
UCL Cancer Institute: IFNA2
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0010629negative regulation of gene expression20554961
GO:0042517positive regulation of tyrosine phosphorylation of Stat3 protein22783022
GO:0045581negative regulation of T cell differentiation20554961
GO:0045892negative regulation of transcription, DNA-templated20554961
GO:0046597negative regulation of viral entry into host cell22783022
GO:0051607defense response to virus22783022
GO:2000552negative regulation of T-helper 2 cell cytokine production20554961
GO:2000663negative regulation of interleukin-5 secretion20554961
GO:2000666negative regulation of interleukin-13 secretion20554961


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Ligand binding site mutations for IFNA2
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
 : non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
T129T129ICOAD1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for IFNA2
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
T129T129I0.025096667
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for IFNA2 from PDB

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Differential gene expression and gene-gene network for IFNA2
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of IFNA2 and the right PPI network was created from samples without mutations in the LBS of IFNA2. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for IFNA2
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0524910Hepatitis C, Chronic134Biomarker, Therapeutic
umls:C0019196Hepatitis C75Biomarker, GeneticVariation, Therapeutic
umls:C0025202Melanoma31Biomarker, GeneticVariation, Therapeutic
umls:C0524909Hepatitis B, Chronic25Biomarker, Therapeutic
umls:C0019163Hepatitis B16Biomarker, GeneticVariation, Therapeutic
umls:C0023473Leukemia, Myelogenous, Chronic, BCR-ABL Positive15Biomarker, Therapeutic
umls:C0019189Hepatitis, Chronic12Biomarker, Therapeutic
umls:C0032463Polycythemia Vera8Biomarker, GeneticVariation, Therapeutic
umls:C0040028Thrombocythemia, Essential7Biomarker, Therapeutic
umls:C0002871Anemia7Biomarker
umls:C0011581Depressive Disorder5Biomarker
umls:C0023530Leukopenia5Biomarker
umls:C0007137Carcinoma, Squamous Cell4Biomarker, Therapeutic
umls:C0026764Multiple Myeloma4Biomarker, Therapeutic
umls:C0040034Thrombocytopenia4Biomarker
umls:C0042170Uveomeningoencephalitic Syndrome4Biomarker
umls:C0002878Anemia, Hemolytic3Biomarker
umls:C0027497Nausea3Biomarker
umls:C0007134Carcinoma, Renal Cell2Biomarker, Therapeutic
umls:C0007138Carcinoma, Transitional Cell2Biomarker, Therapeutic
umls:C0015672Fatigue2Biomarker
umls:C0017636Glioblastoma2Biomarker, Therapeutic
umls:C0019829Hodgkin Disease2Biomarker, Therapeutic
umls:C0005695Urinary Bladder Neoplasms2Biomarker, Therapeutic
umls:C0042749Viremia2Biomarker, Therapeutic
umls:C0015967Fever2Biomarker
umls:C0023493Leukemia-Lymphoma, Adult T-Cell2Therapeutic
umls:C0035305Retinal Detachment2Biomarker
umls:C0042963Vomiting2Biomarker
umls:C0000737Abdominal Pain1Biomarker
umls:C2609414Acute Kidney Injury1Biomarker
umls:C0003123Anorexia1Biomarker
umls:C0003469Anxiety Disorders1Biomarker
umls:C0085593Chills1Biomarker
umls:C0009404Colorectal Neoplasms1Therapeutic
umls:C0011991Diarrhea1Biomarker
umls:C0860207Drug-Induced Liver Injury1Biomarker
umls:C0015695Fatty Liver1Biomarker
umls:C0206608Flavivirus Infections1Therapeutic
umls:C0018681Headache1Biomarker
umls:C0206732Hemangioendothelioma, Epithelioid1Therapeutic
umls:C0020557Hypertriglyceridemia1Biomarker
umls:C0021845Intestinal Perforation1Biomarker
umls:C0023893Liver Cirrhosis, Experimental1Therapeutic
umls:C0024301Lymphoma, Follicular1Therapeutic
umls:C0024305Lymphoma, Non-Hodgkin1Therapeutic
umls:C0025287Meningism1Biomarker
umls:C0004936Mental Disorders1Biomarker
umls:C0027051Myocardial Infarction1Biomarker
umls:C0027947Neutropenia1Biomarker
umls:C0155305Optic Neuropathy, Ischemic1Biomarker
umls:C0030193Pain1Biomarker
umls:C0030297Pancreatic Neoplasms1Therapeutic
umls:C0033999Pterygium1Therapeutic
umls:C0034734Raynaud Disease1Biomarker
umls:C1565489Renal Insufficiency1Biomarker
umls:C0035309Retinal Diseases1Biomarker
umls:C0243026Sepsis1Biomarker
umls:C0037274Skin Diseases1Biomarker
umls:C0037650Somatoform Disorders1Biomarker
umls:C0038362Stomatitis1Biomarker
umls:C0038587Substance Withdrawal Syndrome1Therapeutic
umls:C0040136Thyroid Neoplasms1Therapeutic
umls:C0040264Tinnitus1Biomarker
umls:C0043096Weight Loss1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for IFNA2
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of IFNA2 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS


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Conservation information for LBS of IFNA2
Multiple alignments for P01563 in multiple species
LBSAA sequence# speciesSpecies


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