mutLBSgeneDB |
Gene summary for JUN |
Gene summary |
Basic gene Info. | Gene symbol | JUN |
Gene name | jun proto-oncogene | |
Synonyms | AP-1|AP1|c-Jun | |
Cytomap | UCSC genome browser: 1p32-p31 | |
Type of gene | protein-coding | |
RefGenes | NM_002228.3, | |
Description | Jun activation domain binding proteinactivator protein 1enhancer-binding protein AP1jun oncogenep39proto-oncogene c-Juntranscription factor AP-1v-jun avian sarcoma virus 17 oncogene homologv-jun sarcoma virus 17 oncogene homolog | |
Modification date | 20141222 | |
dbXrefs | MIM : 165160 | |
HGNC : HGNC | ||
Ensembl : ENSG00000177606 | ||
HPRD : 01302 | ||
Vega : OTTHUMG00000008376 | ||
Protein | UniProt: P05412 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_JUN | |
BioGPS: 3725 | ||
Pathway | NCI Pathway Interaction Database: JUN | |
KEGG: JUN | ||
REACTOME: JUN | ||
Pathway Commons: JUN | ||
Context | iHOP: JUN | |
ligand binding site mutation search in PubMed: JUN | ||
UCL Cancer Institute: JUN | ||
Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO Term | PubMed ID | GO:0007179 | transforming growth factor beta receptor signaling pathway | 9732876 | GO:0007184 | SMAD protein import into nucleus | 9732876 | GO:0032321 | positive regulation of Rho GTPase activity | 11804590 | GO:0043392 | negative regulation of DNA binding | 14645924 | GO:0043922 | negative regulation by host of viral transcription | 2833704 | GO:0043923 | positive regulation by host of viral transcription | 2833704 | GO:0045892 | negative regulation of transcription, DNA-templated | 2833704 | GO:0045893 | positive regulation of transcription, DNA-templated | 2833704 | GO:0045944 | positive regulation of transcription from RNA polymerase II promoter | 2833704 | GO:0060395 | SMAD protein signal transduction | 9732876 |
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Ligand binding site mutations for JUN |
Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.) : non-synonymous mutation on LBS, Circle size denotes number of samples. |
Cancer type specific mutLBS sorted by frequency |
LBS | AAchange of nsSNV | Cancer type | # samples | R263 | I264M | LUSC | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for JUN |
Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
: nsSNV at non-LBS: nsSNV at LBS |
nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | R263 | I264M | -0.76516757 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
Structure image for JUN from PDB |
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Differential gene expression and gene-gene network for JUN |
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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Phenotype information for JUN |
Gene level disease information (DisGeNet) |
Disease ID | Disease name | # PubMed | Association type |
umls:C2239176 | Carcinoma, Hepatocellular | 11 | AlteredExpression, Biomarker |
umls:C1458155 | Breast Neoplasms | 7 | AlteredExpression, Biomarker |
umls:C0023903 | Liver Neoplasms | 5 | Biomarker |
umls:C0029463 | Osteosarcoma | 4 | AlteredExpression, Biomarker |
umls:C0038356 | Stomach Neoplasms | 3 | AlteredExpression, Biomarker, PostTranslationalModification |
umls:C0009375 | Colonic Neoplasms | 3 | AlteredExpression, Biomarker |
umls:C0024121 | Lung Neoplasms | 2 | Biomarker |
umls:C0031117 | Peripheral Nervous System Diseases | 2 | Biomarker |
umls:C0270611 | Brain Injuries | 1 | Biomarker |
umls:C0007786 | Brain Ischemia | 1 | Biomarker |
umls:C0007621 | Cell Transformation, Neoplastic | 1 | Biomarker |
umls:C0018843 | Heat Stroke | 1 | Biomarker |
umls:C0018923 | Hemangiosarcoma | 1 | Biomarker |
umls:C0021846 | Intestinal Polyps | 1 | Biomarker |
umls:C0546127 | Mercury Poisoning, Nervous System | 1 | Biomarker |
umls:C0035126 | Reperfusion Injury | 1 | Biomarker |
umls:C0038220 | Status Epilepticus | 1 | Biomarker |
Mutation level pathogenic information (ClinVar annotation) |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for JUN |
Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
Gene-centered drug-gene interaction network |
Drug information targeting mutLBSgene (Approved drugs only) |
Drug status | DrugBank ID | Name | Type | Drug structure |
Approved | DB00570 | Vinblastine | Small molecule | |
Approved|investigational | DB01029 | Irbesartan | Small molecule | |
Approved|investigational | DB01169 | Arsenic trioxide | Small molecule | |
Investigational | DB05785 | LGD-1550 | Small molecule |
Gene-centered ligand-gene interaction network |
Ligands binding to mutated ligand binding site of JUN go to BioLip |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | NUC | Nucleic Acids | 1jnm | A | R263 | NUC | Nucleic Acids | 1jnm | B | R263 |
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Conservation information for LBS of JUN |
Multiple alignments for P05412 in multiple species |
LBS | AA sequence | # species | Species | C269 | IAASKCRKRKL | 4 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus | K273 | KCRKRKLERIA | 4 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus | N262 | RKRMRNRIAAS | 4 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus | R257 | RIKAERKRMRN | 4 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus | R259 | KAERKRMRNRI | 4 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus | R261 | ERKRMRNRIAA | 4 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus | R263 | KRMRNRIAASK | 4 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus | R270 | AASKCRKRKLE | 4 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus | R272 | SKCRKRKLERI | 4 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus |
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