mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for ITGA2
Gene summary
Basic gene Info.Gene symbolITGA2
Gene nameintegrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
SynonymsBR|CD49B|GPIa|HPA-5|VLA-2|VLAA2
CytomapUCSC genome browser: 5q11.2
Type of geneprotein-coding
RefGenesNM_002203.3,
NR_073103.1,NR_073104.1,NR_073105.1,NR_073106.1,
NR_073107.1,
DescriptionCD49 antigen-like family member BVLA2 receptor, alpha-2 subunitcollagen receptorhuman platelet alloantigen system 5integrin alpha-2platelet antigen Brplatelet glycoprotein GPIaplatelet membrane glycoprotein Iavery late activation protein 2 recepto
Modification date20141222
dbXrefs MIM : 192974
HGNC : HGNC
Ensembl : ENSG00000164171
HPRD : 01893
Vega : OTTHUMG00000131165
ProteinUniProt: P17301
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_ITGA2
BioGPS: 3673
PathwayNCI Pathway Interaction Database: ITGA2
KEGG: ITGA2
REACTOME: ITGA2
Pathway Commons: ITGA2
ContextiHOP: ITGA2
ligand binding site mutation search in PubMed: ITGA2
UCL Cancer Institute: ITGA2
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID


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Ligand binding site mutations for ITGA2

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
G247G246CLUAD1
D180D180GSTAD1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for ITGA2
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
G247G246C0.074759597
D180D180G-0.52682496
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for ITGA2 from PDB

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Differential gene expression and gene-gene network for ITGA2
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of ITGA2 and the right PPI network was created from samples without mutations in the LBS of ITGA2. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for ITGA2
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0017661Glomerulonephritis, IGA2Biomarker, GeneticVariation
umls:C0014175Endometriosis1Biomarker
umls:C0017639Gliosis1Biomarker
umls:C0020429Hyperalgesia1Biomarker
umls:C0035328Retinal Vein Occlusion1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for ITGA2
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of ITGA2 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS


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Conservation information for LBS of ITGA2
Multiple alignments for P17301 in multiple species
LBSAA sequence# speciesSpecies


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