mutLBSgeneDB |
Gene summary for ITGA5 |
Gene summary |
Basic gene Info. | Gene symbol | ITGA5 |
Gene name | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | |
Synonyms | CD49e|FNRA|VLA5A | |
Cytomap | UCSC genome browser: 12q11-q13 | |
Type of gene | protein-coding | |
RefGenes | NM_002205.2, | |
Description | CD49 antigen-like family member EVLA-5fibronectin receptor subunit alphafibronectin receptor, alpha subunitintegrin alpha-5integrin alpha-Fvery late activation protein 5, alpha subunit | |
Modification date | 20141222 | |
dbXrefs | MIM : 135620 | |
HGNC : HGNC | ||
Ensembl : ENSG00000161638 | ||
HPRD : 00627 | ||
Vega : OTTHUMG00000169841 | ||
Protein | UniProt: P08648 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_ITGA5 | |
BioGPS: 3678 | ||
Pathway | NCI Pathway Interaction Database: ITGA5 | |
KEGG: ITGA5 | ||
REACTOME: ITGA5 | ||
Pathway Commons: ITGA5 | ||
Context | iHOP: ITGA5 | |
ligand binding site mutation search in PubMed: ITGA5 | ||
UCL Cancer Institute: ITGA5 | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO Term | PubMed ID |
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Ligand binding site mutations for ITGA5 |
Cancer type specific mutLBS sorted by frequency |
LBS | AAchange of nsSNV | Cancer type | # samples | D334,N336 | V335I | BRCA | 1 | D334,N336 | V335I | COAD | 1 | Y471,N469 | G470E | SKCM | 1 | R261 | R261P | SKCM | 1 | D467 | D467N | SKCM | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for ITGA5 |
Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
: nsSNV at non-LBS: nsSNV at LBS |
nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | N336 | V335I | -1.0973784 | D334 | V335I | -1.0973784 | D467 | D467N | -0.6339745 | R261 | R261P | -0.58336517 | Y471 | G470E | -0.38154031 | N469 | G470E | -0.38154031 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
Structure image for ITGA5 from PDB |
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Differential gene expression and gene-gene network for ITGA5 |
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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Phenotype information for ITGA5 |
Gene level disease information (DisGeNet) |
Disease ID | Disease name | # PubMed | Association type |
umls:C0007097 | Carcinoma | 6 | AlteredExpression, Biomarker |
umls:C0007137 | Carcinoma, Squamous Cell | 4 | Biomarker |
umls:C0017639 | Gliosis | 1 | Biomarker |
umls:C0027626 | Neoplasm Invasiveness | 1 | Biomarker |
umls:C0035126 | Reperfusion Injury | 1 | Biomarker |
umls:C0038356 | Stomach Neoplasms | 1 | Biomarker |
Mutation level pathogenic information (ClinVar annotation) |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for ITGA5 |
Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
Drug information targeting mutLBSgene (Approved drugs only) |
Drug status | DrugBank ID | Name | Type | Drug structure |
Gene-centered ligand-gene interaction network |
Ligands binding to mutated ligand binding site of ITGA5 go to BioLip |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
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Conservation information for LBS of ITGA5 |
Multiple alignments for P08648 in multiple species |
LBS | AA sequence | # species | Species |
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