mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for ITGA5
Gene summary
Basic gene Info.Gene symbolITGA5
Gene nameintegrin, alpha 5 (fibronectin receptor, alpha polypeptide)
SynonymsCD49e|FNRA|VLA5A
CytomapUCSC genome browser: 12q11-q13
Type of geneprotein-coding
RefGenesNM_002205.2,
DescriptionCD49 antigen-like family member EVLA-5fibronectin receptor subunit alphafibronectin receptor, alpha subunitintegrin alpha-5integrin alpha-Fvery late activation protein 5, alpha subunit
Modification date20141222
dbXrefs MIM : 135620
HGNC : HGNC
Ensembl : ENSG00000161638
HPRD : 00627
Vega : OTTHUMG00000169841
ProteinUniProt: P08648
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_ITGA5
BioGPS: 3678
PathwayNCI Pathway Interaction Database: ITGA5
KEGG: ITGA5
REACTOME: ITGA5
Pathway Commons: ITGA5
ContextiHOP: ITGA5
ligand binding site mutation search in PubMed: ITGA5
UCL Cancer Institute: ITGA5
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID


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Ligand binding site mutations for ITGA5

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
D334,N336V335IBRCA1
D334,N336V335ICOAD1
Y471,N469G470ESKCM1
R261R261PSKCM1
D467D467NSKCM1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for ITGA5
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
N336V335I-1.0973784
D334V335I-1.0973784
D467D467N-0.6339745
R261R261P-0.58336517
Y471G470E-0.38154031
N469G470E-0.38154031
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for ITGA5 from PDB

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Differential gene expression and gene-gene network for ITGA5
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of ITGA5 and the right PPI network was created from samples without mutations in the LBS of ITGA5. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for ITGA5
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0007097Carcinoma6AlteredExpression, Biomarker
umls:C0007137Carcinoma, Squamous Cell4Biomarker
umls:C0017639Gliosis1Biomarker
umls:C0027626Neoplasm Invasiveness1Biomarker
umls:C0035126Reperfusion Injury1Biomarker
umls:C0038356Stomach Neoplasms1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for ITGA5
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of ITGA5 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS


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Conservation information for LBS of ITGA5
Multiple alignments for P08648 in multiple species
LBSAA sequence# speciesSpecies


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