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mutLBSgeneDB |
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| Gene summary for LGALS4 |
 Gene summary |
| Basic gene Info. | Gene symbol | LGALS4 |
| Gene name | lectin, galactoside-binding, soluble, 4 | |
| Synonyms | GAL4|L36LBP | |
| Cytomap | UCSC genome browser: 19q13.2 | |
| Type of gene | protein-coding | |
| RefGenes | NM_006149.3, | |
| Description | L-36 lactose-binding proteinantigen NY-CO-27gal-4galectin 4galectin-4lactose-binding lectin 4 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 602518 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000171747 | ||
| HPRD : 03949 | ||
| Vega : OTTHUMG00000182608 | ||
| Protein | UniProt: P56470 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_LGALS4 | |
| BioGPS: 3960 | ||
| Pathway | NCI Pathway Interaction Database: LGALS4 | |
| KEGG: LGALS4 | ||
| REACTOME: LGALS4 | ||
| Pathway Commons: LGALS4 | ||
| Context | iHOP: LGALS4 | |
| ligand binding site mutation search in PubMed: LGALS4 | ||
| UCL Cancer Institute: LGALS4 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
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| Ligand binding site mutations for LGALS4 |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | R279 | R279G | BLCA | 1 | R279 | R279H | BRCA | 1 | E259 | E259K | HNSC | 1 | R240 | G242S | LUSC | 1 | W84 | G82R | LUSC | 1 | W84 | G82E | SKCM | 1 | R240 | R240H | STAD | 1 | H236 | L235M | UCEC | 1 | R205 | A204T | UCEC | 1 | R240 | R240H | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for LGALS4 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | E259 | E259K | 0.046515277 | R279 | R279G | -1.6600035 | R240 | R240H | -1.6466146 | R279 | R279H | -1.6141814 | H236 | L235M | -1.4330623 | R240 | G242S | -1.0038966 | W84 | G82R | -0.72715183 | W84 | G82E | -0.7089926 | R205 | A204T | -0.38457009 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for LGALS4 from PDB |
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| Differential gene expression and gene-gene network for LGALS4 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for LGALS4 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for LGALS4 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of LGALS4 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | NAG | ALDEHYDO-N-ACETYL-D-GLUCOSAMINE | 4ylz | A | H236 | NAG | ALDEHYDO-N-ACETYL-D-GLUCOSAMINE | 4ylz | C | H236 | NAG | ALDEHYDO-N-ACETYL-D-GLUCOSAMINE | 4ylz | D | H236 | NAG | ALDEHYDO-N-ACETYL-D-GLUCOSAMINE | 4ym0 | A | H236 | NAG | ALDEHYDO-N-ACETYL-D-GLUCOSAMINE | 4ym0 | B | H236 | LAT | BETA-LACTOSE | 4ylz | A | H236 R240 E259 | LAT | BETA-LACTOSE | 4ylz | C | H236 R240 E259 | LAT | BETA-LACTOSE | 4ylz | D | H236 R240 E259 | LAT | BETA-LACTOSE | 4ym0 | A | H236 R240 E259 | LAT | BETA-LACTOSE | 4ym0 | B | H236 R240 E259 | GAL | BETA-D-GALACTOSE | 4ym0 | D | H236 R240 E259 | LAT | BETA-LACTOSE | 4ym0 | C | H236 R240 E259 | LAT | BETA-LACTOSE | 4ym1 | A | H236 R240 E259 | LAT | BETA-LACTOSE | 4ym1 | B | H236 R240 E259 | SGA | O3-SULFONYLGALACTOSE | 4ym2 | A | H236 R240 E259 | SGA | O3-SULFONYLGALACTOSE | 4ym2 | B | H236 R240 E259 | LAT | BETA-LACTOSE | 4ym2 | C | H236 R240 E259 | LAT | BETA-LACTOSE | 4ym2 | D | H236 R240 E259 | LAT | BETA-LACTOSE | 4ym3 | A | H236 R240 E259 | LAT | BETA-LACTOSE | 4ym3 | B | H236 R240 E259 | LAT | BETA-LACTOSE | 4ym3 | C | H236 R240 E259 | LAT | BETA-LACTOSE | 4ym3 | D | H236 R240 E259 | LAT | BETA-LACTOSE | 5cbl | A | H236 R240 E259 | LAT | BETA-LACTOSE | 5cbl | B | H236 R240 E259 | LAT | BETA-LACTOSE | 5cbl | C | H236 R240 E259 | LAT | BETA-LACTOSE | 5cbl | D | H236 R240 E259 | SO4 | SULFATE | 4ym1 | C | R205 R279 | BGC | BETA-D-GLUCOSE | 4ym2 | A | R240 E259 | BGC | BETA-D-GLUCOSE | 4ym2 | B | R240 E259 | SO4 | SULFATE | 4ym1 | A | R279 |
