mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for KPNB1
Gene summary
Basic gene Info.Gene symbolKPNB1
Gene namekaryopherin (importin) beta 1
CytomapUCSC genome browser: 17q21.32
Type of geneprotein-coding
DescriptionPTAC97importin 1importin 90importin beta-1 subunitimportin subunit beta-1importin-90karyopherin subunit beta-1nuclear factor p97pore targeting complex 97 kDa subunit
Modification date20141207
dbXrefs MIM : 602738
HPRD : 04114
ProteinUniProt: Q14974
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_KPNB1
BioGPS: 3837
PathwayNCI Pathway Interaction Database: KPNB1
Pathway Commons: KPNB1
ContextiHOP: KPNB1
ligand binding site mutation search in PubMed: KPNB1
UCL Cancer Institute: KPNB1
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO:0006606protein import into nucleus15964792
GO:0006610ribosomal protein import into nucleus9687515

Ligand binding site mutations for KPNB1

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for KPNB1
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for KPNB1 from PDB

Differential gene expression and gene-gene network for KPNB1
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of KPNB1 and the right PPI network was created from samples without mutations in the LBS of KPNB1. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for KPNB1
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0019693HIV Infections1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for KPNB1
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of KPNB1 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
IIIPeptide ligand (ALA,PHE,SER,PHE,GLY)1o6oAE214
IIIPeptide ligand (ALA,PHE,SER,PHE,GLY)1o6oBE214
IIIPeptide ligand (PRO,ALA,PHE,SER,PHE,GLY)1o6oCE214
IIIPeptide ligand (LEU,PHE,GLY)1o6pAE214
IIIPeptide ligand (LEU,PHE,GLY)1o6pBE214
IIIPeptide ligand (UNK,UNK,UNK,UNK,ALA,PHE,SER,PHE)1f59AH216
IIIPeptide ligand (UNK,UNK,ALA,PHE,SER,PHE,GLY)1f59BH216

Conservation information for LBS of KPNB1
Multiple alignments for Q14974 in multiple species
LBSAA sequence# speciesSpecies
A259TYMGPALFAIT3Homo sapiens, Rattus norvegicus, Mus musculus
A259HYM-QDIFNIT1Arabidopsis thaliana
A259PYMEQALYALT1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A259FYMEKALFALT1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A259PYMAQALFPIT1Drosophila melanogaster
A586QSLLCATLQNV3Homo sapiens, Rattus norvegicus, Mus musculus
A586QGLLCGCLQVI1Arabidopsis thaliana
A586QSNILTVLAAV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A586QSNLCNVLTSI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A586QSLLCATLQSV1Drosophila melanogaster
C223IMQVVCEATQC3Homo sapiens, Rattus norvegicus, Mus musculus
C223IMRVVCEATLS1Arabidopsis thaliana
C223LMQVVCEATQA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
C223IMQVVCEATQS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C223IMEVVCEATQC1Drosophila melanogaster
D288WSNVCDEEMDL3Homo sapiens, Rattus norvegicus, Mus musculus
D288WSSICDEEIDI1Arabidopsis thaliana
D288WSTICEEEIDI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D288WSTVCEEEIEV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D288WSNVCDEEIDL1Drosophila melanogaster
D339DENDDDDD--W3Homo sapiens, Rattus norvegicus, Mus musculus
D339EEDQDLDEGAW1Arabidopsis thaliana
D339NEDPEDDD--W1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D339DEDADEDD--W1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D339DECDDEDT--W1Drosophila melanogaster
D340ENDDDDD--WN3Homo sapiens, Rattus norvegicus, Mus musculus
D340EDQDLDEGAWN1Arabidopsis thaliana
D340EDPEDDD--WN1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D340EDADEDD--WN1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D340ECDDEDT--WS1Drosophila melanogaster
D426SVVVRDTTAWT2Rattus norvegicus, Mus musculus
D426SVVVRDTAAWT1Homo sapiens
D426SNHVKDTTAWT1Arabidopsis thaliana
D426SLQVKETTAWC1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D426VIFVKDTTAWA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D426SVIVRDTIAWT1Drosophila melanogaster
