mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for MAT2A
Gene summary
Basic gene Info.Gene symbolMAT2A
Gene namemethionine adenosyltransferase II, alpha
SynonymsMATA2|MATII|SAMS2
CytomapUCSC genome browser: 2p11.2
Type of geneprotein-coding
RefGenesNM_005911.5,
DescriptionMAT 2MAT-IIS-adenosylmethionine synthase isoform type-2adoMet synthase 2adoMet synthetase 2methionine adenosyltransferase 2
Modification date20141207
dbXrefs MIM : 601468
HGNC : HGNC
Ensembl : ENSG00000168906
HPRD : 03275
Vega : OTTHUMG00000130174
ProteinUniProt: P31153
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_MAT2A
BioGPS: 4144
PathwayNCI Pathway Interaction Database: MAT2A
KEGG: MAT2A
REACTOME: MAT2A
Pathway Commons: MAT2A
ContextiHOP: MAT2A
ligand binding site mutation search in PubMed: MAT2A
UCL Cancer Institute: MAT2A
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0006556S-adenosylmethionine biosynthetic process10644686


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Ligand binding site mutations for MAT2A

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
D258Q256HBLCA1
D179R177HCOAD1
D179R177COV1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for MAT2A
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
D258Q256H0.21051895
D179R177H-1.2355592
D179R177C-0.92486087
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for MAT2A from PDB

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Differential gene expression and gene-gene network for MAT2A
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of MAT2A and the right PPI network was created from samples without mutations in the LBS of MAT2A. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for MAT2A
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0017661Glomerulonephritis, IGA1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for MAT2A
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
Approved|nutraceuticalDB00118S-AdenosylmethionineSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of MAT2A go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS


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Conservation information for LBS of MAT2A
Multiple alignments for P31153 in multiple species
LBSAA sequence# speciesSpecies
D179PWLRPDSKTQV3Homo sapiens, Rattus norvegicus, Mus musculus
D179EWVRPDSKTQV3Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans
D179PWLRPDTKTQV2Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D179PWLRPDGKTQV1Arabidopsis thaliana
D179AWLRPDTKTQV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D179PWVRPDSKSQV1Caenorhabditis elegans
D179WWARPDSKTQV1Drosophila melanogaster
D258GGPQGDAGLTG6Homo sapiens, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Rattus norvegicus, Mus musculus
D258GGPMGDAGLTG4Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Drosophila melanogaster
D258GGPHGDAGLTG1Arabidopsis thaliana
D258GGPMGDAGVTG1Caenorhabditis elegans
F250QPSGRFVIGGP5Homo sapiens, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Rattus norvegicus, Mus musculus
F250NPCGSFIIGGP2Caenorhabditis elegans, Caenorhabditis elegans
F250NPSGRFVIGGP1Arabidopsis thaliana
F250QPSGRFVVGGP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F250NPCGTFIVGGP1Caenorhabditis elegans
F250NPCGSFVVGGP1Caenorhabditis elegans
F250NPCGLFVIGGP1Drosophila melanogaster
H29SVGEGHPDKIC6Homo sapiens, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Rattus norvegicus, Mus musculus
H29SVSEGHPDKMC4Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans
H29SVNEGHPDKLC1Arabidopsis thaliana
H29SVGEGHPDKMC1Drosophila melanogaster
K181LRPDSKTQVTV3Homo sapiens, Rattus norvegicus, Mus musculus
K181VRPDSKTQVTI3Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans
K181LRPDTKTQVTV2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K181LRPDGKTQVTV1Arabidopsis thaliana
K181LRPDTKTQVTI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K181VRPDSKSQVTI1Caenorhabditis elegans
K181ARPDSKTQVTC1Drosophila melanogaster
P30VGEGHPDKICD6Homo sapiens, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Rattus norvegicus, Mus musculus
P30VSEGHPDKMCD4Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans, Caenorhabditis elegans
P30VNEGHPDKLCD1Arabidopsis thaliana
P30VGEGHPDKMCD1Drosophila melanogaster
R249LQPSGRFVIGG3Homo sapiens, Rattus norvegicus, Mus musculus
R249IQPSGRFVIGG2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R249LNPCGSFIIGG2Caenorhabditis elegans, Caenorhabditis elegans
R249LNPSGRFVIGG1Arabidopsis thaliana
R249IQPSGRFVVGG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R249INPCGTFIVGG1Caenorhabditis elegans
R249LNPCGSFVVGG1Caenorhabditis elegans
R249INPCGLFVIGG1Drosophila melanogaster
S247YHLQPSGRFVI3Homo sapiens, Rattus norvegicus, Mus musculus
S247YFIQPSGRFVI2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S247YHLNPCGSFII2Caenorhabditis elegans, Caenorhabditis elegans
S247FHLNPSGRFVI1Arabidopsis thaliana
S247YHIQPSGRFVV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S247FHINPCGTFIV1Caenorhabditis elegans
S247YHLNPCGSFVV1Caenorhabditis elegans
S247VHINPCGLFVI1Drosophila melanogaster


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