mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for JUN
Gene summary
Basic gene Info.Gene symbolJUN
Gene namejun proto-oncogene
SynonymsAP-1|AP1|c-Jun
CytomapUCSC genome browser: 1p32-p31
Type of geneprotein-coding
RefGenesNM_002228.3,
DescriptionJun activation domain binding proteinactivator protein 1enhancer-binding protein AP1jun oncogenep39proto-oncogene c-Juntranscription factor AP-1v-jun avian sarcoma virus 17 oncogene homologv-jun sarcoma virus 17 oncogene homolog
Modification date20141222
dbXrefs MIM : 165160
HGNC : HGNC
Ensembl : ENSG00000177606
HPRD : 01302
Vega : OTTHUMG00000008376
ProteinUniProt: P05412
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_JUN
BioGPS: 3725
PathwayNCI Pathway Interaction Database: JUN
KEGG: JUN
REACTOME: JUN
Pathway Commons: JUN
ContextiHOP: JUN
ligand binding site mutation search in PubMed: JUN
UCL Cancer Institute: JUN
Assigned class in mutLBSgeneDBB: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0007179transforming growth factor beta receptor signaling pathway9732876
GO:0007184SMAD protein import into nucleus9732876
GO:0032321positive regulation of Rho GTPase activity11804590
GO:0043392negative regulation of DNA binding14645924
GO:0043922negative regulation by host of viral transcription2833704
GO:0043923positive regulation by host of viral transcription2833704
GO:0045892negative regulation of transcription, DNA-templated2833704
GO:0045893positive regulation of transcription, DNA-templated2833704
GO:0045944positive regulation of transcription from RNA polymerase II promoter2833704
GO:0060395SMAD protein signal transduction9732876


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Ligand binding site mutations for JUN
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
 
: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
R263I264MLUSC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for JUN
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
R263I264M-0.76516757
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for JUN from PDB

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Differential gene expression and gene-gene network for JUN
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of JUN and the right PPI network was created from samples without mutations in the LBS of JUN. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for JUN
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C2239176Carcinoma, Hepatocellular11AlteredExpression, Biomarker
umls:C1458155Breast Neoplasms7AlteredExpression, Biomarker
umls:C0023903Liver Neoplasms5Biomarker
umls:C0029463Osteosarcoma4AlteredExpression, Biomarker
umls:C0038356Stomach Neoplasms3AlteredExpression, Biomarker, PostTranslationalModification
umls:C0009375Colonic Neoplasms3AlteredExpression, Biomarker
umls:C0024121Lung Neoplasms2Biomarker
umls:C0031117Peripheral Nervous System Diseases2Biomarker
umls:C0270611Brain Injuries1Biomarker
umls:C0007786Brain Ischemia1Biomarker
umls:C0007621Cell Transformation, Neoplastic1Biomarker
umls:C0018843Heat Stroke1Biomarker
umls:C0018923Hemangiosarcoma1Biomarker
umls:C0021846Intestinal Polyps1Biomarker
umls:C0546127Mercury Poisoning, Nervous System1Biomarker
umls:C0035126Reperfusion Injury1Biomarker
umls:C0038220Status Epilepticus1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for JUN
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
ApprovedDB00570VinblastineSmall molecule
Approved|investigationalDB01029IrbesartanSmall molecule
Approved|investigationalDB01169Arsenic trioxideSmall molecule
InvestigationalDB05785LGD-1550Small molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of JUN go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
NUCNucleic Acids1jnmAR263
NUCNucleic Acids1jnmBR263


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Conservation information for LBS of JUN
Multiple alignments for P05412 in multiple species
LBSAA sequence# speciesSpecies
C269IAASKCRKRKL4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
K273KCRKRKLERIA4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
N262RKRMRNRIAAS4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
R257RIKAERKRMRN4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
R259KAERKRMRNRI4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
R261ERKRMRNRIAA4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
R263KRMRNRIAASK4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
R270AASKCRKRKLE4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
R272SKCRKRKLERI4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus


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