D627GGVQEDALMAV3Homo sapiens, Rattus norvegicus, Mus musculus
D627ATAHEEAMLAI1Arabidopsis thaliana
D627AFIEDDVFYAI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D627SVVHEDVLLAI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D627GVVQEEAFLAV1Drosophila melanogaster
D676VGLVGDLCRAL3Homo sapiens, Rattus norvegicus, Mus musculus
D676VGVVGDVCRAL1Arabidopsis thaliana
D676VGFIADISNSL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D676VGLVGDLARAL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D676VGLTGDIFRAL1Drosophila melanogaster
D719LSVFGDIALAI2Homo sapiens, Mus musculus
D719FSCFGDIALAI1Arabidopsis thaliana
D719LSVFGDIASNI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D719LSCFSDIALAI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D719LSAFGDIALSI1Drosophila melanogaster
D719LSVFGDITLAI1Rattus norvegicus
D779QGLKGDQENVH3Homo sapiens, Rattus norvegicus, Mus musculus
D779QGFKNS-----1Arabidopsis thaliana
D779AGLHDK-----1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D779QAVRTD-----1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D779QGLKGVDQTAH1Drosophila melanogaster
D824AGLIGDLCTAF3Homo sapiens, Rattus norvegicus, Mus musculus
D824IGVLGDLADTL1Arabidopsis thaliana
D824VGLIGDIAAMF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D824LGLLGDLAESF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D824AGFIGDLCTSF1Drosophila melanogaster
E212ANFDKESERHF3Homo sapiens, Rattus norvegicus, Mus musculus
E212ANFNNDMERDY1Arabidopsis thaliana
E212NNMEREGERNY1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E212ENFNNEYERNY1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E212SNFEKDMERNF1Drosophila melanogaster
E214FDKESERHFIM3Homo sapiens, Rattus norvegicus, Mus musculus
E214FNNDMERDYIM1Arabidopsis thaliana
E214MEREGERNYLM1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E214FNNEYERNYIM1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E214FEKDMERNFIM1Drosophila melanogaster
E224MQVVCEATQCP3Homo sapiens, Rattus norvegicus, Mus musculus
E224MRVVCEATLSP1Arabidopsis thaliana
E224MQVVCEATQAE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E224MQVVCEATQSP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E224MEVVCEATQCQ1Drosophila melanogaster
E281ALQGIEFWSNV4Homo sapiens, Drosophila melanogaster, Rattus norvegicus, Mus musculus
E281ALQAIEFWSSI1Arabidopsis thaliana
E281ASMTVEFWSTI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E281ALQAVEFWSTV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E395FGSILEGPEPN2Rattus norvegicus, Mus musculus
E395FGCILEGPEPS1Homo sapiens
E395FGSILEGPSAD1Arabidopsis thaliana
E395FGSIMDGPDKV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E395FGSVLEGPNVA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E395FGSVLNGLETN1Drosophila melanogaster
E437VGRICELLPEA3Homo sapiens, Rattus norvegicus, Mus musculus
E437LGRIFEFLHGS1Arabidopsis thaliana
E437IGRIADSVAES1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E437LGQISSFVADA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E437FGRICDIIPEA1Drosophila melanogaster
E530RSSAYESLMEI3Homo sapiens, Rattus norvegicus, Mus musculus
E530RTAAYEALNEV1Arabidopsis thaliana
E530RASAFSALTTM1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E530RTSGYETLGTL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E530RCAAYQALMDM1Drosophila melanogaster
E534YESLMEIVKNS3Homo sapiens, Rattus norvegicus, Mus musculus
E534YEALNEVVRCS1Arabidopsis thaliana
E534FSALTTMVEYA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E534YETLGTLITFS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E534YQALMDMIKNS1Drosophila melanogaster
E626SGGVQEDALMA3Homo sapiens, Rattus norvegicus, Mus musculus
E626SATAHEEAMLA1Arabidopsis thaliana
E626SAFIEDDVFYA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E626QSVVHEDVLLA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E626SGVVQEEAFLA1Drosophila melanogaster
E637VSTLVEVLGGE3Homo sapiens, Rattus norvegicus, Mus musculus
E637IGALAYAAGPN1Arabidopsis thaliana
