mutLBSgeneDB |
Gene summary for ITGA2 |
Gene summary |
Basic gene Info. | Gene symbol | ITGA2 |
Gene name | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | |
Synonyms | BR|CD49B|GPIa|HPA-5|VLA-2|VLAA2 | |
Cytomap | UCSC genome browser: 5q11.2 | |
Type of gene | protein-coding | |
RefGenes | NM_002203.3, NR_073103.1,NR_073104.1,NR_073105.1,NR_073106.1, NR_073107.1, | |
Description | CD49 antigen-like family member BVLA2 receptor, alpha-2 subunitcollagen receptorhuman platelet alloantigen system 5integrin alpha-2platelet antigen Brplatelet glycoprotein GPIaplatelet membrane glycoprotein Iavery late activation protein 2 recepto | |
Modification date | 20141222 | |
dbXrefs | MIM : 192974 | |
HGNC : HGNC | ||
Ensembl : ENSG00000164171 | ||
HPRD : 01893 | ||
Vega : OTTHUMG00000131165 | ||
Protein | UniProt: P17301 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_ITGA2 | |
BioGPS: 3673 | ||
Pathway | NCI Pathway Interaction Database: ITGA2 | |
KEGG: ITGA2 | ||
REACTOME: ITGA2 | ||
Pathway Commons: ITGA2 | ||
Context | iHOP: ITGA2 | |
ligand binding site mutation search in PubMed: ITGA2 | ||
UCL Cancer Institute: ITGA2 | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO Term | PubMed ID |
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Ligand binding site mutations for ITGA2 |
Cancer type specific mutLBS sorted by frequency |
LBS | AAchange of nsSNV | Cancer type | # samples | G247 | G246C | LUAD | 1 | D180 | D180G | STAD | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for ITGA2 |
Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
: nsSNV at non-LBS: nsSNV at LBS |
nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | G247 | G246C | 0.074759597 | D180 | D180G | -0.52682496 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
Structure image for ITGA2 from PDB |
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Differential gene expression and gene-gene network for ITGA2 |
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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Phenotype information for ITGA2 |
Gene level disease information (DisGeNet) |
Disease ID | Disease name | # PubMed | Association type |
umls:C0017661 | Glomerulonephritis, IGA | 2 | Biomarker, GeneticVariation |
umls:C0014175 | Endometriosis | 1 | Biomarker |
umls:C0017639 | Gliosis | 1 | Biomarker |
umls:C0020429 | Hyperalgesia | 1 | Biomarker |
umls:C0035328 | Retinal Vein Occlusion | 1 | Biomarker |
Mutation level pathogenic information (ClinVar annotation) |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for ITGA2 |
Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
Drug information targeting mutLBSgene (Approved drugs only) |
Drug status | DrugBank ID | Name | Type | Drug structure |
Gene-centered ligand-gene interaction network |
Ligands binding to mutated ligand binding site of ITGA2 go to BioLip |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
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Conservation information for LBS of ITGA2 |
Multiple alignments for P17301 in multiple species |
LBS | AA sequence | # species | Species |
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