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| Conservation information for LBS of LGALS4 |
| Multiple alignments for P56470 in multiple species |
| LBS | AA sequence | # species | Species | A222 | TGKSFAINFKV | 1 | Homo sapiens | A222 | TARNFVINFKV | 1 | Mus musculus | A222 | TAKNLIINFKV | 1 | Rattus norvegicus | A222 | TAKSFVINFKV | 1 | Bos taurus | D283 | IRCGLDRFKVY | 1 | Homo sapiens | D283 | IRCGMDRFKVF | 1 | Mus musculus | D283 | IRCGTDRFKVF | 1 | Rattus norvegicus | D283 | VRCGADRFKVY | 1 | Bos taurus | E259 | GSWGSEEKKIT | 1 | Homo sapiens | E259 | GSWGAEERKVA | 1 | Mus musculus | E259 | GSWGSEERKIP | 1 | Rattus norvegicus | E259 | GSWGSEERKVS | 1 | Bos taurus | E311 | RVDTLEIQGDV | 1 | Homo sapiens | E311 | MVDTLEINGDI | 1 | Mus musculus | E311 | RVDMLEIKGDI | 1 | Rattus norvegicus | E311 | RVDLVEIHGDV | 1 | Bos taurus | G281 | LSIRCGLDRFK | 1 | Homo sapiens | G281 | LSIRCGMDRFK | 1 | Mus musculus | G281 | LSIRCGTDRFK | 1 | Rattus norvegicus | G281 | LSVRCGADRFK | 1 | Bos taurus | H236 | GDIALHINPRM | 1 | Homo sapiens | H236 | GDIALHLNPRI | 1 | Mus musculus | H236 | GDIAFHMNPRI | 1 | Rattus norvegicus | H236 | GDVALHINPRM | 1 | Bos taurus | I233 | GSSGDIALHIN | 1 | Homo sapiens | I233 | GSSGDIALHLN | 1 | Mus musculus | I233 | GSTGDIAFHMN | 1 | Rattus norvegicus | I233 | GSSGDVALHIN | 1 | Bos taurus | K226 | FVINFKVGSSG | 2 | Mus musculus, Bos taurus | K226 | FAINFKVGSSG | 1 | Homo sapiens | K226 | LIINFKVGSTG | 1 | Rattus norvegicus | K286 | GLDRFKVYANG | 1 | Homo sapiens | K286 | GMDRFKVFANG | 1 | Mus musculus | K286 | GTDRFKVFANG | 1 | Rattus norvegicus | K286 | GADRFKVYANG | 1 | Bos taurus | L282 | SIRCGLDRFKV | 1 | Homo sapiens | L282 | SIRCGMDRFKV | 1 | Mus musculus | L282 | SIRCGTDRFKV | 1 | Rattus norvegicus | L282 | SVRCGADRFKV | 1 | Bos taurus | N224 | KSFAINFKVGS | 1 | Homo sapiens | N224 | RNFVINFKVGS | 1 | Mus musculus | N224 | KNLIINFKVGS | 1 | Rattus norvegicus | N224 | KSFVINFKVGS | 1 | Bos taurus | N238 | IALHINPRMGN | 1 | Homo sapiens | N238 | IALHLNPRIGD | 1 | Mus musculus | N238 | IAFHMNPRIGD | 1 | Rattus norvegicus | N238 | VALHINPRMTE | 1 | Bos taurus | N249 | GTVVRNSLLNG | 1 | Homo sapiens | N249 | -SVVRNSFMNG | 1 | Mus musculus | N249 | -CVVRNSYMNG | 1 | Rattus norvegicus | N249 | GAVVRNSFLNG | 1 | Bos taurus | Q313 | DTLEIQGDVTL | 1 | Homo sapiens | Q313 | DTLEINGDITL | 1 | Mus musculus | Q313 | DMLEIKGDITL | 1 | Rattus norvegicus | Q313 | DLVEIHGDVTL | 1 | Bos taurus | R205 | GGLTARRTIII | 2 | Homo sapiens, Rattus norvegicus | R205 | GGLTVRRTIII | 1 | Mus musculus | R205 | GGLIVRRTIII | 1 | Bos taurus | R240 | LHINPRMGNGT | 1 | Homo sapiens | R240 | LHLNPRIGD-S | 1 | Mus musculus | R240 | FHMNPRIGD-C | 1 | Rattus norvegicus | R240 | LHINPRMTEGA | 1 | Bos taurus | R279 | FDLSIRCGLDR | 1 | Homo sapiens | R279 | FDLSIRCGMDR | 1 | Mus musculus | R279 | FDLSIRCGTDR | 1 | Rattus norvegicus | R279 | FDLSVRCGADR | 1 | Bos taurus | R284 | RCGLDRFKVYA | 1 | Homo sapiens | R284 | RCGMDRFKVFA | 1 | Mus musculus | R284 | RCGTDRFKVFA | 1 | Rattus norvegicus | R284 | RCGADRFKVYA | 1 | Bos taurus | V247 | GNGTVVRNSLL | 1 | Homo sapiens | V247 | GD-SVVRNSFM | 1 | Mus musculus | V247 | GD-CVVRNSYM | 1 | Rattus norvegicus | V247 | TEGAVVRNSFL | 1 | Bos taurus | W84 | MQSGQWGKEEK | 2 | Mus musculus, Rattus norvegicus | W84 | LQGGKWGSEER | 1 | Homo sapiens | W84 | KQNGSWGQEER | 1 | Bos taurus |
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