E637ISALAASLGKG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E637IGAMMNSLEEQ1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E637VSTLVELLGAQ1Drosophila melanogaster
E763LNELRESCLEA3Homo sapiens, Rattus norvegicus, Mus musculus
E763TNSLRNGILEA1Arabidopsis thaliana
E763QIKVLEAVLDA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E763VDALRLGIVEA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E763INELRESILEA1Drosophila melanogaster
E767RESCLEAYTGI3Homo sapiens, Rattus norvegicus, Mus musculus
E767RNGILEAYSGI1Arabidopsis thaliana
E767LEAVLDAYVGI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E767RLGIVEAYVGI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E767RESILEAYTGI1Drosophila melanogaster
E90ANARREVKNYV3Homo sapiens, Rattus norvegicus, Mus musculus
E90MSTKSQIRAFL1Arabidopsis thaliana
E90PEAKNQIKTNA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E90VEIKQQVKSLA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E90SEIRELIKNNI1Drosophila melanogaster
F217ESERHFIMQVV3Homo sapiens, Rattus norvegicus, Mus musculus
F217DMERDYIMRVV1Arabidopsis thaliana
F217EGERNYLMQVV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F217EYERNYIMQVV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F217DMERNFIMEVV1Drosophila melanogaster
G623TAGSGGVQEDA3Homo sapiens, Rattus norvegicus, Mus musculus
G623-CRSATAHEEA1Arabidopsis thaliana
G623KKDSAFIEDDV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G623APKQSVVHEDV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G623AGKSGVVQEEA1Drosophila melanogaster
G672CLAAVGLVGDL3Homo sapiens, Rattus norvegicus, Mus musculus
G672CAVTVGVVGDV1Arabidopsis thaliana
G672SITAVGFIADI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G672CSVAVGLVGDL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G672CCAAVGLTGDI1Drosophila melanogaster
G778VQGLKGDQENV3Homo sapiens, Rattus norvegicus, Mus musculus
G778FQGFKNS----1Arabidopsis thaliana
G778VAGLHDK----1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G778TQAVRTD----1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G778IQGLKGVDQTA1Drosophila melanogaster
G820VACAAGLIGDL3Homo sapiens, Rattus norvegicus, Mus musculus
G820MKTAIGVLGDL1Arabidopsis thaliana
G820SRAAVGLIGDI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G820TRAALGLLGDL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G820LASAAGFIGDL1Drosophila melanogaster
H216KESERHFIMQV3Homo sapiens, Rattus norvegicus, Mus musculus
H216NDMERDYIMRV1Arabidopsis thaliana
H216REGERNYLMQV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H216NEYERNYIMQV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H216KDMERNFIMEV1Drosophila melanogaster
I178ILTAIIQGMRK3Homo sapiens, Rattus norvegicus, Mus musculus
I178ILTAVVQGMNA1Arabidopsis thaliana
I178ILIAIVQGAQS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I178ILTAVVAGARK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I178VLTAIIHGMRK1Drosophila melanogaster
I218SERHFIMQVVC3Homo sapiens, Rattus norvegicus, Mus musculus
I218MERDYIMRVVC1Arabidopsis thaliana
I218GERNYLMQVVC1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I218YERNYIMQVVC1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I218MERNFIMEVVC1Drosophila melanogaster
I263PALFAITIEAM3Homo sapiens, Rattus norvegicus, Mus musculus
I263QDIFNITAKAV1Arabidopsis thaliana
I263QALYALTIATM1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I263KALFALTTQGM1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I263QALFPITLAAM1Drosophila melanogaster
K211KANFDKESERH3Homo sapiens, Rattus norvegicus, Mus musculus
K211QANFNNDMERD1Arabidopsis thaliana
K211KNNMEREGERN1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K211RENFNNEYERN1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K211KSNFEKDMERN1Drosophila melanogaster
K346-WNPCKAAGVC3Homo sapiens, Rattus norvegicus, Mus musculus
K346AWNIAMAGGTC1Arabidopsis thaliana
K346-WNVSMSAGAC1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K346-WNISMAAATC1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K346-WSPAKAASVC1Drosophila melanogaster
