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mutLBSgeneDB |
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| Gene summary for RHOC |
 Gene summary |
| Basic gene Info. | Gene symbol | RHOC |
| Gene name | ras homolog family member C | |
| Synonyms | ARH9|ARHC|H9|RHOH9 | |
| Cytomap | UCSC genome browser: 1p13.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001042678.1, NM_001042679.1,NM_175744.4, | |
| Description | RAS-related homolog 9oncogene RHO H9ras homolog gene family, member Crho cDNA clone 9rho-related GTP-binding protein RhoCrhoC GTPasesmall GTP binding protein RhoC | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 165380 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000155366 | ||
| HPRD : 01322 | ||
| Vega : OTTHUMG00000011905 | ||
| Protein | UniProt: P08134 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_RHOC | |
| BioGPS: 389 | ||
| Pathway | NCI Pathway Interaction Database: RHOC | |
| KEGG: RHOC | ||
| REACTOME: RHOC | ||
| Pathway Commons: RHOC | ||
| Context | iHOP: RHOC | |
| ligand binding site mutation search in PubMed: RHOC | ||
| UCL Cancer Institute: RHOC | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0000910 | cytokinesis | 16236794 | GO:0043297 | apical junction assembly | 20974804 |
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| Ligand binding site mutations for RHOC |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | D120 | D120N | COAD | 1 | K162 | K162N | LUSC | 1 | F30 | P31S | SKCM | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for RHOC |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | K162 | K162N | -1.3226513 | F30 | P31S | -0.84475333 | D120 | D120N | -0.70806955 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for RHOC from PDB |
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| Differential gene expression and gene-gene network for RHOC |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for RHOC |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C0151744 | Myocardial Ischemia | 1 | Biomarker |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for RHOC |
| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of RHOC go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | GNP | PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | 1z2c | A | F30 D120 K162 | GNP | PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | 1z2c | C | F30 D120 K162 | GDP | GUANOSINE-5'-DIPHOSPHATE | 2gcn | A | F30 D120 K162 | GNP | PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | 2gco | A | F30 D120 K162 | GNP | PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | 2gco | B | F30 D120 K162 | GSP | GUANOSINE 5'-[GAMMA-THIO]TRIPHOSPHATE | 2gcp | A | F30 D120 K162 |
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| Conservation information for LBS of RHOC |
| Multiple alignments for P08134 in multiple species |
| LBS | AA sequence | # species | Species | A15 | IVGDGACGKTC | 8 | Homo sapiens, Caenorhabditis elegans, Bos taurus, Mus musculus, Gallus gallus, Danio rerio, Danio rerio, Danio rerio | A161 | YLECSAKTKEG | 5 | Homo sapiens, Bos taurus, Mus musculus, Gallus gallus, Danio rerio | A161 | YLECSAKTKDG | 3 | Caenorhabditis elegans, Danio rerio, Danio rerio | C16 | VGDGACGKTCL | 8 | Homo sapiens, Caenorhabditis elegans, Bos taurus, Mus musculus, Gallus gallus, Danio rerio, Danio rerio, Danio rerio | C20 | ACGKTCLLIVF | 8 | Homo sapiens, Caenorhabditis elegans, Bos taurus, Mus musculus, Gallus gallus, Danio rerio, Danio rerio, Danio rerio | D120 | VGNKKDLRNDE | 4 | Gallus gallus, Danio rerio, Danio rerio, Danio rerio | D120 | VGNKKDLRQDE | 3 | Homo sapiens, Bos taurus, Mus musculus | D120 | VGNKRDLRSDP | 1 | Caenorhabditis elegans | F30 | FSKDQFPEVYV | 7 | Homo sapiens, Bos taurus, Mus musculus, Gallus gallus, Danio rerio, Danio rerio, Danio rerio | F30 | FSKDQFPDVYV | 1 | Caenorhabditis elegans | G14 | VIVGDGACGKT | 8 | Homo sapiens, Caenorhabditis elegans, Bos taurus, Mus musculus, Gallus gallus, Danio rerio, Danio rerio, Danio rerio | G17 | GDGACGKTCLL | 8 | Homo sapiens, Caenorhabditis elegans, Bos taurus, Mus musculus, Gallus gallus, Danio rerio, Danio rerio, Danio rerio | G62 | LWDTAGQEDYD | 8 | Homo sapiens, Caenorhabditis elegans, Bos taurus, Mus musculus, Gallus gallus, Danio rerio, Danio rerio, Danio rerio | K118 | ILVGNKKDLRN | 4 | Gallus gallus, Danio rerio, Danio rerio, Danio rerio | K118 | ILVGNKKDLRQ | 3 | Homo sapiens, Bos taurus, Mus musculus | K118 | ILVGNKRDLRS | 1 | Caenorhabditis elegans | K162 | LECSAKTKEGV | 5 | Homo sapiens, Bos taurus, Mus musculus, Gallus gallus, Danio rerio | K162 | LECSAKTKDGV | 2 | Danio rerio, Danio rerio | K162 | LECSAKTKDGI | 1 | Caenorhabditis elegans | K18 | DGACGKTCLLI | 8 | Homo sapiens, Caenorhabditis elegans, Bos taurus, Mus musculus, Gallus gallus, Danio rerio, Danio rerio, Danio rerio | L121 | GNKKDLRNDEH | 4 | Gallus gallus, Danio rerio, Danio rerio, Danio rerio | L121 | GNKKDLRQDEH | 3 | Homo sapiens, Bos taurus, Mus musculus | L121 | GNKRDLRSDPQ | 1 | Caenorhabditis elegans | R145 | KPEEGRDMANR | 4 | Gallus gallus, Danio rerio, Danio rerio, Danio rerio | R145 | RSEEGRDMANR | 3 | Homo sapiens, Bos taurus, Mus musculus | R145 | KPEQGRAIAEQ | 1 | Caenorhabditis elegans | S160 | GYLECSAKTKE | 5 | Homo sapiens, Bos taurus, Mus musculus, Gallus gallus, Danio rerio | S160 | GYLECSAKTKD | 2 | Danio rerio, Danio rerio | S160 | AYLECSAKTKD | 1 | Caenorhabditis elegans | T19 | GACGKTCLLIV | 8 | Homo sapiens, Caenorhabditis elegans, Bos taurus, Mus musculus, Gallus gallus, Danio rerio, Danio rerio, Danio rerio | T37 | EVYVPTVFENY | 7 | Homo sapiens, Bos taurus, Mus musculus, Gallus gallus, Danio rerio, Danio rerio, Danio rerio | T37 | DVYVPTVFENY | 1 | Caenorhabditis elegans | V35 | FPEVYVPTVFE | 7 | Homo sapiens, Bos taurus, Mus musculus, Gallus gallus, Danio rerio, Danio rerio, Danio rerio | V35 | FPDVYVPTVFE | 1 | Caenorhabditis elegans | Y156 | ISAFGYLECSA | 4 | Homo sapiens, Bos taurus, Mus musculus, Danio rerio | Y156 | INAFGYLECSA | 3 | Gallus gallus, Danio rerio, Danio rerio | Y156 | IGAFAYLECSA | 1 | Caenorhabditis elegans |
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