K857RSKTNKAKTLA3Homo sapiens, Rattus norvegicus, Mus musculus
K857SSEDHTIKEAA1Arabidopsis thaliana
K857QLFSQATKDTA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K857KISSQQTKDLA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K857RSKAQRTKMLC1Drosophila melanogaster
L174S-NEILTAIIQ3Homo sapiens, Rattus norvegicus, Mus musculus
L174HVNKILTAVVQ1Arabidopsis thaliana
L174S-NNILIAIVQ1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L174S-NAILTAVVA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L174S-NDVLTAIIH1Drosophila melanogaster
L583NDLQSLLCATL4Homo sapiens, Drosophila melanogaster, Rattus norvegicus, Mus musculus
L583NELQGLLCGCL1Arabidopsis thaliana
L583QELQSNILTVL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L583DELQSNLCNVL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L722FGDIALAIGGE2Homo sapiens, Mus musculus
L722FGDIALAIGED1Arabidopsis thaliana
L722FGDIASNIGAD1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L722FSDIALAIGAA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L722FGDIALSIGNH1Drosophila melanogaster
L722FGDITLAIGGE1Rattus norvegicus
M219ERHFIMQVVCE3Homo sapiens, Rattus norvegicus, Mus musculus
M219ERDYIMRVVCE1Arabidopsis thaliana
M219ERNYLMQVVCE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
M219ERNYIMQVVCE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M219ERNFIMEVVCE1Drosophila melanogaster
M353AGVCLMLLSTC2Rattus norvegicus, Mus musculus
M353AGVCLMLLATC1Homo sapiens
M353GGTCLGLVARA1Arabidopsis thaliana
M353AGACLQLFAQN1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
M353AATCLQLFAQV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M353ASVCLMVLATC1Drosophila melanogaster
M388RDAAVMAFGSI2Rattus norvegicus, Mus musculus
M388RDAAVMAFGCI1Homo sapiens
M388REAATYAFGSI1Arabidopsis thaliana
M388REAAVMAFGSI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
M388REAAVMAFGSV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M388RDAAVMTFGSV1Drosophila melanogaster
M533AYESLMEIVKN3Homo sapiens, Rattus norvegicus, Mus musculus
M533AYEALNEVVRC1Arabidopsis thaliana
M533AFSALTTMVEY1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
M533GYETLGTLITF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M533AYQALMDMIKN1Drosophila melanogaster
M630QEDALMAVSTL3Homo sapiens, Rattus norvegicus, Mus musculus
M630HEEAMLAIGAL1Arabidopsis thaliana
M630EDDVFYAISAL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
M630HEDVLLAIGAM1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M630QEEAFLAVSTL1Drosophila melanogaster
N171QDKS-NEILTA3Homo sapiens, Rattus norvegicus, Mus musculus
N171EQEHVNKILTA1Arabidopsis thaliana
N171VSSS-NNILIA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N171SAQS-NAILTA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N171ENQS-NDVLTA1Drosophila melanogaster
N200TNALLNSLEFT3Homo sapiens, Rattus norvegicus, Mus musculus
N200TRALYMALGFA1Arabidopsis thaliana
N200LNALADSLIFI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N200LGALYDSLEFV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N200TTALHNSLEFT1Drosophila melanogaster
N208EFTKANFDKES3Homo sapiens, Rattus norvegicus, Mus musculus
N208GFAQANFNNDM1Arabidopsis thaliana
N208IFIKNNMEREG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N208EFVRENFNNEY1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N208EFTKSNFEKDM1Drosophila melanogaster
N469PRVASNVCWAF3Homo sapiens, Rattus norvegicus, Mus musculus
N469PNVAEKACGAL1Arabidopsis thaliana
N469PKVATNCSWTI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N469PRIVANCCWAF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N469PRVAANVCWAF1Drosophila melanogaster
N86A-IDANARREV3Homo sapiens, Rattus norvegicus, Mus musculus
N86A-LDMSTKSQI1Arabidopsis thaliana
N86TQVSPEAKNQI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N86S-LPVEIKQQV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N86Q-FPSEIRELI1Drosophila melanogaster
P140ANVTNPNSTEH3Homo sapiens, Rattus norvegicus, Mus musculus
P140SNI--HQLPAH1Arabidopsis thaliana
P140DNT-GAEQPEN1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P140ANV-GEGQPSA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P140NKVVSEGSSEM1Drosophila melanogaster
Q159IGYICQDIDP-3Homo sapiens, Rattus norvegicus, Mus musculus
Q159LGYLCEEVSP-1Arabidopsis thaliana
Q159LGYMCESADPQ1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q159IGYICESVSP-1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q159IGYICQDIRF-1Drosophila melanogaster
Q179LTAIIQGMRKE3Homo sapiens, Rattus norvegicus, Mus musculus
Q179LTAVVQGMNAA1Arabidopsis thaliana
Q179LIAIVQGAQST1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q179LTAVVAGARKE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q179LTAIIHGMRKV1Drosophila melanogaster
Q220RHFIMQVVCEA3Homo sapiens, Rattus norvegicus, Mus musculus
Q220RDYIMRVVCEA1Arabidopsis thaliana
Q220RNYLMQVVCEA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q220RNYIMQVVCEA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q220RNFIMEVVCEA1Drosophila melanogaster
Q239RVAALQNLVKI3Homo sapiens, Rattus norvegicus, Mus musculus
Q239RQAAFECLVSI1Arabidopsis thaliana
Q239QAAAFGCLCKI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q239QTAAFGCLVKI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q239CVAALQCLVKI1Drosophila melanogaster
Q278DEVALQGIEFW3Homo sapiens, Rattus norvegicus, Mus musculus
Q278ESVALQAIEFW1Arabidopsis thaliana
Q278DKVASMTVEFW1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q278EQVALQAVEFW1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q278DAVALQGIEFW1Drosophila melanogaster
Q589LCATLQNVLRK2Homo sapiens, Mus musculus
Q589LCGCLQVIIQK1Arabidopsis thaliana
Q589ILTVLAAVIRK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q589LCNVLTSIIRR1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q589LCATLQSVLRK1Drosophila melanogaster
Q589LCATLQNVLWK1Rattus norvegicus
Q665NYAEYQVCLAA2Homo sapiens, Mus musculus
Q665NFEEYQVCAVT1Arabidopsis thaliana
Q665NQVDSPVSITA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q665NEQEYQLCSVA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q665NFQEYQVCCAA1Drosophila melanogaster
Q665NYAECQVCLAA1Rattus norvegicus
Q682LCRALQSNILP2Rattus norvegicus, Mus musculus
Q682LCRALQSNIIP1Homo sapiens
Q682VCRALEDKILP1Arabidopsis thaliana
Q682ISNSLEEDFRR1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q682LARALNAKILP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q682IFRALKDLMVP1Drosophila melanogaster
Q774YTGIVQGLKGD3Homo sapiens, Rattus norvegicus, Mus musculus
Q774YSGIFQGFKNS1Arabidopsis thaliana
Q774YVGIVAGLHDK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q774YVGITQAVRTD1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q774YTGIIQGLKGV1Drosophila melanogaster
R182IIQGMRKEEPS3Homo sapiens, Rattus norvegicus, Mus musculus
R182VVQGMNAAEGN1Arabidopsis thaliana
R182IVQGAQSTETS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R182VVAGARKEEPD1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R182IIHGMRKVEPS1Drosophila melanogaster
R434AWTVGRICELL3Homo sapiens, Rattus norvegicus, Mus musculus
R434AWTLGRIFEFL1Arabidopsis thaliana
R434AWCIGRIADSV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R434AWALGQISSFV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R434AWTFGRICDII1Drosophila melanogaster
R593LQNVLRKVQHQ2Homo sapiens, Mus musculus
R593LQVIIQKLGSE1Arabidopsis thaliana
R593LAAVIRK-SPS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R593LTSIIRRFGP-1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R593LQSVLRKVHEQ1Drosophila melanogaster
R593LQNVLWKVQHQ1Rattus norvegicus
R679VGDLCRALQSN3Homo sapiens, Rattus norvegicus, Mus musculus
R679VGDVCRALEDK1Arabidopsis thaliana
R679IADISNSLEED1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R679VGDLARALNAK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R679TGDIFRALKDL1Drosophila melanogaster
S213NFDKESERHFI3Homo sapiens, Rattus norvegicus, Mus musculus
S213NFNNDMERDYI1Arabidopsis thaliana
S213NMEREGERNYL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S213NFNNEYERNYI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S213NFEKDMERNFI1Drosophila melanogaster
S582FNDLQSLLCAT4Homo sapiens, Drosophila melanogaster, Rattus norvegicus, Mus musculus
S582QNELQGLLCGC1Arabidopsis thaliana
S582LQELQSNILTV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S582HDELQSNLCNV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S633ALMAVSTLVEV3Homo sapiens, Rattus norvegicus, Mus musculus
S633AMLAIGALAYA1Arabidopsis thaliana
S633VFYAISALAAS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S633VLLAIGAMMNS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S633AFLAVSTLVEL1Drosophila melanogaster
S715KPQILSVFGDI3Homo sapiens, Rattus norvegicus, Mus musculus
S715KPPIFSCFGDI1Arabidopsis thaliana
S715KPAVLSVFGDI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S715KPAILSCFSDI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S715KPQVLSAFGDI1Drosophila melanogaster
T175-NEILTAIIQG3Homo sapiens, Rattus norvegicus, Mus musculus
T175VNKILTAVVQG1Arabidopsis thaliana
T175-NNILIAIVQG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T175-NAILTAVVAG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T175-NDVLTAIIHG1Drosophila melanogaster
T35VENLPTFLVEL3Homo sapiens, Rattus norvegicus, Mus musculus
T35EQNLAGFLLSL1Arabidopsis thaliana
T35NDNFLQFAGLS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T35RTDFAQYMVLL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T35ASNLPEFLKAL1Drosophila melanogaster
T770CLEAYTGIVQG3Homo sapiens, Rattus norvegicus, Mus musculus
T770ILEAYSGIFQG1Arabidopsis thaliana
T770VLDAYVGIVAG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T770IVEAYVGITQA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T770ILEAYTGIIQG1Drosophila melanogaster
V55SQVARVAAGLQ3Homo sapiens, Rattus norvegicus, Mus musculus
V55PVDSRKLAGLV1Arabidopsis thaliana
V55KLEGRILAALT1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V55MPYIRMAAGLA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V55SAVARMAAGLQ1Drosophila melanogaster
W342DDD--WNPCKA3Homo sapiens, Rattus norvegicus, Mus musculus
W342LDEGAWNIAMA1Arabidopsis thaliana
W342DDD--WNVSMS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
W342EDD--WNISMA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
W342EDT--WSPAKA1Drosophila melanogaster
W430RDTTAWTVGRI2Rattus norvegicus, Mus musculus
W430RDTAAWTVGRI1Homo sapiens
W430KDTTAWTLGRI1Arabidopsis thaliana
W430KETTAWCIGRI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
W430KDTTAWALGQI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
W430RDTIAWTFGRI1Drosophila melanogaster
W472ASNVCWAFSSL3Homo sapiens, Rattus norvegicus, Mus musculus
W472AEKACGALYFL1Arabidopsis thaliana
W472ATNCSWTIINL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
W472VANCCWAFMNL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
W472AANVCWAFIGL1Drosophila melanogaster
W864KTLATWATKEL3Homo sapiens, Rattus norvegicus, Mus musculus
W864KEAAEWAKHAI1Arabidopsis thaliana
W864KDTARWAREQQ1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
W864KDLARWATEQV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
W864KMLCTWAVKEI1Drosophila melanogaster
Y104LGTETYR-PSS3Homo sapiens, Rattus norvegicus, Mus musculus
Y104LSAPVPDVRST1Arabidopsis thaliana
Y104LVSIEPRIANA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y104LGSSEHQAGQS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y104LGTENTR-PSC1Drosophila melanogaster
Y156LEAIGYICQDI4Homo sapiens, Drosophila melanogaster, Rattus norvegicus, Mus musculus
Y156LETLGYLCEEV1Arabidopsis thaliana
Y156LLALGYMCESA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y156LQTIGYICESV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y255QYMETYMGPAL3Homo sapiens, Rattus norvegicus, Mus musculus
Y255EKLAHYM-QDI1Arabidopsis thaliana
Y255TFMKPYMEQAL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y255DTMPFYMEKAL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y255QYMEPYMAQAL1Drosophila melanogaster

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